Htra1 (HtrA serine peptidase 1) - Rat Genome Database

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Gene: Htra1 (HtrA serine peptidase 1) Rattus norvegicus
Symbol: Htra1
Name: HtrA serine peptidase 1
RGD ID: 69235
Description: Predicted to enable identical protein binding activity; molecular function activator activity; and serine-type endopeptidase activity. Involved in dentinogenesis; negative regulation of defense response to virus; and positive regulation of epithelial cell proliferation. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Previously known as: high-temperature requirement A serine peptidase 1; MGC93339; protease serine 11; protease serine 11 (Igf binding); protease, serine, 11; protease, serine, 11 (Igf binding); Prss11; serine protease 11; serine protease HTRA1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81194,928,069 - 194,977,619 (+)NCBIGRCr8
mRatBN7.21185,497,815 - 185,547,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,497,735 - 185,547,379 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,848,030 - 193,897,573 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,026,602 - 201,075,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01193,698,377 - 193,747,515 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01201,499,067 - 201,548,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1201,499,028 - 201,548,513 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01208,532,013 - 208,581,538 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,257,899 - 190,308,325 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11190,407,779 - 190,458,206 (+)NCBI
Celera1183,110,143 - 183,159,496 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3',5'-cyclic AMP  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetazolamide  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chloropicrin  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
dimethylarsinous acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gefitinib  (ISO)
gentamycin  (EXP)
graphene oxide  (ISO)
graphite  (EXP)
isotretinoin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thyroxine  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Low HtrA1 expression in patients with long‑standing ulcerative colitis and colorectal cancer. Altobelli E, etal., Oncol Rep. 2017 Jul;38(1):418-426. doi: 10.3892/or.2017.5700. Epub 2017 Jun 6.
2. Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration. Andreoli MT, etal., Am J Ophthalmol. 2009 Dec;148(6):869-74. doi: 10.1016/j.ajo.2009.07.002. Epub 2009 Oct 1.
3. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Baldi A, etal., Pharmacogenomics. 2008 Aug;9(8):1069-77. doi: 10.2217/14622416.9.8.1069.
4. HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration. Cameron DJ, etal., Cell Cycle. 2007 May 2;6(9):1122-5. Epub 2007 May 16.
5. HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Catalano V, etal., Histopathology. 2011 Apr;58(5):669-78. doi: 10.1111/j.1365-2559.2011.03818.x. Epub 2011 Mar 30.
6. Genetic and functional dissection of ARMS2 in age-related macular degeneration and polypoidal choroidal vasculopathy. Cheng Y, etal., PLoS One. 2013;8(1):e53665. doi: 10.1371/journal.pone.0053665. Epub 2013 Jan 9.
7. Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. Deangelis MM, etal., Ophthalmology. 2008 Jul;115(7):1209-1215.e7. doi: 10.1016/j.ophtha.2007.10.032. Epub 2007 Dec 27.
8. Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. Feehan M, etal., BMC Med Genet. 2011 Jun 17;12:83. doi: 10.1186/1471-2350-12-83.
9. Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population. Francis PJ, etal., Mol Vis. 2008 Aug 4;14:1395-400.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration. Gibbs D, etal., Vision Res. 2008 Feb;48(5):685-9. doi: 10.1016/j.visres.2007.10.022. Epub 2008 Jan 22.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. Goto A, etal., J Ocul Biol Dis Infor. 2009 Dec 22;2(4):164-175.
14. Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10, region q26. Hadley D, etal., Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2191-6. doi: 10.1167/iovs.09-3798. Epub 2009 Nov 20.
15. Association of pattern dystrophy with an HTRA1 single-nucleotide polymorphism. Jaouni T, etal., Arch Ophthalmol. 2012 Aug;130(8):987-91. doi: 10.1001/archophthalmol.2012.1483.
16. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Jones A, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14578-83. doi: 10.1073/pnas.1102853108. Epub 2011 Aug 15.
17. Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Kaur I, etal., Invest Ophthalmol Vis Sci. 2008 May;49(5):1771-6. doi: 10.1167/iovs.07-0560.
18. Quantitative determination of high-temperature requirement protein A1 and its possible associated molecules during induced reparative dentin formation. Li X, etal., J Endod. 2012 Jun;38(6):814-20. doi: 10.1016/j.joen.2012.03.009.
19. [Interaction of susceptibility genes in patients with exudative age-related macular degeneration]. Liang X, etal., Zhonghua Yan Ke Za Zhi. 2012 Mar;48(3):241-5.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. ARMS2/HTRA1 and CFH polymorphisms are not associated with choroidal neovascularization in highly myopic eyes of the elderly Japanese population. Nakanishi H, etal., Eye (Lond). 2010 Jun;24(6):1078-84. doi: 10.1038/eye.2009.215. Epub 2009 Aug 14.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. Sheng J, etal., BMC Cell Biol. 2004 Aug 27;5:32.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
30. Association of genetic polymorphisms and age-related macular degeneration in Chinese population. Tian J, etal., Invest Ophthalmol Vis Sci. 2012 Jun 28;53(7):4262-9. doi: 10.1167/iovs.11-8542.
31. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Wang W, etal., Mol Cancer. 2020 Sep 2;19(1):134. doi: 10.1186/s12943-020-01256-9.
32. Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear factor-κB signaling pathway. Xia J, etal., Tumour Biol. 2013 Feb;34(1):317-28. doi: 10.1007/s13277-012-0553-6. Epub 2012 Oct 19.
33. HtrA1 Down-regulation Induces Cisplatin Resistance in Colon Cancer by Increasing XIAP and Activating PI3K/Akt Pathway. Xiong Z, etal., Ann Clin Lab Sci. 2017 May;47(3):264-270.
34. HtrA1 downregulation induces cisplatin resistance in lung adenocarcinoma by promoting cancer stem cell-like properties. Xu Y, etal., J Cell Biochem. 2014 Jun;115(6):1112-21. doi: 10.1002/jcb.24751.
35. Biologic Evaluation of Diabetes and Local Recurrence in Non-Small Cell Lung Cancer. Yang X, etal., Pathol Oncol Res. 2017 Jan;23(1):73-77. doi: 10.1007/s12253-016-0086-1. Epub 2016 Jul 13.
36. Effect of HtrA1 Polymorphism on Sensitivity to Chemotherapy in Patients with Colon Cancer. Yao Y and Li N, Med Sci Monit. 2020 Mar 27;26:e921933. doi: 10.12659/MSM.921933.
37. HtrA1 expression associated with the occurrence and development of esophageal cancer. Yu Y, etal., World J Surg Oncol. 2012 Aug 30;10:179. doi: 10.1186/1477-7819-10-179.
38. Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer. Zhao Z, etal., Med Oncol. 2015 Apr;32(4):112. doi: 10.1007/s12032-015-0524-z. Epub 2015 Mar 12.
39. HtrA1 regulates epithelial-mesenchymal transition in hepatocellular carcinoma. Zhu F, etal., Biochem Biophys Res Commun. 2015 Nov 20;467(3):589-94. doi: 10.1016/j.bbrc.2015.09.105. Epub 2015 Sep 25.
40. Serine protease HtrA1 expression in human hepatocellular carcinoma. Zhu F, etal., Hepatobiliary Pancreat Dis Int. 2010 Oct;9(5):508-12.
41. Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer. Zurawa-Janicka D, etal., Int J Mol Sci. 2020 May 31;21(11). pii: ijms21113947. doi: 10.3390/ijms21113947.
Additional References at PubMed
PMID:9852107   PMID:14973287   PMID:15206957   PMID:19199708   PMID:20551380   PMID:21297635   PMID:22578544   PMID:23376485   PMID:23979707   PMID:24006456   PMID:25446274   PMID:25931508  
PMID:27068509   PMID:36042379  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81194,928,069 - 194,977,619 (+)NCBIGRCr8
mRatBN7.21185,497,815 - 185,547,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1185,497,735 - 185,547,379 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,848,030 - 193,897,573 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01201,026,602 - 201,075,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01193,698,377 - 193,747,515 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01201,499,067 - 201,548,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1201,499,028 - 201,548,513 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01208,532,013 - 208,581,538 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,257,899 - 190,308,325 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11190,407,779 - 190,458,206 (+)NCBI
Celera1183,110,143 - 183,159,496 (+)NCBICelera
Cytogenetic Map1q41NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3810122,461,553 - 122,514,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10122,458,551 - 122,514,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710124,221,069 - 124,274,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610124,211,047 - 124,264,413 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410124,211,110 - 124,264,413NCBI
Celera10117,953,296 - 118,006,683 (+)NCBICelera
Cytogenetic Map10q26.13NCBI
HuRef10117,851,770 - 117,905,378 (+)NCBIHuRef
CHM1_110124,505,637 - 124,559,026 (+)NCBICHM1_1
T2T-CHM13v2.010123,357,406 - 123,410,753 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397130,537,933 - 130,587,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7130,537,841 - 130,587,390 (+)EnsemblGRCm39 Ensembl
GRCm387130,936,203 - 130,985,658 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7130,936,111 - 130,985,660 (+)EnsemblGRCm38mm10GRCm38
MGSCv377138,079,717 - 138,129,172 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367130,727,377 - 130,776,801 (+)NCBIMGSCv36mm8
Celera7130,747,058 - 130,797,116 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map773.2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955477761,127 - 808,994 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955477761,127 - 808,396 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v28134,316,807 - 134,370,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110134,322,279 - 134,375,624 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010119,030,409 - 119,083,682 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110122,437,914 - 122,495,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10122,441,098 - 122,494,733 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12832,133,779 - 32,157,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2832,132,547 - 32,157,409 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2832,180,049 - 32,232,586 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02832,639,924 - 32,693,737 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2832,640,671 - 32,693,730 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12832,172,101 - 32,225,511 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,194,497 - 32,247,262 