Slc5a5 (solute carrier family 5 member 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc5a5 (solute carrier family 5 member 5) Rattus norvegicus
Analyze
Symbol: Slc5a5
Name: solute carrier family 5 member 5
RGD ID: 69267
Description: Enables sodium:iodide symporter activity. Involved in iodide transmembrane transport and sodium ion transport. Is active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/I(-) cotransporter; na(+)/I(-) symporter; na(+)/I(-)-symporter; Na+/I- symporter; Nis; sodium-iodide symporter; sodium/iodide cotransporter; sodium/iodide symporter; solute carrier family 5 (sodium iodide symporter) member 5; solute carrier family 5 (sodium iodide symporter), member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; solute carrier family 5, member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,580,705 - 18,590,692 (+)NCBIGRCr8
mRatBN7.21618,546,709 - 18,556,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,588,940 - 18,598,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,721,618 - 19,731,542 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,641,881 - 18,651,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Celera1618,739,349 - 18,749,322 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-benzothiazole-2-thiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
adenosine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[ghi]perylene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (EXP,ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
cortisol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
depsipeptide  (ISO)
dexamethasone  (ISO)
Di-n-octyl phthalate  (EXP,ISO)
dibutyl phthalate  (ISO)
diiodine  (EXP,ISO)
Diisodecyl phthalate  (EXP,ISO)
doxorubicin  (ISO)
dysidenin  (ISO)
efavirenz  (ISO)
elemental selenium  (EXP)
ethylparaben  (ISO)
fipronil  (EXP)
furan  (EXP)
genistein  (ISO)
glyphosate  (EXP)
indometacin  (ISO)
iodide salt  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
Licochalcone B  (ISO)
LY294002  (EXP,ISO)
mancozeb  (ISO)
masoprocol  (EXP)
mercaptopurine  (EXP)
methimazole  (EXP,ISO)
metiram  (ISO)
mibolerone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nevirapine  (ISO)
ouabain  (ISO)
PCB138  (ISO)
perchlorate  (EXP,ISO)
phenobarbital  (EXP)
potassium iodide  (EXP)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
SB 431542  (EXP)
selenium atom  (EXP)
sodium bromide  (ISO)
sodium chlorate  (ISO)
sodium iodide  (EXP,ISO)
sodium perchlorate  (EXP,ISO)
sodium thiocyanate  (ISO)
tazarotene  (ISO)
tebuconazole  (ISO)
technetium atom  (ISO)
tetraoxorhenate(1-)  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiocyanate  (ISO)
thyroxine  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclocarban  (EXP,ISO)
triclosan  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
extracellular exosome  (IEA)
nucleus  (ISO)
plasma membrane  (IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inter-species variation in monovalent anion substrate selectivity and inhibitor sensitivity in the sodium iodide symporter (NIS). Concilio SC, etal., PLoS One. 2020 Feb 21;15(2):e0229085. doi: 10.1371/journal.pone.0229085. eCollection 2020.
2. Cloning and characterization of the thyroid iodide transporter. Dai G, etal., Nature 1996 Feb 1;379(6564):458-60.
3. Na(+)/I(-) symporter activity requires a small and uncharged amino acid residue at position 395. Dohan O, etal., Mol Endocrinol 2002 Aug;16(8):1893-902.
4. Thyroid Na+/I- symporter. Mechanism, stoichiometry, and specificity. Eskandari S, etal., J Biol Chem. 1997 Oct 24;272(43):27230-8. doi: 10.1074/jbc.272.43.27230.
5. Congenital hypothyroidism caused by a mutation in the Na+/I- symporter. Fujiwara H, etal., Nat Genet. 1997 Jun;16(2):124-5.
6. PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression. Garcia B and Santisteban P, Mol Endocrinol 2002 Feb;16(2):342-52.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Molecular characterization of V59E NIS, a Na+/I- symporter mutant that causes congenital I- transport defect. Reed-Tsur MD, etal., Endocrinology. 2008 Jun;149(6):3077-84. doi: 10.1210/en.2008-0027. Epub 2008 Mar 13.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10022892   PMID:11431151   PMID:12021185   PMID:14623893   PMID:15009910   PMID:15522214   PMID:15961562   PMID:16322051   PMID:17408651   PMID:17639055   PMID:17913707  
PMID:18165779   PMID:19052257   PMID:19199708   PMID:20107044   PMID:20667985   PMID:21209020   PMID:21225541   PMID:21389275   PMID:21988488   PMID:22157753   PMID:23255420   PMID:23542164  
PMID:23675434   PMID:24424051   PMID:24691731   PMID:24769233   PMID:24888603   PMID:25319483   PMID:26009546   PMID:26599396   PMID:26650895   PMID:26831514   PMID:26872612   PMID:29112772  
PMID:32049985   PMID:35455992   PMID:36517601  


Genomics

Comparative Map Data
Slc5a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,580,705 - 18,590,692 (+)NCBIGRCr8
mRatBN7.21618,546,709 - 18,556,698 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,588,940 - 18,598,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,721,618 - 19,731,542 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,641,881 - 18,651,805 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Celera1618,739,349 - 18,749,322 (+)NCBICelera
Cytogenetic Map16p14NCBI
SLC5A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,871,945 - 17,895,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,871,945 - 17,895,174 (+)EnsemblGRCh38hg38GRCh38
GRCh371917,982,754 - 18,005,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,843,782 - 17,865,897 (+)NCBINCBI36Build 36hg18NCBI36
Build 341917,843,781 - 17,865,897NCBI
Celera1917,884,497 - 17,907,699 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,548,153 - 17,571,202 (+)NCBIHuRef
CHM1_11917,982,521 - 18,005,714 (+)NCBICHM1_1
T2T-CHM13v2.01918,005,850 - 18,029,260 (+)NCBIT2T-CHM13v2.0
Slc5a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,335,529 - 71,345,429 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,335,533 - 71,345,401 (-)EnsemblGRCm39 Ensembl
GRCm38870,882,885 - 70,892,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,882,889 - 70,892,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,406,788 - 73,416,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,812,491 - 73,821,713 (-)NCBIMGSCv36mm8
Celera873,444,192 - 73,454,060 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.36NCBI
Slc5a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,372,539 - 3,380,758 (-)NCBIChiLan1.0ChiLan1.0
SLC5A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,734,367 - 22,760,028 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,741,167 - 21,769,744 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,352,635 - 17,377,130 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,327,410 - 18,344,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,327,410 - 18,344,480 (+)Ensemblpanpan1.1panPan2
SLC5A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,017,939 - 45,030,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,018,119 - 45,030,209 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,930,090 - 44,942,416 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,502,644 - 45,514,972 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,502,824 - 45,514,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,739,503 - 44,751,827 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,149,996 - 45,162,311 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,425,947 - 45,438,272 (-)NCBIUU_Cfam_GSD_1.0
Slc5a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,623,144 - 203,639,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,177,422 - 3,188,637 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,176,009 - 3,188,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,869,155 - 59,885,266 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,869,157 - 59,885,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,438,591 - 59,454,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,346,361 - 16,367,833 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660743,017,539 - 3,040,333 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc5a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,401,829 - 1,409,538 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,401,812 - 1,410,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc5a5
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:87
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000025576
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
D16Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,555,802 - 18,556,095 (+)MAPPERmRatBN7.2
Rnor_6.01620,306,506 - 20,306,798NCBIRnor6.0
Rnor_5.01620,164,050 - 20,164,342UniSTSRnor5.0
RGSC_v3.41619,055,386 - 19,055,678UniSTSRGSC3.4
Celera1618,748,427 - 18,748,719UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 8 27 11 18 11 8 8 66 9 11 10 8
Below cutoff 1 6 28 28 1 28 3 8 24 23 1

Sequence


RefSeq Acc Id: ENSRNOT00000025576   ⟹   ENSRNOP00000025577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)Ensembl
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101929   ⟹   ENSRNOP00000077683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,546,709 - 18,556,697 (+)Ensembl
RefSeq Acc Id: NM_052983   ⟹   NP_443215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,580,705 - 18,590,692 (+)NCBI
mRatBN7.21618,546,709 - 18,556,698 (+)NCBI
Rnor_6.01620,297,414 - 20,307,401 (+)NCBI
Rnor_5.01620,154,958 - 20,164,945 (+)NCBI
RGSC_v3.41619,046,200 - 19,056,281 (+)RGD
Celera1618,739,349 - 18,749,322 (+)RGD
Sequence:
RefSeq Acc Id: NP_443215   ⟸   NM_052983
- UniProtKB: Q63008 (UniProtKB/Swiss-Prot),   F1LR66 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025577   ⟸   ENSRNOT00000025576
RefSeq Acc Id: ENSRNOP00000077683   ⟸   ENSRNOT00000101929

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63008-F1-model_v2 AlphaFold Q63008 1-618 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700012
Promoter ID:EPDNEW_R10535
Type:single initiation site
Name:Slc5a5_1
Description:solute carrier family 5 member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,297,402 - 20,297,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69267 AgrOrtholog
BioCyc Gene G2FUF-11814 BioCyc
Ensembl Genes ENSRNOG00000018822 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025576 ENTREZGENE
  ENSRNOT00000025576.4 UniProtKB/TrEMBL
  ENSRNOT00000101929.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLC5A5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114613 ENTREZGENE
PANTHER SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM/IODIDE COTRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SSF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB SLC5A5 RGD
PhenoGen Slc5a5 PhenoGen
PROSITE NA_SOLUT_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018822 RatGTEx
UniProt A0A0E3KKA7_RAT UniProtKB/TrEMBL
  A0A8I5Y1G6_RAT UniProtKB/TrEMBL
  A6K9Y8_RAT UniProtKB/TrEMBL
  F1LR66 ENTREZGENE, UniProtKB/TrEMBL
  Q63008 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc5a5  solute carrier family 5 member 5  Slc5a5  solute carrier family 5 (sodium/iodide cotransporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc5a5  solute carrier family 5 (sodium/iodide cotransporter), member 5  Slc5a5  solute carrier family 5 (sodium iodide symporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc5a5  solute carrier family 5 (sodium iodide symporter), member 5    solute carrier family 5, member 5  Name updated 1299863 APPROVED
2002-06-10 Slc5a5  solute carrier family 5, member 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference