ESR2 (estrogen receptor 2) - Rat Genome Database

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Gene: ESR2 (estrogen receptor 2) Homo sapiens
Symbol: ESR2
Name: estrogen receptor 2
RGD ID: 69213
HGNC Page HGNC:3468
Description: Enables several functions, including estrogen response element binding activity; nuclear estrogen receptor activity; and nuclear receptor activity. Involved in cellular response to lipid and regulation of DNA-templated transcription. Located in mitochondrion and nucleoplasm. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Biomarker of several diseases, including Alzheimer's disease; Crohn's disease; aortic valve stenosis; autoimmune disease (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ER beta; ER-BETA; Erb; ESR-BETA; ESRB; ESTRB; estrogen nuclear receptor beta variant a; estrogen nuclear receptor beta variant b; estrogen receptor 2 (ER beta); estrogen receptor beta; estrogen receptor beta 2; estrogen receptor beta 4; estrogen receptor beta splice variant, ERbeta2delta7; estrogen receptor beta splice variant, ERbeta4delta7; estrogen receptor beta splice variant, ERbeta6; estrogen receptor beta splice variant, ERbeta6delta7; estrogen receptor beta splice variant, ERbeta7; estrogen receptor beta splice variant, ERbeta7delta7; estrogen receptor beta splice variant, ERbetaEx. 4L; estrogen receptor beta splice variant, ERbetaEx. 6L; NR3A2; nuclear receptor subfamily 3 group A member 2; ODG8; oestrogen receptor beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1464,084,232 - 64,338,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBINCBI36Build 36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBICelera
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (EXP)
adenoma  (IEP)
alopecia  (IAGP)
Alzheimer's disease  (IAGP,IEP,ISO)
Animal Mammary Neoplasms  (EXP)
anxiety disorder  (ISO)
aortic valve stenosis  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (EXP)
Blast Crisis  (ISO)
brain ischemia  (ISO)
breast cancer  (IAGP,ISO)
Breast Neoplasms  (EXP,IEP)
carcinoma  (EXP)
Cardiac Arrhythmias  (EXP)
Cocaine-Related Disorders  (EXP)
Cognitive Dysfunction  (IAGP)
colitis  (ISO)
colon cancer  (ISO)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
contact dermatitis  (ISO)
coronary artery disease  (EXP,IAGP)
Coronary Disease  (EXP)
Crohn's disease  (IEP)
cystitis  (ISO)
Deafness  (ISO)
Endometrial Neoplasms  (EXP)
endometriosis  (EXP,ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Mammary Neoplasms  (EXP,ISO)
Experimental Melanoma  (ISO)
Female Infertility  (EXP,ISO)
glomerulosclerosis  (ISO)
Graves' disease  (IAGP)
Hand Osteoarthritis  (IAGP)
Hashimoto Disease  (IAGP)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
Hot Flashes  (ISO)
Hyperalgesia  (ISO)
hypertension  (IAGP,ISO)
hypospadias  (IAGP)
in situ carcinoma  (IEP)
inflammatory bowel disease  (ISO)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (IAGP)
Left Ventricular Hypertrophy  (IAGP)
Lithiasis  (EXP)
Lung Injury  (ISO)
malignant astrocytoma  (EXP)
medulloblastoma  (EXP)
melanoma  (IEP)
mental depression  (ISO)
molybdenum cofactor deficiency type C  (IAGP)
myasthenia gravis  (IEP)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
osteoarthritis  (IAGP)
osteoporosis  (IAGP,ISO)
Osteoporotic Fractures  (IAGP,ISO)
ovarian dysgenesis 8  (IAGP)
Parkinson's disease  (IAGP)
peritonitis  (ISO)
Pituitary Neoplasms  (IEP)
Postmenopausal Osteoporosis  (IAGP)
pre-eclampsia  (IAGP)
primary open angle glaucoma  (IAGP)
prostate cancer  (IAGP)
prostate carcinoma in situ  (EXP,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP,IEP)
pulmonary hypertension  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (IAGP)
Sepsis  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (IAGP,IEP,ISO)
systemic scleroderma  (IAGP)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (EXP)
ulcerative colitis  (IEP)
urinary bladder cancer  (EXP,IEP)
Urination Disorders  (ISO)
Varicose Ulcer  (IAGP)
Vulvar Lichen Sclerosus  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(24S)-24-hydroxycholesterol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(3-phenoxyphenyl)methanol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (EXP)
1-naphthol  (EXP)
10H-phenothiazine  (EXP)
16-Ketoestrone  (EXP)
17alpha-estradiol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2'-Bisphenol F  (EXP)
2,2'-Dihydroxy-4-methoxybenzophenone  (EXP)
2,2,2-trichloroethanol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (EXP)
2,4-Dihydroxybenzophenone  (EXP)
2,6-diisopropylnaphthalene  (EXP)
2,6-dimethylnaphthalene  (EXP)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (EXP)
2-tert-butylhydroquinone  (EXP)
2-tert-Butylphenol  (EXP)
22-Hydroxycholesterol  (EXP)
25-hydroxycholesterol  (EXP)
