Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp27b1 (cytochrome P450, family 27, subfamily b, polypeptide 1) Rattus norvegicus
Symbol: Cyp27b1
Name: cytochrome P450, family 27, subfamily b, polypeptide 1
RGD ID: 69192
Description: Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1); PARTICIPATES IN steroid biosynthetic pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Previously known as: 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; 25-OHD-1 alpha-hydroxylase; calcidiol 1-monooxygenase; Cyp40; cytochrome p450 27B1; cytochrome P450 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450, subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase), polypeptide 1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; LOC100909462; P450C1 alpha; P450VD1-alpha; VD3 1A hydroxylase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cyp27b1em1Thka  
Genetic Models: W-Cyp27b1em1Thka
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8764,756,626 - 64,761,570 (+)NCBIGRCr8
mRatBN7.2762,869,340 - 62,876,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,760,608 - 64,765,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,963,010 - 66,967,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,764,060 - 66,769,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,333,150 - 70,340,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,512,763 - 70,517,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera760,014,507 - 60,019,451 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
biochanin A  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
caesium atom  (EXP)
calcidiol  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dioxygen  (EXP)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
fructose  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
medroxyprogesterone acetate  (ISO)
melphalan  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
oxybenzone  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
PD 0325901  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
sulfasalazine  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triadimefon  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin D  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Parathyroid hormone stimulation of the renal 25-hydroxyvitamin D-1alpha-hydroxylase--effect of age and free radicals. Armbrecht HJ, etal., J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):330-3. Epub 2007 Jan 12.
2. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Bailey R, etal., Diabetes. 2007 Oct;56(10):2616-21. Epub 2007 Jul 2.
3. Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice. Borges CC, etal., J Nutr Sci Vitaminol (Tokyo). 2018;64(2):106-115. doi: 10.3177/jnsv.64.106.
4. Metabolism of 25-hydroxyvitamin D in copper-laden rat: a model of Wilson's disease. Carpenter TO, etal., Am J Physiol. 1988 Feb;254(2 Pt 1):E150-4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency. Ghazarian JG, etal., Endocrinology. 1983 Aug;113(2):476-84.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Role of insulin in the stimulation of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase by phosphorus deprivation in rats. Ikeda K, etal., Metabolism. 1987 Jun;36(6):555-7.
9. Hydroxylation of 25-hydroxyvitamin D3 by renal mitochondria from rats of different ages. Ishida M, etal., Endocrinology. 1987 Aug;121(2):443-8.
10. Metabolic acidosis suppresses 25-hydroxyvitamin in D3-1alpha-hydroxylase in the rat kidney. Distinct site and mechanism of action. Kawashima H, etal., J Clin Invest. 1982 Jul;70(1):135-40.
11. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka S, etal., N Engl J Med. 1998 Mar 5;338(10):653-61.
12. Effects of prostaglandin E2 and indomethacin on 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in isolated kidney cells of normal and streptozotocin-induced diabetic rats. Kurose H, etal., Calcif Tissue Int. 1985 Dec;37(6):625-9.
13. Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. Lange CM, etal., J Hepatol. 2011 May;54(5):887-93. doi: 10.1016/j.jhep.2010.08.036. Epub 2011 Jan 20.
14. Parathyroidectomy abolishes the increase of renal 25-hydroxyvitamin D-1 alpha-hydroxylase in lactating rats. Lobaugh B, etal., Am J Physiol. 1993 Jun;264(6 Pt 1):E981-5.
15. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Ma R, etal., Am J Physiol Endocrinol Metab. 2012 Oct 1;303(7):E928-35. doi: 10.1152/ajpendo.00279.2012. Epub 2012 Aug 7.
16. The deficiency and the supplementation of vitamin D and liver: Lessons of chronic fructose-rich diet in mice. Maia-Ceciliano TC, etal., J Steroid Biochem Mol Biol. 2019 Sep;192:105399. doi: 10.1016/j.jsbmb.2019.105399. Epub 2019 Jun 5.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Possible mechanism of impaired calcium and vitamin D metabolism in nephrotic rats. Mizokuchi M, etal., Kidney Int. 1992 Aug;42(2):335-40.
