Mre11 (MRE11 homolog, double strand break repair nuclease) - Rat Genome Database

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Gene: Mre11 (MRE11 homolog, double strand break repair nuclease) Rattus norvegicus
Analyze
Symbol: Mre11
Name: MRE11 homolog, double strand break repair nuclease
RGD ID: 69263
Description: Predicted to enable 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and host-mediated suppression of symbiont invasion. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: double-strand break repair protein MRE11; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; meiotic recombination 11 homolog A (S. cerevisiae); MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Mre11a
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,900,211 - 19,961,906 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl819,913,772 - 19,961,904 (+)EnsemblGRCr8
mRatBN7.2811,618,876 - 11,680,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx815,618,017 - 15,661,868 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,915,762 - 13,959,614 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,891,307 - 11,935,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)Ensemblrn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera813,102,879 - 13,146,939 (+)NCBICelera
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Cytogenetic Map8q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bromoacetate  (ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capecitabine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxifluridine  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
ferroheme b  (ISO)
folic acid  (ISO)
FR900359  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
isocyanates  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
myristicin  (ISO)
N,N-dimethylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
Nonidet P-40  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentamidine  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
veliparib  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Angele S, etal., Histopathology. 2003 Oct;43(4):347-53.
2. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Bartkova J, etal., Mol Oncol. 2008 Dec;2(4):296-316. Epub 2008 Oct 7.
3. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
4. Analysis of variants in DNA damage signalling genes in bladder cancer. Choudhury A, etal., BMC Med Genet. 2008 Jul 18;9:69.
5. Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation. Crowe SL, etal., Eur J Neurosci. 2006 May;23(9):2351-61.
6. A Rad50-dependent pathway of DNA repair is deficient in Fanconi anemia fibroblasts. Donahue SL and Campbell C, Nucleic Acids Res 2004 Jun 15;32(10):3248-57. Print 2004.
7. Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and rat. Eijpe M, etal., Chromosoma. 2000;109(1-2):123-32.
8. Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Fernet M, etal., Hum Mol Genet. 2005 Jan 15;14(2):307-18. Epub 2004 Dec 1.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Human MRE11 is inactivated in mismatch repair-deficient cancers. Giannini G, etal., EMBO Rep. 2002 Mar;3(3):248-54. Epub 2002 Feb 15.
11. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Giannini G, etal., Oncogene. 2004 Apr 8;23(15):2640-7.
12. Adenovirus type 5 early region 1B 55-kDa oncoprotein can promote cell transformation by a mechanism independent from blocking p53-activated transcription. Hartl B, etal., Oncogene. 2008 Jun 12;27(26):3673-84. Epub 2008 Jan 21.
13. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
14. Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
15. Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array. Jiang Z, etal., Neurosci Lett. 2006 Dec 1;409(2):112-7. Epub 2006 Oct 10.
16. The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. Lanson NA Jr, etal., Nucleic Acids Res 2000 Aug 1;28(15):2882-92.
17. Terminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins. Lovric J, etal., Mol Ther. 2012 Nov;20(11):2087-97. doi: 10.1038/mt.2012.144. Epub 2012 Jul 31.
18. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
21. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. MRE11 expression is impaired in gastric cancer with microsatellite instability. Ottini L, etal., Carcinogenesis. 2004 Dec;25(12):2337-43. Epub 2004 Aug 19.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
Additional References at PubMed
PMID:9224597   PMID:9590181   PMID:9651580   PMID:9705271   PMID:10811102   PMID:12687013   PMID:14690604   PMID:15149599   PMID:15364958   PMID:15790808   PMID:15916964   PMID:15917200  
PMID:16374507   PMID:17291760   PMID:17500065   PMID:18614044   PMID:19135898   PMID:19151086   PMID:22078559   PMID:23444137   PMID:24270157   PMID:25468996   PMID:29290612   PMID:29670289  
PMID:30612738  


Genomics

Comparative Map Data
Mre11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,900,211 - 19,961,906 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl819,913,772 - 19,961,904 (+)EnsemblGRCr8
mRatBN7.2811,618,876 - 11,680,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx815,618,017 - 15,661,868 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,915,762 - 13,959,614 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,891,307 - 11,935,517 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)Ensemblrn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera813,102,879 - 13,146,939 (+)NCBICelera
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Cytogenetic Map8q12NCBI
MRE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,415,570 - 94,512,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,415,570 - 94,493,885 (-)Ensemblhg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
T2T-CHM13v2.01194,422,612 - 94,519,751 (-)NCBIT2T-CHM13v2.0
Mre11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,971 - 14,748,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)Ensemblmm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBIMGSCv36mm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.33NCBI
MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,258,930 - 95,341,115 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,350,676 - 96,432,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,418,537 - 89,500,705 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,908,403 - 92,985,966 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,918,549 - 92,985,966 (-)EnsemblpanPan2panpan1.1
MRE11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,630,485 - 6,708,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,363,444 - 79,439,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674466,456 - 530,317 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936674466,495 - 528,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,572,361 - 26,634,567 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1926,572,352 - 26,634,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,330,565 - 30,388,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRE11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,615,448 - 85,694,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,610,819 - 85,694,269 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604340,060,929 - 40,162,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mre11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473539,092,781 - 39,153,920 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mre11
259 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000012940
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012940   ⟹   ENSRNOP00000012940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl819,915,883 - 19,955,130 (+)Ensembl
mRatBN7.2 Ensembl811,634,427 - 11,673,675 (+)Ensembl
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100883   ⟹   ENSRNOP00000086786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl819,913,772 - 19,961,904 (+)Ensembl
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105497   ⟹   ENSRNOP00000092951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl819,913,772 - 19,961,904 (+)Ensembl
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129576   ⟹   ENSRNOP00000105662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl819,913,800 - 19,961,903 (+)Ensembl
RefSeq Acc Id: NM_022279   ⟹   NP_071615
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,914,651 - 19,958,723 (+)NCBI
mRatBN7.2811,633,195 - 11,677,268 (+)NCBI
Rnor_6.0813,305,239 - 13,349,311 (+)NCBI
Rnor_5.0813,244,991 - 13,290,976 (+)NCBI
RGSC_v3.4811,588,409 - 11,632,483 (+)RGD
Celera813,102,879 - 13,146,939 (+)RGD
Sequence:
RefSeq Acc Id: XM_006242532   ⟹   XP_006242594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,741 - 19,961,906 (+)NCBI
mRatBN7.2811,632,293 - 11,680,451 (+)NCBI
Rnor_6.0813,304,355 - 13,350,329 (+)NCBI
Rnor_5.0813,244,991 - 13,290,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242533   ⟹   XP_006242595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,761 - 19,961,906 (+)NCBI
mRatBN7.2811,632,312 - 11,680,451 (+)NCBI
Rnor_6.0813,304,402 - 13,350,329 (+)NCBI
Rnor_5.0813,244,991 - 13,290,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006242534   ⟹   XP_006242596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,778 - 19,961,906 (+)NCBI
mRatBN7.2811,632,457 - 11,680,451 (+)NCBI
Rnor_6.0813,304,625 - 13,350,329 (+)NCBI
Rnor_5.0813,244,991 - 13,290,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082071   ⟹   XP_038937999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,900,211 - 19,961,906 (+)NCBI
mRatBN7.2811,618,876 - 11,680,451 (+)NCBI
RefSeq Acc Id: XM_039082072   ⟹   XP_038938000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,918,810 - 19,961,906 (+)NCBI
mRatBN7.2811,637,354 - 11,680,451 (+)NCBI
RefSeq Acc Id: XM_039082073   ⟹   XP_038938001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,918,810 - 19,961,906 (+)NCBI
mRatBN7.2811,637,354 - 11,680,451 (+)NCBI
RefSeq Acc Id: XM_063266066   ⟹   XP_063122136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,744 - 19,961,906 (+)NCBI
RefSeq Acc Id: XM_063266067   ⟹   XP_063122137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,798 - 19,961,906 (+)NCBI
RefSeq Acc Id: XM_063266068   ⟹   XP_063122138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,915,993 - 19,961,906 (+)NCBI
RefSeq Acc Id: XM_063266069   ⟹   XP_063122139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,913,744 - 19,939,103 (+)NCBI
RefSeq Acc Id: NP_071615   ⟸   NM_022279
- UniProtKB: Q9JIM0 (UniProtKB/Swiss-Prot),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242594   ⟸   XM_006242532
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242595   ⟸   XM_006242533
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242596   ⟸   XM_006242534
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012940   ⟸   ENSRNOT00000012940
RefSeq Acc Id: XP_038937999   ⟸   XM_039082071
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938000   ⟸   XM_039082072
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038938001   ⟸   XM_039082073
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000086786   ⟸   ENSRNOT00000100883
Ensembl Acc Id: ENSRNOP00000092951   ⟸   ENSRNOT00000105497
RefSeq Acc Id: XP_063122136   ⟸   XM_063266066
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122139   ⟸   XM_063266069
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063122137   ⟸   XM_063266067
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A2X5 (UniProtKB/TrEMBL),   A6JNA3 (UniProtKB/TrEMBL),   A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122138   ⟸   XM_063266068
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AEW0 (UniProtKB/TrEMBL),   A6JNA5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105662   ⟸   ENSRNOT00000129576
Protein Domains
Mre11 DNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIM0-F1-model_v2 AlphaFold Q9JIM0 1-706 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69263 AgrOrtholog
BioCyc Gene G2FUF-31683 BioCyc
Ensembl Genes ENSRNOG00000009506 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000012940 ENTREZGENE
  ENSRNOT00000100883 ENTREZGENE
  ENSRNOT00000129576 ENTREZGENE
Gene3D-CATH 3.30.110.110 UniProtKB/Swiss-Prot
  3.60.21.10 UniProtKB/Swiss-Prot
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  Mre11 UniProtKB/Swiss-Prot
  Mre11_DNA-bd UniProtKB/Swiss-Prot
  Mre11_DNA-bd_sf UniProtKB/Swiss-Prot
  Mre11_N UniProtKB/Swiss-Prot
KEGG Report rno:64046 UniProtKB/Swiss-Prot
NCBI Gene 64046 ENTREZGENE
PANTHER DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/Swiss-Prot
  DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
  Mre11_DNA_bind UniProtKB/Swiss-Prot
PhenoGen Mre11 PhenoGen
PIRSF DSB_repair_MRE11 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009506 RatGTEx
SMART Mre11_DNA_bind UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A8I6A2X5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEW0 ENTREZGENE, UniProtKB/TrEMBL
  A6JNA3 ENTREZGENE, UniProtKB/TrEMBL
  A6JNA5 ENTREZGENE, UniProtKB/TrEMBL
  G3V781_RAT UniProtKB/TrEMBL
  MRE11_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mre11  MRE11 homolog, double strand break repair nuclease  Mre11a  MRE11 homolog A, double strand break repair nuclease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-30 Mre11a  MRE11 homolog A, double strand break repair nuclease  Mre11a  MRE11 homolog, double strand break repair nuclease A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-09 Mre11a  MRE11 homolog, double strand break repair nuclease A  Mre11a  MRE11 meiotic recombination 11 homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Mre11a  MRE11 meiotic recombination 11 homolog A (S. cerevisiae)  Mre11a  meiotic recombination 11 homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mre11a  meiotic recombination 11 homolog A (S. cerevisiae)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in immortalized cardiomyocytes and in testis 68816