26-hydroxycholesterol  (EXP,ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,3'-Dimethylbenzidine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (EXP)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (EXP)
4-Androstenediol  (ISO)
4-chloro-3,5-dimethylphenol  (EXP)
4-ethylphenol  (EXP,ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (EXP)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (ISO)
4-nitrotoluene  (EXP)
4-nonylphenol  (EXP,ISO)
4-octylphenol  (EXP,ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (EXP)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5alpha-androstane-3alpha,17beta-diol  (ISO)
5alpha-androstane-3beta,17beta-diol  (ISO)
6-oxocampestanol  (EXP)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
9-phenanthrol  (EXP)
acetochlor  (EXP)
acetophenone  (EXP)
acrylamide  (EXP)
adenosine  (EXP,ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (EXP)
aldrin  (EXP)
all-trans-phytoene  (EXP)
all-trans-phytofluene  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
androst-4-ene-3,17-dione  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (EXP)
apigenin  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atrazine  (EXP,ISO)
azadirachtin A  (EXP,ISO)
bazedoxifene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzophenone  (EXP)
benzyl benzoate  (EXP)
Benzyl parahydroxybenzoate  (EXP)
Benzyl salicylate  (EXP)
beta-carotene  (EXP)
beta-hexachlorocyclohexane  (EXP,ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
beta-Zearalanol  (ISO)
bexarotene  (EXP)
bicalutamide  (EXP)
bifenthrin  (EXP)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (EXP)
biphenyl-4-ol  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (EXP)
brassinolide  (EXP)
Bromofos  (EXP)
Bromophos-ethyl  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (EXP)
butylbenzene  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
butyric acid  (EXP,ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
camptothecin  (EXP)
carbaryl  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
carfilzomib  (EXP)
cedrol  (EXP)
CGP 52608  (EXP)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chloropropylate  (EXP)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (EXP)
chromium(6+)  (ISO)
chrysin  (EXP)
cisplatin  (EXP)
citral  (EXP)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumaphos  (EXP)
coumestrol  (EXP,ISO)
Cuprizon  (ISO)
cyanazine  (EXP)
Cyanofenphos  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cyproterone acetate  (EXP)
D-aspartic acid  (ISO)
D-glucose  (EXP)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
Decamethylcyclopentasiloxane  (EXP)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (EXP)
delta-tocopherol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (EXP)
diarsenic trioxide  (EXP)
diarylheptanoid  (EXP)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (EXP)
dicofol  (EXP)
Dicyclohexyl phthalate  (EXP)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (EXP)
dioscin  (EXP,ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diphenylmethanol  (EXP)
dipropyl phthalate  (EXP)
disodium selenite  (EXP)
diuron  (EXP)
doxorubicin  (EXP)
dronedarone  (EXP)
emetine  (EXP)
emodin  (EXP)
endosulfan  (EXP,ISO)
endrin  (EXP)
enilconazole  (EXP,ISO)
enzacamene  (EXP,ISO)
equilin  (EXP)
equol  (EXP)
estradiol  (ISO)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (ISO)
ethanol  (ISO)
ethion  (EXP)
Ethyl cinnamate  (EXP)
ethyl myristate  (EXP)
ethylparaben  (EXP,ISO)
etoposide  (EXP)
eugenol  (EXP)
fenamiphos  (EXP)
fenarimol  (EXP,ISO)
fenbuconazole  (EXP)
fenhexamid  (EXP)
fenitrothion  (EXP)
fenpyroximate  (EXP)
fenthion  (EXP)
fentin chloride  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (EXP)
fipronil  (EXP)
flavone  (EXP)
fludioxonil  (EXP)
fluoranthene  (EXP)
fluoxastrobin  (EXP)
flutamide  (EXP,ISO)
formononetin  (EXP)
fulvestrant  (EXP,ISO)
galaxolide  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geranial  (EXP)
geraniol  (EXP)
glucose  (EXP)
glycitein  (EXP,ISO)
glycitin  (ISO)
glyphosate  (EXP,ISO)
heptachlor  (EXP)
Heptachlor epoxide  (EXP)
herbicide  (EXP)
hexachlorobenzene  (EXP)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP,ISO)
ICI-164384  (ISO)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (EXP)
iprodione  (EXP)
irilone  (EXP)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (EXP)
isorhamnetin  (EXP)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
kresoxim-methyl  (EXP)
L-ascorbic acid  (ISO)
lamivudine  (ISO)
lasofoxifene  (ISO)
leptophos  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
liquiritigenin  (EXP)
luteolin  (EXP)
lycopene  (EXP)
M1  (EXP)
mancozeb  (EXP)
melatonin  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
mestranol  (EXP)
metconazole  (EXP)
metformin  (ISO)
methimazole  (ISO)
methiocarb  (EXP)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (EXP)
Methyl palmitate  (EXP)
methylparaben  (EXP)
methylseleninic acid  (EXP)
methyltestosterone  (EXP)
metolachlor  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (EXP)
MK 571  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP,ISO)
monoethyl phthalate  (ISO)
Moxestrol  (ISO)
mycophenolic acid  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-butylbenzenesulfonamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
n-propyl gallate  (EXP)
Nafoxidine  (ISO)
nandrolone  (ISO)
Nandrolone decanoate  (ISO)
napropamide  (EXP)
naringin  (ISO)
nebivolol  (EXP)
Nonylphenol  (EXP,ISO)
norethisterone  (EXP)
Norethynodrel  (ISO)
notoginsenoside R1  (ISO)
nuarimol  (EXP)
O-Desmethylangolensin  (EXP)
octocrylene  (EXP)
ormeloxifene  (ISO)
oryzalin  (EXP)
Osajin  (EXP)
Oxadiazon  (EXP)
oxybenzone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
p-tolualdehyde  (EXP)
paclitaxel  (EXP)
parathion-methyl  (EXP)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenanthrene  (EXP)
phenothrin  (EXP)
phloretin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phthalic acid  (EXP)
phytoestrogen  (EXP)
picoxystrobin  (EXP)
Pomiferin  (EXP)
potassium dichromate  (ISO)
prallethrin  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propamocarb  (EXP)
propargite  (EXP)
propiconazole  (EXP)
propylparaben  (EXP,ISO)
propyzamide  (EXP)
prothiofos  (EXP)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (EXP)
pyrene  (EXP)
pyridaben  (EXP)
quercetin  (EXP)
quinalphos  (EXP)
raloxifene  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Rhapontigenin  (EXP)
rifapentine  (EXP)
Rosavin  (EXP)
rotenone  (EXP)
royal jelly  (EXP)
rubitecan  (EXP)
rutin  (ISO)
salicylates  (EXP)
saquinavir  (ISO)
SB 203580  (EXP)
serpentine asbestos  (EXP)
silibinin  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium hypochlorite  (EXP)
sophoraflavanone B  (EXP,ISO)
staurosporine  (EXP)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (EXP)
testosterone  (EXP,ISO)
Testosterone propionate  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (ISO)
tetrachlorvinphos  (EXP)
tetradifon  (EXP)
tetralin  (EXP)
tetramethrin  (ISO)
tibolone  (EXP)
tolclofos-methyl  (EXP)
topotecan  (EXP)
toremifene  (EXP,ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
Tri-2-ethylhexyl trimellitate  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP,ISO)
trifloxystrobin  (EXP)
trifluralin  (EXP)
trifluridine  (EXP)
trilostane  (ISO)
triphenyl phosphate  (EXP)
Triphenylethylene  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
undecan-2-one  (EXP)
Urolithin A  (EXP)
valinomycin  (EXP)
valproic acid  (EXP)
vinclozolin  (EXP,ISO)
vinyl carbamate  (ISO)
vitamin D  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (ISO)
androgen receptor signaling pathway  (ISO)
behavioral fear response  (ISO)
brain development  (ISO)
cell population proliferation  (ISO)
cell-cell signaling  (TAS)
cellular response to estradiol stimulus  (IDA,IEA,ISO)
cellular response to magnetism  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cerebellum development  (ISO)
DNA-templated transcription  (IEA)
epithelial cell maturation involved in prostate gland development  (ISO)
epithelial cell proliferation  (ISO)
estrous cycle  (ISO)
female gonad development  (ISO)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (ISO)
intracellular estrogen receptor signaling pathway  (IDA,IEA,ISO,TAS)
intracellular receptor signaling pathway  (IEA)
intracellular steroid hormone receptor signaling pathway  (IBA,ISO)
learning or memory  (ISO)
male gonad development  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (NAS)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of feeding behavior  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of signaling receptor activity  (IEA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
neuron migration  (ISO)
ovarian follicle development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
prostate gland development  (ISO)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA,TAS)
regulation of neuron apoptotic process  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (ISO)
response to bisphenol A  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to genistein  (ISO)
response to hormone  (ISO)
response to human chorionic gonadotropin  (ISO)
response to insecticide  (ISO)
response to lipid  (IEA)
response to nutrient levels  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to salt  (ISO)
response to testosterone  (ISO)
response to water deprivation  (ISO)
response to xenobiotic stimulus  (ISO)
Sertoli cell development  (ISO)
Sertoli cell proliferation  (ISO)
signal transduction  (TAS)
steroid hormone mediated signaling pathway  (IEA)
transcription initiation at RNA polymerase II promoter  (IEA)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
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94. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. Rosa FE, etal., Hum Pathol. 2008 Jan 29;.
95. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
96. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, etal., Cell. 2011 May 13;145(4):584-95.
97. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Sato H, etal., Rheumatol Int. 2011 Apr 27.
98. Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. Sharawy N, etal., Microvasc Res. 2013 Jan;85:118-27. doi: 10.1016/j.mvr.2012.10.002. Epub 2012 Oct 11.
99. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Shim GJ, etal., Proc Natl Acad Sci U S A 2003 May 27;100(11):6694-9. Epub 2003 May 9.
100. Inner ear pathology and loss of hearing in estrogen receptor-beta deficient mice. Simonoska R, etal., J Endocrinol. 2009 Jun;201(3):397-406. doi: 10.1677/JOE-09-0060. Epub 2009 Mar 17.
101. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. Sonestedt E, etal., J Nutr. 2009 May;139(5):993-1001. doi: 10.3945/jn.108.101691. Epub 2009 Mar 25.
102. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8beta-VE2. Sun J, etal., J Cardiovasc Pharmacol. 2011 Oct;58(4):399-405.
103. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
104. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. Treeck O, etal., J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):207-11. doi: 10.1016/j.jsbmb.2009.02.012. Epub 2009 Mar 3.
105. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Tsezou A, etal., Breast. 2008 Apr;17(2):159-66. Epub 2007 Sep 29.
106. Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats. Umar S, etal., Am J Respir Crit Care Med. 2011 Jun 23.
107. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Wang J, etal., Lupus. 2010 May;19(6):734-40. Epub 2010 Mar 19.
108. Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Wang L, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):703-8. Epub 2003 Jan 6.
109. Estrogen receptor beta mediates acute myocardial protection following ischemia. Wang M, etal., Surgery. 2008 Aug;144(2):233-8. Epub 2008 May 9.
110. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. Weigt C, etal., Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38. doi: 10.1016/j.mce.2011.12.013. Epub 2011 Dec 30.
111. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Westberg L, etal., Psychoneuroendocrinology. 2004 Sep;29(8):993-8.
112. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. Wise BL, etal., J Rheumatol. 2009 Dec;36(12):2772-9. doi: 10.3899/jrheum.081208. Epub 2009 Nov 2.
113. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. Witkowska HE, etal., Steroids. 1997 Aug-Sep;62(8-9):621-31.
114. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
115. Estrogen receptor-beta in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. Xue B, etal., Hypertension. 2013 Jun;61(6):1255-62. doi: 10.1161/HYPERTENSIONAHA.111.00903. Epub 2013 Apr 22.
116. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Yaffe K, etal., Neurobiol Aging. 2009 Apr;30(4):607-14. Epub 2007 Sep 21.
117. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. Yang F, etal., Neuroreport. 2014 Jan 22;25(2):100-4. doi: 10.1097/WNR.0000000000000052.
118. Expression of oestrogen receptor-alpha and oestrogen receptor-beta in prostate cancer. Yang GS, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1611-5.
119. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Yip L, etal., Br J Dermatol. 2012 May;166(5):1131-4. doi: 10.1111/j.1365-2133.2011.10702.x. Epub 2012 Mar 5.
120. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. Zhai G, etal., PLoS One. 2013 May 21;8(5):e64445. doi: 10.1371/journal.pone.0064445. Print 2013.
121. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Zheng SL, etal., Cancer Res. 2003 Nov 15;63(22):7624-9.
122. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. Zheng Y, etal., PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
123. [The relationship of vitamin D endocrine system and estrogen receptor expression with bone mineral density in initial systemic lupus erythematosus]. Zheng YJ, etal., Zhonghua Nei Ke Za Zhi. 2010 Apr;49(4):309-12.
124. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu Y, etal., Science 2002 Jan 18;295(5554):505-8.
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