Sqstm1 (sequestosome 1) - Rat Genome Database

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Gene: Sqstm1 (sequestosome 1) Rattus norvegicus
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Symbol: Sqstm1
Name: sequestosome 1
RGD ID: 69287
Description: Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body. Is active in glutamatergic synapse. Biomarker of acute myocardial infarction; glaucoma; and hypertension. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1); PARTICIPATES IN interleukin-1 signaling pathway; mitochondrial autophagy pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH (+)-schisandrin B; (-)-anisomycin; 1,3-dichloropropan-2-ol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: induced oxidative stress-like; Osi; oxidative stress induced; PKC-zeta-interacting protein; protein kinase C-zeta-interacting protein; sequestosome-1; ubiquitin-binding protein p62; ZIP; ZIP3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,026,598 - 35,037,750 (-)NCBIGRCr8
mRatBN7.21034,525,517 - 34,536,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,525,519 - 34,536,673 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,200,880 - 39,212,041 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,740,133 - 7,751,294 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,194,553 - 34,205,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,704,728 - 35,716,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,704,730 - 35,716,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,463,172 - 35,474,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,751,300 - 35,762,630 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,752,706 - 35,763,676 (-)NCBI
Celera1033,874,680 - 33,885,832 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
(S)-ropivacaine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,4-benzoquinone  (ISO)
1-monopalmitoylglycerol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(chloromethyl)pyridine  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-methoxy-TEMPO  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7beta-aminocephalosporanic acid  (ISO)
A-967079  (ISO)
abamectin  (ISO)
ABT-737  (ISO)
acarbose  (ISO)
acetaldehyde  (ISO)
acetylcholine  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
Aescin  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
Ajugasterone C  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
aloxistatin  (ISO)
alpha,alpha-trehalose  (EXP,ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
Alpinetin  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
ammonium hexachloroplatinate  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apilimod  (ISO)
aprepitant  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
astemizole  (EXP)
astragaloside IV  (EXP)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
avobenzone  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP,ISO)
Bafilomycin B1  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
benzene-1,2,4-triol  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
beta-thujaplicin  (ISO)
bexarotene  (EXP)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
bortezomib  (EXP,ISO)
brazilin  (ISO)
Brusatol  (EXP)
buprofezin  (ISO)
busulfan  (ISO)
butachlor  (ISO)
butane-2,3-dione  (ISO)
butyric acid  (ISO)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
camptothecin  (ISO)
cannabidiol  (ISO)
capivasertib  (ISO)
carbamazepine  (EXP,ISO)
carbon disulfide  (EXP,ISO)
carbon nanotube  (ISO)
carglumic acid  (ISO)
CCCP  (ISO)
celastrol  (EXP,ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloroacetaldehyde  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (ISO)
cholic acid  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (EXP,ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (EXP,ISO)
cortisol  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cryptotanshinone  (ISO)
cucurbitacin E  (ISO)
curcumin  (ISO)
Curcumol  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP,ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
dapagliflozin  (EXP)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenzofuran  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diisononyl phthalate  (ISO)
dimethyl fumarate  (ISO)
dinitrogen  (ISO)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium oxide  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP,ISO)
Doramectin  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
embelin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
Enterolactone  (ISO)
epichlorohydrin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etomoxir  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
fangchinoline  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
fenvalerate  (EXP)
ferrostatin-1  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavokawain B  (ISO)
flufenoxuron  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
Forsythiaside  (ISO)
FR900359  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furosemide  (EXP)
Fusaric acid  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gefitinib  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
Ginkgoic acid  (ISO)
ginsenoside Rb1  (EXP,ISO)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
glycine  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (EXP)
gossypetin  (ISO)
graphene oxide  (ISO)
graphite  (EXP,ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
Honokiol  (ISO)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inositol  (EXP)
iodixanol  (EXP)
iohexol  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
Isobavachin  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
Jujuboside A  (ISO)
kainic acid  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-leucine  (ISO)
lactucin  (ISO)
lactulose  (EXP,ISO)
lanthanum trichloride  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
linagliptin  (EXP)
lipopolysaccharide  (EXP,ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lithium chloride  (ISO)
LY294002  (ISO)
lycopene  (EXP,ISO)
Maduramicin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
melibiose  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mesalamine  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
metronidazole  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mirtazapine  (EXP,ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (EXP)
monocrotaline  (EXP)
Morroniside  (EXP)
morusin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nintedanib  (ISO)
NMN zwitterion  (ISO)
Nonidet P-40  (ISO)
notoginsenoside R1  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
octreotide  (ISO)
olaparib  (EXP)
oleanolic acid  (ISO)
oleic acid  (ISO)
oligomycin A  (ISO)
organoselenium compound  (ISO)
osimertinib  (ISO)
osthole  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraformaldehyde macromolecule  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PCB138  (EXP)
pectolinarigenin  (ISO)
pentachlorophenol  (ISO)
pepstatin A  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (EXP)
permethrin  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
Plantamajoside  (ISO)
plumbagin  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (EXP)
prodigiosin  (ISO)
progesterone  (ISO)
promethazine  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
quinolinic acid  (EXP)
rac-1-monopalmitoylglycerol  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rhein  (ISO)
rifampicin  (ISO)
Riluzole  (ISO)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
SCH772984  (ISO)
Securinine  (ISO)
selenium atom  (EXP)
sepantronium  (ISO)
sertraline  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP)
SKF-96365 hydrochloride  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Sodium oleate  (ISO)
Soman  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (EXP)
stattic  (ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
swainsonine  (EXP,ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
Temsirolimus  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
Thiamet G  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trans-piceid  (ISO)
triacsin C  (ISO)
tributylstannane  (ISO)
tricalcium bis(phosphate)  (ISO)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
trimethyltin  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
tyloxapol  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
venetoclax  (ISO)
venlafaxine hydrochloride  (EXP)
vincristine  (ISO)
vismodegib  (ISO)
vitamin D  (ISO)
water  (ISO)
wortmannin  (ISO)
XAV939  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
aggresome  (IBA,IEA,ISO)
amphisome  (IBA,IEA,ISO)
autolysosome  (IEA,ISO)
autophagosome  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA)
endosome  (IEA)
glutamatergic synapse  (IDA)
inclusion body  (IEA,ISO)
late endosome  (IEA)
Lewy body  (IDA)
lysosome  (IEA)
mitochondrion  (IEA,ISO)
nucleus  (IEA)
P-body  (IEA,ISO,ISS)
phagophore assembly site  (IEA,ISO)
PML body  (IEA,ISO)
sarcomere  (IEA)
sperm midpiece  (IEA,ISO)
synapse  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease. Babuta M, etal., Hepatology. 2019 Dec;70(6):2123-2141. doi: 10.1002/hep.30766. Epub 2019 Jun 24.
2. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Castillo K, etal., Autophagy. 2013 Sep;9(9):1308-20. doi: 10.4161/auto.25188. Epub 2013 Jun 6.
3. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, etal., J Biol Chem 2003 Feb 21;278(8):6128-35.
4. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Gong J, etal., Science. 1999 Sep 3;285(5433):1565-9.
7. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
8. Angiotensin-(1-7) inhibits autophagy in the brain of spontaneously hypertensive rats. Jiang T, etal., Pharmacol Res. 2013 May;71:61-8. doi: 10.1016/j.phrs.2013.03.001. Epub 2013 Mar 15.
9. Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration. Kitaoka Y, etal., Cell Death Dis. 2013 Oct 17;4:e860. doi: 10.1038/cddis.2013.391.
10. Mitochondria and mitophagy: the yin and yang of cell death control. Kubli DA and Gustafsson AB, Circ Res. 2012 Oct 12;111(9):1208-21. doi: 10.1161/CIRCRESAHA.112.265819.
11. Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone. Laurin N, etal., Am J Hum Genet. 2002 Jun;70(6):1582-8. Epub 2002 Apr 30.
12. Acute hyperglycemia together with hematoma of high-glucose blood exacerbates neurological injury in a rat model of intracerebral hemorrhage. Liu RY, etal., Neurosci Bull. 2014 Feb;30(1):90-8. doi: 10.1007/s12264-013-1371-6. Epub 2013 Jul 25.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease. Nakaso K, etal., Brain Res. 2004 Jun 25;1012(1-2):42-51.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Bassoon Controls Presynaptic Autophagy through Atg5. Okerlund ND, etal., Neuron. 2017 Feb 22;93(4):897-913.e7. doi: 10.1016/j.neuron.2017.01.026.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Puls A, etal., Proc Natl Acad Sci U S A 1997 Jun 10;94(12):6191-6.
