Kcnj11 (potassium inwardly rectifying channel, subfamily J, member 11) - Rat Genome Database

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Gene: Kcnj11 (potassium inwardly rectifying channel, subfamily J, member 11) Mus musculus
Analyze
Symbol: Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
RGD ID: 69099
MGI Page MGI
Description: Enables ATP binding activity; ATP-activated inward rectifier potassium channel activity; and ankyrin binding activity. Involved in negative regulation of insulin secretion and potassium ion import across plasma membrane. Acts upstream of or within several processes, including CAMKK-AMPK signaling cascade; determination of adult lifespan; and response to ischemia. Located in T-tubule. Part of inward rectifying potassium channel. Is active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; cardiovascular system; gut; skeletal muscle tissue; and testis. Used to study permanent neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI842722; ATP-sensitive inward rectifier potassium channel 11; AW491124; inward rectifier K(+) channel Kir6.2; Kir6; Kir6.2; mBIR; potassium channel, inwardly rectifying subfamily J member 11; potassium unwardly rectifying channel, subfamily J, member 11
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,545 - 45,750,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)EnsemblGRCm39 Ensembl
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBIMGSCv36mm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (EXP)
2-deoxy-D-glucose  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
adenosine 5'-monophosphate  (EXP)
AICA ribonucleotide  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
ATP  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cantharidin  (EXP)
carvedilol  (EXP)
chlorpropamide  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
creatine  (EXP)
dantrolene  (EXP)
dexamethasone  (ISO)
diazoxide  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
doxorubicin  (ISO)
ethylparaben  (ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gliclazide  (ISO)
glimepiride  (ISO)
glyburide  (EXP)
lovastatin  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
mitiglinide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
oxidopamine  (ISO)
paracetamol  (ISO)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phlorizin  (EXP)
picrotoxin  (ISO)
Pinacidil  (EXP)
pioglitazone  (EXP)
potassium atom  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
rubidium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium disulfite  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
Terfenadine  (ISO)
testosterone  (ISO)
tolbutamide  (ISO)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA,ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal ear morphology  (IEA)
abnormal emotion/affect behavior  (IAGP)
abnormal food intake  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal muscle relaxation  (IAGP)
abnormal nerve fiber response  (IAGP)
abnormal nerve fiber response intensity  (IAGP)
abnormal pancreatic beta cell physiology  (IAGP)
abnormal spatial reference memory  (IAGP)
convulsive seizures  (IAGP)
decreased abdominal fat pad weight  (IAGP)
decreased aerobic running capacity  (IAGP)
decreased anxiety-related response  (IAGP)
decreased circulating insulin level  (IAGP)
decreased exploration in new environment  (IAGP)
decreased fasting circulating glucose level  (IEA)
decreased glucagon secretion  (IAGP)
decreased hemoglobin content  (IEA)
decreased insulin secretion  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased vertical activity  (IAGP)
hypoglycemia  (IAGP)
impaired coordination  (IAGP)
impaired glucose tolerance  (IAGP)
impaired skeletal muscle contractility  (IAGP)
improved glucose tolerance  (IAGP)
increased anxiety-related response  (IAGP)
increased circulating atrial natriuretic factor  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased energy expenditure  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased mean systemic arterial blood pressure  (IAGP)
increased muscle fatigability  (IAGP)
increased oxygen consumption  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
myoclonus  (IAGP)
slow postnatal weight gain  (IAGP)
tonic-clonic seizures  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. A syndrome of congenital hyperinsulinism and rhabdomyolysis is caused by KCNJ11 mutation. Albaqumi M, etal., J Med Genet. 2014 Apr;51(4):271-4. doi: 10.1136/jmedgenet-2013-102085. Epub 2014 Jan 13.
2. Identification of two novel frameshift mutations in the KCNJ11 gene in two Italian patients affected by Congenital Hyperinsulinism of Infancy. Biagiotti L, etal., Exp Mol Pathol. 2007 Aug;83(1):59-64. Epub 2007 Jan 17.
3. An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. Craig TJ, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.
4. Congenital hyperinsulinism: clinical and molecular analysis of a large Italian cohort. Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
5. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
6. Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. Gaber EM, etal., Exp Physiol. 2014 Jun;99(6):881-93. doi: 10.1113/expphysiol.2013.077594. Epub 2014 Mar 28.
7. Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
8. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. Girard CA, etal., J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.
9. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Gloyn AL, etal., Eur J Hum Genet. 2006 Jul;14(7):824-30. Epub 2006 May 3.
10. Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
11. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. Gloyn AL, etal., J Clin Endocrinol Metab. 2004 Aug;89(8):3932-5.
12. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. Gloyn AL, etal., N Engl J Med. 2004 Apr 29;350(18):1838-49.
13. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
14. Channel regulation of glucose sensing in the pancreatic beta-cell. Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
15. Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Hu X, etal., Circ Res. 2008 Oct 24;103(9):1009-17. doi: 10.1161/CIRCRESAHA.107.170795. Epub 2008 Sep 18.
16. Pregabalin attenuates excitotoxicity in diabetes. Huang CW, etal., PLoS One. 2013 Jun 13;8(6):e65154. doi: 10.1371/journal.pone.0065154. Print 2013.
17. The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
18. Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function. Marthinet E, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5401-6. Epub 2005 Jul 5.
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. Clinical and genetic evaluation of patients with KATP channel mutations from the German registry for congenital hyperinsulinism. Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
21. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
26. Mouse MP Annotation Import Pipeline RGD automated import pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
30. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
31. Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney. Shimizu S, etal., Br J Pharmacol. 2011 May;163(2):272-82. doi: 10.1111/j.1476-5381.2011.01231.x.
32. Genetic analysis of Italian patients with congenital hyperinsulinism of infancy. Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
33. Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes with Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5 327 Non-diabetic Finnish Men. Stancakova A, etal., Diabetes. 2009 Jun 5.
34. The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. Wan TC, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):234-43. Epub 2007 Sep 28.
35. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
36. Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
37. Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury. Yin XF, etal., Eur Neurol. 2007;57(1):4-10. Epub 2006 Nov 14.
38. The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. Zhou D, etal., J Hum Genet. 2009 Jun 5.
Additional References at PubMed
PMID:7502040   PMID:8549751   PMID:8630239   PMID:8889548   PMID:9130167   PMID:9287044   PMID:9342346   PMID:9488482   PMID:9724715   PMID:9813050   PMID:10022826   PMID:10099692  
PMID:10349636   PMID:10373428   PMID:10868950   PMID:11029282   PMID:11042159   PMID:11073877   PMID:11076861   PMID:11217851   PMID:11272201   PMID:11278532   PMID:11282890   PMID:11310506  
PMID:11319559   PMID:11375491   PMID:11854323   PMID:12149271   PMID:12205184   PMID:12271142   PMID:12388128   PMID:12477932   PMID:12486236   PMID:12524524   PMID:12598229   PMID:12627323  
PMID:12805206   PMID:12860923   PMID:12885877   PMID:12933351   PMID:15080888   PMID:15118262   PMID:15331375   PMID:15362972   PMID:15457338   PMID:15489334   PMID:15504956   PMID:15561906  
PMID:15561907   PMID:15561908   PMID:15561946   PMID:15598870   PMID:15650751   PMID:15749783   PMID:15760904   PMID:15782099   PMID:15793244   PMID:15914579   PMID:15941784   PMID:15949470  
PMID:16085792   PMID:16107509   PMID:16141072   PMID:16141073   PMID:16166157   PMID:16170200   PMID:16280460   PMID:16299504   PMID:16308567   PMID:16354731   PMID:16368354   PMID:16498401  
PMID:16501027   PMID:16530794   PMID:16752175   PMID:16782803   PMID:16797737   PMID:16902404   PMID:16924481   PMID:16936192   PMID:16962131   PMID:16985003   PMID:16996082   PMID:17038430  
PMID:17065331   PMID:17085424   PMID:17116877   PMID:17167224   PMID:17175112   PMID:17189350   PMID:17327429   PMID:17339028   PMID:17351068   PMID:17369816   PMID:17445233   PMID:17449558  
PMID:17468960   PMID:17503968   PMID:17510180   PMID:17510189   PMID:17656102   PMID:17673911   PMID:17883401   PMID:18001767   PMID:18042662   PMID:18043710   PMID:18346985   PMID:18420708  
PMID:18434629   PMID:18450778   PMID:18524485   PMID:18524696   PMID:18554416   PMID:18573285   PMID:18586858   PMID:18591420   PMID:18703018   PMID:18708750   PMID:18787024   PMID:18977736  
PMID:19059420   PMID:19266181   PMID:19502550   PMID:19673485   PMID:19805355   PMID:19805629   PMID:19931596   PMID:19933268   PMID:20032456   PMID:20074528   PMID:20202704   PMID:20208975  
PMID:20383647   PMID:20610380   PMID:20694718   PMID:20731746   PMID:20857084   PMID:20858756   PMID:21035764   PMID:21267068   PMID:21271337   PMID:21479273   PMID:21674179   PMID:21677750  
PMID:21828183   PMID:21873635   PMID:21984445   PMID:22003059   PMID:22013016   PMID:22207763   PMID:22252471   PMID:22632729   PMID:22902720   PMID:23116567   PMID:23193182   PMID:23223335  
PMID:23585131   PMID:23608222   PMID:23624089   PMID:23659427   PMID:23778875   PMID:23798684   PMID:24011078   PMID:24037327   PMID:24101510   PMID:24194600   PMID:24258027   PMID:24308936  
PMID:24498880   PMID:25471572   PMID:25774850   PMID:25934393   PMID:26378152   PMID:26554594   PMID:26901059   PMID:26964104   PMID:27037371   PMID:27086859   PMID:27292642   PMID:27488667  
PMID:27586053   PMID:28100774   PMID:28209764   PMID:28464250   PMID:28576773   PMID:28667052   PMID:28842488   PMID:28893911   PMID:29368690   PMID:29392534   PMID:29432787   PMID:29540778  
PMID:29564810   PMID:29594720   PMID:29896801   PMID:30115649   PMID:30171894   PMID:30226997   PMID:30631919   PMID:31061431   PMID:31243295   PMID:31808063   PMID:33196462   PMID:33568422  
PMID:33758250   PMID:34673451   PMID:34715352   PMID:34766906   PMID:35005553   PMID:35212627   PMID:35513538   PMID:35681537   PMID:37129980   PMID:38355793  


Genomics

Comparative Map Data
Kcnj11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,545 - 45,750,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)EnsemblGRCm39 Ensembl
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBIMGSCv36mm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
KCNJ11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,385,248 - 17,389,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,365,172 - 17,389,331 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,406,795 - 17,410,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,363,371 - 17,366,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,364,788 - 17,366,737NCBI
Celera1117,536,622 - 17,540,705 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,090,617 - 17,094,700 (-)NCBIHuRef
CHM1_11117,406,598 - 17,410,681 (-)NCBICHM1_1
T2T-CHM13v2.01117,482,848 - 17,486,946 (-)NCBIT2T-CHM13v2.0
Kcnj11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,727,473 - 105,731,167 (-)NCBIGRCr8
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
Kcnj11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,210,545 - 32,211,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,209,426 - 32,212,424 (-)NCBIChiLan1.0ChiLan1.0
KCNJ11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,706,414 - 19,723,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,125,885 - 17,129,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensemblpanpan1.1panPan2
KCNJ11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,953,461 - 39,957,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,955,551 - 39,956,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,454,228 - 39,457,833 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,059,361 - 41,062,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,060,903 - 41,062,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,072,057 - 40,075,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,279,502 - 40,283,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,618,209 - 40,621,814 (-)NCBIUU_Cfam_GSD_1.0
Kcnj11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,651,254 - 45,654,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,685,924 - 1,687,096 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,685,015 - 1,688,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,757,356 - 41,765,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,756,637 - 41,760,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,815,173 - 44,817,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,582,519 - 47,586,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,583,629 - 47,584,801 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,013,121 - 145,016,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,013,225 - 9,014,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,012,166 - 9,015,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnj11
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:194
Interacting mature miRNAs:211
Transcripts:ENSMUST00000180081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
12738416Lfibq14_mliver fibrosis QTL 14 (mouse)74564899345816434Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
12738430Lfibq21_mliver fibrosis QTL 21 (mouse)74564899345816434Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse

Markers in Region
AI842722  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38746,097,237 - 46,097,324UniSTSGRCm38
MGSCv37753,352,607 - 53,352,694UniSTSGRCm37
Celera741,570,558 - 41,570,646UniSTS
Cytogenetic Map7B4UniSTS
cM Map741.0UniSTS
Whitehead/MRC_RH7578.94UniSTS
PMC312732P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38746,098,867 - 46,099,366UniSTSGRCm38
MGSCv37753,354,237 - 53,354,736UniSTSGRCm37
Celera741,572,185 - 41,572,684UniSTS
Cytogenetic Map7B4UniSTS
cM Map741.0UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000180081   ⟹   ENSMUSP00000136002
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,748,297 - 45,750,188 (-)Ensembl
GRCm38.p6 Ensembl746,098,873 - 46,100,764 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209291   ⟹   ENSMUSP00000147801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,748,844 - 45,750,082 (-)Ensembl
GRCm38.p6 Ensembl746,099,420 - 46,100,658 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209863
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,743,377 - 45,747,850 (-)Ensembl
GRCm38.p6 Ensembl746,093,953 - 46,098,426 (-)Ensembl
Ensembl Acc Id: ENSMUST00000209881   ⟹   ENSMUSP00000148249
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,748,723 - 45,749,327 (-)Ensembl
GRCm38.p6 Ensembl746,099,299 - 46,099,903 (-)Ensembl
Ensembl Acc Id: ENSMUST00000211674   ⟹   ENSMUSP00000147439
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl745,746,520 - 45,749,661 (-)Ensembl
GRCm38.p6 Ensembl746,097,096 - 46,100,237 (-)Ensembl
RefSeq Acc Id: NM_001204411   ⟹   NP_001191340
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,746,545 - 45,750,215 (-)NCBI
GRCm38746,097,123 - 46,100,764 (-)NCBI
Celera741,570,444 - 41,574,072 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001412604   ⟹   NP_001399533
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,746,545 - 45,750,215 (-)NCBI
RefSeq Acc Id: NM_010602   ⟹   NP_034732
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39745,746,545 - 45,750,215 (-)NCBI
GRCm38746,097,123 - 46,100,237 (-)NCBI
MGSCv37753,352,532 - 53,355,607 (-)RGD
Celera741,570,444 - 41,574,072 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034732   ⟸   NM_010602
- Peptide Label: isoform 1
- UniProtKB: Q9QX21 (UniProtKB/Swiss-Prot),   Q61743 (UniProtKB/Swiss-Prot),   Q8CCI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001191340   ⟸   NM_001204411
- Peptide Label: isoform 2
- UniProtKB: Q8CCI6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000147439   ⟸   ENSMUST00000211674
Ensembl Acc Id: ENSMUSP00000148249   ⟸   ENSMUST00000209881
Ensembl Acc Id: ENSMUSP00000136002   ⟸   ENSMUST00000180081
Ensembl Acc Id: ENSMUSP00000147801   ⟸   ENSMUST00000209291
RefSeq Acc Id: NP_001399533   ⟸   NM_001412604
- Peptide Label: isoform 3 precursor
- UniProtKB: Q8CCI6 (UniProtKB/TrEMBL)
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61743-F1-model_v2 AlphaFold Q61743 1-390 view protein structure

Promoters
RGD ID:6841378
Promoter ID:MM_KWN:50483
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_010602
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36753,352,581 - 53,354,982 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107501 AgrOrtholog
Ensembl Genes ENSMUSG00000096146 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000180081 ENTREZGENE
  ENSMUST00000180081.3 UniProtKB/TrEMBL
  ENSMUST00000209291.2 UniProtKB/TrEMBL
  ENSMUST00000209881.2 UniProtKB/TrEMBL
  ENSMUST00000211674 ENTREZGENE
  ENSMUST00000211674.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir6.2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kir_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16514 UniProtKB/Swiss-Prot
MGD MGI:107501 ENTREZGENE
NCBI Gene 16514 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11767:SF44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB KCNJ11 RGD
PhenoGen Kcnj11 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS KIR62CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1B0GS56_MOUSE UniProtKB/TrEMBL
  A0A1B0GT90_MOUSE UniProtKB/TrEMBL
  A0A1C7CYV4_MOUSE UniProtKB/TrEMBL
  KCJ11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CCI6 ENTREZGENE, UniProtKB/TrEMBL
  Q9QX21 ENTREZGENE
UniProt Secondary Q9QX21 UniProtKB/Swiss-Prot