Casp2 (caspase 2) - Rat Genome Database

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Gene: Casp2 (caspase 2) Rattus norvegicus
Analyze
Symbol: Casp2
Name: caspase 2
RGD ID: 69274
Description: Predicted to enable cysteine-type endopeptidase activity; identical protein binding activity; and protein domain specific binding activity. Involved in luteolysis; neural retina development; and positive regulation of neuron apoptotic process. Predicted to be located in nucleus. Predicted to be part of endopeptidase complex. Predicted to be active in cytoplasm. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2); INTERACTS WITH (R)-noradrenaline; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CASP-2; caspase-2; ICH-1 protease; protease ICH-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,116,265 - 72,134,023 (+)NCBIGRCr8
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,069,535 - 76,087,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,982,792 - 72,000,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,402,261 - 70,419,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Celera466,080,364 - 66,098,003 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(R)-noradrenaline  (EXP)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methoxyethanol  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-nitropropanoic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amsacrine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
betaxolol  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brefeldin A  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
casticin  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chitosan  (EXP)
chromium(6+)  (ISO)
Cinobufotalin  (ISO)
cisplatin  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimethyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epichlorohydrin  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenpropathrin  (EXP)
flavanones  (ISO)
folic acid  (ISO)
furan  (EXP)
furosemide  (EXP)
gardenin B  (ISO)
gentamycin  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lovastatin  (ISO)
LY294002  (EXP)
manganese(II) chloride  (EXP)
mechlorethamine  (ISO)
menadione  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
Mitotane  (EXP)
mitoxantrone  (ISO)
Myrtucommulone A  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (ISO)
nickel dichloride  (EXP)
nicotine  (EXP)
norfloxacin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (ISO)
picoxystrobin  (ISO)
picrotoxin  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
podophyllotoxin  (ISO)
Pranoprofen  (ISO)
propylparaben  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP,ISO)
triadimefon  (EXP)
Tributyltin oxide  (EXP)
tunicamycin  (ISO)
undecane  (EXP)
urethane  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
violacein  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
endopeptidase complex  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. Cowan KN, etal., FASEB J. 2005 Nov;19(13):1848-50. Epub 2005 Aug 25.
2. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Flaws JA, etal., Endocrinology 1995 Nov;136(11):5042-53.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia. Jin K, etal., J Neurochem. 2002 Apr;81(1):25-35.
5. Role of caspase 2 in apoptotic signaling in primate and murine germ cells. Johnson C, etal., Biol Reprod. 2008 Nov;79(5):806-14. Epub 2008 Jul 9.
6. Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury. Kaushal GP, etal., Am J Physiol 1998 Mar;274(3 Pt 2):F587-95.
7. Expression of Nedd2/ICH-1 (caspase-2) in the developing rat retina. Kojima M, etal., Neurosci Res. 1998 Jul;31(3):211-7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Increased expression of caspase 2 in experimental and human temporal lobe epilepsy. Narkilahti S, etal., Neuromolecular Med. 2007;9(2):129-44.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. Peluffo MC, etal., Reproduction. 2006 Sep;132(3):465-75.
12. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Cloning and expression of the cDNA encoding rat caspase-2. Sato N, etal., Gene 1997 Nov 20;202(1-2):127-32.
16. Differential expression of rat brain caspase family proteins during development and aging. Shimohama S, etal., Biochem Biophys Res Commun. 2001 Dec 21;289(5):1063-6.
17. Differential subcellular localization of caspase family proteins in the adult rat brain. Shimohama S, etal., Neurosci Lett. 2001 Nov 27;315(3):125-8.
18. Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs. Zhang Y, etal., Exp Gerontol. 2002 Jun;37(6):777-89.
19. ARC protects rat cardiomyocytes against oxidative stress through inhibition of caspase-2 mediated mitochondrial pathway. Zhang YQ and Herman B, J Cell Biochem. 2006 Oct 1;99(2):575-88.