19. Purification and characterization of 25-hydroxyvitamin D3 1alpha-hydroxylase from rat kidney mitochondria. Nakamura Y, etal., FEBS Lett. 1997 Dec 8;419(1):45-8.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions. Nishikawa M, etal., Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.
22. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Panda DK, etal., Proc Natl Acad Sci U S A 2001 Jun 19;98(13):7498-503.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Gestational diabetes mellitus and vitamin D deficiency: genetic contribution of CYP27B1 and CYP2R1 polymorphisms. Ramos-Lopez E, etal., Diabetes Obes Metab. 2008 Aug;10(8):683-5. Epub 2008 May 12.
27. CYP2R1-, CYP27B1- and CYP24-mRNA expression in German type 1 diabetes patients. Ramos-Lopez E, etal., J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):807-10. Epub 2007 Jan 16.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Comprehensive gene review and curation RGD comprehensive gene curation
32. Effects of repeated administration of rifampicin and isoniazid on vitamin D metabolism in mice. Sheng L, etal., Steroids. 2015 Dec;104:203-7. doi: 10.1016/j.steroids.2015.10.004. Epub 2015 Oct 22.
33. Cloning and expression of rat 25-hydroxyvitamin D3-1alpha-hydroxylase cDNA. Shinki T, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):12920-5.
34. Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha-hydroxylase gene in normocalcemic rats. Shinki T, etal., Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8253-8.
35. The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. St-Arnaud R, etal., J Bone Miner Res 1997 Oct;12(10):1552-9.
36. Gene expression of vitamin D hydroxylase and megalin in the remnant kidney of nephrectomized rats. Takemoto F, etal., Kidney Int. 2003 Aug;64(2):414-20.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
39. Regulation of renal vitamin D hydroxylase activity in vitamin D deficient rats. Warner M and Tenenhouse A, Can J Physiol Pharmacol. 1985 Aug;63(8):978-82.
40. Dietary phosphorus deprivation induces 25-hydroxyvitamin D(3) 1alpha-hydroxylase gene expression. Yoshida T, etal., Endocrinology 2001 May;142(5):1720-6.
41. Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection. Zhu Q, etal., Genet Test Mol Biomarkers. 2012 Sep;16(9):1115-21. doi: 10.1089/gtmb.2012.0148.
Additional References at PubMed
PMID:9282826   PMID:9295274   PMID:9415400   PMID:9488468   PMID:10518789   PMID:12205031   PMID:12496369   PMID:12855575   PMID:14651853   PMID:15589699   PMID:15795327   PMID:15972816  
PMID:16549446   PMID:16720713   PMID:17023519   PMID:18614015   PMID:18797846   PMID:18840526   PMID:18979155   PMID:19542734   PMID:20236619   PMID:20969950   PMID:22862690   PMID:23816829  
PMID:26342089   PMID:27074284   PMID:33596463  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8764,756,626 - 64,761,570 (+)NCBIGRCr8
mRatBN7.2762,869,340 - 62,876,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx764,760,608 - 64,765,551 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0766,963,010 - 66,967,953 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0766,764,060 - 66,769,003 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,333,150 - 70,340,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,512,763 - 70,517,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera760,014,507 - 60,019,451 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,762,334 - 57,768,986 (-)EnsemblGRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,861 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
T2T-CHM13v2.01257,730,683 - 57,735,427 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910126,884,115 - 126,891,897 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10126,884,119 - 126,888,875 (+)EnsemblGRCm39 Ensembl
GRCm3810127,048,246 - 127,054,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,048,250 - 127,053,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,485,302 - 126,490,062 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,451,200 - 126,455,955 (+)NCBIMGSCv36mm8
Celera10129,440,145 - 129,444,905 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,472,404 - 5,477,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,472,404 - 5,477,001 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21036,572,617 - 36,578,661 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,569,388 - 36,575,667 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,158,814 - 31,164,462 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,419,773 - 31,424,822 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,419,773 - 31,424,822 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,825,224 - 1,830,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,826,046 - 1,829,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,888,246 - 1,893,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,834,457 - 1,840,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,834,464 - 1,839,154 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,812,161 - 1,817,832 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0102,054,207 - 2,059,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0102,179,134 - 2,184,808 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494556,964,979 - 56,970,660 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,900,259 - 1,904,104 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,899,686 - 1,904,104 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl523,053,892 - 23,058,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,053,129 - 23,058,865 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,675,704 - 53,681,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,675,226 - 53,680,443 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,280,050 - 192,285,176 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462480210,176,919 - 10,181,657 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,176,865 - 10,181,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cyp27b1
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:608
Count of miRNA genes:252
Interacting mature miRNAs:307
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat

Genetic Models
This gene Cyp27b1 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 1 2 12 12 12 43 25 27
Below cutoff 2 22 33 18 17 18 1 2 30 10 13 7 1


RefSeq Acc Id: ENSRNOT00000072176   ⟹   ENSRNOP00000064023
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl762,871,297 - 62,876,241 (+)Ensembl
Rnor_6.0 Ensembl770,335,061 - 70,340,005 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084933   ⟹   ENSRNOP00000075713
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl770,335,071 - 70,340,005 (+)Ensembl
RefSeq Acc Id: NM_053763   ⟹   NP_446215
Rat AssemblyChrPosition (strand)Source
GRCr8764,756,626 - 64,761,570 (+)NCBI
mRatBN7.2762,871,297 - 62,876,241 (+)NCBI
Rnor_6.0770,335,061 - 70,340,005 (+)NCBI
Rnor_5.0770,512,763 - 70,517,707 (+)NCBI
Celera760,014,507 - 60,019,451 (+)RGD
Protein Sequences
Protein RefSeqs NP_446215 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB86461 (Get FASTA)   NCBI Sequence Viewer  
  BAA23271 (Get FASTA)   NCBI Sequence Viewer  
  EDM16504 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064023
GenBank Protein O35132 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446215   ⟸   NM_053763
- UniProtKB: O35076 (UniProtKB/Swiss-Prot),   O35132 (UniProtKB/Swiss-Prot),   A6HQR8 (UniProtKB/TrEMBL),   M0R3V1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075713   ⟸   ENSRNOT00000084933
RefSeq Acc Id: ENSRNOP00000064023   ⟸   ENSRNOT00000072176

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K339-F1-model_v2 AlphaFold A0A0G2K339 1-454 view protein structure
AF-O35132-F1-model_v2 AlphaFold O35132 1-501 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69192 AgrOrtholog
BioCyc Gene G2FUF-33778 BioCyc
BioCyc Pathway PWY-6076 [vitamin D3 biosynthesis] BioCyc
BioCyc Pathway Image PWY-6076 BioCyc
Ensembl Genes ENSRNOG00000046214 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00065016075 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072176 ENTREZGENE
  ENSRNOT00000072176.3 UniProtKB/TrEMBL
  ENSRNOT00065026720 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114700 UniProtKB/Swiss-Prot
  PTHR24279 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp27b1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046214 RatGTEx
  ENSRNOG00065016075 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC212238
  CP27B_RAT UniProtKB/Swiss-Prot
UniProt Secondary O35076 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cyp27b1  cytochrome P450, family 27, subfamily b, polypeptide 1  LOC100909462  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like  Data merged from RGD:6503722 737654 PROVISIONAL
2012-07-05 LOC100909462  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Cyp27b1  cytochrome P450, family 27, subfamily b, polypeptide 1    cytochrome P450, subfamily 27b, polypeptide 1  Name updated 1299863 APPROVED
2002-06-10 Cyp27b1  cytochrome P450, subfamily 27b, polypeptide 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency may be associated with pseudovitamin D-deficiency rickets (PDDR) 69373
gene_expression expressed in renal proximal tubular cells 69372
gene_expression elevated in hypophosphatemic rats, low in thyroparatomized rats; elevated in vitamin D3-deficiency  
gene_expression elevated in hypophosphatemic rats, low in thyroparatomized rats 68680
gene_expression elevated in vitamin D3-deficiency 68680
gene_process involved in vitamin D metabolism 68680
gene_process involved in vitamin D metabolism 69373
gene_process increased levels may be associated with hypophosphatemia 68680
gene_protein predicted 501 amino acid protein 69372
gene_regulation regulated by a series of modulators, including PTH, calcitonin, insulin-like growth factor 1 68680