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02832,398,590 - 32,451,692 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721314,244,028 - 14,290,168 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648611,271,130 - 11,316,739 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648611,271,130 - 11,317,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14132,041,934 - 132,103,595 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114132,043,044 - 132,103,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214143,497,521 - 143,558,513 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.19115,197,543 - 115,250,092 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9115,197,566 - 115,253,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604876,496,054 - 76,549,359 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473724,216,525 - 24,267,827 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473724,217,260 - 24,267,836 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Htra1
391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:47
Interacting mature miRNAs:58
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1178810256188377506Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,538,160 - 185,538,396 (+)MAPPERmRatBN7.2
Rnor_6.01201,539,293 - 201,539,526NCBIRnor6.0
Rnor_5.01208,572,323 - 208,572,556UniSTSRnor5.0
RGSC_v3.41190,299,110 - 190,299,344RGDRGSC3.4
RGSC_v3.41190,299,111 - 190,299,344UniSTSRGSC3.4
RGSC_v3.11190,448,820 - 190,449,237RGD
Celera1183,150,289 - 183,150,522UniSTS
SHRSP x BN Map194.7699RGD
SHRSP x BN Map194.7699UniSTS
Cytogenetic Map1q37UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,501,767 - 185,501,858 (+)MAPPERmRatBN7.2
Rnor_6.01201,503,020 - 201,503,110NCBIRnor6.0
Rnor_5.01208,535,966 - 208,536,056UniSTSRnor5.0
RGSC_v3.41190,261,852 - 190,261,942UniSTSRGSC3.4
Celera1183,114,096 - 183,114,186UniSTS
RH 3.4 Map11422.5UniSTS
Cytogenetic Map1q37UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21185,547,109 - 185,547,269 (+)MAPPERmRatBN7.2
Rnor_6.01201,548,238 - 201,548,397NCBIRnor6.0
Rnor_5.01208,581,268 - 208,581,427UniSTSRnor5.0
RGSC_v3.41190,308,055 - 190,308,214UniSTSRGSC3.4
Celera1183,159,226 - 183,159,385UniSTS
RH 3.4 Map11427.0UniSTS
Cytogenetic Map1q37UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 31 34 19 18 19 8 11 31 21 33 11 8
Low 12 23 22 1 22 43 14 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000027860   ⟹   ENSRNOP00000027860
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,497,735 - 185,547,379 (+)Ensembl
Rnor_6.0 Ensembl1201,499,028 - 201,548,513 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111703   ⟹   ENSRNOP00000083542
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,499,343 - 185,547,376 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115809   ⟹   ENSRNOP00000092383
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1185,497,817 - 185,547,376 (+)Ensembl
RefSeq Acc Id: NM_031721   ⟹   NP_113909
Rat AssemblyChrPosition (strand)Source
GRCr81194,928,069 - 194,977,619 (+)NCBI
mRatBN7.21185,497,815 - 185,547,380 (+)NCBI
Rnor_6.01201,499,067 - 201,548,508 (+)NCBI
Rnor_5.01208,532,013 - 208,581,538 (+)NCBI
RGSC_v3.41190,257,899 - 190,308,325 (+)RGD
Celera1183,110,143 - 183,159,496 (+)RGD
Protein Sequences
Protein RefSeqs NP_113909 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD52683 (Get FASTA)   NCBI Sequence Viewer  
  AAH81767 (Get FASTA)   NCBI Sequence Viewer  
  EDM17131 (Get FASTA)   NCBI Sequence Viewer  
  EDM17132 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027860
GenBank Protein Q9QZK5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113909   ⟸   NM_031721
- Peptide Label: precursor
- UniProtKB: Q9QZK5 (UniProtKB/Swiss-Prot),   A0A8L2QHG9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027860   ⟸   ENSRNOT00000027860
RefSeq Acc Id: ENSRNOP00000092383   ⟸   ENSRNOT00000115809
RefSeq Acc Id: ENSRNOP00000083542   ⟸   ENSRNOT00000111703
Protein Domains
IGFBP N-terminal   Kazal-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZK5-F1-model_v2 AlphaFold Q9QZK5 1-480 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690471
Promoter ID:EPDNEW_R996
Type:initiation region
Description:HtrA serine peptidase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01201,499,019 - 201,499,079EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69235 AgrOrtholog
BioCyc Gene G2FUF-57245 BioCyc
Ensembl Genes ENSRNOG00000020533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027860 ENTREZGENE
  ENSRNOT00000027860.5 UniProtKB/TrEMBL
  ENSRNOT00000111703.1 UniProtKB/TrEMBL
  ENSRNOT00000115809.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGFBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65164 UniProtKB/Swiss-Prot
Pfam IGFBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Htra1 PhenoGen
PROSITE IGFBP_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020533 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217138

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Htra1  HtrA serine peptidase 1  Prss11  protease, serine, 11 (Igf binding)  Symbol and Name updated 1299863 APPROVED
2004-09-10 Prss11  protease, serine, 11 (Igf binding)    protease, serine, 11  Name updated 1299863 APPROVED
2002-06-10 Prss11  protease, serine, 11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference