Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) - Rat Genome Database

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Gene: Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) Rattus norvegicus
Analyze
Symbol: Hgs
Name: hepatocyte growth factor-regulated tyrosine kinase substrate
RGD ID: 69225
Description: Predicted to enable several functions, including ubiquitin binding activity; ubiquitin-dependent protein binding activity; and ubiquitin-like protein ligase binding activity. Involved in endosome to lysosome transport. Located in cytosol; membrane; and secretory granule. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate); PARTICIPATES IN autophagy pathway; vascular endothelial growth factor signaling pathway; endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: HGF-regulated tyrosine kinase substrate; Hrs; SNAP-25-interacting protein Hrs-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210105,739,617 - 105,757,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,739,296 - 105,757,835 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,844,188 - 110,862,000 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010110,307,219 - 110,325,031 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010105,660,239 - 105,678,295 (+)NCBIRnor_WKY
Rnor_6.010109,638,944 - 109,657,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,638,767 - 109,657,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,232,509 - 109,250,728 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,861,289 - 109,869,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,875,792 - 109,883,652 (+)NCBI
Celera10104,283,857 - 104,301,769 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15. Bean AJ, etal., J Biol Chem. 2000 May 19;275(20):15271-8.
2. Hrs-2 is an ATPase implicated in calcium-regulated secretion. Bean AJ, etal., Nature 1997 Feb 27;385(6619):826-9.
3. Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor. Chin LS, etal., J Biol Chem 2001 Mar 9;276(10):7069-78.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis. Kwong J, etal., J Cell Sci 2000 Jun;113 ( Pt 12):2273-84.
7. Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. Leithe E, etal., J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.
8. Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking. Li Y, etal., J Biol Chem 2002 Aug 2;277(31):28212-21.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. How do ESCRT proteins control autophagy? Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.
14. Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. Stephens DJ and Banting G, J Biol Chem. 1999 Oct 15;274(42):30080-6.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7565774   PMID:9798906   PMID:10510169   PMID:10861283   PMID:11916981   PMID:11984006   PMID:12444102   PMID:12477932   PMID:12847087   PMID:15489334   PMID:15611048   PMID:16083858  
PMID:16615908   PMID:17062640   PMID:17714434   PMID:18767904   PMID:18977327   PMID:19056867   PMID:19351881   PMID:20675381   PMID:22871113   PMID:24105262   PMID:24790097  


Genomics

Comparative Map Data
Hgs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210105,739,617 - 105,757,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,739,296 - 105,757,835 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,844,188 - 110,862,000 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010110,307,219 - 110,325,031 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010105,660,239 - 105,678,295 (+)NCBIRnor_WKY
Rnor_6.010109,638,944 - 109,657,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,638,767 - 109,657,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,232,509 - 109,250,728 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,861,289 - 109,869,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,875,792 - 109,883,652 (+)NCBI
Celera10104,283,857 - 104,301,769 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
HGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,684,011 - 81,702,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1781,683,326 - 81,703,138 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,651,041 - 79,669,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,261,425 - 77,279,553 (+)NCBINCBI36Build 36hg18NCBI36
Build 341777,261,424 - 77,279,550NCBI
Celera1776,295,942 - 76,314,294 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,097,132 - 75,115,050 (+)NCBIHuRef
CHM1_11779,737,183 - 79,755,370 (+)NCBICHM1_1
T2T-CHM13v2.01782,600,905 - 82,619,025 (+)NCBIT2T-CHM13v2.0
Hgs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,358,431 - 120,374,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,358,461 - 120,374,805 (+)EnsemblGRCm39 Ensembl
GRCm3811120,467,605 - 120,483,984 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,467,635 - 120,483,979 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,328,949 - 120,345,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,283,781 - 120,300,069 (+)NCBIMGSCv36mm8
Celera11132,203,066 - 132,219,316 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.16NCBI
Hgs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,405,543 - 1,418,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,405,543 - 1,418,095 (-)NCBIChiLan1.0ChiLan1.0
HGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11781,844,379 - 81,862,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,844,379 - 81,862,335 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01776,143,212 - 76,161,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19499,071 - 513,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9499,116 - 514,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,101,298 - 1,115,455 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,092,550 - 1,106,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,092,550 - 1,107,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,117,545 - 1,131,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,244,142 - 1,258,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,323,173 - 1,337,298 (-)NCBIUU_Cfam_GSD_1.0
Hgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,110,692 - 1,126,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,285,551 - 5,301,233 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365945,285,678 - 5,301,267 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,207,036 - 1,219,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,207,036 - 1,219,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,613,711 - 73,632,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,613,786 - 73,632,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,022,394 - 45,041,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hgs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,620,753 - 10,634,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hgs
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:195
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000054966
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat

Markers in Region
RH138117  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,737,931 - 105,738,095 (+)MAPPERmRatBN7.2
Rnor_6.010109,637,247 - 109,637,410NCBIRnor6.0
Rnor_5.010109,230,811 - 109,230,974UniSTSRnor5.0
Celera10104,281,966 - 104,282,129UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 54 38 19 38 1 4 74 35 41 11 1
Low 7 3 3 3 7 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000054966   ⟹   ENSRNOP00000051849
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,739,296 - 105,757,835 (+)Ensembl
Rnor_6.0 Ensembl10109,638,767 - 109,657,456 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110912   ⟹   ENSRNOP00000087685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,740,724 - 105,757,400 (+)Ensembl
RefSeq Acc Id: NM_019387   ⟹   NP_062260
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,823 - 105,757,837 (+)NCBI
Rnor_6.010109,639,138 - 109,657,459 (+)NCBI
Rnor_5.010109,232,509 - 109,250,728 (+)NCBI
RGSC_v3.410109,861,289 - 109,869,587 (+)RGD
Celera10104,283,857 - 104,301,769 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247908   ⟹   XP_006247970
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,617 - 105,757,837 (+)NCBI
Rnor_6.010109,638,944 - 109,657,460 (+)NCBI
Rnor_5.010109,232,509 - 109,250,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247909   ⟹   XP_006247971
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,617 - 105,757,829 (+)NCBI
Rnor_6.010109,638,944 - 109,657,459 (+)NCBI
Rnor_5.010109,232,509 - 109,250,728 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086708   ⟹   XP_038942636
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,617 - 105,757,838 (+)NCBI
RefSeq Acc Id: XM_039086709   ⟹   XP_038942637
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,617 - 105,757,798 (+)NCBI
RefSeq Acc Id: XM_039086710   ⟹   XP_038942638
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,739,617 - 105,757,838 (+)NCBI
RefSeq Acc Id: XM_039086712   ⟹   XP_038942640
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210105,740,026 - 105,757,798 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062260   ⟸   NM_019387
- UniProtKB: Q9JJ50 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247970   ⟸   XM_006247908
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006247971   ⟸   XM_006247909
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000051849   ⟸   ENSRNOT00000054966
RefSeq Acc Id: XP_038942636   ⟸   XM_039086708
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942638   ⟸   XM_039086710
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942637   ⟸   XM_039086709
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942640   ⟸   XM_039086712
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000087685   ⟸   ENSRNOT00000110912
Protein Domains
FYVE-type   UIM   VHS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ50-F1-model_v2 AlphaFold Q9JJ50 1-776 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69225 AgrOrtholog
BioCyc Gene G2FUF-22427 BioCyc
Ensembl Genes ENSRNOG00000036696 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051849 ENTREZGENE
  ENSRNOP00000051849.5 UniProtKB/TrEMBL
  ENSRNOP00000087685 ENTREZGENE
  ENSRNOP00000087685.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054966 ENTREZGENE
  ENSRNOT00000054966.5 UniProtKB/TrEMBL
  ENSRNOT00000110912 ENTREZGENE
  ENSRNOT00000110912.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.90 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133877 IMAGE-MGC_LOAD
InterPro ENTH_VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRS_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubi-bd_Hrs_VPS27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56084 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93483 IMAGE-MGC_LOAD
NCBI Gene 56084 ENTREZGENE
PANTHER HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46275 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hrs_helical UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hgs PhenoGen
PIRSF Hrs_Vps27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FYVE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VHS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48464 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229632
UniProt A0A140TAH1_RAT UniProtKB/TrEMBL
  A0A8I6A993_RAT UniProtKB/TrEMBL
  HGS_RAT UniProtKB/Swiss-Prot
  Q76N76 ENTREZGENE
  Q9JJ50 ENTREZGENE
UniProt Secondary P97847 UniProtKB/Swiss-Prot
  Q5XIV8 UniProtKB/Swiss-Prot
  Q76N76 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Hgs  hepatocyte growth factor-regulated tyrosine kinase substrate  Hgs  HGF-regulated tyrosine kinase substrate  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hgs  HGF-regulated tyrosine kinase substrate      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to both cytosolic and membrane-associated pools 632855