Smad7 (SMAD family member 7) - Rat Genome Database

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Gene: Smad7 (SMAD family member 7) Mus musculus
Symbol: Smad7
Name: SMAD family member 7
RGD ID: 69141
Description: Enables collagen binding activity. Involved in several processes, including circulatory system development; negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and negative regulation of protein phosphorylation. Acts upstream of or within cellular response to leukemia inhibitory factor; negative regulation of BMP signaling pathway; and transforming growth factor beta receptor signaling pathway. Located in nucleus. Part of protein-containing complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in colorectal cancer and pancreatic adenocarcinoma. Orthologous to human SMAD7 (SMAD family member 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAD homolog 7; MAD homolog 8; Madh; Madh7; madh8; mothers against decapentaplegic homolog 7; mothers against decapentaplegic homolog 8; mothers against DPP homolog 7; mothers against DPP homolog 8; SMAD 7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391875,500,436 - 75,529,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)EnsemblGRCm39 Ensembl
GRCm381875,367,365 - 75,395,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371875,527,019 - 75,555,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,492,894 - 75,521,292 (+)NCBIMGSCv36mm8
Celera1876,602,062 - 76,630,688 (+)NCBICelera
Cytogenetic Map18E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,3-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
acteoside  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
Ammothamnine  (EXP)
antigen  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
cadmium sulfate  (EXP)
calcitriol  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (EXP)
carvedilol  (ISO)
chlordecone  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
isobutyl nitrite  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
Monobutylphthalate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalenes  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
octreotide  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pasireotide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
picrotoxin  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
SB 431542  (EXP,ISO)
serpentine asbestos  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenite  (ISO)
sorafenib  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thiabendazole  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triptonide  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction assembly  (ISO)
anatomical structure morphogenesis  (IBA)
artery morphogenesis  (IMP)
cell differentiation  (IBA)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to transforming growth factor beta stimulus  (IMP,ISO)
intracellular signal transduction  (ISO)
negative regulation of BMP signaling pathway  (IDA,ISO)
negative regulation of chondrocyte proliferation  (IDA)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ossification  (IDA)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of peptidyl-serine phosphorylation  (IMP,ISO)
negative regulation of peptidyl-threonine phosphorylation  (IMP,ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of T cell cytokine production  (IMP)
negative regulation of T-helper 17 cell differentiation  (IMP)
negative regulation of T-helper 17 type immune response  (IMP)
negative regulation of transcription by competitive promoter binding  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of ubiquitin-protein transferase activity  (ISO)
pathway-restricted SMAD protein phosphorylation  (IMP)
positive regulation of cell-cell adhesion  (IMP,ISO)
positive regulation of chondrocyte hypertrophy  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein ubiquitination  (ISO)
protein stabilization  (ISO)
protein-containing complex localization  (ISO)
regulation of activin receptor signaling pathway  (ISO)
regulation of cardiac muscle contraction  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial to mesenchymal transition  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transforming growth factor beta receptor signaling pathway  (IC,ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (IC)
response to laminar fluid shear stress  (ISO)
SMAD protein signal transduction  (IBA)
transforming growth factor beta receptor signaling pathway  (IBA,IDA)
ureteric bud development  (IEP)
ventricular cardiac muscle tissue morphogenesis  (IMP)
ventricular septum morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal artery development  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal blood circulation  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal pancreatic beta cell differentiation  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal QRS complex  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
cleft palate  (IAGP)
decreased activated T cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased birth body size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-9 secretion  (IAGP)
decreased litter size  (IAGP)
decreased pancreatic alpha cell number  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased T cell proliferation  (IAGP)
increased B cell apoptosis  (IAGP)
increased transforming growth factor beta level  (IAGP)
irregular heartbeat  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
paralysis  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
prolonged RR interval  (IAGP)
skin edema  (IAGP)
thin ventricular wall  (IAGP)
thymus hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
ventricular septal defect  (IAGP)

References - curated
# Reference Title Reference Citation
1. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64.
2. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Dowdy SC, etal., Gynecol Oncol. 2005 Feb;96(2):368-73.
3. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Feng T, etal., Clin Sci (Lond). 2015 Jun;128(11):761-74. doi: 10.1042/CS20140606.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. Kleeff J, etal., Oncogene. 1999 Sep 23;18(39):5363-72. doi: 10.1038/sj.onc.1202909.
6. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
19. Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis. Uchida K, etal., Mol Cell Biol Res Commun. 2000 Aug;4(2):98-105.
20. Mutation analysis of the Smad6 and Smad7 gene in human ovarian cancers. Wang D, etal., Int J Oncol. 2000 Dec;17(6):1087-91.
Additional References at PubMed
PMID:9335505   PMID:9335507   PMID:9738003   PMID:10349636   PMID:10376010   PMID:10393693   PMID:10559222   PMID:10823886   PMID:10828018   PMID:10887185   PMID:10899902   PMID:10906784  
PMID:11042159   PMID:11076861   PMID:11231077   PMID:11278814   PMID:11557747   PMID:11560950   PMID:11854453   PMID:11934870   PMID:12032071   PMID:12118366   PMID:12149478   PMID:12397035  
PMID:12477932   PMID:12520002   PMID:12545162   PMID:12588798   PMID:12650946   PMID:12761254   PMID:12815042   PMID:12839562   PMID:12904583   PMID:12943993   PMID:12944489   PMID:14559231  
PMID:14610273   PMID:14633701   PMID:14651998   PMID:14656760   PMID:14657019   PMID:14734769   PMID:15100250   PMID:15173588   PMID:15464984   PMID:15496141   PMID:15618518   PMID:15761153  
PMID:15788474   PMID:15855641   PMID:16027725   PMID:16123376   PMID:16141072   PMID:16141073   PMID:16260615   PMID:16287485   PMID:16435884   PMID:16443684   PMID:16571110   PMID:16584530  
PMID:16601693   PMID:16602821   PMID:16709837   PMID:16880533   PMID:16890162   PMID:16902401   PMID:16917010   PMID:16943282   PMID:16950122   PMID:17098745   PMID:17142805   PMID:17306381  
PMID:17467076   PMID:17510063   PMID:17513491   PMID:17553571   PMID:17657819   PMID:17967808   PMID:18069690   PMID:18095342   PMID:18189266   PMID:18246199   PMID:18266971   PMID:18287559  
PMID:18539898   PMID:18593713   PMID:18602923   PMID:18644788   PMID:18684712   PMID:18702012   PMID:18781153   PMID:18799693   PMID:18832392   PMID:18952608   PMID:18988920   PMID:19015026  
PMID:19096081   PMID:19192480   PMID:19266485   PMID:19415626   PMID:19717565   PMID:19796622   PMID:19850029   PMID:19855134   PMID:19995910   PMID:20007998   PMID:20040761   PMID:20065295  
PMID:20354004   PMID:20377917   PMID:20412781   PMID:20439489   PMID:20457144   PMID:20479122   PMID:20488955   PMID:20534673   PMID:20663871   PMID:20807502   PMID:20980457   PMID:21267068  
PMID:21362339   PMID:21386907   PMID:21555266   PMID:21677750   PMID:21731673   PMID:21795538   PMID:21873635   PMID:21907140   PMID:21931165   PMID:21944279   PMID:22028324   PMID:22048127  
PMID:22086159   PMID:22326534   PMID:22330342   PMID:22365546   PMID:22383537   PMID:22656308   PMID:22960056   PMID:23011393   PMID:23213415   PMID:23301086   PMID:23390194   PMID:23426374  
PMID:23455153   PMID:23509008   PMID:23537899   PMID:23603491   PMID:23610558   PMID:23620745   PMID:23625826   PMID:23633623   PMID:23709694   PMID:23761400   PMID:23804438   PMID:23894614  
PMID:23903754   PMID:23986258   PMID:23994637   PMID:24262754   PMID:24293546   PMID:24474796   PMID:24556688   PMID:24639504   PMID:24791137   PMID:24835278   PMID:24862634   PMID:24863656  
PMID:24952961   PMID:24998669   PMID:25043473   PMID:25063542   PMID:25197075   PMID:25501551   PMID:25550343   PMID:25612247   PMID:25642768   PMID:25715398   PMID:25809484   PMID:25815684  
PMID:25854148   PMID:25867271   PMID:25885904   PMID:26055326   PMID:26238476   PMID:26334580   PMID:26460584   PMID:26651974   PMID:26818761   PMID:26837421   PMID:26952187   PMID:27040500  
PMID:27224923   PMID:27292644   PMID:27303812   PMID:27349482   PMID:27536941   PMID:27731365   PMID:27742678   PMID:27770432   PMID:27827819   PMID:27924807   PMID:28057752   PMID:28167776  
PMID:28258388   PMID:28566468   PMID:28571007   PMID:28807595   PMID:28808068   PMID:28874583   PMID:29154818   PMID:29237592   PMID:29307832   PMID:29503843   PMID:29575577   PMID:29668937  
PMID:30054990   PMID:30219864   PMID:30315770   PMID:30423327   PMID:30450102   PMID:30566624   PMID:30850474   PMID:30958854   PMID:31039140   PMID:31059771   PMID:31173246   PMID:31499015  
PMID:31553906   PMID:31698731   PMID:31796589   PMID:31845891   PMID:31898747   PMID:31941699   PMID:32122971   PMID:32143362   PMID:32325033   PMID:32971298   PMID:33166654   PMID:33264418  
PMID:33368437   PMID:33540482   PMID:33641444   PMID:33920230   PMID:34061176   PMID:34157307   PMID:34184034   PMID:34769006   PMID:34822715   PMID:34905511   PMID:34948395   PMID:35137923  
PMID:35378135   PMID:35695814   PMID:36038590   PMID:36134711   PMID:36195241  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391875,500,436 - 75,529,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)EnsemblGRCm39 Ensembl
GRCm381875,367,365 - 75,395,935 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)EnsemblGRCm38mm10GRCm38
MGSCv371875,527,019 - 75,555,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361875,492,894 - 75,521,292 (+)NCBIMGSCv36mm8
Celera1876,602,062 - 76,630,688 (+)NCBICelera
Cytogenetic Map18E3NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381848,919,853 - 48,950,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1848,919,853 - 48,950,965 (-)EnsemblGRCh38hg38GRCh38
GRCh371846,446,223 - 46,477,335 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361844,700,221 - 44,731,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 341844,700,221 - 44,731,079NCBI
Celera1843,299,268 - 43,330,141 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1843,299,249 - 43,329,936 (-)NCBIHuRef
CHM1_11846,441,162 - 46,472,026 (-)NCBICHM1_1
T2T-CHM13v2.01849,115,112 - 49,146,228 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21868,988,429 - 69,016,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1868,988,429 - 69,016,765 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1871,094,956 - 71,123,284 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01871,764,762 - 71,793,114 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01869,620,987 - 69,649,318 (+)NCBIRnor_WKY
Rnor_6.01871,395,830 - 71,424,164 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1871,395,830 - 71,424,157 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01870,530,559 - 70,558,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41872,294,803 - 72,323,354 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11872,368,075 - 72,396,625 (+)NCBI
Celera1867,155,575 - 67,183,461 (+)NCBICelera
Cytogenetic Map18q12.2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540234,028,063 - 34,058,291 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540234,028,184 - 34,058,949 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11845,659,375 - 45,689,505 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01842,306,324 - 42,337,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1779,706,485 - 79,734,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl779,706,705 - 79,734,749 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha779,113,271 - 79,142,567 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0779,776,182 - 79,805,641 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl779,776,387 - 79,805,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1779,490,141 - 79,519,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0779,520,644 - 79,548,552 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0779,805,995 - 79,834,706 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494438,655,545 - 38,682,943 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649713,894,580 - 13,922,065 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493649713,894,586 - 13,921,978 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl198,514,267 - 98,542,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1198,512,800 - 98,543,924 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21108,087,677 - 108,118,319 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11831,993,543 - 32,024,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1831,993,681 - 32,024,850 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660506,227,954 - 6,258,760 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462477812,415,282 - 12,444,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477812,415,364 - 12,444,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID

Predicted Target Of
Summary Value
Count of predictions:1442
Count of miRNA genes:578
Interacting mature miRNAs:710
Transcripts:ENSMUST00000026999, ENSMUST00000168918, ENSMUST00000172718, ENSMUST00000174411, ENSMUST00000174843
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301368Par2_mpulmonary adenoma resistance 2 (mouse)Not determined187036233376707156Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187274559484144595Mouse
4142153Idd21.1_minsulin dependent diabetes susceptibility 21.1 (mouse)Not determined187456233884144595Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381875,369,425 - 75,370,915UniSTSGRCm38
MGSCv371875,529,079 - 75,530,569UniSTSGRCm37
Celera1876,604,182 - 76,605,672UniSTS
Cytogenetic Map18E2UniSTS
cM Map18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381875,388,953 - 75,389,072UniSTSGRCm38
MGSCv371875,548,607 - 75,548,726UniSTSGRCm37
Celera1876,623,705 - 76,623,836UniSTS
Cytogenetic Map18E2UniSTS
cM Map1847.0UniSTS
Whitehead Genetic1831.7UniSTS
Whitehead_YAC18 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381875,370,679 - 75,370,782UniSTSGRCm38
MGSCv371875,530,333 - 75,530,436UniSTSGRCm37
Celera1876,605,436 - 76,605,539UniSTS
Cytogenetic Map18E2UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000026999   ⟹   ENSMUSP00000026999
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1875,500,600 - 75,529,006 (+)Ensembl
GRCm38.p6 Ensembl1875,367,529 - 75,395,935 (+)Ensembl
RefSeq Acc Id: ENSMUST00000168918   ⟹   ENSMUSP00000129322
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1875,501,954 - 75,528,550 (+)Ensembl
GRCm38.p6 Ensembl1875,368,883 - 75,395,479 (+)Ensembl
RefSeq Acc Id: ENSMUST00000172718
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1875,507,985 - 75,527,072 (+)Ensembl
GRCm38.p6 Ensembl1875,374,914 - 75,394,001 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174411   ⟹   ENSMUSP00000133696
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1875,503,047 - 75,527,436 (+)Ensembl
GRCm38.p6 Ensembl1875,369,976 - 75,394,365 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174843   ⟹   ENSMUSP00000133544
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1875,502,061 - 75,527,057 (+)Ensembl
GRCm38.p6 Ensembl1875,368,990 - 75,393,986 (+)Ensembl
RefSeq Acc Id: NM_001042660   ⟹   NP_001036125
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391875,500,436 - 75,529,005 (+)NCBI
GRCm381875,367,365 - 75,395,934 (+)NCBI
MGSCv371875,527,019 - 75,555,588 (+)RGD
Celera1876,602,062 - 76,630,688 (+)RGD
RefSeq Acc Id: XM_006525703   ⟹   XP_006525766
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391875,501,600 - 75,529,006 (+)NCBI
GRCm381875,368,529 - 75,395,935 (+)NCBI
RefSeq Acc Id: XM_036161005   ⟹   XP_036016898
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm391875,501,600 - 75,529,006 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001036125   ⟸   NM_001042660
- UniProtKB: O88709 (UniProtKB/Swiss-Prot),   O35253 (UniProtKB/Swiss-Prot),   B2RPW6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525766   ⟸   XM_006525703
- Peptide Label: isoform X1
- UniProtKB: O35253 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026999   ⟸   ENSMUST00000026999
RefSeq Acc Id: ENSMUSP00000133544   ⟸   ENSMUST00000174843
RefSeq Acc Id: ENSMUSP00000133696   ⟸   ENSMUST00000174411
RefSeq Acc Id: ENSMUSP00000129322   ⟸   ENSMUST00000168918
RefSeq Acc Id: XP_036016898   ⟸   XM_036161005
- Peptide Label: isoform X2
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35253-F1-model_v2 AlphaFold O35253 1-426 view protein structure

RGD ID:13678184
Promoter ID:EPDNEW_M23241
Type:initiation region
Description:Mus musculus SMAD family member 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M23242  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381875,367,364 - 75,367,424EPDNEW
RGD ID:13678186
Promoter ID:EPDNEW_M23242
Type:single initiation site
Description:Mus musculus SMAD family member 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M23241  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381875,368,515 - 75,368,575EPDNEW
RGD ID:6829547
Promoter ID:MM_KWN:25709
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000059530,   UC008FQE.1
Mouse AssemblyChrPosition (strand)Source
MGSCv361875,526,361 - 75,529,197 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100518 AgrOrtholog
Ensembl Genes ENSMUSG00000025880 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026999 ENTREZGENE
  ENSMUSP00000026999.4 UniProtKB/Swiss-Prot
  ENSMUSP00000129322.2 UniProtKB/Swiss-Prot
  ENSMUSP00000133544.2 UniProtKB/TrEMBL
  ENSMUSP00000133696.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026999 ENTREZGENE
  ENSMUST00000026999.10 UniProtKB/Swiss-Prot
  ENSMUST00000168918.8 UniProtKB/Swiss-Prot
  ENSMUST00000174411.2 UniProtKB/TrEMBL
  ENSMUST00000174843.8 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad7 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD7_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary O88709 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Smad7  SMAD family member 7  Smad7  MAD homolog 7 (Drosophila)  Symbol and/or name change 5135510 APPROVED