Additional References at PubMed
PMID:9044836   PMID:10931486   PMID:10980123   PMID:11536012   PMID:12477715   PMID:16183742   PMID:18181021   PMID:19593445   PMID:21677688   PMID:21726810   PMID:21903589   PMID:22531785  
PMID:23451279   PMID:23815625   PMID:25416956   PMID:26871637   PMID:30193318   PMID:31515488   PMID:31533600   PMID:32605511  


Genomics

Comparative Map Data
Casp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,116,265 - 72,134,023 (+)NCBIGRCr8
mRatBN7.2471,149,632 - 71,167,388 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,069,535 - 76,087,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,982,792 - 72,000,428 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,402,261 - 70,419,895 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,652,358 - 71,670,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,454,723 - 136,474,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,029,728 - 70,047,164 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1470,305,857 - 70,323,294 (+)NCBI
Celera466,080,364 - 66,098,003 (+)NCBICelera
Cytogenetic Map4q24NCBI
CASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,288,351 - 143,307,696 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,288,215 - 143,307,696 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,985,444 - 143,004,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,695,524 - 142,714,907 (+)NCBINCBI36Build 36hg18NCBI36
Celera7137,822,267 - 137,841,650 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,322,670 - 137,342,153 (+)NCBIHuRef
CHM1_17142,922,195 - 142,941,676 (+)NCBICHM1_1
T2T-CHM13v2.07144,643,759 - 144,663,112 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,387,424 - 142,406,906 (+)NCBI
Casp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,241,942 - 42,259,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,241,919 - 42,259,442 (+)EnsemblGRCm39 Ensembl
GRCm38642,264,902 - 42,282,508 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,264,985 - 42,282,508 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,215,038 - 42,232,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,194,646 - 42,212,103 (+)NCBIMGSCv36mm8
Celera642,209,337 - 42,226,794 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.54NCBI
Casp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494353,310 - 368,873 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955494353,572 - 369,207 (-)NCBIChiLan1.0ChiLan1.0
CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,141,294 - 180,166,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,151,551 - 32,176,835 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,283,072 - 135,307,855 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,773,749 - 147,792,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,773,749 - 147,792,958 (+)Ensemblpanpan1.1panPan2
CASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,378,447 - 6,396,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,379,913 - 6,396,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,368,808 - 7,385,123 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,232,171 - 6,251,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,232,210 - 6,250,056 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,181,045 - 6,197,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,032,942 - 6,049,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,108,280 - 6,124,667 (-)NCBIUU_Cfam_GSD_1.0
Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,149,166 - 12,164,126 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527739,281 - 754,331 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527739,325 - 754,259 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,941,937 - 6,966,061 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,946,432 - 6,966,088 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,183,208 - 7,206,964 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,172,614 - 112,189,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,172,733 - 112,188,744 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,895,441 - 8,914,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,451,038 - 11,468,205 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480011,451,784 - 11,468,791 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Casp2
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:394
Count of miRNA genes:218
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000022543, ENSRNOT00000022672
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat

Markers in Region
RH127476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,167,193 - 71,167,375 (+)MAPPERmRatBN7.2
Rnor_6.0471,670,034 - 71,670,215NCBIRnor6.0
Rnor_5.04136,474,431 - 136,474,612UniSTSRnor5.0
Celera466,097,809 - 66,097,990UniSTS
RH 3.4 Map4434.8UniSTS
Cytogenetic Map4q23UniSTS
RH140969  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,148,728 - 71,148,932 (+)MAPPERmRatBN7.2
Rnor_6.0471,651,439 - 71,651,642NCBIRnor6.0
Rnor_5.04136,453,800 - 136,454,003UniSTSRnor5.0
RGSC_v3.4470,028,735 - 70,028,938UniSTSRGSC3.4
Celera466,079,371 - 66,079,574UniSTS
RH 3.4 Map4433.61UniSTS
Cytogenetic Map4q23UniSTS
MARC_16655-16656:1017778016:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,152,168 - 71,152,636 (+)MAPPERmRatBN7.2
Rnor_6.0471,655,009 - 71,655,476NCBIRnor6.0
Rnor_5.04136,459,406 - 136,459,873UniSTSRnor5.0
Rnor_5.04136,457,492 - 136,457,959UniSTSRnor5.0
RGSC_v3.4470,031,877 - 70,032,344UniSTSRGSC3.4
Celera466,082,786 - 66,083,253UniSTS
Cytogenetic Map4q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000022543   ⟹   ENSRNOP00000022543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl471,149,724 - 71,165,417 (+)Ensembl
Rnor_6.0 Ensembl471,652,434 - 71,668,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000022672   ⟹   ENSRNOP00000022672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl471,149,669 - 71,167,379 (+)Ensembl
Rnor_6.0 Ensembl471,652,354 - 71,670,239 (+)Ensembl
RefSeq Acc Id: NM_022522   ⟹   NP_071967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,357 - 72,134,023 (+)NCBI
mRatBN7.2471,149,722 - 71,167,388 (+)NCBI
Rnor_6.0471,652,432 - 71,670,228 (+)NCBI
Rnor_5.04136,454,723 - 136,474,625 (+)NCBI
RGSC_v3.4470,029,728 - 70,047,164 (+)RGD
Celera466,080,364 - 66,098,003 (+)RGD
Sequence:
RefSeq Acc Id: XM_039108318   ⟹   XP_038964246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,265 - 72,123,581 (+)NCBI
mRatBN7.2471,149,634 - 71,156,942 (+)NCBI
RefSeq Acc Id: XM_063286661   ⟹   XP_063142731
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,265 - 72,131,459 (+)NCBI
RefSeq Acc Id: XM_063286662   ⟹   XP_063142732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,269 - 72,120,749 (+)NCBI
RefSeq Acc Id: XM_063286663   ⟹   XP_063142733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,116,270 - 72,120,124 (+)NCBI
RefSeq Acc Id: NP_071967   ⟸   NM_022522
- UniProtKB: O55194 (UniProtKB/Swiss-Prot),   O35398 (UniProtKB/Swiss-Prot),   Q9WUI6 (UniProtKB/Swiss-Prot),   P55215 (UniProtKB/Swiss-Prot),   A6IF65 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022543   ⟸   ENSRNOT00000022543
Ensembl Acc Id: ENSRNOP00000022672   ⟸   ENSRNOT00000022672
RefSeq Acc Id: XP_038964246   ⟸   XM_039108318
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142731   ⟸   XM_063286661
- Peptide Label: isoform X1
- UniProtKB: A6IF66 (UniProtKB/TrEMBL),   D3ZLT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142732   ⟸   XM_063286662
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142733   ⟸   XM_063286663
- Peptide Label: isoform X4
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55215-F1-model_v2 AlphaFold P55215 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693008
Promoter ID:EPDNEW_R3531
Type:initiation region
Name:Casp2_1
Description:caspase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0471,652,346 - 71,652,406EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69274 AgrOrtholog
BioCyc Gene G2FUF-45094 BioCyc
Ensembl Genes ENSRNOG00000016707 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022543.6 UniProtKB/TrEMBL
  ENSRNOT00000022672 ENTREZGENE
  ENSRNOT00000022672.7 UniProtKB/Swiss-Prot
  ENSRNOT00000112830 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASP2_CARD UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_2 UniProtKB/Swiss-Prot
  Caspase_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C14A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64314 ENTREZGENE
PANTHER CASPASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Casp2 PhenoGen
PIRSF Caspase_ICE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016707 RatGTEx
SMART CARD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CASc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6IF65 ENTREZGENE, UniProtKB/TrEMBL
  A6IF66 ENTREZGENE, UniProtKB/TrEMBL
  CASP2_RAT UniProtKB/Swiss-Prot
  D3ZLT0 ENTREZGENE, UniProtKB/TrEMBL
  O35398 ENTREZGENE
  O55194 ENTREZGENE
  P55215 ENTREZGENE
  Q9WUI6 ENTREZGENE
UniProt Secondary O35398 UniProtKB/Swiss-Prot
  O55194 UniProtKB/Swiss-Prot
  Q9WUI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Casp2  caspase 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the ICE/Ced-3 (caspase) family of proteases 68881