Cdkn1b (cyclin dependent kinase inhibitor 1B) - Rat Genome Database

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Gene: Cdkn1b (cyclin dependent kinase inhibitor 1B) Mus musculus
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Symbol: Cdkn1b
Name: cyclin dependent kinase inhibitor 1B
RGD ID: 69116
MGI Page MGI
Description: Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including G1/S transition of mitotic cell cycle; heart development; and negative regulation of cardiac muscle tissue regeneration. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of microtubule polymerization; and regulation of exit from mitosis. Located in cytosol and nucleus. Is expressed in several structures, including brain; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA408329; AI843786; cyclin-dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor p27; Kip1; p2; p27; p27K; p27Kip1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396134,897,364 - 134,902,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,897,364 - 134,902,476 (+)EnsemblGRCm39 Ensembl
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,920,401 - 134,925,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBIMGSCv36mm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
acute myeloid leukemia  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chloracne  (ISO)
chronic myeloid leukemia  (ISO)
Diabetic Nephropathies  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fallopian Tube Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (ISO)
glaucoma  (ISO)
Helicobacter Infections  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hyperthyroidism  (ISO)
infertility  (ISO)
influenza  (IMP)
Intestinal Neoplasms  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
Leydig cell tumor  (IEP)
Liver Neoplasms  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Mesothelioma  (ISO)
multiple endocrine neoplasia  (ISO)
multiple endocrine neoplasia type 4  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (IMP,ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
obesity  (IEP)
ovarian cancer  (ISO)
Ovarian Neoplasms  (IEP,ISO)
paraganglioma  (ISO)
pheochromocytoma  (ISO)
pituitary adenoma  (ISO)
Pituitary Neoplasms  (ISO)
primary hyperparathyroidism  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (IMP,ISO)
pulmonary hypertension  (ISO)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
senile cataract  (ISO)
Sezary's disease  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
Testicular Neoplasms  (IEP)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (IAGP,ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1-naphthyl isothiocyanate  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-cyclopenten-1-one  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (ISO)
25-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (EXP)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (EXP)
afimoxifene  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
allose  (ISO)
Allylamine  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
anilines  (ISO)
anthocyanin  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
aspartame  (EXP,ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bosutinib  (EXP)
BQ 123  (ISO)
brassinolide  (ISO)
Brodifacoum  (ISO)
bucladesine  (ISO)
budesonide  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (ISO)
Calpeptin  (EXP)
capsaicin  (EXP,ISO)
captan  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (ISO)
carnosic acid  (ISO)
casticin  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
choline  (EXP)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clobenpropit  (ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
cordycepin  (EXP,ISO)
corticosterone  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
cytochalasin B  (ISO)
D-glucose  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diacetylmonoxime  (EXP)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethanolamine  (EXP,ISO)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
digitonin  (EXP)
digitoxin  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyldithiocarbamate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (EXP,ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
ellipticine  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (EXP)
esculetin  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fasudil  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
flavanone  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (ISO)
ganglioside GM1  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
geraniol  (ISO)
gingerol  (ISO)
glafenine  (ISO)
glucose  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
harmine  (ISO)
hemin  (ISO)
heparin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydroxyurea  (ISO)
indirubin  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (EXP)
isoeugenol  (ISO)
isoflavones  (ISO)
isoliquiritigenin  (EXP)
isoprene  (ISO)
isosilybin A  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP)
L-mimosine  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lapatinib  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linalool  (ISO)
lipopolysaccharide  (EXP)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
Maxacalcitol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methidathion  (EXP)
methotrexate  (ISO)
methoxsalen  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
ML-7  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
monobenzyl phthalate  (EXP)
monoethyl phthalate  (EXP)
monosodium L-glutamate  (EXP)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naphthalene  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nilutamide  (EXP)
nimesulide  (ISO)
nitroglycerin  (ISO)
NS-398  (ISO)
ochratoxin A  (ISO)
oleanolic acid  (EXP,ISO)
orlistat  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perillyl alcohol  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidylcholine  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisone  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
pyrimidines  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quinazolines  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
rubitecan  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Sanggenon C  (ISO)
sapanisertib  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (EXP)
silibinin  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP,ISO)
staurosporine  (ISO)
sterigmatocystin  (ISO)
stilbenoid  (ISO)
sulindac  (ISO)
sulindac sulfone  (ISO)
tacrolimus hydrate  (ISO)
taiwanin C  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
temozolomide  (EXP,ISO)
terazosin  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiophenes  (ISO)
thiram  (ISO)
tipifarnib  (ISO)
tolbutamide  (ISO)
toluene 2,4-diisocyanate  (EXP)
Tomentosin  (ISO)
topotecan  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IMP)
autophagic cell death  (ISO)
cellular response to antibiotic  (IDA)
cellular response to hypoxia  (ISO)
cellular response to lithium ion  (ISO)
cellular response to organic cyclic compound  (IDA)
epithelial cell apoptotic process  (IMP)
epithelial cell proliferation involved in prostate gland development  (IMP)
G1/S transition of mitotic cell cycle  (IBA,IDA)
heart development  (IMP)
inner ear development  (IMP)
negative regulation of cardiac muscle tissue regeneration  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IBA,IMP,ISO)
negative regulation of cyclin-dependent protein kinase activity  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IBA,IDA,ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell apoptotic process  (IMP)
negative regulation of epithelial cell proliferation  (IMP)
negative regulation of epithelial cell proliferation involved in prostate gland development  (IMP)
negative regulation of kinase activity  (ISO)
negative regulation of mitotic cell cycle  (IBA)
negative regulation of phosphorylation  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
Notch signaling pathway  (IDA)
nuclear export  (ISO)
placenta development  (IGI)
positive regulation of cell population proliferation  (IMP)
positive regulation of cellular process  (ISO)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
positive regulation of microtubule polymerization  (IGI)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
potassium ion transport  (IGI)
regulation of cell cycle  (IMP,ISO)
regulation of cell cycle G1/S phase transition  (ISO)
regulation of cell migration  (IDA)
regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
regulation of exit from mitosis  (IGI)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of lens fiber cell differentiation  (IGI)
regulation of mitotic cell cycle  (IDA)
response to amino acid  (ISO)
response to cadmium ion  (ISO)
response to estradiol  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal behavior  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal corpus luteum morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal embryo turning  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal epithalamus morphology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal ileum morphology  (IAGP)
abnormal junctional epithelium morphology  (IAGP)
abnormal mitosis  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal organ of Corti morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovary physiology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal pillar cell morphology  (IAGP)
abnormal pituitary intermediate lobe morphology  (IAGP)
abnormal prostate gland dorsolateral lobe morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal reflex  (IAGP)
abnormal response to injury  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina neuronal layer morphology  (IAGP)
abnormal retina outer limiting membrane morphology  (IAGP)
abnormal retina photoreceptor morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal uterus morphology  (IAGP)
absent corpus luteum  (IAGP)
absent tertiary ovarian follicles  (IAGP)
adrenal medulla hyperplasia  (IAGP)
ataxia  (IAGP)
bradykinesia  (IAGP)
cachexia  (IAGP)
decreased body size  (IAGP)
decreased body temperature  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating testosterone level  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased keratinocyte proliferation  (IAGP)
decreased myocardial fiber size  (IAGP)
decreased prostate gland anterior lobe weight  (IAGP)
decreased prostate gland dorsolateral lobe weight  (IAGP)
decreased prostate gland ventral lobe weight  (IAGP)
decreased seminal vesicle weight  (IAGP)
decreased T cell proliferation  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor-free survival time  (IAGP)
dehydration  (IAGP)
delayed wound healing  (IAGP)
disorganized retina layers  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
endometrium hyperplasia  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged heart  (IAGP)
enlarged ovary  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged pituitary gland  (IAGP)
enlarged prostate gland  (IAGP)
enlarged spleen  (IAGP)
enlarged testis  (IAGP)
enlarged thymus  (IAGP)
female infertility  (IAGP)
heart hyperplasia  (IAGP)
hepatic steatosis  (IAGP)
hydrocephaly  (IAGP)
hyperglycemia  (IAGP)
hyperlipidemia  (IAGP)
impaired glucose tolerance  (IAGP)
impaired hearing  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
impaired righting response  (IAGP)
increased adrenal gland tumor incidence  (IAGP)
increased amacrine cell number  (IAGP)
increased body size  (IAGP)
increased body weight  (IAGP)
increased brain weight  (IAGP)
increased brown adipose tissue amount  (IAGP)
increased carcinoma incidence  (IAGP)
increased cell proliferation  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased cochlear hair cell number  (IAGP)
increased cochlear inner hair cell number  (IAGP)
increased cochlear outer hair cell number  (IAGP)
increased food intake  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased heart weight  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased kidney weight  (IAGP)
increased lean body mass  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased medulloblastoma incidence  (IAGP)
increased mitotic index  (IAGP)
increased myocardial fiber number  (IAGP)
increased neuron apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased organ of Corti supporting cell number  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary adenoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased parametrial fat pad weight  (IAGP)
increased parathyroid gland tumor incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased pituitary gland tumor incidence  (IAGP)
increased pituitary gland weight  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased rhabdomyosarcoma incidence  (IAGP)
increased sarcoma incidence  (IAGP)
increased spleen weight  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased T cell proliferation  (IAGP)
increased testis tumor incidence  (IAGP)
increased thymocyte number  (IAGP)
increased thymus weight  (IAGP)
increased thyroid adenoma incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased total body fat amount  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor-free survival time  (IAGP)
increased urine protein level  (IAGP)
increased white fat cell number  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
limb grasping  (IAGP)
muscle hypertonia  (IAGP)
obese  (IAGP)
paresis  (IAGP)
photosensitivity  (IAGP)
pituitary gland hyperplasia  (IAGP)
pituitary intermediate lobe hyperplasia  (IAGP)
polyphagia  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
preneoplasia  (IAGP)
prolonged estrous cycle  (IAGP)
prolonged estrus  (IAGP)
respiratory distress  (IAGP)
seizures  (IAGP)
spleen hyperplasia  (IAGP)
spleen hypoplasia  (IAGP)
testicular hyperplasia  (IAGP)
thymus hyperplasia  (IAGP)
thymus hypoplasia  (IAGP)
thyroid gland hyperplasia  (IAGP)
tremors  (IAGP)
weight loss  (IAGP)
References

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PMID: