Smad4 (SMAD family member 4) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Smad4 (SMAD family member 4) Mus musculus
Symbol: Smad4
Name: SMAD family member 4
RGD ID: 69092
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; collagen binding activity; and identical protein binding activity. Involved in several processes, including heart development; regulation of DNA-templated transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including positive regulation of gonadotropin secretion; regulation of DNA-templated transcription; and reproductive structure development. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and respiratory system. Used to study colorectal cancer; juvenile polyposis syndrome; and osteogenesis imperfecta. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW743858; D18Wsu70; D18Wsu70e; deletion target in pancreatic carcinoma 4 homolog; DPC; DPC4; expressed sequence AW743858; MAD homolog 4; Madh; Madh4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; Smad 4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)EnsemblGRCm39 Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBIMGSCv36mm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acro-Osteolysis  (ISO)
aortic disease  (ISO)
brachydactyly  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cicatrix  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
colorectal adenoma  (ISO)
colorectal cancer  (ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
Craniofacial Abnormalities  (ISO)
Cronkhite-Canada syndrome  (ISO)
Deafness  (ISO)
endometrial carcinoma  (ISO)
esophageal carcinoma  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Colitis  (IMP)
Experimental Liver Cirrhosis  (ISO)
gallbladder cancer  (ISO)
Gallstones  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal system cancer  (ISO)
genetic disease  (ISO)
Growth Mental Deficiency Syndrome of Myhre  (ISO)
head and neck squamous cell carcinoma  (IMP,ISO)
hemorrhagic disease  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary hemorrhagic telangiectasia  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Heterotopic Ossification  (ISO)
Human Viral Hepatitis  (ISO)
Hypoglossal Nerve Injuries  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
invasive ductal carcinoma  (ISO)
juvenile polyposis syndrome  (IAGP,ISO)
juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome  (ISO)
Liver Metastasis  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lymphatic Metastasis  (ISO)
Lynch syndrome  (ISO)
metabolic dysfunction-associated steatohepatitis  (IMP,ISO)
Microphthalmia, Cataracts, and Iris Abnormalities  (IMP)
muscular disease  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
Odontogenic Cysts  (IMP)
osteogenesis imperfecta  (IAGP)
ovarian cancer  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
Parasitic Liver Diseases  (ISO)
pre-malignant neoplasm  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
prostate adenocarcinoma  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
seminoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-methoxyethanol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amlodipine  (ISO)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
bellidifolin  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Candesartan cilexetil  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
chromium atom  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
dibenziodolium  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
farrerol  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
galangin  (ISO)
gallic acid  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
icariin  (EXP)
Isoangustone A  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
leptomycin B  (EXP)
lipopolysaccharide  (ISO)
Methylazoxymethanol acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
osthole  (ISO)
ouabain  (ISO)
paracetamol  (EXP,ISO)
patulin  (ISO)
pentacarbonyliron  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
phosphane  (ISO)
picoxystrobin  (ISO)
platycodin D  (ISO)
progesterone  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rolipram  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 431542  (EXP,ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
tamibarotene  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theobromine  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (NAS)
adrenal gland development  (ISO)
anatomical structure morphogenesis  (IBA,IMP)
anterior/posterior pattern specification  (IMP)
atrioventricular canal development  (IGI)
atrioventricular valve formation  (IGI)
axon guidance  (IMP)
BMP signaling pathway  (IBA,IMP,ISO)
brainstem development  (IMP)
branching involved in ureteric bud morphogenesis  (IGI)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac septum development  (IGI)
cell differentiation  (IBA,IMP)
cell population proliferation  (IGI,IMP)
cellular response to glucose stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
developmental growth  (IMP)
DNA-templated transcription  (ISO)
embryonic digit morphogenesis  (IMP)
endocardial cell differentiation  (IMP)
endoderm development  (IMP)
endothelial cell activation  (IMP)
epithelial cell migration  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IMP)
ERK1 and ERK2 cascade  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
female gonad development  (IGI)
female gonad morphogenesis  (IMP)
formation of anatomical boundary  (IMP)
gastrulation  (IMP)
gastrulation with mouth forming second  (IMP)
in utero embryonic development  (IMP)
interleukin-6-mediated signaling pathway  (IDA)
intracellular iron ion homeostasis  (IMP)
intracellular signal transduction  (ISO)
kidney development  (IMP)
left ventricular cardiac muscle tissue morphogenesis  (IMP)
male gonad development  (IMP)
mesendoderm development  (IMP)
mesoderm development  (IMP)
metanephric mesenchyme morphogenesis  (IMP)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (IMP)
negative regulation of cardiac myofibril assembly  (IMP)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IGI)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of protein catabolic process  (ISO)
negative regulation of transcription by RNA polymerase II  (IMP)
nephrogenic mesenchyme morphogenesis  (IMP)
neural crest cell differentiation  (IMP)
neuron fate commitment  (IMP)
neuron fate specification  (ISO)
osteoblast differentiation  (ISO)
outflow tract septum morphogenesis  (IGI)
ovarian follicle development  (IGI,IMP,ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell proliferation involved in heart valve morphogenesis  (IMP)
positive regulation of DNA-templated transcription  (IDA,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of extracellular matrix assembly  (ISO)
positive regulation of follicle-stimulating hormone secretion  (IGI,IMP)
positive regulation of gene expression  (ISO)
positive regulation of luteinizing hormone secretion  (IGI,IMP)
positive regulation of miRNA transcription  (IMP)
positive regulation of SMAD protein signal transduction  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of cell population proliferation  (IGI,IMP)
regulation of DNA-templated transcription  (NAS)
regulation of hair follicle development  (IMP)
regulation of transcription by RNA polymerase II  (IBA,IDA)
regulation of transforming growth factor beta receptor signaling pathway  (ISO)
regulation of transforming growth factor beta2 production  (ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (ISO)
sebaceous gland development  (IMP)
secondary palate development  (IMP)
seminiferous tubule development  (IMP)
single fertilization  (IGI)
SMAD protein signal transduction  (IBA,IMP,ISO)
somite rostral/caudal axis specification  (IMP)
spermatogenesis  (IMP)
tissue morphogenesis  (IMP)
transcription by RNA polymerase II  (IMP)
transforming growth factor beta receptor signaling pathway  (IBA,IGI,IMP,ISO,NAS)
uterus development  (IGI)
ventricular septum morphogenesis  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal bile duct morphology  (IAGP)
abnormal bone collagen fibril morphology  (IAGP)
abnormal cecum morphology  (IAGP)
abnormal cerebellar molecular layer  (IAGP)
abnormal compact bone lamellar structure  (IAGP)
abnormal cumulus expansion  (IAGP)
abnormal dorsal-ventral axis patterning  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal enamel morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal hair follicle regression  (IAGP)
abnormal hair growth  (IAGP)
abnormal heart right ventricle morphology  (IAGP)
abnormal heart ventricle outflow tract morphology  (IAGP)
abnormal hindbrain development  (IAGP)
abnormal hypodermis morphology  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal keratinocyte physiology  (IAGP)
abnormal kidney development  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal male meiosis  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal ovarian folliculogenesis  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal rhombomere morphology  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal secondary ovarian follicle morphology  (IAGP)
abnormal skin appearance  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal stomach glandular epithelium morphology  (IAGP)
abnormal thymus physiology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal trabecula carnea morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent anterior visceral endoderm  (IAGP)
absent atrioventricular cushions  (IAGP)
absent cumulus expansion  (IAGP)
absent egg cylinders  (IAGP)
absent foregut  (IAGP)
absent hindgut  (IAGP)
absent mesoderm  (IAGP)
absent primordial germ cells  (IAGP)
alopecia  (IAGP)
anemia  (IAGP)
chronic pancreas inflammation  (IAGP)
clavicle hypoplasia  (IAGP)
colon polyps  (IAGP)
decreased body size  (IAGP)
decreased bone mineral density  (IAGP)
decreased cell proliferation  (IAGP)
decreased compact bone thickness  (IAGP)
decreased diameter of tibia  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic epiblast cell proliferation  (IAGP)
decreased inner cell mass proliferation  (IAGP)
decreased kidney collecting duct number  (IAGP)
decreased litter size  (IAGP)
decreased oocyte number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased ovulation rate  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
decreased tumor-free survival time  (IAGP)
delayed bone ossification  (IAGP)
dilated pancreatic duct  (IAGP)
disorganized extraembryonic tissue  (IAGP)
disorganized stomach mucosa  (IAGP)
double outlet right ventricle  (IAGP)
duodenum polyps  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged hair follicles  (IAGP)
enlarged liver  (IAGP)
enlarged pancreas  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged spleen  (IAGP)
epidermal cyst  (IAGP)
epithelioid cyst  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
fused somites  (IAGP)
gastric polyps  (IAGP)
hair follicle degeneration  (IAGP)
hepatic steatosis  (IAGP)
hydroureter  (IAGP)
hyperkeratosis  (IAGP)
increased adenoma incidence  (IAGP)
increased carcinoma incidence  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating progesterone level  (IAGP)
increased compact bone thickness  (IAGP)
increased duodenum adenocarcinoma incidence  (IAGP)
increased gastric adenocarcinoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased keratinocyte proliferation  (IAGP)
increased liver weight  (IAGP)
increased lung tumor incidence  (IAGP)
increased mammary adenocarcinoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased Reichert's membrane thickness  (IAGP)
increased secondary ovarian follicle number  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor incidence  (IAGP)
increased vertical activity  (IAGP)
infertility  (IAGP)
intestine polyps  (IAGP)
kidney cyst  (IAGP)
malocclusion  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreas cyst  (IAGP)
pancreas fibrosis  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
rib fractures  (IAGP)
rostral body truncation  (IAGP)
short tibia  (IAGP)
small ectoplacental cone  (IAGP)
small incisors  (IAGP)
small kidney  (IAGP)
small thoracic cavity  (IAGP)
small thymus  (IAGP)
stomach epithelial hyperplasia  (IAGP)
thick epidermis  (IAGP)
thick epidermis stratum basale  (IAGP)
thick hair follicle outer root sheath  (IAGP)
thick skin  (IAGP)
thin ventricle myocardium compact layer  (IAGP)
ventricular septal defect  (IAGP)

References - curated
# Reference Title Reference Citation
1. SMAD4 mutation segregating in a family with juvenile polyposis, aortopathy, and mitral valve dysfunction. Andrabi S, etal., Am J Med Genet A. 2011 May;155A(5):1165-9. doi: 10.1002/ajmg.a.33968. Epub 2011 Apr 4.
2. Genotype-defined cancer risk in juvenile polyposis syndrome. Aytac E, etal., Br J Surg. 2015 Jan;102(1):114-8. doi: 10.1002/bjs.9693. Epub 2014 Nov 12.
3. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. Bornstein S, etal., J Clin Invest. 2009 Nov;119(11):3408-19. doi: 10.1172/JCI38854. Epub 2009 Oct 19.
4. A novel SMAD4 gene mutation in seminoma germ cell tumors. Bouras M, etal., Cancer Res. 2000 Feb 15;60(4):922-8.
5. Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. Cardillo MR, etal., Anal Quant Cytol Histol. 2001 Apr;23(2):109-17.
6. [Effect of Budesonide on Smad4, PDGF-A and PAI-1 in a rat model of pulmonary fibrosis]. Chen JP, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 May;28(5):478-80.
7. Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation. Dong MX, etal., World J Gastroenterol. 2009 Oct 14;15(38):4753-62.
8. [Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica]. Fan LH, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011 Apr;29(4):255-9.
9. Zhonghua zhong liu za zhi [Chinese journal of oncology] Fan Z, etal., Zhonghua Zhong Liu Za Zhi. 2001 Mar;23(2):135-7.
10. Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. Gallione C, etal., Am J Med Genet A. 2010 Feb;152A(2):333-9. doi: 10.1002/ajmg.a.33206.
11. SMAD4 mutations found in unselected HHT patients. Gallione CJ, etal., J Med Genet. 2006 Oct;43(10):793-7. Epub 2006 Apr 13.
12. A combined syndrome of juvenile polyposis and hereditary haemorrhagic telangiectasia associated with mutations in MADH4 (SMAD4). Gallione CJ, etal., Lancet. 2004 Mar 13;363(9412):852-9.
13. Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice. Gao Y, etal., Mol Cell Biol. 2009 Nov;29(21):5941-51. doi: 10.1128/MCB.00706-09. Epub 2009 Aug 24.
14. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Hao J, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3020-30.
15. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Hara S, etal., Exp Toxicol Pathol. 2014 Aug;66(5-6):225-34. doi: 10.1016/j.etp.2014.02.002. Epub 2014 Mar 26.
16. Prevalence of thoracic aortopathy in patients with juvenile Polyposis Syndrome-Hereditary Hemorrhagic Telangiectasia due to SMAD4. Heald B, etal., Am J Med Genet A. 2015 Aug;167A(8):1758-62. doi: 10.1002/ajmg.a.37093. Epub 2015 Apr 30.
17. Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Horvath LG, etal., Prostate. 2004 May 15;59(3):234-42.
18. Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot. Howe JR, etal., Am J Hum Genet. 2002 May;70(5):1357-62. Epub 2002 Mar 27.
19. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Howe JR, etal., Science. 1998 May 15;280(5366):1086-8.
20. [Changes in TGF-beta1/Smads signaling pathway in rats with chemical hepatocarcinogenesis]. Hua YP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Oct;28(10):1848-52.
21. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
22. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
23. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
24. SMAD4 germinal mosaicism in a family with juvenile polyposis and hypertrophic osteoarthropathy. Lamireau T, etal., J Pediatr Gastroenterol Nutr. 2005 Jul;41(1):117-20.
25. Mutations at a single codon in Mad homology 2 domain of SMAD4 cause Myhre syndrome. Le Goff C, etal., Nat Genet. 2011 Dec 11;44(1):85-8. doi: 10.1038/ng.1016.
26. Expression of DPC4/Smad4 gene in stone-containing intrahepatic bile duct. Lee KT, etal., J Surg Oncol. 2006 Sep 15;94(4):338-43. doi: 10.1002/jso.20517.
27. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Liu X, etal., Mol Pharmacol. 2006 Dec;70(6):1992-2003. Epub 2006 Sep 7.
28. Inactivation of Smad4 leads to impaired ocular development and cataract formation. Liu Y, etal., Biochem Biophys Res Commun. 2010 Oct 1;400(4):476-82. doi: 10.1016/j.bbrc.2010.08.065. Epub 2010 Aug 22.
29. Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. Losi L, etal., Oncol Rep. 2007 May;17(5):1095-9.
30. Effects of platycodins on liver complications of type 2 diabetes. Luan H, etal., Mol Med Rep. 2014 Sep;10(3):1597-603. doi: 10.3892/mmr.2014.2363. Epub 2014 Jul 4.
31. Downregulation of secretory leukocyte proteinase inhibitor in chronic obstructive lung disease: the role of TGF-beta/Smads signaling pathways. Luo BL, etal., Arch Med Res. 2008 May;39(4):388-96. doi: 10.1016/j.arcmed.2008.02.002.
32. Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer. Maliekal TT, etal., Oncogene. 2003 Jul 31;22(31):4889-97.
33. TGFbeta in Cancer. Massagué J, Cell. 2008 Jul 25;134(2):215-30. doi: 10.1016/j.cell.2008.07.001.
34. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
35. MGDs mouse GO annotations MGD data from the GO Consortium
37. KAI1, CAR, and Smad4 expression in the progression of colorectal tumor. Mikami T, etal., J Gastroenterol. 2001 Jul;36(7):465-9. doi: 10.1007/s005350170069.
38. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis. Miyaki M, etal., Oncogene. 1999 May 20;18(20):3098-103. doi: 10.1038/sj.onc.1202642.
39. SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases. Mizuno T, etal., Eur J Surg Oncol. 2018 May;44(5):684-692. doi: 10.1016/j.ejso.2018.02.247. Epub 2018 Mar 7.
40. Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Morty RE, etal., Arterioscler Thromb Vasc Biol. 2007 May;27(5):1072-8. Epub 2007 Mar 8.
41. Significance of pSmad2/3 and Smad4 in hepatitis C virus-related liver fibrosis and hepatocellular carcinoma. Moussa MM, etal., APMIS. 2018 Jun;126(6):477-485. doi: 10.1111/apm.12844.
42. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
43. Altered expression of Smad family members in injured motor neurons of rat. Okuyama N, etal., Brain Res. 2007 Feb 9;1132(1):36-41. Epub 2006 Dec 12.
44. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
45. cDNA cloning and chromosomal mapping of rat Smad2 and Smad4 and their expression in cultured rat articular chondrocytes. Osaki M, etal., Endocr J 1999 Oct;46(5):695-701.
46. TGF-beta signaling is disrupted in endometrioid-type endometrial carcinomas. Piestrzeniewicz-Ulanska D, etal., Gynecol Oncol. 2004 Oct;95(1):173-80.
47. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
48. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
49. Deletion of Smad4 reduces hepatic inflammation and fibrogenesis during nonalcoholic steatohepatitis progression. Qin G, etal., J Dig Dis. 2018 May;19(5):301-313. doi: 10.1111/1751-2980.12599. Epub 2018 Jun 6.
50. Smad signaling in the rat model of monocrotaline pulmonary hypertension. Ramos MF, etal., Toxicol Pathol. 2008 Feb;36(2):311-20. doi: 10.1177/0192623307311402. Epub 2008 Mar 26.
51. Mouse MP Annotation Import Pipeline RGD automated import pipeline
52. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
53. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
54. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal. Roth S, etal., J Med Genet. 2000 Apr;37(4):298-300.
55. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
56. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
57. Association between Altered Expression and Genetic Variations of Transforming Growth Factor ß-Smad Pathway with Chronic Myeloid Leukemia. Shokeen Y, etal., Int J Hematol Oncol Stem Cell Res. 2018 Jan 1;12(1):14-22.
58. Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer. Sunde JS, etal., Cancer Res. 2006 Sep 1;66(17):8404-12.
59. SMAD4 haploinsufficiency associates with augmented colonic inflammation in select humans and mice. Szigeti R, etal., Ann Clin Lab Sci. 2012 Fall;42(4):401-8.
60. Biologically different subgroups of invasive ductal carcinoma of the pancreas: Dpc4 status according to the ratio of intraductal carcinoma components. Takahashi H, etal., Clin Cancer Res. 2004 Jun 1;10(11):3772-9. doi: 10.1158/1078-0432.CCR-03-0120.
61. Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers. Takakura S, etal., Genes Chromosomes Cancer. 1999 Mar;24(3):264-71.
62. Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4: a preliminary report. Tan WQ, etal., Exp Dermatol. 2011 Feb;20(2):119-24. doi: 10.1111/j.1600-0625.2010.01186.x.
63. [Smad4 and TGF-beta1 expression and clinical significance in bladder transitional cell carcinoma] Tang ZY, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun;31(3):363-6.
64. MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. Wang Y, etal., PLoS One. 2013 Jul 29;8(7):e68744. doi: 10.1371/journal.pone.0068744. Print 2013.
65. [Expressions of transforming growth factor-beta(1) and Smad4 in rat models of chronic nonbacterial prostatitis and their clinical significance]. Wang YM, etal., Zhonghua Nan Ke Xue. 2010 Jun;16(6):490-4.
66. Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats. Wei XH, etal., Microcirculation. 2013 Jan;20(1):17-29. doi: 10.1111/micc.12002.
67. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, etal., Mol Cancer Res. 2020 Mar;18(3):414-423. doi: 10.1158/1541-7786.MCR-19-0525. Epub 2020 Jan 13.
68. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
69. Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers. Woodford-Richens KL, etal., Am J Pathol. 2001 Oct;159(4):1293-300.
70. Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study. Xie W, etal., Cancer Res. 2002 Jan 15;62(2):497-505.
71. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
72. Non-virus-mediated transfer of siRNAs against Runx2 and Smad4 inhibit heterotopic ossification in rats. Xue T, etal., Gene Ther. 2010 Mar;17(3):370-9. doi: 10.1038/gt.2009.154. Epub 2009 Nov 26.
73. Reduced Expression of SMAD4 Is Associated with Poor Survival in Colon Cancer. Yan P, etal., Clin Cancer Res. 2016 Jun 15;22(12):3037-47. doi: 10.1158/1078-0432.CCR-15-0939. Epub 2016 Feb 9.
74. Inactivation of Smad4 is a prognostic factor in intrahepatic cholangiocarcinoma. Yan XQ, etal., Chin Med J (Engl). 2013 Aug;126(16):3039-43.
75. Smad4 expression in hepatocellular carcinoma differs by hepatitis status. Yao L, etal., Asian Pac J Cancer Prev. 2012;13(4):1297-303. doi: 10.7314/apjcp.2012.13.4.1297.
76. Apoptosis incidence and protein expression of p53, TGF-beta receptor II, p27Kip1, and Smad4 in benign, premalignant, and malignant human prostate. Zeng L, etal., Hum Pathol. 2004 Mar;35(3):290-7.
77. Involvement of mutations in the DPC4 promoter in endometrial carcinoma development. Zhou Y, etal., Mol Carcinog. 1999 May;25(1):64-72.
Additional References at PubMed
PMID:9166592   PMID:9288972   PMID:9328171   PMID:9393997   PMID:9420335   PMID:9506519   PMID:9520423   PMID:9529255   PMID:9702197   PMID:10030593   PMID:10341708   PMID:10349617  
PMID:10349636   PMID:10376010   PMID:10400677   PMID:10511616   PMID:10626800   PMID:10636910   PMID:10708952   PMID:10708962   PMID:10725249   PMID:10773876   PMID:10922068   PMID:11042159  
PMID:11076861   PMID:11106407   PMID:11163184   PMID:11169847   PMID:11195460   PMID:11197776   PMID:11231077   PMID:11788714   PMID:11809702   PMID:11850197   PMID:11857783   PMID:12096346  
PMID:12145309   PMID:12270938   PMID:12374795   PMID:12414519   PMID:12421925   PMID:12426318   PMID:12432092   PMID:12477932   PMID:12520002   PMID:12524424   PMID:12543979   PMID:12557227  
PMID:12584607   PMID:12588798   PMID:12672795   PMID:12753287   PMID:12782414   PMID:12842913   PMID:12857787   PMID:12861029   PMID:12896967   PMID:12943993   PMID:14502566   PMID:14551209  
PMID:14559231   PMID:14570593   PMID:14597578   PMID:14610273   PMID:14633973   PMID:14635047   PMID:14651998   PMID:14656760   PMID:14662776   PMID:14691138   PMID:14760387   PMID:14764653  
PMID:15135236   PMID:15150278   PMID:15215210   PMID:15226823   PMID:15260977   PMID:15282343   PMID:15292219   PMID:15342483   PMID:15459107   PMID:15464984   PMID:15525990   PMID:15610403  
PMID:15618518   PMID:15657445   PMID:15737733   PMID:15741177   PMID:15830383   PMID:15883213   PMID:15899814   PMID:15923624   PMID:15925496   PMID:15963972   PMID:16023633   PMID:16115198  
PMID:16123376   PMID:16141072   PMID:16141073   PMID:16151019   PMID:16170355   PMID:16195406   PMID:16201233   PMID:16204035   PMID:16288217   PMID:16288220   PMID:16322555   PMID:16330325  
PMID:16477644   PMID:16513794   PMID:16518688   PMID:16556916   PMID:16602821   PMID:16650383   PMID:16735447   PMID:16767220   PMID:16791201   PMID:16849541   PMID:16869739   PMID:16887829  
PMID:16890162   PMID:17059883   PMID:17072319   PMID:17114584   PMID:17142805   PMID:17151782   PMID:17159989   PMID:17168649   PMID:17177285   PMID:17182123   PMID:17213286   PMID:17226765  
PMID:17300215   PMID:17339028   PMID:17349581   PMID:17353364   PMID:17369830   PMID:17429065   PMID:17452626   PMID:17467076   PMID:17493607   PMID:17550966   PMID:17568773   PMID:17585069  
PMID:17596282   PMID:17628518   PMID:17638848   PMID:17698011   PMID:17724086   PMID:17804724   PMID:17823941   PMID:17869237   PMID:17916348   PMID:17964566   PMID:17997817   PMID:18024957  
PMID:18045816   PMID:18069690   PMID:18079204   PMID:18087045   PMID:18089935   PMID:18095342   PMID:18171930   PMID:18184786   PMID:18212064   PMID:18268325   PMID:18287559   PMID:18315922  
PMID:18334251   PMID:18353861   PMID:18385792   PMID:18446800   PMID:18539898   PMID:18566469   PMID:18585065   PMID:18602626   PMID:18618014   PMID:18692037   PMID:18694570   PMID:18695001  
PMID:18783722   PMID:18794355   PMID:18799693   PMID:18804071   PMID:18974875   PMID:18981480   PMID:18986983   PMID:18988856   PMID:19002110   PMID:19073883   PMID:19170762   PMID:19204324  
PMID:19224984   PMID:19251704   PMID:19361496   PMID:19366691   PMID:19369394   PMID:19385047   PMID:19401440   PMID:19451264   PMID:19521500   PMID:19556507   PMID:19578404   PMID:19580641  
PMID:19582869   PMID:19597490   PMID:19603510   PMID:19661464   PMID:19733164   PMID:19737861   PMID:19793887   PMID:19793892   PMID:19796622   PMID:19834456   PMID:19836350   PMID:19837676  
PMID:19849841   PMID:19865483   PMID:19888897   PMID:19901970   PMID:19926752   PMID:19959815   PMID:20019187   PMID:20059953   PMID:20196951   PMID:20211142   PMID:20231279   PMID:20238004  
PMID:20371653   PMID:20412781   PMID:20427661   PMID:20454682   PMID:20498064   PMID:20573697   PMID:20621052   PMID:20689554   PMID:20727852   PMID:20852387   PMID:20877696   PMID:20889504  
PMID:20933217   PMID:20941375   PMID:20969946   PMID:21089072   PMID:21145499   PMID:21194568   PMID:21267068   PMID:21273545   PMID:21289624   PMID:21300867   PMID:21330551   PMID:21368882  
PMID:21376704   PMID:21397841   PMID:21471525   PMID:21490069   PMID:21493862   PMID:21571225   PMID:21596989   PMID:21677750   PMID:21721476   PMID:21724602   PMID:21728174   PMID:21731673  
PMID:21822279   PMID:21873635   PMID:21881210   PMID:21900682   PMID:22036565   PMID:22045334   PMID:22046433   PMID:22048127   PMID:22115830   PMID:22121131   PMID:22208613   PMID:22282597  
PMID:22305567   PMID:22341455   PMID:22366399   PMID:22370000   PMID:22371886   PMID:22418736   PMID:22438570   PMID:22442258   PMID:22469842   PMID:22498737   PMID:22542937   PMID:22560297  
PMID:22644379   PMID:22689943   PMID:22772757   PMID:22888807   PMID:22932243   PMID:22945649   PMID:23034633   PMID:23103586   PMID:23201680   PMID:23221368   PMID:23406900   PMID:23426367  
PMID:23459943   PMID:23497137   PMID:23592428   PMID:23595735   PMID:23603491   PMID:23610450   PMID:23610558   PMID:23620745   PMID:23648546   PMID:23765158   PMID:23816882   PMID:23818325  
PMID:23830984   PMID:23863096   PMID:23973329   PMID:23999427   PMID:24006258   PMID:24048844   PMID:24076600   PMID:24095903   PMID:24101723   PMID:24108699   PMID:24127404   PMID:24223846  
PMID:24257627   PMID:24307592   PMID:24334458   PMID:24384683   PMID:24501173   PMID:24553180   PMID:24625091   PMID:24739304   PMID:24784840   PMID:24837432   PMID:24899714   PMID:24952961  
PMID:24982181   PMID:25029242   PMID:25070948   PMID:25127126   PMID:25190145   PMID:25236771   PMID:25243859   PMID:25274628   PMID:25322725   PMID:25428125   PMID:25502579   PMID:25523394  
PMID:25547285   PMID:25559195   PMID:25577439   PMID:25605784   PMID:25637015   PMID:25641697   PMID:25680269   PMID:25752506   PMID:25753424   PMID:25770424   PMID:25803032   PMID:25865348  
PMID:25893305   PMID:26002469   PMID:26004068   PMID:26022109   PMID:26113728   PMID:26215566   PMID:26303528   PMID:26420484   PMID:26444546   PMID:26491026   PMID:26494787   PMID:26583325  
PMID:26657771   PMID:26699655   PMID:26701088   PMID:26876150   PMID:26918315   PMID:27006499   PMID:27068110   PMID:27156386   PMID:27164167   PMID:27194944   PMID:27224923   PMID:27265621  
PMID:27271228   PMID:27300434   PMID:27335065   PMID:27335460   PMID:27398409   PMID:27494603   PMID:27585718   PMID:27599295   PMID:27606421   PMID:27650609   PMID:27686408   PMID:27708166  
PMID:27731422   PMID:27750112   PMID:27855784   PMID:27880731   PMID:27920253   PMID:27922669   PMID:27994055   PMID:28059064   PMID:28167493   PMID:28287406   PMID:28321130   PMID:28468752  
PMID:28487943   PMID:28572510   PMID:28607111   PMID:28622298   PMID:28655168   PMID:28663280   PMID:28669622   PMID:28713933   PMID:28759002   PMID:28759045   PMID:28922976   PMID:28937836  
PMID:29069290   PMID:29072299   PMID:29150241   PMID:29247325   PMID:29281831   PMID:29352019   PMID:29437830   PMID:29460088   PMID:29463648   PMID:29483830   PMID:29507213   PMID:29528141  
PMID:29663368   PMID:29735531   PMID:29800110   PMID:29930104   PMID:29934328   PMID:29958137   PMID:29976569   PMID:29986996   PMID:30109253   PMID:30183689   PMID:30188869   PMID:30352686  
PMID:30444564   PMID:30530919   PMID:30548566   PMID:30550785   PMID:30571376   PMID:30576242   PMID:30630826   PMID:30659096   PMID:30692543   PMID:30702346   PMID:30718277   PMID:30787001  
PMID:30842446   PMID:30940539   PMID:30988513   PMID:31039140   PMID:31089135   PMID:31160676   PMID:31209059   PMID:31248101   PMID:31398665   PMID:31585123   PMID:31587991   PMID:31770533  
PMID:31845891   PMID:31857584   PMID:31862386   PMID:31916354   PMID:32155285   PMID:32191302   PMID:32325033   PMID:32341026   PMID:32358507   PMID:32369449   PMID:32385075   PMID:32434004  
PMID:32457763   PMID:32470079   PMID:32473314   PMID:32537777   PMID:32572167   PMID:32620760   PMID:32827457   PMID:32929850   PMID:32968282   PMID:33248111   PMID:33329939   PMID:33574455  
PMID:33757801   PMID:33759564   PMID:34082069   PMID:34157307   PMID:34273276   PMID:34381046   PMID:34453124   PMID:34473197   PMID:34509805   PMID:34549820   PMID:34822715   PMID:34851738  
PMID:34878095   PMID:35034624   PMID:35084365   PMID:35139769   PMID:35274815   PMID:35359452   PMID:35522298   PMID:35895826   PMID:35977478   PMID:36045676   PMID:36066360   PMID:36232998  
PMID:36239525   PMID:36314682   PMID:36351408   PMID:36445780   PMID:36477656   PMID:36791722   PMID:36828547   PMID:36897957   PMID:36915676   PMID:37237002   PMID:37261975   PMID:37322178  
PMID:37402125   PMID:37490341   PMID:37539462   PMID:37610394   PMID:37650555   PMID:37865088   PMID:37962020   PMID:38003328   PMID:38415925   PMID:38456416  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391873,767,861 - 73,836,862 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)EnsemblGRCm39 Ensembl
GRCm381873,634,790 - 73,703,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv371873,798,667 - 73,863,395 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361873,764,382 - 73,829,110 (-)NCBIMGSCv36mm8
Celera1874,884,056 - 74,923,073 (-)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1849.51NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381851,030,213 - 51,085,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1851,028,528 - 51,085,045 (+)EnsemblGRCh38hg38GRCh38
GRCh371848,556,583 - 48,611,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361846,810,611 - 46,860,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 341846,810,610 - 46,860,144NCBI
Celera1845,413,367 - 45,468,195 (+)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1845,411,927 - 45,466,923 (+)NCBIHuRef
CHM1_11848,551,997 - 48,606,836 (+)NCBICHM1_1
T2T-CHM13v2.01851,231,926 - 51,286,759 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81869,518,988 - 69,549,684 (-)NCBIGRCr8
mRatBN7.21867,243,742 - 67,274,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1867,243,742 - 67,274,438 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1869,351,818 - 69,382,528 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01870,026,538 - 70,057,217 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01867,891,801 - 67,922,479 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01869,626,682 - 69,657,373 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1869,627,757 - 69,671,199 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01868,773,326 - 68,802,354 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41870,432,705 - 70,461,541 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11870,504,785 - 70,534,814 (-)NCBI
Celera1865,246,042 - 65,276,480 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540235,961,165 - 35,994,538 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540235,956,080 - 36,001,746 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21768,549,261 - 68,603,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11854,241,866 - 54,296,559 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01844,402,112 - 44,456,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11847,692,311 - 47,802,530 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1847,764,568 - 47,797,359 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1123,875,989 - 23,930,027 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,882,139 - 23,969,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,868,005 - 24,956,178 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,767,402 - 23,821,366 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,772,519 - 23,821,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,833,038 - 23,921,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,719,264 - 23,807,404 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,987,158 - 24,041,139 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494437,008,523 - 37,038,961 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649712,249,140 - 12,278,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649712,242,869 - 12,278,012 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1100,589,850 - 100,628,029 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11100,521,843 - 100,633,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21110,456,997 - 110,568,659 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11829,894,157 - 29,951,445 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1829,897,621 - 29,934,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660504,018,900 - 4,079,370 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462477814,570,348 - 14,630,325 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477814,570,025 - 14,629,950 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Smad4
2922 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:853
Count of miRNA genes:421
Interacting mature miRNAs:484
Transcripts:ENSMUST00000025393, ENSMUST00000114939, ENSMUST00000129326, ENSMUST00000131339, ENSMUST00000142672, ENSMUST00000147315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25823173Hrsq12_mhost response to SARS QTL 12, hemorrhage (mouse)182489588178339555Mouse
1357639Obsty4_mobesity 4 (mouse)Not determined183961991484638778Mouse
1301902Hrtfm4_mheart failure modifier 4 (mouse)Not determined184331112077311343Mouse
12904745Carcdq2_mcardiac collagen deposition QTL 2 (mouse)184642328780423287Mouse
11039493Ltpr8d_mLeishmania tropica response 8d (mouse)184687490380875042Mouse
11039494Ltpr8b_mLeishmania tropica response 8b (mouse)184687490380875042Mouse
1357630Tgq1_mtriglyceride QTL 1 (mouse)Not determined185105215685052311Mouse
11252137Modvl5_mmodifier of vacuolated lens 5 (mouse)185105215685052311Mouse
10412244Par5_mpulmonary adenoma resistance 5 (mouse)Not determined185166830085668468Mouse
1302099Hdlq30_mHDL QTL 30 (mouse)Not determined185166830085668468Mouse
1301853Heal9_mwound healing/regeneration 9 (mouse)Not determined185280527686805416Mouse
4142443Pgis1_mproteoglycan induced spondylitis 1 (mouse)Not determined185329102276914293Mouse
1301500Szs4_mseizure susceptibility 4 (mouse)Not determined185497587385514143Mouse
12880410V125Dq13_mvitamin D active form serum level QTL 13 (mouse)185643307190433071Mouse
12880430Fgf23lq4_mFGF23 serum level QTL 4 (mouse)185643307190433071Mouse
12880428V125Dq14_mvitamin D active form serum level QTL 14 (mouse)185743307190720763Mouse
1301353Lbw6_mlupus NZB x NZW 6 (mouse)Not determined185756233890720763Mouse
4141132Eae18_mexperimental allergic encephalomyelitis susceptibility 18 (mouse)Not determined5759055982604728Mouse
4140971Mbmq1_mmale body mass QTL 1 (mouse)Not determined5799028190720763Mouse
11049564Lmr29_mleishmaniasis resistance 29 (mouse)185918009290720763Mouse
11039495Ltpr8c_mLeishmania tropica response 8c (mouse)185918009290720763Mouse
11039492Ltpr8a_mLeishmania tropica response 8a (mouse)185918009290720763Mouse
1301103Pgia11_mproteoglycan induced arthritis 11 (mouse)Not determined185991418490720763Mouse
1302109Sluc28_msusceptibility to lung cancer 28 (mouse)Not determined185993532190720763Mouse
38455998Cdtm1_mCD62L+ CD8 TM cells 1 (mouse)186013307280043215Mouse
4142239Idd21.2_minsulin dependent diabetes susceptibility 21.2 (mouse)Not determined186127244874562414Mouse
1558803W3q16_mweight 3 weeks QTL 16 (mouse)Not determined186127244881491831Mouse
1558782Orgwq9_morgan weight QTL 9 (mouse)Not determined186127244882604728Mouse
11039518Ltpr8_mLeishmania tropica response 8 (mouse)186387490376180241Mouse
1301798Hdlq31_mHDL QTL 31 (mouse)Not determined186714438990720763Mouse
10401904Sicd4_mseizure-induced cell death 4 (mouse)Not determined186980527685514143Mouse
1301368Par2_mpulmonary adenoma resistance 2 (mouse)Not determined187036233376707156Mouse
15014786Mvlq2_mmacrovesicular liver lesion QTL 2 (mouse)187156938890720763Mouse
1302183Pas7_mpulmonary adenoma susceptibility 7 (mouse)Not determined187274559484144595Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,667,710 - 73,667,893UniSTSGRCm38
MGSCv371873,827,364 - 73,827,547UniSTSGRCm37
Celera1874,912,742 - 74,912,925UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,650,984 - 73,651,604UniSTSGRCm38
MGSCv371873,810,638 - 73,811,258UniSTSGRCm37
Celera1874,896,042 - 74,896,662UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,650,984 - 73,651,695UniSTSGRCm38
MGSCv371873,810,638 - 73,811,349UniSTSGRCm37
Celera1874,896,042 - 74,896,753UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,651,123 - 73,651,604UniSTSGRCm38
MGSCv371873,810,777 - 73,811,258UniSTSGRCm37
Celera1874,896,181 - 74,896,662UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,649,730 - 73,649,898UniSTSGRCm38
MGSCv371873,809,384 - 73,809,552UniSTSGRCm37
Celera1874,894,788 - 74,894,956UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,658,594 - 73,658,875UniSTSGRCm38
MGSCv371873,818,248 - 73,818,529UniSTSGRCm37
Celera1874,903,644 - 74,903,925UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,649,252 - 73,649,515UniSTSGRCm38
MGSCv371873,808,906 - 73,809,169UniSTSGRCm37
Celera1874,894,310 - 74,894,573UniSTS
Cytogenetic Map18E2UniSTS
cM Map1848.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381873,639,070 - 73,639,319UniSTSGRCm38
MGSCv371873,798,724 - 73,798,973UniSTSGRCm37
Celera1874,884,113 - 74,884,362UniSTS
Cytogenetic Map18E2UniSTS
cM Map1847.0UniSTS
cM Map1848.0UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001364967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001364968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_157374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006525701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011246855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC134447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY119788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY493561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY742922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU072920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U79748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000025393   ⟹   ENSMUSP00000025393
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,772,080 - 73,836,851 (-)Ensembl
GRCm38.p6 Ensembl1873,639,009 - 73,703,780 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114939   ⟹   ENSMUSP00000110589
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,072 - 73,811,302 (-)Ensembl
GRCm38.p6 Ensembl1873,640,001 - 73,678,231 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129326
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,791,850 - 73,808,189 (-)Ensembl
GRCm38.p6 Ensembl1873,658,779 - 73,675,118 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131339
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,229 - 73,775,634 (-)Ensembl
GRCm38.p6 Ensembl1873,640,158 - 73,642,563 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142672
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,294 - 73,795,846 (-)Ensembl
GRCm38.p6 Ensembl1873,640,223 - 73,662,775 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147315
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1873,773,283 - 73,782,890 (-)Ensembl
GRCm38.p6 Ensembl1873,640,212 - 73,649,819 (-)Ensembl
RefSeq Acc Id: NM_001364967   ⟹   NP_001351896
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
RefSeq Acc Id: NM_001364968   ⟹   NP_001351897
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
RefSeq Acc Id: NM_008540   ⟹   NP_032566
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
MGSCv371873,798,667 - 73,863,395 (-)RGD
Celera1874,884,056 - 74,923,073 (-)RGD
RefSeq Acc Id: NR_157374
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391873,767,861 - 73,836,862 (-)NCBI
GRCm381873,634,790 - 73,703,791 (-)NCBI
RefSeq Acc Id: XM_006525701   ⟹   XP_006525764
Mouse AssemblyChrPosition (strand)Source
GRCm391873,769,251 - 73,836,640 (-)NCBI
GRCm381873,634,858 - 73,703,512 (-)NCBI
RefSeq Acc Id: XM_011246855   ⟹   XP_011245157
Mouse AssemblyChrPosition (strand)Source
GRCm391873,769,251 - 73,836,831 (-)NCBI
GRCm381873,634,858 - 73,703,512 (-)NCBI
RefSeq Acc Id: NP_032566   ⟸   NM_008540
- Peptide Label: isoform 1
- UniProtKB: Q6GTP6 (UniProtKB/Swiss-Prot),   Q9CW56 (UniProtKB/Swiss-Prot),   P97471 (UniProtKB/Swiss-Prot),   Q811W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006525764   ⟸   XM_006525701
- Peptide Label: isoform X2
- UniProtKB: Q811W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011245157   ⟸   XM_011246855
- Peptide Label: isoform X1
- UniProtKB: E3SRH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001351897   ⟸   NM_001364968
- Peptide Label: isoform 3
- UniProtKB: E3SRG8 (UniProtKB/TrEMBL),   Q811W8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001351896   ⟸   NM_001364967
- Peptide Label: isoform 2
- UniProtKB: E3SRG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000110589   ⟸   ENSMUST00000114939
RefSeq Acc Id: ENSMUSP00000025393   ⟸   ENSMUST00000025393
Protein Domains
MH1   MH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97471-F1-model_v2 AlphaFold P97471 1-551 view protein structure

RGD ID:13678136
Promoter ID:EPDNEW_M23217
Type:single initiation site
Description:Mus musculus SMAD family member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M23218  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381873,701,755 - 73,701,815EPDNEW
RGD ID:13678138
Promoter ID:EPDNEW_M23218
Type:initiation region
Description:Mus musculus SMAD family member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M23217  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381873,703,791 - 73,703,851EPDNEW
RGD ID:6829544
Promoter ID:MM_KWN:25663
SO ACC ID:SO:0000170
Tissues & Cell Lines:Brain
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,801,686 - 73,802,186 (-)MPROMDB
RGD ID:6829543
Promoter ID:MM_KWN:25666
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,835,466 - 73,835,966 (-)MPROMDB
RGD ID:6828987
Promoter ID:MM_KWN:25668
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK028578_4930578L24RIK,   OTTMUST00000049897
Mouse AssemblyChrPosition (strand)Source
MGSCv361873,863,301 - 73,863,801 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894293 AgrOrtholog
Ensembl Genes ENSMUSG00000024515 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025393 ENTREZGENE
  ENSMUST00000025393.14 UniProtKB/Swiss-Prot
  ENSMUST00000114939.2 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.520.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Dwarfin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology1_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAD_homology_MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_dom_Dwarfin-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_MH1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17128 UniProtKB/Swiss-Prot
  PTHR13703 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Smad4 PhenoGen
PROSITE MH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DWB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6GTP6 UniProtKB/Swiss-Prot
  Q9CW56 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Smad4  SMAD family member 4  AW743858  expressed sequence AW743858  Data merged from RGD:1611564 737654 PROVISIONAL
2012-07-10 Smad4  SMAD family member 4  Smad4  MAD homolog 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED