Slc5a5 (solute carrier family 5 member 5) - Rat Genome Database

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Gene: Slc5a5 (solute carrier family 5 member 5) Rattus norvegicus
Analyze
Symbol: Slc5a5
Name: solute carrier family 5 member 5
RGD ID: 69267
Description: Enables sodium:iodide symporter activity. Involved in iodide transmembrane transport and sodium ion transport. Is active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/I(-) cotransporter; na(+)/I(-) symporter; na(+)/I(-)-symporter; Na+/I- symporter; Nis; sodium-iodide symporter; sodium/iodide cotransporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter) member 5; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; solute carrier family 5, member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,580,705 - 18,590,692 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,580,705 - 18,590,691 (+)EnsemblGRCr8
mRatBN7.21618,546,709 - 18,556,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,588,940 - 18,598,864 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,721,618 - 19,731,542 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,641,881 - 18,651,805 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)Ensemblrn6Rnor6.0
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,739,349 - 18,749,322 (+)NCBICelera
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
adenosine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
calcitriol  (EXP)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
depsipeptide  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diiodine  (EXP,ISO)
Diisodecyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
dysidenin  (ISO)
efavirenz  (ISO)
elemental selenium  (EXP)
ethylparaben  (ISO)
etoxazole  (EXP,ISO)
fipronil  (EXP)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP,ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
iodide salt  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Licochalcone B  (ISO)
LY294002  (EXP,ISO)
mancozeb  (ISO)
masoprocol  (EXP)
melatonin  (ISO)
mepanipyrim  (EXP,ISO)
mercaptopurine  (EXP)
methimazole  (EXP,ISO)
methoxyfenozide  (EXP,ISO)
metiram  (ISO)
mibolerone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
myricetin  (ISO)
N-acetyl-L-cysteine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nevirapine  (ISO)
niclosamide  (EXP,ISO)
ouabain  (ISO)
Oxyfluorfen  (EXP,ISO)
PCB138  (ISO)
perchlorate  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
potassium iodide  (EXP)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (EXP)
sodium arsenite  (EXP)
sodium bromide  (ISO)
sodium chlorate  (ISO)
sodium iodide  (EXP,ISO)
sodium perchlorate  (EXP,ISO)
sodium thiocyanate  (ISO)
tazarotene  (ISO)
tebuconazole  (ISO)
technetium atom  (ISO)
tetraoxorhenate(1-)  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiocyanate  (ISO)
thiram  (ISO)
thyroxine  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
membrane  (IEA)
nucleus  (ISO)
plasma membrane  (IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). Concilio SC, etal., PLoS One. 2020 Feb 21;15(2):e0229085. doi: 10.1371/journal.pone.0229085. eCollection 2020.
2. Cloning and characterization of the thyroid iodide transporter. Dai G, etal., Nature 1996 Feb 1;379(6564):458-60.
3. Na(+)/I(-) symporter activity requires a small and uncharged amino acid residue at position 395. Dohan O, etal., Mol Endocrinol 2002 Aug;16(8):1893-902.
4. Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. Eskandari S, etal., J Biol Chem. 1997 Oct 24;272(43):27230-8. doi: 10.1074/jbc.272.43.27230.
5. Congenital hypothyroidism caused by a mutation in the Na+/I- symporter. Fujiwara H, etal., Nat Genet. 1997 Jun;16(2):124-5.
6. PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression. Garcia B and Santisteban P, Mol Endocrinol 2002 Feb;16(2):342-52.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Molecular characterization of V59E NIS, a Na+/I- symporter mutant that causes congenital I- transport defect. Reed-Tsur MD, etal., Endocrinology. 2008 Jun;149(6):3077-84. doi: 10.1210/en.2008-0027. Epub 2008 Mar 13.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10022892   PMID:11431151   PMID:12021185   PMID:14623893   PMID:15009910   PMID:15522214   PMID:15961562   PMID:16322051   PMID:17408651   PMID:17639055   PMID:17913707  
PMID:18165779   PMID:19052257   PMID:19199708   PMID:20107044   PMID:20667985   PMID:21209020   PMID:21225541   PMID:21389275   PMID:21988488   PMID:22157753   PMID:23255420   PMID:23542164  
PMID:23675434   PMID:24424051   PMID:24691731   PMID:24769233   PMID:24888603   PMID:25319483   PMID:26009546   PMID:26599396   PMID:26650895   PMID:26831514   PMID:26872612   PMID:29112772  
PMID:32049985   PMID:35455992   PMID:36517601  


Genomics

Comparative Map Data
Slc5a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,580,705 - 18,590,692 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,580,705 - 18,590,691 (+)EnsemblGRCr8
mRatBN7.21618,546,709 - 18,556,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,588,940 - 18,598,864 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,721,618 - 19,731,542 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,641,881 - 18,651,805 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)Ensemblrn6Rnor6.0
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,739,349 - 18,749,322 (+)NCBICelera
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Cytogenetic Map16p14NCBI
SLC5A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,871,945 - 17,895,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,871,945 - 17,895,174 (+)Ensemblhg38GRCh38
GRCh371917,982,754 - 18,005,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,843,782 - 17,865,897 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341917,843,781 - 17,865,897NCBI
Celera1917,884,497 - 17,907,699 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,548,153 - 17,571,202 (+)NCBIHuRef
CHM1_11917,982,521 - 18,005,714 (+)NCBICHM1_1
T2T-CHM13v2.01918,005,850 - 18,029,260 (+)NCBIT2T-CHM13v2.0
Slc5a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,335,529 - 71,345,429 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,335,533 - 71,345,401 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38870,882,885 - 70,892,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,882,889 - 70,892,757 (-)Ensemblmm10GRCm38
MGSCv37873,406,788 - 73,416,656 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36873,812,491 - 73,821,713 (-)NCBIMGSCv36mm8
Celera873,444,192 - 73,454,060 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.36NCBI
Slc5a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,375,085 - 3,380,758 (-)Ensembl
ChiLan1.0NW_0049555243,372,539 - 3,380,758 (-)NCBIChiLan1.0ChiLan1.0
SLC5A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,734,367 - 22,760,028 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,741,167 - 21,769,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,352,635 - 17,377,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,327,410 - 18,344,480 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,327,410 - 18,344,480 (+)EnsemblpanPan2panpan1.1
SLC5A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,017,939 - 45,030,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,018,119 - 45,030,209 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2044,930,090 - 44,942,416 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02045,502,644 - 45,514,972 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,502,824 - 45,514,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,739,503 - 44,751,827 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,149,996 - 45,162,311 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,425,947 - 45,438,272 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc5a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,623,144 - 203,639,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,177,422 - 3,188,637 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,176,009 - 3,188,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,869,155 - 59,885,266 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1259,869,157 - 59,885,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,438,591 - 59,454,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,346,361 - 16,367,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,017,539 - 3,040,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,401,829 - 1,409,538 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249081,401,812 - 1,410,471 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc5a5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11313,128,659 - 13,137,502 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc5a5
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:87
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000025576
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,555,802 - 18,556,095 (+)MAPPERmRatBN7.2
Rnor_6.01620,306,506 - 20,306,798NCBIRnor6.0
Rnor_5.01620,164,050 - 20,164,342UniSTSRnor5.0
RGSC_v3.41619,055,386 - 19,055,678UniSTSRGSC3.4
Celera1618,748,427 - 18,748,719UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 31 148 89 88 57 28 57 6 219 92 10 120 46 78 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000025576   ⟹   ENSRNOP00000025577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,580,705 - 18,590,691 (+)Ensembl
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)Ensembl
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101929   ⟹   ENSRNOP00000077683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,580,705 - 18,590,691 (+)Ensembl
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153185   ⟹   ENSRNOP00000101382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,580,705 - 18,590,691 (+)Ensembl
RefSeq Acc Id: NM_052983   ⟹   NP_443215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,580,705 - 18,590,692 (+)NCBI
mRatBN7.21618,546,709 - 18,556,698 (+)NCBI
Rnor_6.01620,297,414 - 20,307,401 (+)NCBI
Rnor_5.01620,154,958 - 20,164,945 (+)NCBI
RGSC_v3.41619,046,200 - 19,056,281 (+)RGD
Celera1618,739,349 - 18,749,322 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_443215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB03338 (Get FASTA)   NCBI Sequence Viewer  
  AAB88004 (Get FASTA)   NCBI Sequence Viewer  
  AKA88571 (Get FASTA)   NCBI Sequence Viewer  
  BAA76286 (Get FASTA)   NCBI Sequence Viewer  
  EDL90749 (Get FASTA)   NCBI Sequence Viewer  
  EDL90750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025577
GenBank Protein Q63008 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_443215   ⟸   NM_052983
- UniProtKB: Q63008 (UniProtKB/Swiss-Prot),   F1LR66 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025577   ⟸   ENSRNOT00000025576
Ensembl Acc Id: ENSRNOP00000077683   ⟸   ENSRNOT00000101929
Ensembl Acc Id: ENSRNOP00000101382   ⟸   ENSRNOT00000153185

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63008-F1-model_v2 AlphaFold Q63008 1-618 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700012
Promoter ID:EPDNEW_R10535
Type:single initiation site
Name:Slc5a5_1
Description:solute carrier family 5 member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,297,402 - 20,297,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69267 AgrOrtholog
BioCyc Gene G2FUF-11814 BioCyc
Ensembl Genes ENSRNOG00000018822 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025576 ENTREZGENE
Gene3D-CATH 1.20.1730.10 UniProtKB/Swiss-Prot
InterPro Na/Glc_symporter_sf UniProtKB/Swiss-Prot
  Na/solute_symporter UniProtKB/Swiss-Prot
  Na/solute_symporter_CS UniProtKB/Swiss-Prot
  SLC5A5 UniProtKB/Swiss-Prot
  Sodium:Solute_Symporter_SSF UniProtKB/Swiss-Prot
KEGG Report rno:114613 UniProtKB/Swiss-Prot
NCBI Gene 114613 ENTREZGENE
PANTHER SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot
  SODIUM/IODIDE COTRANSPORTER UniProtKB/Swiss-Prot
Pfam SSF UniProtKB/Swiss-Prot
PharmGKB SLC5A5 RGD
PhenoGen Slc5a5 PhenoGen
PROSITE NA_SOLUT_SYMP_1 UniProtKB/Swiss-Prot
  NA_SOLUT_SYMP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018822 RatGTEx
UniProt A0A0E3KKA7_RAT UniProtKB/TrEMBL
  A0A8I5Y1G6_RAT UniProtKB/TrEMBL
  A0ABK0L8H1_RAT UniProtKB/TrEMBL
  A6K9Y8_RAT UniProtKB/TrEMBL
  F1LR66 ENTREZGENE, UniProtKB/TrEMBL
  Q63008 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc5a5  solute carrier family 5 member 5  Slc5a5  solute carrier family 5 (sodium/iodide cotransporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc5a5  solute carrier family 5 (sodium/iodide cotransporter), member 5  Slc5a5  solute carrier family 5 (sodium iodide symporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc5a5  solute carrier family 5 (sodium iodide symporter), member 5    solute carrier family 5, member 5  Name updated 1299863 APPROVED
2002-06-10 Slc5a5  solute carrier family 5, member 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference