LEP Human (+)-catechin multiple interactions ISO Lep (Rattus norvegicus) 6480464 Catechin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23365609 LEP Human (+)-catechin decreases expression ISO Lep (Mus musculus) 6480464 Catechin results in decreased expression of LEP protein CTD PMID:30445784 LEP Human (+)-catechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 LEP Human (+)-epicatechin-3-O-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 LEP Human (-)-epigallocatechin 3-gallate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 LEP Human (R)-lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 LEP Human (R)-lipoic acid decreases expression ISO Lep (Rattus norvegicus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 LEP Human (R)-lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 LEP Human (S)-nicotine increases expression ISO Lep (Rattus norvegicus) 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 LEP Human (S)-nicotine decreases response to substance ISO Lep (Rattus norvegicus) 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 LEP Human 1,4-bis(2-ethylhexyl) sulfosuccinate increases expression ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of LEP mRNA CTD PMID:30728429 LEP Human 1,4-bis(2-ethylhexyl) sulfosuccinate multiple interactions ISO Lep (Mus musculus) 6480464 Dioctyl Sulfosuccinic Acid results in increased expression of and results in increased secretion of LEP protein CTD PMID:30728429 LEP Human 1,8-cineole multiple interactions ISO Lep (Mus musculus) 6480464 Eucalyptol inhibits the reaction [LEP gene mutant form results in decreased expression of CTTN protein] more ... CTD PMID:31483951 LEP Human 1-(3-chlorophenyl)piperazine multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 LEP Human 1-naphthyl isothiocyanate affects expression ISO Lep (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate affects the expression of LEP protein CTD PMID:25051504 LEP Human 15-deoxy-Delta(12,14)-prostaglandin J2 increases secretion EXP 6480464 15-deoxy-delta(12 and 14)-prostaglandin J2 results in increased secretion of LEP protein CTD PMID:11092516 LEP Human 15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactions EXP 6480464 [Dexamethasone co-treated with 15-deoxy-delta(12 and 14)-prostaglandin J2] results in decreased secretion of LEP protein CTD PMID:11092516 LEP Human 17alpha-ethynylestradiol decreases expression ISO Lep (Rattus norvegicus) 6480464 Ethinyl Estradiol results in decreased expression of LEP protein CTD PMID:25051504 LEP Human 17beta-estradiol increases expression ISO Lep (Mus musculus) 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:18359623 LEP Human 17beta-estradiol increases expression ISO Lep (Rattus norvegicus) 6480464 Estradiol results in increased expression of LEP mRNA CTD PMID:26164745 LEP Human 17beta-estradiol multiple interactions EXP 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[Estradiol co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 LEP Human 17beta-hydroxy-5alpha-androstan-3-one decreases expression EXP 6480464 Dihydrotestosterone results in decreased expression of LEP mRNA CTD PMID:18801408 LEP Human 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:23618531 more ... LEP Human 2,2',4,4',5,5'-hexachlorobiphenyl increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24978599 LEP Human 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:24559133 LEP Human 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO Lep (Rattus norvegicus) 6480464 2 more ... CTD PMID:27291303 LEP Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of LEP protein more ... CTD PMID:19063610 more ... LEP Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of LEP mRNA CTD PMID:21570461 and PMID:26377647 LEP Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of AGRP mRNA more ... CTD PMID:15977195 LEP Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Lep (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA CTD PMID:19063610 LEP Human 2,4-dinitrophenol multiple interactions ISO Lep (Mus musculus) 6480464 [2 and 4-Dinitrophenol co-treated with Dietary Fats] affects the expression of LEP mRNA CTD PMID:24872412 LEP Human 2,6-di-tert-butyl-4-methylphenol multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 LEP Human 2-acetamidofluorene increases expression ISO Lep (Rattus norvegicus) 6480464 2-Acetylaminofluorene results in increased expression of LEP protein CTD PMID:25051504 LEP Human 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA more ... CTD PMID:19913045 LEP Human 2-amino-2-deoxy-D-galactopyranose increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 LEP Human 2-amino-2-deoxy-D-glucopyranose 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 LEP Human 2-aminopurine multiple interactions ISO Lep (Mus musculus) 6480464 2-Aminopurine affects the reaction [LEP protein affects the expression of ADGRE1 mRNA] more ... CTD PMID:24150608 LEP Human 2-arachidonoylglycerol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with LEP protein] results in increased chemical synthesis of glyceryl 2-arachidonate CTD PMID:27071101 LEP Human 2-deoxy-D-glucose multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 LEP Human 2-deoxy-D-glucose decreases secretion ISO Lep (Rattus norvegicus) 6480464 Deoxyglucose results in decreased secretion of LEP protein CTD PMID:10780946 LEP Human 2-hydroxypropanoic acid affects expression EXP 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 LEP Human 2-methyl-4-chlorophenoxybutyric acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 LEP Human 2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 LEP Human 24,25-Dihydroxyvitamin D decreases expression EXP 6480464 24 and 25-Dihydroxyvitamin D 3 results in decreased expression of LEP protein CTD PMID:18379402 LEP Human 3',5'-cyclic AMP increases abundance EXP 6480464 LEP protein results in increased abundance of Cyclic AMP CTD PMID:11342529 LEP Human 3',5'-cyclic AMP increases expression ISO Lep (Mus musculus) 6480464 Cyclic AMP analog results in increased expression of LEP mRNA CTD PMID:27381457 LEP Human 3',5'-cyclic AMP multiple interactions ISO Lep (Mus musculus) 6480464 3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile inhibits the reaction [Cyclic AMP analog results in increased expression of LEP mRNA] CTD PMID:27381457 LEP Human 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:28973532 LEP Human 3,3',5,5'-tetrabromobisphenol A increases expression ISO Lep (Mus musculus) 6480464 tetrabromobisphenol A results in increased expression of LEP mRNA CTD PMID:30496566 LEP Human 3,4-methylenedioxymethamphetamine affects expression ISO Lep (Rattus norvegicus) 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine affects the expression of LEP protein CTD PMID:17910739 LEP Human 3,5-diethoxycarbonyl-1,4-dihydrocollidine decreases expression ISO Lep (Mus musculus) 6480464 3 more ... CTD PMID:20512997 LEP Human 3-aminobenzamide increases expression ISO Lep (Rattus norvegicus) 6480464 3-aminobenzamide results in increased expression of LEP mRNA CTD PMID:18815186 LEP Human 3-chloropropane-1,2-diol decreases expression ISO Lep (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in decreased expression of LEP mRNA CTD PMID:20409345 LEP Human 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 4 more ... CTD PMID:19186324 more ... LEP Human 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... LEP Human 4,4'-sulfonyldiphenol increases secretion ISO Lep (Mus musculus) 6480464 bisphenol S results in increased secretion of LEP protein CTD PMID:25111128 and PMID:31820560 LEP Human 4,4'-sulfonyldiphenol decreases methylation ISO Lep (Mus musculus) 6480464 bisphenol S results in decreased methylation of LEP promoter CTD PMID:33297965 LEP Human 4,4'-sulfonyldiphenol multiple interactions ISO Lep (Mus musculus) 6480464 bisphenol S affects the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27241191 LEP Human 4,4'-sulfonyldiphenol decreases expression EXP 6480464 bisphenol S results in decreased expression of LEP mRNA CTD PMID:27685785 LEP Human 4-hydroxy-17beta-estradiol increases abundance EXP 6480464 LEP protein results in increased abundance of 4-hydroxyestradiol CTD PMID:24631339 LEP Human 4-hydroxy-TEMPO multiple interactions ISO Lep (Rattus norvegicus) 6480464 tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 LEP Human 4-hydroxybenzoic acid decreases expression EXP 6480464 4-hydroxybenzoic acid results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human 4-hydroxyphenyl retinamide decreases expression ISO Lep (Mus musculus) 6480464 Fenretinide results in decreased expression of LEP mRNA CTD PMID:28973697 LEP Human 4-nonylphenol increases expression ISO Lep (Rattus norvegicus) 6480464 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 LEP Human 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 trichostatin A promotes the reaction [Decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 LEP Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 [Decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA and Decitabine results in increased expression of LEP mRNA CTD PMID:17502362 LEP Human 5-aza-2'-deoxycytidine decreases methylation EXP 6480464 Decitabine results in decreased methylation of LEP promoter CTD PMID:17502362 LEP Human 6-propyl-2-thiouracil decreases expression ISO Lep (Rattus norvegicus) 6480464 Propylthiouracil results in decreased expression of LEP mRNA CTD PMID:24534949 LEP Human 8-Br-cAMP multiple interactions EXP 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] more ... CTD PMID:19849856 LEP Human 8-Br-cAMP decreases response to substance EXP 6480464 LEP protein results in decreased susceptibility to 8-Bromo Cyclic Adenosine Monophosphate CTD PMID:19849856 LEP Human 9-cis-retinoic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 LEP Human AACOCF3 multiple interactions ISO Lep (Mus musculus) 6480464 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 LEP Human acarbose decreases expression ISO Lep (Rattus norvegicus) 6480464 Acarbose results in decreased expression of LEP protein CTD PMID:18290871 LEP Human acetaldehyde multiple interactions ISO Lep (Mus musculus) 6480464 Acetaldehyde inhibits the reaction [LEP protein results in increased expression of ADIPOR2 protein] more ... CTD PMID:15130784 and PMID:17949463 LEP Human acetylsalicylic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [lipopolysaccharide and Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein CTD PMID:15024038 LEP Human actinomycin D multiple interactions ISO Lep (Rattus norvegicus) 6480464 Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 LEP Human Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] multiple interactions EXP 6480464 adenosine-3' more ... CTD PMID:11342529 LEP Human Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate] decreases response to substance EXP 6480464 adenosine-3' and 5'-cyclic phosphorothioate results in decreased susceptibility to LEP protein CTD PMID:11342529 LEP Human aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of LEP gene CTD PMID:27153756 LEP Human AH23848 multiple interactions EXP 6480464 AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LEP Human aldehydo-D-glucosamine 6-phosphate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-phosphate results in decreased expression of LEP mRNA CTD PMID:19427183 LEP Human aldehydo-D-glucose multiple interactions EXP 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 LEP Human aldehydo-D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 LEP Human aldehydo-D-glucose increases secretion ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 LEP Human aldehydo-D-glucose increases expression ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... LEP Human aldehydo-D-glucose increases response to substance EXP 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 LEP Human aldehydo-D-glucose multiple interactions ISO Lep (Rattus norvegicus) 6480464 1 more ... CTD PMID:10780946 more ... LEP Human all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:32929351 LEP Human all-trans-retinol multiple interactions ISO Lep (Rattus norvegicus) 6480464 LEP gene mutant form promotes the reaction [Vitamin A results in increased expression of UCP1 mRNA] CTD PMID:16493122 LEP Human allopurinol multiple interactions ISO Lep (Rattus norvegicus) 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 LEP Human alpha-Zearalanol multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LEP mRNA CTD PMID:35163327 LEP Human AM-251 multiple interactions ISO Lep (Mus musculus) 6480464 AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA] more ... CTD PMID:27071101 LEP Human Amibegron multiple interactions ISO Lep (Rattus norvegicus) 6480464 3-(2-ethylphenoxy)-1-(1 more ... CTD PMID:9718277 LEP Human Amibegron decreases expression ISO Lep (Rattus norvegicus) 6480464 amibegron results in decreased expression of LEP mRNA CTD PMID:9718277 LEP Human amlodipine decreases expression EXP 6480464 Amlodipine results in decreased expression of LEP and Amlodipine results in decreased expression of LEP protein CTD PMID:18199500 and PMID:19059660 LEP Human ammonium chloride affects expression ISO Lep (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of LEP mRNA CTD PMID:16483693 LEP Human anandamide decreases abundance EXP 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:16154199 LEP Human anandamide multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats inhibits the reaction [LEP protein results in decreased abundance of anandamide] CTD PMID:29967158 LEP Human anandamide decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of anandamide CTD PMID:29967158 LEP Human anandamide decreases activity EXP 6480464 LEP protein results in decreased activity of anandamide CTD PMID:16154199 LEP Human anandamide decreases transport EXP 6480464 LEP protein results in decreased transport of anandamide CTD PMID:16154199 LEP Human androst-4-ene-3,17-dione multiple interactions ISO Lep (Rattus norvegicus) 6480464 LEP protein inhibits the reaction [CGA protein results in increased secretion of Androstenedione] CTD PMID:14657608 LEP Human anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and pyrazolanthrone inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LEP Human apigenin increases expression ISO Lep (Mus musculus) 6480464 Apigenin results in increased expression of LEP mRNA and Apigenin results in increased expression of LEP protein CTD PMID:18359623 LEP Human apocynin multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 LEP Human arachidonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 LEP Human arsane affects expression EXP 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 LEP Human arsane multiple interactions EXP 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA more ... CTD PMID:32525701 and PMID:36989998 LEP Human arsenic atom affects expression EXP 6480464 Arsenic affects the expression of LEP protein CTD PMID:20940111 LEP Human arsenic atom multiple interactions EXP 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA more ... CTD PMID:32525701 and PMID:36989998 LEP Human arsenite(3-) decreases methylation EXP 6480464 arsenite results in decreased methylation of LEP promoter CTD PMID:23974009 LEP Human arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 LEP Human aspartame decreases expression ISO Lep (Rattus norvegicus) 6480464 Aspartame results in decreased expression of LEP protein CTD PMID:11890951 LEP Human aspartame multiple interactions ISO Lep (Mus musculus) 6480464 [Fats more ... CTD PMID:23783067 LEP Human atorvastatin calcium multiple interactions ISO Lep (Rattus norvegicus) 6480464 Atorvastatin affects the reaction [Fructose results in increased expression of LEP protein] CTD PMID:21122807 LEP Human ATP multiple interactions ISO Lep (Rattus norvegicus) 6480464 [[Glucose co-treated with INS1 protein] results in increased abundance of Adenosine Triphosphate] which results in increased secretion of LEP protein and [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] which results in decreased secretion of LEP protein CTD PMID:10780946 LEP Human Aurothioglucose multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP mRNA and [Sodium Glutamate co-treated with Aurothioglucose] results in increased expression of LEP protein CTD PMID:9794456 LEP Human Aurothioglucose increases expression ISO Lep (Mus musculus) 6480464 Aurothioglucose results in increased expression of LEP mRNA and Aurothioglucose results in increased expression of LEP protein CTD PMID:15809509 more ... LEP Human azoxystrobin multiple interactions ISO Lep (Mus musculus) 6480464 [azoxystrobin co-treated with Dietary Fats] affects the expression of LEP protein CTD PMID:24726979 LEP Human Bardoxolone methyl multiple interactions ISO Lep (Mus musculus) 6480464 bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein] and bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27417254 LEP Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of LEP intron CTD PMID:30157460 LEP Human Benzyl parahydroxybenzoate increases expression ISO Lep (Mus musculus) 6480464 benzylparaben results in increased expression of LEP mRNA CTD PMID:22956630 LEP Human Benzyl parahydroxybenzoate decreases expression EXP 6480464 benzylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human beta-D-glucosamine 6-sulfate decreases expression ISO Lep (Mus musculus) 6480464 glucosamine 6-O-sulfate results in decreased expression of LEP mRNA CTD PMID:19520133 LEP Human beta-naphthoflavone decreases expression EXP 6480464 beta-Naphthoflavone results in decreased expression of LEP mRNA CTD PMID:32858204 LEP Human bezafibrate decreases expression EXP 6480464 Bezafibrate results in decreased expression of LEP CTD PMID:10726910 LEP Human bezafibrate multiple interactions ISO Lep (Mus musculus) 6480464 Bezafibrate inhibits the reaction [Sodium Glutamate results in increased expression of LEP protein] CTD PMID:21549692 LEP Human bezafibrate decreases expression ISO Lep (Rattus norvegicus) 6480464 Bezafibrate results in decreased expression of LEP mRNA CTD PMID:11216866 and PMID:11473052 LEP Human bezafibrate multiple interactions ISO Lep (Rattus norvegicus) 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] CTD PMID:17379010 LEP Human bis(2-ethylhexyl) phthalate increases expression ISO Lep (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of LEP mRNA and Diethylhexyl Phthalate results in increased expression of LEP protein CTD PMID:22588786 and PMID:35550907 LEP Human bis(2-ethylhexyl) phthalate multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP mRNA and [Diethylhexyl Phthalate co-treated with Dietary Fats] results in increased expression of LEP protein CTD PMID:33166671 LEP Human bis(2-ethylhexyl) phthalate decreases expression ISO Lep (Rattus norvegicus) 6480464 Diethylhexyl Phthalate results in decreased expression of LEP protein CTD PMID:33309551 LEP Human bis(2-ethylhexyl) phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein more ... CTD PMID:29175711 more ... LEP Human bis(2-ethylhexyl) phthalate increases expression ISO LEP (Homo sapiens) 25330351 bis(2-ethylhexyl) phthalate increases expression of LEP in adipose tissue (rat) RGD LEP Human bisphenol A increases expression ISO Lep (Mus musculus) 6480464 bisphenol A results in increased expression of LEP more ... CTD PMID:18359623 more ... LEP Human bisphenol A increases expression ISO Lep (Rattus norvegicus) 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:34947998 and PMID:37570835 LEP Human bisphenol A decreases secretion EXP 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:29223775 LEP Human bisphenol A multiple interactions ISO Lep (Rattus norvegicus) 6480464 bisphenol A results in increased expression of and results in increased secretion of LEP protein and Resveratrol inhibits the reaction [bisphenol A results in decreased expression of LEP protein] CTD PMID:32339907 and PMID:37570835 LEP Human bisphenol A increases secretion ISO Lep (Mus musculus) 6480464 bisphenol A results in increased secretion of LEP protein CTD PMID:31820560 LEP Human bisphenol A decreases secretion ISO Lep (Rattus norvegicus) 6480464 bisphenol A results in decreased secretion of LEP protein CTD PMID:31697385 LEP Human bisphenol A decreases expression ISO Lep (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of LEP mRNA CTD PMID:30816183 and PMID:32528016 LEP Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of LEP mRNA and bisphenol A results in decreased expression of LEP protein CTD PMID:24349194 more ... LEP Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of LEP mRNA and bisphenol A results in increased expression of LEP protein CTD PMID:25878060 more ... LEP Human bisphenol A multiple interactions EXP 6480464 [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [[bisphenol A co-treated with LEP protein] results in decreased activity of CASP3 protein] more ... CTD PMID:23850738 LEP Human bisphenol A multiple interactions ISO Lep (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:23493373 more ... LEP Human Bisphenol A diglycidyl ether increases expression ISO Lep (Mus musculus) 6480464 2 and 2-bis(4-glycidyloxyphenyl)propane results in increased expression of LEP mRNA CTD PMID:22763116 LEP Human Bisphenol A diglycidyl ether multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 LEP Human Bisphenol B increases secretion ISO Lep (Mus musculus) 6480464 bisphenol B results in increased secretion of LEP protein CTD PMID:31820560 LEP Human bisphenol F increases secretion ISO Lep (Mus musculus) 6480464 bisphenol F results in increased secretion of LEP protein CTD PMID:31820560 LEP Human bleomycin A2 increases expression ISO Lep (Mus musculus) 6480464 Bleomycin results in increased expression of LEP protein CTD PMID:29175452 LEP Human boric acid multiple interactions ISO Lep (Mus musculus) 6480464 boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA] and boric acid results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:28285642 LEP Human boron atom multiple interactions ISO Lep (Rattus norvegicus) 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 LEP Human BQ 123 multiple interactions ISO Lep (Mus musculus) 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [LEP protein affects the abundance of Calcium] more ... CTD PMID:16380530 LEP Human bromodichloromethane increases expression ISO Lep (Mus musculus) 6480464 bromodichloromethane results in increased expression of LEP mRNA CTD PMID:23640861 LEP Human bromodichloromethane multiple interactions ISO Lep (Mus musculus) 6480464 bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA] more ... CTD PMID:23438451 and PMID:24211274 LEP Human bromodichloromethane decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to bromodichloromethane CTD PMID:23640861 LEP Human bucladesine decreases expression ISO Lep (Mus musculus) 6480464 Bucladesine results in decreased expression of LEP mRNA CTD PMID:9002984 LEP Human Butylbenzyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 LEP Human Butylparaben decreases expression EXP 6480464 butylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human Butylparaben increases expression ISO Lep (Mus musculus) 6480464 butylparaben results in increased expression of LEP mRNA CTD PMID:22956630 LEP Human butyric acid multiple interactions ISO Lep (Mus musculus) 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 LEP Human cadmium atom decreases expression ISO Lep (Rattus norvegicus) 6480464 Cadmium results in decreased expression of LEP mRNA CTD PMID:36278208 LEP Human cadmium atom multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP protein CTD PMID:38712533 LEP Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 LEP Human cadmium dichloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:23921151 and PMID:27814245 LEP Human cadmium dichloride multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP protein CTD PMID:38712533 LEP Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LEP mRNA CTD PMID:35301059 LEP Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of LEP mRNA CTD PMID:19847775 LEP Human cadmium dichloride increases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in increased expression of LEP protein CTD PMID:27634282 LEP Human cadmium dichloride decreases expression ISO Lep (Mus musculus) 6480464 Cadmium Chloride results in decreased expression of LEP mRNA and Cadmium Chloride results in decreased expression of LEP protein CTD PMID:23921151 LEP Human caffeine decreases expression ISO Lep (Mus musculus) 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:23727198 LEP Human caffeine multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] and Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 LEP Human caffeine decreases expression ISO Lep (Rattus norvegicus) 6480464 Caffeine results in decreased expression of LEP mRNA and Caffeine results in decreased expression of LEP protein CTD PMID:23727198 and PMID:26367767 LEP Human caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of LEP mRNA CTD PMID:26367767 LEP Human calcitriol decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcitriol CTD PMID:14657008 LEP Human calcium atom multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 LEP Human calcium atom multiple interactions ISO Lep (Rattus norvegicus) 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 LEP Human calcium atom affects secretion ISO Lep (Rattus norvegicus) 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 LEP Human calcium atom affects expression ISO Lep (Rattus norvegicus) 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 LEP Human calcium atom decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 LEP Human calcium atom affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 LEP Human calcium atom increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 LEP Human calcium(0) multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] more ... CTD PMID:16380530 and PMID:20107083 LEP Human calcium(0) multiple interactions ISO Lep (Rattus norvegicus) 6480464 Calcium deficiency inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 LEP Human calcium(0) affects secretion ISO Lep (Rattus norvegicus) 6480464 Calcium deficiency affects the secretion of LEP protein CTD PMID:10780946 LEP Human calcium(0) affects expression ISO Lep (Rattus norvegicus) 6480464 Calcium affects the expression of LEP mRNA CTD PMID:15913539 LEP Human calcium(0) decreases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased abundance of Calcium CTD PMID:14657008 LEP Human calcium(0) affects abundance ISO Lep (Mus musculus) 6480464 LEP protein affects the abundance of Calcium CTD PMID:16380530 LEP Human calcium(0) increases transport ISO Lep (Mus musculus) 6480464 LEP protein results in increased transport of Calcium CTD PMID:20107083 LEP Human candesartan multiple interactions EXP 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 LEP Human candesartan increases response to substance ISO Lep (Rattus norvegicus) 6480464 LEP protein results in increased susceptibility to candesartan CTD PMID:21287150 LEP Human candesartan decreases expression EXP 6480464 candesartan results in decreased expression of LEP CTD PMID:19059660 LEP Human cannabidiol multiple interactions ISO Lep (Mus musculus) 6480464 Cannabidiol analog inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:30382123 LEP Human capsaicin decreases expression ISO Lep (Mus musculus) 6480464 Capsaicin results in decreased expression of LEP protein CTD PMID:17295509 and PMID:19798065 LEP Human capsaicin multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] more ... CTD PMID:20359164 and PMID:22150557 LEP Human capsaicin increases expression ISO Lep (Rattus norvegicus) 6480464 Capsaicin results in increased expression of LEP mRNA and Capsaicin results in increased expression of LEP protein CTD PMID:16278290 and PMID:22150557 LEP Human capsazepine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 LEP Human carbon nanotube increases expression ISO Lep (Mus musculus) 6480464 Nanotubes and Carbon results in increased expression of LEP protein CTD PMID:20381574 LEP Human carvacrol multiple interactions ISO Lep (Rattus norvegicus) 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 LEP Human CCCP decreases response to substance EXP 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased susceptibility to LEP protein CTD PMID:11342529 LEP Human CCCP multiple interactions EXP 6480464 Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 LEP Human cerulenin affects response to substance ISO Lep (Mus musculus) 6480464 LEP protein affects the susceptibility to Cerulenin CTD PMID:11289036 LEP Human CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to LEP gene] CTD PMID:28238834 LEP Human CGS-21680 multiple interactions EXP 6480464 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 LEP Human chlorohydrocarbon multiple interactions ISO Lep (Mus musculus) 6480464 [LEP protein co-treated with Hydrocarbons more ... CTD PMID:31313498 LEP Human chloroquine multiple interactions ISO Lep (Mus musculus) 6480464 Chloroquine inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 LEP Human chlorpromazine increases expression ISO Lep (Rattus norvegicus) 6480464 Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 LEP Human chlorpyrifos decreases expression ISO Lep (Rattus norvegicus) 6480464 Chlorpyrifos results in decreased expression of LEP protein CTD PMID:33994353 LEP Human chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of LEP mRNA CTD PMID:30879083 LEP Human choline multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... LEP Human chromium atom decreases expression ISO Lep (Rattus norvegicus) 6480464 Chromium results in decreased expression of LEP protein CTD PMID:17114815 LEP Human chromium atom increases expression ISO Lep (Rattus norvegicus) 6480464 Chromium deficiency results in increased expression of LEP mRNA and Chromium deficiency results in increased expression of LEP protein CTD PMID:19846803 LEP Human chromium atom multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 LEP Human chrysin decreases expression ISO Lep (Mus musculus) 6480464 chrysin results in decreased expression of LEP protein CTD PMID:30445784 LEP Human cisplatin affects expression ISO Lep (Rattus norvegicus) 6480464 Cisplatin affects the expression of LEP protein CTD PMID:25051504 LEP Human clofibrate multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 LEP Human clofibrate multiple interactions ISO Lep (Rattus norvegicus) 6480464 [alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 LEP Human clozapine affects response to substance EXP 6480464 LEP protein affects the susceptibility to Clozapine CTD PMID:17502770 LEP Human clozapine increases expression ISO Lep (Rattus norvegicus) 6480464 Clozapine results in increased expression of LEP protein CTD PMID:16402076 LEP Human cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 LEP Human cobalt dichloride multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 LEP Human cobalt dichloride increases expression ISO Lep (Rattus norvegicus) 6480464 cobaltous chloride results in increased expression of LEP mRNA CTD PMID:12032628 LEP Human cobalt dichloride increases secretion ISO Lep (Rattus norvegicus) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 LEP Human cobalt dichloride increases secretion EXP 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:12032628 LEP Human cobalt dichloride increases secretion ISO Lep (Mus musculus) 6480464 cobaltous chloride results in increased secretion of LEP protein CTD PMID:22019852 LEP Human colforsin daropate hydrochloride decreases secretion ISO Lep (Mus musculus) 6480464 Colforsin results in decreased secretion of LEP protein CTD PMID:27381457 LEP Human colforsin daropate hydrochloride multiple interactions EXP 6480464 Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] CTD PMID:26367767 LEP Human colforsin daropate hydrochloride decreases expression ISO Lep (Mus musculus) 6480464 Colforsin results in decreased expression of LEP mRNA CTD PMID:27381457 and PMID:9002984 LEP Human conjugated linoleic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Linoleic Acids and Conjugated co-treated with Chromium] results in decreased expression of LEP protein CTD PMID:16933788 LEP Human conjugated linoleic acid decreases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in decreased expression of LEP protein CTD PMID:16933788 LEP Human conjugated linoleic acid increases expression ISO Lep (Mus musculus) 6480464 Linoleic Acids and Conjugated results in increased expression of LEP protein CTD PMID:17322064 LEP Human corn oil multiple interactions ISO Lep (Rattus norvegicus) 6480464 Corn Oil inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:29165388 LEP Human corticosterone multiple interactions ISO Lep (Mus musculus) 6480464 1-(3-chlorophenyl)piperazine inhibits the reaction [Corticosterone results in decreased expression of LEP protein] more ... CTD PMID:28186389 and PMID:29751049 LEP Human corticosterone decreases expression ISO Lep (Mus musculus) 6480464 Corticosterone results in decreased expression of LEP protein CTD PMID:28186389 LEP Human crocidolite asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Crocidolite results in decreased expression of LEP mRNA CTD PMID:23917077 LEP Human cycloheximide multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein inhibits the reaction [Cycloheximide results in decreased expression of LEPR protein] CTD PMID:31199479 LEP Human cyclosporin A decreases expression ISO Lep (Rattus norvegicus) 6480464 Cyclosporine results in decreased expression of LEP protein CTD PMID:25051504 LEP Human cyhalothrin increases expression ISO Lep (Rattus norvegicus) 6480464 cyhalothrin results in increased expression of LEP protein CTD PMID:27348886 LEP Human cyromazine multiple interactions ISO Lep (Rattus norvegicus) 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 LEP Human D-glucose multiple interactions ISO Lep (Rattus norvegicus) 6480464 1 more ... CTD PMID:10780946 more ... LEP Human D-glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 LEP Human D-glucose increases expression ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... LEP Human D-glucose increases secretion ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 LEP Human D-glucose increases response to substance EXP 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 LEP Human D-glucose multiple interactions EXP 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 LEP Human dantrolene decreases expression ISO Lep (Rattus norvegicus) 6480464 Dantrolene results in decreased expression of LEP protein CTD PMID:25051504 LEP Human DDE increases secretion ISO Lep (Mus musculus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased secretion of LEP protein CTD PMID:21044676 LEP Human DDE multiple interactions EXP 6480464 Dichlorodiphenyl Dichloroethylene promotes the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:26200599 LEP Human DDT increases expression EXP 6480464 DDT results in increased expression of LEP mRNA CTD PMID:25014179 LEP Human dehydroepiandrosterone decreases expression ISO Lep (Rattus norvegicus) 6480464 Dehydroepiandrosterone results in decreased expression of LEP protein CTD PMID:12659879 LEP Human deoxycholic acid decreases expression ISO Lep (Mus musculus) 6480464 Deoxycholic Acid results in decreased expression of LEP mRNA CTD PMID:23911798 LEP Human desferrioxamine B increases expression EXP 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 LEP Human desferrioxamine B increases secretion ISO Lep (Rattus norvegicus) 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 LEP Human desferrioxamine B increases secretion EXP 6480464 Deferoxamine results in increased secretion of LEP protein CTD PMID:12032628 LEP Human desferrioxamine B increases expression ISO Lep (Rattus norvegicus) 6480464 Deferoxamine results in increased expression of LEP mRNA CTD PMID:12032628 LEP Human dexamethasone multiple interactions EXP 6480464 4 more ... CTD PMID:10946865 more ... LEP Human dexamethasone multiple interactions ISO Lep (Mus musculus) 6480464 [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of LEP mRNA more ... CTD PMID:23086663 more ... LEP Human dexamethasone increases secretion EXP 6480464 Dexamethasone results in increased secretion of LEP protein CTD PMID:10946865 LEP Human dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of LEP mRNA CTD PMID:10946865 and PMID:32976960 LEP Human dexamethasone increases expression ISO Lep (Rattus norvegicus) 6480464 Dexamethasone results in increased expression of LEP mRNA and Dexamethasone results in increased expression of LEP protein CTD PMID:15824971 and PMID:23166830 LEP Human dextran sulfate multiple interactions ISO Lep (Mus musculus) 6480464 [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP mRNA and [Azoxymethane co-treated with Dextran Sulfate] results in increased expression of LEP protein CTD PMID:19931517 LEP Human diallyl trisulfide decreases expression ISO Lep (Rattus norvegicus) 6480464 diallyl trisulfide results in decreased expression of LEP mRNA CTD PMID:34014027 LEP Human diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein and Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 LEP Human diazoxide multiple interactions ISO Lep (Rattus norvegicus) 6480464 Diazoxide inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 LEP Human diazoxide decreases secretion ISO Lep (Rattus norvegicus) 6480464 Diazoxide results in decreased secretion of LEP protein CTD PMID:10780946 LEP Human dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] more ... CTD PMID:17668557 LEP Human dibutyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 LEP Human dibutylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with di-n-butyltin] results in increased expression of LEP protein CTD PMID:29787037 LEP Human diethyl hydrogen phosphate decreases secretion ISO Lep (Rattus norvegicus) 6480464 diethyl phosphate results in decreased secretion of LEP protein CTD PMID:34038317 LEP Human diethyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 LEP Human diethylstilbestrol decreases secretion ISO Lep (Mus musculus) 6480464 Diethylstilbestrol results in decreased secretion of LEP protein CTD PMID:25111128 LEP Human diethylstilbestrol multiple interactions ISO Lep (Mus musculus) 6480464 Diethylstilbestrol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:23493373 LEP Human diiodine multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 LEP Human diisobutyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 LEP Human diisononyl phthalate multiple interactions ISO Lep (Mus musculus) 6480464 [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with diisononyl phthalate co-treated with butylbenzyl phthalate] results in decreased secretion of LEP protein CTD PMID:38954831 LEP Human dioxygen increases secretion EXP 6480464 Oxygen deficiency results in increased secretion of LEP protein CTD PMID:12032628 LEP Human dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of LEP mRNA CTD PMID:12032628 and PMID:23466666 LEP Human dioxygen decreases expression ISO Lep (Mus musculus) 6480464 Oxygen deficiency results in decreased expression of LEP mRNA and Oxygen deficiency results in decreased expression of LEP protein CTD PMID:21531777 and PMID:23539316 LEP Human dipyridamole multiple interactions ISO Lep (Rattus norvegicus) 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 LEP Human dipyridamole increases expression ISO Lep (Rattus norvegicus) 6480464 Dipyridamole results in increased expression of LEP protein CTD PMID:10746648 LEP Human disodium selenite decreases expression ISO Lep (Mus musculus) 6480464 Sodium Selenite results in decreased expression of LEP mRNA CTD PMID:23274088 LEP Human dobutamine decreases secretion EXP 6480464 Dobutamine results in decreased secretion of LEP protein CTD PMID:11022189 LEP Human dobutamine decreases expression ISO Lep (Mus musculus) 6480464 Dobutamine results in decreased expression of LEP mRNA and Dobutamine results in decreased expression of LEP protein CTD PMID:9002984 LEP Human DPCPX multiple interactions ISO Lep (Rattus norvegicus) 6480464 1 and 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 LEP Human edelfosine multiple interactions ISO Lep (Mus musculus) 6480464 edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 LEP Human efavirenz decreases expression EXP 6480464 efavirenz results in decreased expression of LEP mRNA CTD PMID:21619898 LEP Human elemental boron multiple interactions ISO Lep (Rattus norvegicus) 6480464 Boron inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] CTD PMID:36419211 LEP Human elemental selenium decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 LEP Human Elemicin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 LEP Human enalapril increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 LEP Human ethambutol decreases expression ISO Lep (Rattus norvegicus) 6480464 Ethambutol results in decreased expression of LEP protein CTD PMID:25051504 LEP Human ethanol multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:18227024 LEP Human ethanol multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 LEP Human ethionamide decreases expression ISO Lep (Rattus norvegicus) 6480464 Ethionamide results in decreased expression of LEP protein CTD PMID:25051504 LEP Human Ethyl icosapentate increases expression ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA CTD PMID:10753628 LEP Human Ethyl icosapentate increases secretion ISO Lep (Mus musculus) 6480464 eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein CTD PMID:10753628 LEP Human Ethyl icosapentate multiple interactions ISO Lep (Mus musculus) 6480464 Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased expression of LEP mRNA] and Diazooxonorleucine inhibits the reaction [eicosapentaenoic acid ethyl ester results in increased secretion of LEP protein] CTD PMID:10753628 LEP Human ethylparaben decreases expression EXP 6480464 ethyl-p-hydroxybenzoate results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human fenofibrate multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] and Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA] CTD PMID:26973390 LEP Human fenofibrate multiple interactions EXP 6480464 Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein] CTD PMID:32929351 LEP Human fenoterol decreases secretion EXP 6480464 Fenoterol results in decreased secretion of LEP protein CTD PMID:11022189 LEP Human fenvalerate increases expression ISO Lep (Rattus norvegicus) 6480464 fenvalerate results in increased expression of LEP mRNA CTD PMID:30307764 LEP Human flufenamic acid multiple interactions ISO Lep (Mus musculus) 6480464 Flufenamic Acid inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 LEP Human flutamide decreases expression ISO Lep (Rattus norvegicus) 6480464 Flutamide results in decreased expression of LEP protein CTD PMID:25051504 LEP Human fonofos increases methylation EXP 6480464 Fonofos results in increased methylation of LEP promoter CTD PMID:22847954 LEP Human fructose increases expression ISO Lep (Rattus norvegicus) 6480464 Fructose results in increased expression of LEP mRNA and Fructose results in increased expression of LEP protein CTD PMID:11741341 more ... LEP Human fructose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of LEP mRNA CTD PMID:37567420 LEP Human fructose increases secretion ISO Lep (Rattus norvegicus) 6480464 Fructose results in increased secretion of LEP protein CTD PMID:10780946 more ... LEP Human fructose multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:21122807 more ... LEP Human furan decreases expression ISO Lep (Rattus norvegicus) 6480464 furan results in decreased expression of LEP mRNA CTD PMID:25539665 LEP Human gallocatechin multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with gallocatechol co-treated with Catechin co-treated with epigallocatechin gallate co-treated with epicatechin gallate co-treated with gallocatechol co-treated with gallocatechin gallate] affects the expression of LEP protein CTD PMID:25663641 LEP Human gamma-hexachlorocyclohexane affects expression ISO Lep (Rattus norvegicus) 6480464 Hexachlorocyclohexane affects the expression of LEP mRNA CTD PMID:17785943 LEP Human Ganoderic acid A multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with ganoderic acid A] affects the expression of LEP mRNA CTD PMID:29852127 LEP Human gemcitabine decreases expression EXP 6480464 Gemcitabine results in decreased expression of LEP protein CTD PMID:20531411 LEP Human gemfibrozil decreases expression ISO Lep (Rattus norvegicus) 6480464 Gemfibrozil results in decreased expression of LEP protein CTD PMID:25051504 LEP Human gemfibrozil increases expression ISO Lep (Rattus norvegicus) 6480464 Gemfibrozil results in increased expression of LEP protein CTD PMID:25051504 LEP Human genistein decreases expression ISO Lep (Mus musculus) 6480464 Genistein results in decreased expression of LEP mRNA and Genistein results in decreased expression of LEP protein CTD PMID:18359623 LEP Human genistein decreases response to substance EXP 6480464 Genistein results in decreased susceptibility to LEP protein CTD PMID:11342529 LEP Human genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and Genistein inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 LEP Human gentamycin increases expression ISO Lep (Rattus norvegicus) 6480464 Gentamicins results in increased expression of LEP mRNA CTD PMID:33387578 LEP Human gingerol multiple interactions ISO Lep (Mus musculus) 6480464 gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP mRNA] and gingerol inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21851089 LEP Human glucagon multiple interactions ISO Lep (Mus musculus) 6480464 Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein] and Glucagon analog inhibits the reaction [LEPR gene mutant form results in increased expression of and results in increased secretion of LEP protein] CTD PMID:29988851 LEP Human glucose multiple interactions ISO Lep (Rattus norvegicus) 6480464 1 more ... CTD PMID:10780946 more ... LEP Human glucose multiple interactions ISO Lep (Mus musculus) 6480464 [lard co-treated with Cholesterol more ... CTD PMID:27712037 and PMID:37567420 LEP Human glucose increases expression ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased expression of LEP mRNA and Glucose results in increased expression of LEP protein CTD PMID:10780946 more ... LEP Human glucose increases secretion ISO Lep (Rattus norvegicus) 6480464 Glucose results in increased secretion of LEP protein CTD PMID:10780946 LEP Human glucose increases response to substance EXP 6480464 Glucose results in increased susceptibility to LEP protein CTD PMID:11342529 LEP Human glucose multiple interactions EXP 6480464 Glucose promotes the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] and LEP protein promotes the reaction [Glucose results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 LEP Human glycine multiple interactions ISO Lep (Mus musculus) 6480464 Glycine affects the reaction [Sodium Glutamate affects the expression of LEP protein] CTD PMID:18930730 LEP Human hesperidin decreases expression ISO Lep (Rattus norvegicus) 6480464 Hesperidin results in decreased expression of LEP protein CTD PMID:21820093 LEP Human hesperidin multiple interactions ISO Lep (Rattus norvegicus) 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein CTD PMID:21820093 LEP Human hexadecanoic acid decreases expression ISO Lep (Mus musculus) 6480464 Palmitic Acid results in decreased expression of LEP mRNA and Palmitic Acid results in decreased expression of LEP protein CTD PMID:34968464 LEP Human hexadecanoic acid multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of LEP mRNA more ... CTD PMID:34968464 LEP Human hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of LEP mRNA CTD PMID:21179406 LEP Human hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of LEP mRNA CTD PMID:26339600 LEP Human imidacloprid increases secretion ISO Lep (Mus musculus) 6480464 imidacloprid results in increased secretion of LEP protein CTD PMID:27960282 LEP Human imidacloprid multiple interactions ISO Lep (Mus musculus) 6480464 Dietary Fats promotes the reaction [imidacloprid results in increased secretion of LEP protein] and imidacloprid promotes the reaction [Dietary Fats results in increased secretion of LEP protein] CTD PMID:27960282 LEP Human indinavir multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein] CTD PMID:17668557 LEP Human indinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 LEP Human indinavir decreases expression EXP 6480464 Indinavir results in decreased expression of LEP protein CTD PMID:17668557 LEP Human indometacin increases expression ISO Lep (Rattus norvegicus) 6480464 Indomethacin results in increased expression of LEP protein CTD PMID:16280098 and PMID:25051504 LEP Human indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of LEP mRNA more ... CTD PMID:23086663 and PMID:28628672 LEP Human indometacin multiple interactions ISO Lep (Rattus norvegicus) 6480464 BQ 610 inhibits the reaction [Indomethacin results in increased expression of LEP protein] more ... CTD PMID:16280098 and PMID:18181030 LEP Human inulin decreases expression ISO Lep (Rattus norvegicus) 6480464 Inulin results in decreased expression of LEP protein CTD PMID:27760213 LEP Human iodide salt increases expression ISO Lep (Rattus norvegicus) 6480464 Iodides deficiency results in increased expression of LEP protein CTD PMID:26795019 LEP Human iron(2+) sulfate (anhydrous) increases expression EXP 6480464 ferrous sulfate results in increased expression of LEP mRNA CTD PMID:21540303 LEP Human isoflavones increases expression ISO Lep (Rattus norvegicus) 6480464 Isoflavones results in increased expression of LEP protein CTD PMID:22155228 LEP Human isoprenaline increases secretion ISO Lep (Mus musculus) 6480464 Isoproterenol results in increased secretion of LEP protein CTD PMID:25111128 LEP Human isoprenaline increases expression ISO Lep (Rattus norvegicus) 6480464 Isoproterenol results in increased expression of LEP protein CTD PMID:20307649 LEP Human isoprenaline multiple interactions ISO Lep (Rattus norvegicus) 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEP protein] CTD PMID:20307649 LEP Human isoprenaline multiple interactions EXP 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 LEP Human isoprenaline decreases secretion EXP 6480464 Isoproterenol results in decreased secretion of LEP protein CTD PMID:11022189 LEP Human isoscutellarein decreases expression ISO Lep (Mus musculus) 6480464 isoscutellarein results in decreased expression of LEP protein CTD PMID:30445784 LEP Human isotretinoin increases expression ISO Lep (Rattus norvegicus) 6480464 Isotretinoin results in increased expression of LEP mRNA CTD PMID:19212007 LEP Human kaempferol decreases expression ISO Lep (Mus musculus) 6480464 kaempferol results in decreased expression of LEP protein CTD PMID:30445784 LEP Human kainic acid decreases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in decreased susceptibility to Kainic Acid CTD PMID:17993459 LEP Human ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of LEP protein CTD PMID:36907275 LEP Human ketamine multiple interactions EXP 6480464 LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]] more ... CTD PMID:36907275 LEP Human L-ascorbic acid decreases secretion ISO Lep (Rattus norvegicus) 6480464 Ascorbic Acid results in decreased secretion of LEP protein CTD PMID:20400526 LEP Human L-ascorbic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 Ascorbic Acid inhibits the reaction [INS1 protein results in increased secretion of LEP protein] CTD PMID:20400526 LEP Human L-methionine multiple interactions ISO Lep (Mus musculus) 6480464 [3 more ... CTD PMID:24384915 more ... LEP Human lamivudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 LEP Human lanthanum atom multiple interactions ISO Lep (Mus musculus) 6480464 Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 LEP Human lead(0) multiple interactions EXP 6480464 Lead results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24709140 LEP Human Licarin A multiple interactions ISO Lep (Mus musculus) 6480464 [licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of LEP mRNA CTD PMID:29288687 LEP Human lipoic acid decreases secretion ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased secretion of LEP protein CTD PMID:21351249 LEP Human lipoic acid decreases expression ISO Lep (Rattus norvegicus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA and Thioctic Acid results in decreased expression of LEP protein CTD PMID:21351249 LEP Human lipoic acid decreases expression ISO Lep (Mus musculus) 6480464 Thioctic Acid results in decreased expression of LEP mRNA CTD PMID:21351249 LEP Human lipopolysaccharide multiple interactions EXP 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 LEP Human lipopolysaccharide increases expression ISO Lep (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased expression of LEP protein CTD PMID:17379010 LEP Human lipopolysaccharide multiple interactions ISO Lep (Rattus norvegicus) 6480464 Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of LEP protein] and Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17379010 and PMID:17621560 LEP Human lipopolysaccharide multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 LEP Human lipopolysaccharide increases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of LEP mRNA CTD PMID:12057914 LEP Human lipopolysaccharide decreases expression ISO Lep (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of LEP mRNA CTD PMID:12057914 LEP Human loganin affects expression ISO Lep (Mus musculus) 6480464 loganin affects the expression of LEP protein CTD PMID:21864639 LEP Human lopinavir decreases expression EXP 6480464 Lopinavir results in decreased expression of LEP protein CTD PMID:17668557 LEP Human lopinavir multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein] CTD PMID:17668557 LEP Human LY294002 decreases expression ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA CTD PMID:19254925 and PMID:21351249 LEP Human LY294002 multiple interactions ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] CTD PMID:29248466 LEP Human LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LEP Human LY294002 decreases secretion ISO Lep (Mus musculus) 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein CTD PMID:19254925 and PMID:21351249 LEP Human manganese atom decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 LEP Human manganese(0) decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Manganese CTD PMID:10965932 LEP Human melatonin decreases expression EXP 6480464 Melatonin results in decreased expression of LEP mRNA CTD PMID:20738756 LEP Human melatonin decreases expression ISO Lep (Rattus norvegicus) 6480464 Melatonin results in decreased expression of LEP protein CTD PMID:19028472 LEP Human menadione multiple interactions EXP 6480464 1 more ... CTD PMID:16996477 LEP Human menadione increases expression EXP 6480464 Vitamin K 3 results in increased expression of LEP mRNA CTD PMID:16996477 LEP Human mercury dichloride decreases expression ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased expression of LEP mRNA CTD PMID:22019852 LEP Human mercury dichloride increases expression ISO Lep (Rattus norvegicus) 6480464 Mercuric Chloride results in increased expression of LEP mRNA CTD PMID:30807803 LEP Human mercury dichloride decreases secretion ISO Lep (Mus musculus) 6480464 Mercuric Chloride results in decreased secretion of LEP protein CTD PMID:22019852 LEP Human metformin increases expression ISO Lep (Mus musculus) 6480464 Metformin results in increased expression of LEP protein CTD PMID:20869956 LEP Human metformin multiple interactions ISO Lep (Mus musculus) 6480464 Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 LEP Human methacholine chloride increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Methacholine Chloride CTD PMID:12794034 LEP Human methadone increases expression EXP 6480464 Methadone results in increased expression of LEP protein CTD PMID:15717844 LEP Human methapyrilene decreases expression ISO Lep (Rattus norvegicus) 6480464 Methapyrilene results in decreased expression of LEP protein CTD PMID:25051504 LEP Human methotrexate affects expression ISO Lep (Mus musculus) 6480464 Methotrexate affects the expression of LEP mRNA CTD PMID:18502557 LEP Human methylmercury chloride multiple interactions ISO Lep (Mus musculus) 6480464 [Cadmium Chloride co-treated with methylmercuric chloride] results in increased expression of LEP protein more ... CTD PMID:27814245 and PMID:33338554 LEP Human methylmercury chloride decreases expression ISO Lep (Mus musculus) 6480464 methylmercuric chloride results in decreased expression of LEP mRNA CTD PMID:29850906 LEP Human methylparaben decreases expression EXP 6480464 methylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human metronidazole multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 LEP Human metyrapone multiple interactions ISO Lep (Rattus norvegicus) 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA CTD PMID:37088303 LEP Human mevalonic acid multiple interactions ISO Lep (Mus musculus) 6480464 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] and Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 LEP Human MK-2206 multiple interactions ISO Lep (Mus musculus) 6480464 MK 2206 inhibits the reaction [8-(4-chlorophenylthio)-2'-O-methyladenosine-3' and 5'-monophosphate acetoxymethyl ester analog results in increased secretion of LEP protein] CTD PMID:27381457 LEP Human mono(2-ethylhexyl) phthalate decreases secretion EXP 6480464 mono-(2-ethylhexyl)phthalate results in decreased secretion of LEP protein CTD PMID:29223775 LEP Human Monobutylphthalate decreases secretion EXP 6480464 monobutyl phthalate results in decreased secretion of LEP protein CTD PMID:29223775 LEP Human monocrotaline affects expression ISO Lep (Rattus norvegicus) 6480464 Monocrotaline affects the expression of LEP protein CTD PMID:25051504 LEP Human monocrotaline multiple interactions ISO Lep (Mus musculus) 6480464 [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein and TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] CTD PMID:21327618 LEP Human monosodium L-glutamate affects expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate affects the expression of LEP protein CTD PMID:18930730 LEP Human monosodium L-glutamate multiple interactions ISO Lep (Mus musculus) 6480464 [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats more ... CTD PMID:18930730 more ... LEP Human monosodium L-glutamate increases expression ISO Lep (Mus musculus) 6480464 Sodium Glutamate results in increased expression of LEP mRNA and Sodium Glutamate results in increased expression of LEP protein CTD PMID:15809509 more ... LEP Human monosodium L-glutamate increases expression ISO Lep (Rattus norvegicus) 6480464 Sodium Glutamate results in increased expression of LEP protein CTD PMID:14657608 LEP Human morin multiple interactions ISO Lep (Rattus norvegicus) 6480464 morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 LEP Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] more ... CTD PMID:11342529 and PMID:28571770 LEP Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases response to substance EXP 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein CTD PMID:11342529 LEP Human N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO Lep (Mus musculus) 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] CTD PMID:19254925 LEP Human N-methyl-4-phenylpyridinium multiple interactions EXP 6480464 LEP protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA] CTD PMID:19763737 LEP Human N-methyl-N-nitrosourea multiple interactions ISO Lep (Mus musculus) 6480464 Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] more ... CTD PMID:16822543 LEP Human N-methyl-N-nitrosourea increases expression ISO Lep (Mus musculus) 6480464 Methylnitrosourea results in increased expression of LEP protein CTD PMID:16822543 LEP Human N-nitrosodiethylamine increases expression ISO Lep (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of LEP protein CTD PMID:25051504 LEP Human N-nitrosodimethylamine increases expression ISO Lep (Rattus norvegicus) 6480464 Dimethylnitrosamine results in increased expression of LEP mRNA and Dimethylnitrosamine results in increased expression of LEP protein CTD PMID:15798949 LEP Human naproxen multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Naproxen inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 LEP Human naringin multiple interactions ISO Lep (Rattus norvegicus) 6480464 [naringin co-treated with Hesperidin] results in decreased expression of LEP protein and naringin inhibits the reaction [Glucose results in increased expression of LEP protein] CTD PMID:21820093 and PMID:24399619 LEP Human naringin multiple interactions ISO Lep (Mus musculus) 6480464 naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:22198281 LEP Human nelfinavir multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein] CTD PMID:17668557 LEP Human nelfinavir decreases secretion ISO Lep (Mus musculus) 6480464 Nelfinavir results in decreased secretion of LEP protein CTD PMID:19033543 LEP Human nelfinavir decreases expression EXP 6480464 Nelfinavir results in decreased expression of LEP protein CTD PMID:17668557 LEP Human neomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 LEP Human nevirapine increases expression EXP 6480464 Nevirapine results in increased expression of LEP mRNA CTD PMID:21619898 LEP Human nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of LEP mRNA CTD PMID:25583101 LEP Human nickel dichloride multiple interactions EXP 6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of LEP protein CTD PMID:18437699 LEP Human nickel dichloride multiple interactions ISO Lep (Rattus norvegicus) 6480464 nickel chloride inhibits the reaction [[Glucose co-treated with INS1 protein] results in increased secretion of LEP protein] CTD PMID:10780946 LEP Human nickel sulfate multiple interactions EXP 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of LEP mRNA CTD PMID:18832182 LEP Human nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of LEP mRNA CTD PMID:18832182 LEP Human nicotine increases expression ISO Lep (Rattus norvegicus) 6480464 Nicotine results in increased expression of LEP protein CTD PMID:23623838 and PMID:29155039 LEP Human nicotine decreases response to substance ISO Lep (Rattus norvegicus) 6480464 Nicotine results in decreased susceptibility to LEP protein CTD PMID:23623838 LEP Human nicotinic acid increases expression EXP 6480464 Niacin results in increased expression of LEP protein CTD PMID:16887123 LEP Human nicotinic acid increases expression ISO Lep (Mus musculus) 6480464 Niacin results in increased expression of LEP mRNA CTD PMID:21236357 LEP Human nitric oxide multiple interactions EXP 6480464 LEP protein affects the reaction [IL1B protein results in increased chemical synthesis of Nitric Oxide] CTD PMID:9312173 LEP Human Nonylphenol increases expression ISO Lep (Mus musculus) 6480464 nonylphenol results in increased expression of LEP mRNA CTD PMID:18417718 LEP Human norwogonin decreases expression ISO Lep (Mus musculus) 6480464 norwogonin analog results in decreased expression of LEP protein and norwogonin results in decreased expression of LEP protein CTD PMID:30445784 LEP Human NS-398 multiple interactions EXP 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA] and N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 LEP Human olanzapine increases expression EXP 6480464 olanzapine results in increased expression of LEP protein CTD PMID:11927762 and PMID:19512971 LEP Human olanzapine increases expression ISO Lep (Mus musculus) 6480464 Olanzapine results in increased expression of LEP protein CTD PMID:32652086 LEP Human olanzapine multiple interactions ISO Lep (Mus musculus) 6480464 capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein] more ... CTD PMID:32652086 LEP Human oleanolic acid increases expression ISO Lep (Mus musculus) 6480464 Oleanolic Acid results in increased expression of LEP protein CTD PMID:20188082 LEP Human oleic acid decreases expression ISO Lep (Mus musculus) 6480464 Oleic Acid results in decreased expression of LEP mRNA CTD PMID:9002984 LEP Human oleic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 LEP Human oleic acid increases expression ISO Lep (Rattus norvegicus) 6480464 Oleic Acid results in increased expression of LEP mRNA CTD PMID:23395669 LEP Human omaveloxolone multiple interactions ISO Lep (Mus musculus) 6480464 omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein] CTD PMID:32410268 LEP Human orlistat multiple interactions ISO Lep (Rattus norvegicus) 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 LEP Human orlistat multiple interactions ISO Lep (Mus musculus) 6480464 orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 LEP Human ozone multiple interactions ISO Lep (Mus musculus) 6480464 [LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL11 protein more ... CTD PMID:12794034 and PMID:27472835 LEP Human ozone multiple interactions ISO Lep (Rattus norvegicus) 6480464 [[Air Pollutants results in increased abundance of Ozone] which co-treated with Metyrapone] results in increased expression of LEP mRNA more ... CTD PMID:23968387 more ... LEP Human ozone decreases secretion ISO Lep (Mus musculus) 6480464 Ozone results in decreased secretion of LEP protein CTD PMID:27240593 LEP Human ozone increases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in increased susceptibility to Ozone and LEP protein results in increased susceptibility to Ozone CTD PMID:12794034 more ... LEP Human ozone increases expression ISO Lep (Rattus norvegicus) 6480464 Ozone results in increased expression of LEP and Ozone results in increased expression of LEP protein CTD PMID:24103449 more ... LEP Human paracetamol multiple interactions ISO Lep (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of LEP mRNA] CTD PMID:17585979 LEP Human paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of LEP mRNA CTD PMID:26690555 LEP Human paracetamol affects expression ISO Lep (Mus musculus) 6480464 Acetaminophen affects the expression of LEP mRNA CTD PMID:17562736 LEP Human paraquat affects expression ISO Lep (Rattus norvegicus) 6480464 Paraquat affects the expression of LEP mRNA CTD PMID:18198484 LEP Human parathion increases methylation EXP 6480464 Parathion results in increased methylation of LEP promoter CTD PMID:22847954 LEP Human perfluorohexanesulfonic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 LEP Human perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of LEP mRNA CTD PMID:28011154 LEP Human perfluorooctane-1-sulfonic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [perfluorooctane sulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 LEP Human perfluorooctane-1-sulfonic acid affects expression EXP 6480464 perfluorooctane sulfonic acid affects the expression of LEP mRNA CTD PMID:30738844 LEP Human perfluorooctanoic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 [perfluorooctane sulfonic acid co-treated with perfluorooctanoic acid co-treated with perfluorohexanesulfonic acid co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:34464680 and PMID:35163327 LEP Human perindopril decreases expression ISO Lep (Rattus norvegicus) 6480464 Perindopril results in decreased expression of LEP protein CTD PMID:18083506 LEP Human permethrin multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 LEP Human phencyclidine increases expression ISO Lep (Mus musculus) 6480464 Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 LEP Human phenethyl caffeate decreases expression ISO Lep (Mus musculus) 6480464 caffeic acid phenethyl ester results in decreased expression of LEP mRNA and caffeic acid phenethyl ester results in decreased expression of LEP protein CTD PMID:21467634 LEP Human phenobarbital affects expression ISO Lep (Rattus norvegicus) 6480464 Phenobarbital affects the expression of LEP protein CTD PMID:25051504 LEP Human phenobarbital multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP mRNA and [Carbon Tetrachloride co-treated with Phenobarbital] results in increased expression of LEP protein CTD PMID:14758566 LEP Human phloretin multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 LEP Human phlorizin multiple interactions ISO Lep (Mus musculus) 6480464 2 more ... CTD PMID:32408695 LEP Human phosphatidylcholine decreases expression ISO Lep (Mus musculus) 6480464 Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 LEP Human phosphoramidon decreases expression ISO Lep (Rattus norvegicus) 6480464 phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 LEP Human pioglitazone increases expression ISO Lep (Rattus norvegicus) 6480464 pioglitazone results in increased expression of LEP protein CTD PMID:15655531 LEP Human piperine multiple interactions ISO Lep (Rattus norvegicus) 6480464 piperine inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:25087745 LEP Human pirimicarb multiple interactions ISO Lep (Rattus norvegicus) 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 LEP Human pirinixic acid multiple interactions ISO Lep (Mus musculus) 6480464 pirinixic acid inhibits the reaction [rosiglitazone results in increased expression of LEP protein] CTD PMID:16306350 LEP Human pitavastatin multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 LEP Human pitavastatin(1-) multiple interactions ISO Lep (Mus musculus) 6480464 pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 LEP Human pluronic P-123 increases secretion ISO Lep (Rattus norvegicus) 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 LEP Human pluronic P-123 multiple interactions ISO Lep (Rattus norvegicus) 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 LEP Human Poloxamer increases secretion ISO Lep (Rattus norvegicus) 6480464 Poloxamer results in increased secretion of LEP protein CTD PMID:29071762 LEP Human Poloxamer multiple interactions ISO Lep (Rattus norvegicus) 6480464 carvacrol inhibits the reaction [Poloxamer results in increased secretion of LEP protein] and Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 LEP Human potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of LEP mRNA CTD PMID:11678601 LEP Human pravastatin multiple interactions ISO Lep (Mus musculus) 6480464 Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA] more ... CTD PMID:18323514 LEP Human prochloraz decreases expression EXP 6480464 prochloraz results in decreased expression of LEP mRNA CTD PMID:30879083 LEP Human progesterone decreases secretion EXP 6480464 Progesterone results in decreased secretion of LEP protein CTD PMID:16048798 LEP Human progesterone multiple interactions EXP 6480464 LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone] and LEPR protein affects the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased chemical synthesis of Progesterone]] CTD PMID:19849856 LEP Human progesterone increases expression ISO Lep (Mus musculus) 6480464 Progesterone results in increased expression of LEP mRNA CTD PMID:15713686 LEP Human propranolol multiple interactions EXP 6480464 Propranolol inhibits the reaction [Isoproterenol results in decreased secretion of LEP protein] CTD PMID:11022189 LEP Human propranolol increases expression ISO Lep (Rattus norvegicus) 6480464 Propranolol results in increased expression of LEP protein CTD PMID:24250662 LEP Human propylparaben increases expression ISO Lep (Mus musculus) 6480464 propylparaben results in increased expression of LEP mRNA CTD PMID:22956630 LEP Human propylparaben decreases expression EXP 6480464 propylparaben results in decreased expression of LEP mRNA CTD PMID:22956630 LEP Human prostaglandin E2 increases secretion ISO Lep (Rattus norvegicus) 6480464 Dinoprostone results in increased secretion of LEP protein CTD PMID:11060898 LEP Human prostaglandin E2 increases expression ISO Lep (Rattus norvegicus) 6480464 Dinoprostone results in increased expression of LEP protein CTD PMID:11060898 LEP Human prostaglandin E2 increases abundance ISO Lep (Rattus norvegicus) 6480464 LEP protein results in increased abundance of Dinoprostone CTD PMID:16015682 LEP Human Ptaquiloside decreases expression ISO Lep (Mus musculus) 6480464 ptaquiloside results in decreased expression of LEP mRNA CTD PMID:23274088 LEP Human Pyridostigmine bromide multiple interactions ISO Lep (Mus musculus) 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein and Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of LEP protein] CTD PMID:29751049 LEP Human pyruvic acid increases secretion ISO Lep (Rattus norvegicus) 6480464 Pyruvic Acid results in increased secretion of LEP protein CTD PMID:10780946 LEP Human pyruvic acid multiple interactions ISO Lep (Rattus norvegicus) 6480464 INS1 protein promotes the reaction [Pyruvic Acid results in increased secretion of LEP protein] CTD PMID:10780946 LEP Human quercetin multiple interactions ISO Lep (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Dietary Fats results in increased expression of LEP protein] more ... CTD PMID:22426011 more ... LEP Human quercetin increases expression EXP 6480464 Quercetin results in increased expression of LEP mRNA and Quercetin results in increased expression of LEP protein CTD PMID:22230496 LEP Human quercetin decreases expression ISO Lep (Mus musculus) 6480464 Quercetin results in decreased expression of LEP mRNA and Quercetin results in decreased expression of LEP protein CTD PMID:19914226 and PMID:30445784 LEP Human quercetin decreases secretion ISO Lep (Mus musculus) 6480464 Quercetin results in decreased secretion of LEP protein CTD PMID:19914226 LEP Human quercetin multiple interactions ISO Lep (Mus musculus) 6480464 Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA] more ... CTD PMID:19914226 more ... LEP Human rac-lactic acid affects expression EXP 6480464 Lactic Acid affects the expression of LEP mRNA CTD PMID:30851411 LEP Human ramipril multiple interactions EXP 6480464 candesartan promotes the reaction [Ramipril results in increased expression of LEP] and Ramipril promotes the reaction [candesartan results in increased expression of LEP] CTD PMID:17483542 LEP Human ramipril decreases expression EXP 6480464 Ramipril results in decreased expression of LEP CTD PMID:19059660 LEP Human reactive oxygen species multiple interactions EXP 6480464 adenosine-3' more ... CTD PMID:11342529 LEP Human reactive oxygen species increases chemical synthesis EXP 6480464 LEP protein results in increased chemical synthesis of Reactive Oxygen Species CTD PMID:11342529 LEP Human rebaudioside A multiple interactions ISO Lep (Mus musculus) 6480464 rebaudioside A affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 LEP Human reserpine increases expression ISO Lep (Mus musculus) 6480464 Reserpine results in increased expression of LEP mRNA CTD PMID:10050748 LEP Human resveratrol decreases secretion ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased secretion of LEP protein and resveratrol results in decreased secretion of LEP protein CTD PMID:23717508 LEP Human resveratrol multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Resveratrol] results in increased expression of LEP mRNA more ... CTD PMID:29197120 and PMID:31881177 LEP Human resveratrol multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA] more ... CTD PMID:26973390 and PMID:37570835 LEP Human resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of LEP mRNA and resveratrol results in decreased expression of LEP protein CTD PMID:21713995 and PMID:23536519 LEP Human resveratrol decreases expression ISO Lep (Mus musculus) 6480464 resveratrol metabolite results in decreased expression of LEP mRNA more ... CTD PMID:23717508 more ... LEP Human rifampicin increases expression ISO Lep (Rattus norvegicus) 6480464 Rifampin results in increased expression of LEP protein CTD PMID:25051504 LEP Human rimonabant multiple interactions ISO Lep (Mus musculus) 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased secretion of LEP protein] more ... CTD PMID:19030233 and PMID:26967640 LEP Human ritonavir multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 LEP Human ritonavir decreases expression EXP 6480464 Ritonavir results in decreased expression of LEP protein CTD PMID:17668557 LEP Human rotenone decreases response to substance EXP 6480464 Rotenone results in decreased susceptibility to LEP protein CTD PMID:11342529 LEP Human rotenone multiple interactions EXP 6480464 Rotenone inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species] CTD PMID:11342529 LEP Human roxarsone decreases expression EXP 6480464 Roxarsone results in decreased expression of LEP mRNA CTD PMID:18414637 LEP Human ruthenium red multiple interactions ISO Lep (Mus musculus) 6480464 Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein] CTD PMID:32652086 LEP Human rutin multiple interactions ISO Lep (Rattus norvegicus) 6480464 Rutin inhibits the reaction [Fructose results in increased expression of LEP protein] CTD PMID:22426011 LEP Human S-adenosyl-L-methioninate multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 LEP Human S-adenosyl-L-methionine multiple interactions EXP 6480464 S-Adenosylmethionine inhibits the reaction [LEP protein results in increased expression of COL1A1 mRNA] and S-Adenosylmethionine inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 LEP Human saquinavir multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 LEP Human SB 203580 multiple interactions EXP 6480464 SB 203580 inhibits the reaction [LEP protein inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR protein]] and SB 203580 inhibits the reaction [Vitamin K 3 results in increased expression of LEP mRNA] CTD PMID:16996477 and PMID:19849856 LEP Human SB 203580 decreases response to substance EXP 6480464 SB 203580 results in decreased susceptibility to LEP protein CTD PMID:19849856 LEP Human selenium atom decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Selenium CTD PMID:10965932 LEP Human serpentine asbestos decreases expression ISO Lep (Mus musculus) 6480464 Asbestos and Serpentine results in decreased expression of LEP mRNA CTD PMID:23917077 LEP Human silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of LEP mRNA CTD PMID:23806026 LEP Human silicon dioxide decreases expression ISO Lep (Rattus norvegicus) 6480464 Silicon Dioxide results in decreased expression of LEP mRNA CTD PMID:32721576 LEP Human simvastatin multiple interactions ISO Lep (Mus musculus) 6480464 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA] more ... CTD PMID:19254925 LEP Human simvastatin multiple interactions ISO Lep (Rattus norvegicus) 6480464 Simvastatin inhibits the reaction [Poloxamer results in increased secretion of LEP protein] CTD PMID:29071762 LEP Human simvastatin decreases secretion ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased secretion of LEP protein CTD PMID:19254925 LEP Human simvastatin decreases expression ISO Lep (Mus musculus) 6480464 Simvastatin results in decreased expression of LEP mRNA and Simvastatin results in decreased expression of LEP mRNA alternative form CTD PMID:19254925 LEP Human SKF-96365 hydrochloride multiple interactions ISO Lep (Mus musculus) 6480464 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 LEP Human sodium arsenate multiple interactions EXP 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of LEP mRNA CTD PMID:32525701 LEP Human sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of LEP mRNA CTD PMID:25879800 LEP Human sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:37956786 LEP Human sodium arsenite decreases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in decreased expression of LEP mRNA CTD PMID:34968464 and PMID:36209798 LEP Human sodium arsenite multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LEP mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of LEP protein CTD PMID:36989998 LEP Human sodium arsenite increases expression ISO Lep (Mus musculus) 6480464 sodium arsenite results in increased expression of LEP protein CTD PMID:28593471 and PMID:29755549 LEP Human sodium arsenite multiple interactions ISO Lep (Mus musculus) 6480464 [Palmitic Acid co-treated with sodium arsenite] results in decreased expression of LEP mRNA more ... CTD PMID:28593471 more ... LEP Human sodium arsenite affects expression ISO Lep (Mus musculus) 6480464 sodium arsenite affects the expression of LEP mRNA and sodium arsenite affects the expression of LEP protein CTD PMID:25367288 and PMID:28206643 LEP Human sodium perchlorate multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein CTD PMID:30090431 LEP Human Sophocarpine multiple interactions ISO Lep (Rattus norvegicus) 6480464 sophocarpine inhibits the reaction [Oleic Acid results in increased expression of LEP mRNA] CTD PMID:23395669 LEP Human stavudine decreases expression EXP 6480464 Stavudine results in decreased expression of LEP protein CTD PMID:17668557 LEP Human steviol multiple interactions ISO Lep (Mus musculus) 6480464 steviol affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACACA mRNA] more ... CTD PMID:25554529 LEP Human stevioside multiple interactions ISO Lep (Mus musculus) 6480464 stevioside affects the reaction [[LEP protein co-treated with LDLR protein] affects the expression of ACOX1 mRNA] more ... CTD PMID:25554529 LEP Human streptozocin multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein more ... CTD PMID:24854284 LEP Human streptozocin multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein more ... CTD PMID:29988851 and PMID:32410268 LEP Human sumatriptan multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of LEP protein] and Sumatriptan inhibits the reaction [Capsaicin results in increased expression of LEP protein] CTD PMID:22150557 LEP Human superoxide multiple interactions ISO Lep (Mus musculus) 6480464 acetovanillone inhibits the reaction [LEP protein results in increased abundance of Superoxides] more ... CTD PMID:16380530 LEP Human superoxide multiple interactions EXP 6480464 [LEP protein results in increased oxidation of Fatty Acids] which results in increased chemical synthesis of Superoxides CTD PMID:11342529 LEP Human superoxide increases abundance ISO Lep (Mus musculus) 6480464 LEP protein results in increased abundance of Superoxides CTD PMID:16380530 LEP Human terbufos increases methylation EXP 6480464 terbufos results in increased methylation of LEP promoter CTD PMID:22847954 LEP Human terbutaline decreases expression ISO Lep (Mus musculus) 6480464 Terbutaline results in decreased expression of LEP mRNA and Terbutaline results in decreased expression of LEP protein CTD PMID:9002984 LEP Human testosterone affects secretion ISO Lep (Mus musculus) 6480464 LEP protein affects the secretion of Testosterone CTD PMID:24502529 LEP Human testosterone multiple interactions ISO Lep (Mus musculus) 6480464 alpha-cyano-(3 more ... CTD PMID:24502529 LEP Human tetrachloromethane multiple interactions ISO Lep (Mus musculus) 6480464 LEP protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] more ... CTD PMID:11481614 more ... LEP Human tetrachloromethane increases expression ISO Lep (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:29987408 LEP Human tetrachloromethane increases expression ISO Lep (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of LEP protein CTD PMID:27623180 LEP Human tetrachloromethane multiple interactions ISO Lep (Rattus norvegicus) 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEP protein more ... CTD PMID:14758566 and PMID:18227024 LEP Human Theaflavin 3,3'-digallate multiple interactions ISO Lep (Mus musculus) 6480464 theaflavin-3 more ... CTD PMID:36105184 LEP Human thioacetamide decreases response to substance ISO Lep (Mus musculus) 6480464 LEP gene mutant form results in decreased susceptibility to Thioacetamide CTD PMID:12085344 LEP Human thioacetamide increases expression ISO Lep (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of LEP protein CTD PMID:17621560 LEP Human thioacetamide multiple interactions ISO Lep (Rattus norvegicus) 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in increased expression of LEP protein] CTD PMID:17621560 LEP Human thioacetamide increases response to substance ISO Lep (Mus musculus) 6480464 LEP protein results in increased susceptibility to Thioacetamide CTD PMID:12085344 LEP Human thioacetamide multiple interactions ISO Lep (Mus musculus) 6480464 [Thioacetamide co-treated with LEP protein] results in increased expression of COL1A1 mRNA more ... CTD PMID:11481614 more ... LEP Human thiram multiple interactions ISO Lep (Rattus norvegicus) 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 LEP Human titanium dioxide decreases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in decreased expression of LEP mRNA CTD PMID:23131501 and PMID:35295148 LEP Human titanium dioxide increases expression ISO Lep (Mus musculus) 6480464 titanium dioxide results in increased expression of LEP mRNA CTD PMID:29264374 LEP Human triazophos decreases secretion ISO Lep (Rattus norvegicus) 6480464 triazophos results in decreased secretion of LEP protein CTD PMID:34038317 LEP Human tributylstannane increases secretion ISO Lep (Rattus norvegicus) 6480464 tributyltin results in increased secretion of LEP protein CTD PMID:28161095 LEP Human tributylstannane increases expression ISO Lep (Rattus norvegicus) 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 LEP Human tributylstannane decreases expression ISO Lep (Mus musculus) 6480464 tributyltin results in decreased expression of LEP protein CTD PMID:27310180 LEP Human tributylstannane increases expression ISO Lep (Mus musculus) 6480464 tributyltin results in increased expression of LEP protein CTD PMID:30172001 LEP Human tributylstannane multiple interactions ISO Lep (Mus musculus) 6480464 [Dietary Fats co-treated with tributyltin] results in increased expression of LEP protein CTD PMID:29787037 LEP Human tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of LEP mRNA CTD PMID:28011154 LEP Human trichloroethene multiple interactions ISO Lep (Mus musculus) 6480464 Trichloroethylene inhibits the reaction [Dietary Fats affects the expression of LEP mRNA] CTD PMID:29669109 LEP Human trichloroethene decreases expression ISO Lep (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of LEP mRNA CTD PMID:33387578 LEP Human trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of LEP mRNA CTD PMID:17502362 LEP Human trichostatin A multiple interactions EXP 6480464 trichostatin A promotes the reaction [decitabine results in increased expression of LEP mRNA] CTD PMID:17502362 LEP Human triclosan increases expression EXP 6480464 Triclosan results in increased expression of LEP mRNA CTD PMID:38048832 LEP Human triflumizole multiple interactions EXP 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of LEP mRNA] CTD PMID:23086663 LEP Human triflumizole multiple interactions ISO Lep (Mus musculus) 6480464 [triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA and T 0070907 inhibits the reaction [[triflumizol co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LEP mRNA] CTD PMID:23086663 LEP Human triphenyl phosphate multiple interactions ISO Lep (Mus musculus) 6480464 [tris(1 more ... CTD PMID:29112739 LEP Human triptonide increases expression ISO Lep (Mus musculus) 6480464 triptonide results in increased expression of LEP mRNA CTD PMID:33045310 LEP Human troglitazone decreases expression ISO Lep (Rattus norvegicus) 6480464 troglitazone results in decreased expression of LEP mRNA and troglitazone results in decreased expression of LEP protein CTD PMID:11909685 more ... LEP Human troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of LEP protein CTD PMID:10946865 and PMID:9727893 LEP Human troglitazone decreases expression ISO Lep (Mus musculus) 6480464 troglitazone results in decreased expression of LEP mRNA CTD PMID:10753628 LEP Human troglitazone increases secretion EXP 6480464 troglitazone results in increased secretion of LEP protein CTD PMID:11092516 LEP Human troglitazone multiple interactions EXP 6480464 [Dexamethasone co-treated with troglitazone] results in decreased secretion of LEP protein more ... CTD PMID:10946865 and PMID:11092516 LEP Human U-73122 multiple interactions ISO Lep (Mus musculus) 6480464 1-(6-((3-methoxyestra-1 more ... CTD PMID:20107083 LEP Human ursolic acid increases expression ISO Lep (Mus musculus) 6480464 Ursolic Acid results in increased expression of LEP protein CTD PMID:20869956 LEP Human vanadium atom multiple interactions ISO Lep (Rattus norvegicus) 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 LEP Human vanadium(0) multiple interactions ISO Lep (Rattus norvegicus) 6480464 Vanadium promotes the reaction [LEP protein results in increased expression of UCP1 protein] and Vanadium promotes the reaction [LEP protein results in increased phosphorylation of STAT3 protein] CTD PMID:16195403 LEP Human vancomycin multiple interactions ISO Lep (Mus musculus) 6480464 [Vancomycin co-treated with Neomycin co-treated with Metronidazole co-treated with elemicin] results in increased expression of LEP mRNA CTD PMID:34979169 LEP Human vinclozolin decreases expression ISO Lep (Rattus norvegicus) 6480464 vinclozolin results in decreased expression of LEP mRNA CTD PMID:23160963 LEP Human vitamin E multiple interactions ISO Lep (Rattus norvegicus) 6480464 Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP mRNA] and Vitamin E inhibits the reaction [Dietary Fats results in decreased expression of LEP protein] CTD PMID:20404018 LEP Human wogonin decreases expression ISO Lep (Mus musculus) 6480464 wogonin analog results in decreased expression of LEP protein and wogonin results in decreased expression of LEP protein CTD PMID:30445784 LEP Human wortmannin decreases expression ISO Lep (Mus musculus) 6480464 wortmannin results in decreased expression of LEP mRNA CTD PMID:19254925 LEP Human wortmannin multiple interactions ISO Lep (Mus musculus) 6480464 wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 LEP Human wortmannin decreases secretion ISO Lep (Mus musculus) 6480464 wortmannin results in decreased secretion of LEP protein CTD PMID:19254925 LEP Human xanthone multiple interactions ISO Lep (Rattus norvegicus) 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein] and xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467 LEP Human zidovudine decreases expression EXP 6480464 Zidovudine results in decreased expression of LEP protein CTD PMID:17668557 LEP Human zidovudine multiple interactions ISO Lep (Mus musculus) 6480464 [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of LEP mRNA and [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA CTD PMID:16931933 LEP Human zinc atom decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 LEP Human zinc atom multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 LEP Human zinc atom increases expression ISO Lep (Rattus norvegicus) 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 LEP Human zinc atom decreases expression EXP 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 LEP Human zinc atom multiple interactions EXP 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 LEP Human zinc atom decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 LEP Human zinc dichloride increases expression EXP 6480464 zinc chloride results in increased expression of LEP mRNA CTD PMID:21540303 LEP Human zinc molecular entity multiple interactions ISO Lep (Rattus norvegicus) 6480464 Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein] CTD PMID:24854284 LEP Human zinc sulfate decreases expression ISO Lep (Rattus norvegicus) 6480464 Zinc Sulfate deficiency results in decreased expression of LEP mRNA CTD PMID:11568307 LEP Human zinc sulfate multiple interactions ISO Lep (Rattus norvegicus) 6480464 Zinc Sulfate deficiency results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:11568307 LEP Human zinc(0) decreases expression ISO Lep (Mus musculus) 6480464 Zinc deficiency results in decreased expression of LEP protein CTD PMID:25088245 LEP Human zinc(0) decreases abundance EXP 6480464 LEP gene mutant form results in decreased abundance of Zinc CTD PMID:10965932 LEP Human zinc(0) multiple interactions EXP 6480464 IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] and MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of LEP mRNA] CTD PMID:18316168 LEP Human zinc(0) decreases expression EXP 6480464 Zinc results in decreased expression of LEP mRNA CTD PMID:18316168 LEP Human zinc(0) increases expression ISO Lep (Rattus norvegicus) 6480464 Zinc deficiency results in increased expression of LEP protein CTD PMID:20660286 LEP Human zinc(0) multiple interactions ISO Lep (Mus musculus) 6480464 [Zinc deficiency co-treated with Ethanol] results in decreased expression of and results in decreased secretion of LEP protein CTD PMID:24155903 LEP Human ziram multiple interactions ISO Lep (Rattus norvegicus) 6480464 [2-amino-3-chloro-1 and 4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614