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and methoxyacetic acid. Syed V and Hecht NB, Endocrinology 1998 Aug;139(8):3503-11.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Regulation of endoplasmic reticulum stress in rat cortex by p62/ZIP through the Keap1-Nrf2-ARE signalling pathway after transient focal cerebral ischaemia. Wang W, etal., Brain Inj. 2013;27(7-8):924-33. doi: 10.3109/02699052.2013.793397. Epub 2013 Jun 19.
27. Increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux. Wu X, etal., J Mol Cell Cardiol. 2018 Nov;124:70-82. doi: 10.1016/j.yjmcc.2018.08.018. Epub 2018 Aug 23.
28. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Zhang XX, etal., Biomed Microdevices. 2022 Oct 29;24(4):37. doi: 10.1007/s10544-022-00622-2.
Additional References at PubMed
PMID:8650207   PMID:10366737   PMID:11162503   PMID:11244088   PMID:11500922   PMID:11981755   PMID:12857745   PMID:14676191   PMID:15143057   PMID:15489334   PMID:15802564   PMID:16079148  
PMID:16169070   PMID:16246731   PMID:16252010   PMID:17580304   PMID:17699685   PMID:18174161   PMID:18374665   PMID:19004011   PMID:19056867   PMID:19182904   PMID:19640926   PMID:20168092  
PMID:20173742   PMID:20357094   PMID:20421418   PMID:20452972   PMID:20457763   PMID:20562859   PMID:20814419   PMID:20979579   PMID:21173155   PMID:21220506   PMID:21455601   PMID:21536669  
PMID:21707618   PMID:21900206   PMID:22033522   PMID:22622177   PMID:22761437   PMID:22792322   PMID:22948227   PMID:23148214   PMID:24035364   PMID:24713655   PMID:24954904   PMID:24959866  
PMID:25127057   PMID:25150927   PMID:25416956   PMID:25686248   PMID:25708205   PMID:25761618   PMID:26199377   PMID:26284655   PMID:26364802   PMID:27368102   PMID:27564518   PMID:27631370  
PMID:28076378   PMID:28404643   PMID:28655770   PMID:29057768   PMID:29554128   PMID:30273743   PMID:30744518   PMID:34581931   PMID:37466855   PMID:38308640  


Genomics

Comparative Map Data
Sqstm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,026,598 - 35,037,750 (-)NCBIGRCr8
mRatBN7.21034,525,517 - 34,536,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,525,519 - 34,536,673 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,200,880 - 39,212,041 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,740,133 - 7,751,294 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,194,553 - 34,205,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,704,728 - 35,716,316 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,704,730 - 35,716,294 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,463,172 - 35,474,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,751,300 - 35,762,630 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,752,706 - 35,763,676 (-)NCBI
Celera1033,874,680 - 33,885,832 (-)NCBICelera
Cytogenetic Map10q22NCBI
SQSTM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,806,393 - 179,838,078 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,806,398 - 179,838,078 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,233,393 - 179,265,078 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,180,503 - 179,197,684 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,180,502 - 179,197,681NCBI
Celera5174,858,545 - 174,890,234 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,959,564 - 173,990,246 (+)NCBIHuRef
CHM1_15178,665,789 - 178,697,494 (+)NCBICHM1_1
T2T-CHM13v2.05180,361,589 - 180,393,289 (+)NCBIT2T-CHM13v2.0
Sqstm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,090,979 - 50,105,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,090,193 - 50,101,654 (-)EnsemblGRCm39 Ensembl
GRCm381150,200,152 - 50,210,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,199,366 - 50,210,827 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,013,654 - 50,024,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,043,575 - 50,054,213 (-)NCBIMGSCv36mm8
Celera1154,760,561 - 54,771,199 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.36NCBI
Sqstm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408757,426 - 771,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955408757,426 - 764,989 (-)NCBIChiLan1.0ChiLan1.0
SQSTM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,749,439 - 174,778,646 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,889,121 - 172,918,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,960,727 - 174,989,946 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,271,070 - 182,299,093 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,284,436 - 182,299,093 (+)Ensemblpanpan1.1panPan2
SQSTM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,859,776 - 1,869,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,859,465 - 1,870,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,982,949 - 1,993,602 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,834,485 - 1,844,494 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,834,122 - 1,844,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,805,423 - 1,816,088 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,884,694 - 1,895,335 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,124,878 - 2,135,544 (-)NCBIUU_Cfam_GSD_1.0
Sqstm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,733,303 - 119,745,506 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739938,745 - 955,263 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739943,080 - 955,296 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SQSTM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,752,771 - 78,763,938 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,752,768 - 78,763,998 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,318,820 - 80,330,048 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SQSTM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,536,271 - 81,571,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,558,082 - 81,574,830 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,913,848 - 12,950,392 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sqstm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,691,841 - 42,700,916 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,689,454 - 42,700,916 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sqstm1
36 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:230
Count of miRNA genes:92
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000004308, ENSRNOT00000059255
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH130114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,525,258 - 34,525,456 (+)MAPPERmRatBN7.2
Rnor_6.01035,704,470 - 35,704,667NCBIRnor6.0
Rnor_5.01035,462,914 - 35,463,111UniSTSRnor5.0
RGSC_v3.41035,751,042 - 35,751,239UniSTSRGSC3.4
Celera1033,874,422 - 33,874,619UniSTS
RH 3.4 Map10368.7UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map10q21UniSTS
AI851514  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,525,312 - 34,525,424 (+)MAPPERmRatBN7.2
Rnor_6.01035,704,524 - 35,704,635NCBIRnor6.0
Rnor_5.01035,462,968 - 35,463,079UniSTSRnor5.0
RGSC_v3.41035,751,096 - 35,751,207UniSTSRGSC3.4
Celera1033,874,476 - 33,874,587UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map10q21UniSTS
RH128379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,525,674 - 34,525,860 (+)MAPPERmRatBN7.2
Rnor_6.01035,704,886 - 35,705,071NCBIRnor6.0
Rnor_5.01035,463,330 - 35,463,515UniSTSRnor5.0
RGSC_v3.41035,751,458 - 35,751,643UniSTSRGSC3.4
Celera1033,874,838 - 33,875,023UniSTS
RH 3.4 Map10349.6UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map10q21UniSTS
RH143664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21034,525,619 - 34,525,734 (+)MAPPERmRatBN7.2
Rnor_6.01035,704,831 - 35,704,945NCBIRnor6.0
Rnor_5.01035,463,275 - 35,463,389UniSTSRnor5.0
RGSC_v3.41035,751,403 - 35,751,517UniSTSRGSC3.4
Celera1033,874,783 - 33,874,897UniSTS
RH 3.4 Map10368.7UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004308   ⟹   ENSRNOP00000004308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,525,519 - 34,536,670 (-)Ensembl
Rnor_6.0 Ensembl1035,712,615 - 35,716,260 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000059255   ⟹   ENSRNOP00000056021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,525,519 - 34,536,670 (-)Ensembl
Rnor_6.0 Ensembl1035,704,730 - 35,716,294 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098202   ⟹   ENSRNOP00000091620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,525,734 - 34,536,673 (-)Ensembl
RefSeq Acc Id: NM_001393884   ⟹   NP_001380813
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,026,598 - 35,037,750 (-)NCBI
mRatBN7.21034,525,517 - 34,536,670 (-)NCBI
RefSeq Acc Id: NM_001393885   ⟹   NP_001380814
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,026,598 - 35,037,750 (-)NCBI
mRatBN7.21034,525,517 - 34,536,670 (-)NCBI
RefSeq Acc Id: NM_001393886   ⟹   NP_001380815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,026,598 - 35,037,750 (-)NCBI
mRatBN7.21034,525,517 - 34,536,670 (-)NCBI
RefSeq Acc Id: NM_175843   ⟹   NP_787037
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,026,598 - 35,037,750 (-)NCBI
mRatBN7.21034,525,517 - 34,536,670 (-)NCBI
Rnor_6.01035,704,728 - 35,716,294 (-)NCBI
Rnor_5.01035,463,172 - 35,474,754 (-)NCBI
RGSC_v3.41035,751,300 - 35,762,630 (-)RGD
Celera1033,874,680 - 33,885,832 (-)RGD
Sequence:
RefSeq Acc Id: NM_181550   ⟹   NP_853528
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81035,034,558 - 35,037,750 (-)NCBI
mRatBN7.21034,533,478 - 34,536,670 (-)NCBI
Rnor_6.01035,713,103 - 35,716,260 (-)NCBI
Rnor_5.01035,463,172 - 35,474,754 (-)NCBI
RGSC_v3.41035,751,300 - 35,762,630 (-)RGD
Celera1033,882,640 - 33,885,798 (-)NCBI
Sequence:
RefSeq Acc Id: NP_787037   ⟸   NM_175843
- Peptide Label: isoform 1
- UniProtKB: Q8CH59 (UniProtKB/Swiss-Prot),   O08623 (UniProtKB/Swiss-Prot),   A6HE00 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_853528   ⟸   NM_181550
- Peptide Label: isoform 2
- UniProtKB: A6HE03 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004308   ⟸   ENSRNOT00000004308
Ensembl Acc Id: ENSRNOP00000056021   ⟸   ENSRNOT00000059255
Ensembl Acc Id: ENSRNOP00000091620   ⟸   ENSRNOT00000098202
RefSeq Acc Id: NP_001380815   ⟸   NM_001393886
- Peptide Label: isoform 5
- UniProtKB: A6HE02 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380813   ⟸   NM_001393884
- Peptide Label: isoform 3
- UniProtKB: A6HE00 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380814   ⟸   NM_001393885
- Peptide Label: isoform 4
- UniProtKB: A6HE02 (UniProtKB/TrEMBL)
Protein Domains
PB1   UBA   ZZ-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08623-F1-model_v2 AlphaFold O08623 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697149
Promoter ID:EPDNEW_R7674
Type:single initiation site
Name:Sqstm1_1
Description:sequestosome 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,716,294 - 35,716,354EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69287 AgrOrtholog
BioCyc Gene G2FUF-25250 BioCyc
Ensembl Genes ENSRNOG00000003147 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004308 ENTREZGENE
  ENSRNOT00000004308.7 UniProtKB/Swiss-Prot
  ENSRNOT00000059255 ENTREZGENE
  ENSRNOT00000059255.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.90 UniProtKB/Swiss-Prot
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887571 IMAGE-MGC_LOAD
InterPro Autophagy_Rcpt_SigReg UniProtKB/Swiss-Prot
  PB1-like UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PB1_p62 UniProtKB/Swiss-Prot
  SQSTM_UBA UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
  Znf_ZZ UniProtKB/Swiss-Prot
  Znf_ZZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:113894 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72976 IMAGE-MGC_LOAD
NCBI Gene 113894 ENTREZGENE
PANTHER SEQUESTOSOME 1-RELATED UniProtKB/Swiss-Prot
  SEQUESTOSOME-1 UniProtKB/Swiss-Prot
Pfam PB1 UniProtKB/Swiss-Prot
  PF00569 UniProtKB/Swiss-Prot
  UBA_5 UniProtKB/Swiss-Prot
PhenoGen Sqstm1 PhenoGen
PROSITE PB1 UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  ZF_ZZ_1 UniProtKB/Swiss-Prot
  ZF_ZZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003147 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  ZnF_ZZ UniProtKB/Swiss-Prot
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  RING/U-box UniProtKB/Swiss-Prot
  SSF46934 UniProtKB/Swiss-Prot
TIGR TC204232
UniProt A0A0H2UHB5_RAT UniProtKB/TrEMBL
  A0A8I6AET9_RAT UniProtKB/TrEMBL
  A6HE00 ENTREZGENE, UniProtKB/TrEMBL
  A6HE01_RAT UniProtKB/TrEMBL
  A6HE02 ENTREZGENE, UniProtKB/TrEMBL
  A6HE03 ENTREZGENE, UniProtKB/TrEMBL
  O08623 ENTREZGENE
  Q8CH59 ENTREZGENE
  SQSTM_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8CH59 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-05-02 Sqstm1  sequestosome 1  Osi  oxidative stress induced  Data merged from RGD:621858 737654 APPROVED
2002-08-07 Osi  oxidative stress induced      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Sqstm1  sequestosome 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains ZZ-zinc finger domain which interacts with 10 amino acids of rho 1-3 634214
gene_expression expressed in the non-neuronal, neuronal tissues and the retina 634214
gene_transcript splice variant of PKC-zeta interacting protein family 634214