Cdkn1b (cyclin-dependent kinase inhibitor 1B) - Rat Genome Database

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Gene: Cdkn1b (cyclin-dependent kinase inhibitor 1B) Rattus norvegicus
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
RGD ID: 69062
Description: Enables Hsp70 protein binding activity. Involved in several processes, including cellular response to hypoxia; negative regulation of vascular associated smooth muscle cell proliferation; and response to estradiol. Part of protein-containing complex. Used to study cataract; endocrine organ benign neoplasm (multiple); infertility; multiple endocrine neoplasia; and myocardial infarction. Biomarker of several diseases, including acute kidney failure; glomerulonephritis (multiple); obesity; pulmonary hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-pilocarpine; (Z)-3-butylidenephthalide; 1,2-dimethylhydrazine.
Type: protein-coding
Previously known as: Cdki1b; CDKN4; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; cyclin-dependent kinase inhibitor p27/Kip1; Kip1; p27; P27KIP1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Cdkn1bwe   Cdkn1bem1Musc   Cdkn1bem4Musc  
Genetic Models: SD-Cdkn1bwe ACI.Cg.-Cdkn1bem4Musc ACI.Cg.-Cdkn1bem1Musc
Candidate Gene For: Ept5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84169,491,273 - 169,496,500 (+)NCBIGRCr8
mRatBN7.24167,760,067 - 167,765,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,760,181 - 167,764,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,053,581 - 174,058,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,836,661 - 169,841,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,460,545 - 168,465,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,689,043 - 168,694,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,689,163 - 168,693,964 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,962,218 - 232,967,323 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,841,705 - 171,846,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,086,631 - 172,091,508 (+)NCBI
Celera4156,357,827 - 156,362,628 (+)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP)
acute myeloid leukemia  (ISO)
autosomal dominant intellectual developmental disorder 6  (ISO)
Brain Injuries  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
cataract  (IAGP,IMP)
cervix uteri carcinoma in situ  (ISO)
Chloracne  (ISO)
chronic myeloid leukemia  (ISO)
Diabetic Nephropathies  (IEP)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Experimental Liver Neoplasms  (IEP)
Experimental Mammary Neoplasms  (IDA,IEP)
Fallopian Tube Neoplasms  (ISO)
Familial Prostate Cancer  (ISO)
Fibrosis  (IEP)
genetic disease  (ISO)
glaucoma  (IEP)
Helicobacter Infections  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
hyperthyroidism  (ISO)
infertility  (IMP)
influenza  (ISO)
Intestinal Neoplasms  (ISO)
Kidney Neoplasms  (ISO)
Left Ventricular Hypertrophy  (IEP)
Leukoencephalopathies  (IDA)
Leydig cell tumor  (ISO)
Liver Neoplasms  (ISO)
lung cancer  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (IEP)
membranous glomerulonephritis  (IEP)
Mesothelioma  (ISO)
multiple endocrine neoplasia  (IAGP,ISO)
multiple endocrine neoplasia type 4  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (IMP,ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
obesity  (IEP)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
paraganglioma  (IAGP)
pheochromocytoma  (IAGP)
pituitary adenoma  (IAGP)
Pituitary Neoplasms  (ISO)
primary hyperparathyroidism  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP)
rectal benign neoplasm  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
sciatic neuropathy  (IEP)
senile cataract  (ISO)
Sezary's disease  (ISO)
Spinal Cord Injuries  (IDA)
Stomach Neoplasms  (ISO)
Testicular Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-(-)-perillyl alcohol  (ISO)
(S)-nicotine  (ISO)
(Z)-3-butylidenephthalide  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-thiazolidine-2,4-dione  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-cyclopenten-1-one  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methoxyethanol  (EXP)
25-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-iodotubercidin  (EXP)
6-propyl-2-thiouracil  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
acrylonitrile  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allose  (ISO)
Allylamine  (EXP)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
ammonium chloride  (EXP)
anilines  (ISO)
anthocyanin  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (EXP)
beta-hexachlorocyclohexane  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bosutinib  (ISO)
BQ 123  (ISO)
brassinolide  (ISO)
Brodifacoum  (EXP)
bucladesine  (EXP)
budesonide  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium dichloride  (EXP)
Calpeptin  (ISO)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (EXP)
carnosic acid  (ISO)
casticin  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
clobenpropit  (ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (EXP,ISO)
corticosterone  (EXP)
cudraflavone B  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytochalasin B  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
diacetylmonoxime  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenzofuran  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethanolamine  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
digitonin  (ISO)
digitoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyldithiocarbamate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (ISO)
ellipticine  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
esculetin  (ISO)
etoposide  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fasudil  (EXP)
fenofibrate  (EXP,ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
flavanone  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (ISO)
gamma-tocopherol  (ISO)
ganglioside GM1  (EXP)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
geraniol  (ISO)
gingerol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
harmine  (EXP)
hemin  (ISO)
heparin  (ISO)
hesperetin  (ISO)
hesperidin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
hydrogen chloride  (ISO)
hydroxyurea  (ISO)
indirubin  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoliquiritigenin  (ISO)
isoprene  (ISO)
isosilybin A  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-ascorbic acid  (EXP)
L-cysteine  (ISO)
L-methionine  (ISO)
L-mimosine  (ISO)
lactacystin  (ISO)
lamivudine  (ISO)
lapatinib  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (ISO)
lithium hydride  (EXP)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
Maxacalcitol  (ISO)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methylseleninic acid  (EXP,ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
monosodium L-glutamate  (ISO)
motexafin gadolinium  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
naphthalene  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nicotinamide  (EXP)
nicotine  (ISO)
nilutamide  (ISO)
nimesulide  (ISO)
nitroglycerin  (EXP)
NS-398  (ISO)
ochratoxin A  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perillyl alcohol  (ISO)
phenethyl caffeate  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
prednisone  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
pyrimidines  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quinazolines  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
ritonavir  (ISO)
Ro 41-5253  (ISO)
rubitecan  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Sanggenon C  (ISO)
SB 203580  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
serpentine asbestos  (ISO)
silibinin  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sorafenib  (EXP,ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
stilbenoid  (ISO)
sulindac  (EXP)
sulindac sulfone  (ISO)
tacrolimus hydrate  (EXP)
taiwanin C  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
terazosin  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (EXP,ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
tipifarnib  (ISO)
tolbutamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wogonin  (EXP,ISO)
wortmannin  (ISO)
Y-27632  (EXP)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
autophagic cell death  (ISO)
cellular response to antibiotic  (ISO)
cellular response to hypoxia  (IEP)
cellular response to lithium ion  (ISO)
cellular response to organic cyclic compound  (ISO)
epithelial cell apoptotic process  (ISO)
epithelial cell proliferation involved in prostate gland development  (ISO)
G1/S transition of mitotic cell cycle  (IBA,ISO)
heart development  (ISO)
inner ear development  (ISO)
negative regulation of cardiac muscle tissue regeneration  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (IBA,IMP,ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IMP)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
negative regulation of mitotic cell cycle  (IBA)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP,ISO)
Notch signaling pathway  (ISO)
nuclear export  (ISO)
placenta development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular process  (IMP)
positive regulation of cyclin-dependent protein serine/threonine kinase activity  (IMP)
positive regulation of microtubule polymerization  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein phosphorylation  (IMP)
potassium ion transport  (ISO)
regulation of cell cycle  (ISO)
regulation of cell cycle G1/S phase transition  (ISO)
regulation of cell migration  (ISO)
regulation of exit from mitosis  (ISO)
regulation of G1/S transition of mitotic cell cycle  (ISO)
regulation of lens fiber cell differentiation  (ISO)
regulation of mitotic cell cycle  (ISO)
response to amino acid  (IEP)
response to cadmium ion  (IEP)
response to estradiol  (IEP)
response to glucose  (IEP)
response to hypoxia  (IEP)
response to organic cyclic compound  (IEP)
response to peptide hormone  (IEP)
response to xenobiotic stimulus  (IEP)
sensory perception of sound  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. Akashiba H, etal., Cell Mol Life Sci. 2006 Oct;63(19-20):2397-404.
2. Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons. Akashiba H, etal., J Neurochem. 2006 Nov;99(3):733-44. Epub 2006 Aug 8.
3. Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. Andreasson P, etal., Genes Chromosomes Cancer. 1997 Jun;19(2):77-83.
4. Transcriptional responses of rat skeletal muscle following hypoxia-reoxygenation and near ischaemia-reperfusion. Aravindan N, etal., Acta Physiol Scand. 2005 Apr;183(4):367-77.
5. The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. Bahnassy AA, etal., J Egypt Natl Canc Inst. 2006 Dec;18(4):292-302.
6. Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers. Brunner A, etal., Pathobiology. 2008;75(1):25-33. Epub 2008 Mar 11.
7. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
8. Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Chu S, etal., Leukemia. 2010 Apr;24(4):779-87. doi: 10.1038/leu.2010.24. Epub 2010 Mar 4.
9. Inhibin and p27 interact to regulate gonadal tumorigenesis. Cipriano SC, etal., Mol Endocrinol. 2001 Jun;15(6):985-96.
10. New insights into the tumor suppression function of P27(kip1) Clurman BE and Porter P, Proc Natl Acad Sci U S A 1998 Dec 22;95(26):15158-60.
11. Impairment of rat postnatal lung alveolar development by glucocorticoids: involvement of the p21CIP1 and p27KIP1 cyclin-dependent kinase inhibitors. Corroyer S, etal., Pediatr Res 2002 Feb;51(2):169-76.
12. Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. Ding L, etal., PLoS Genet. 2019 Mar 20;15(3):e1008002. doi: 10.1371/journal.pgen.1008002. eCollection 2019 Mar.
13. Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas. Dobashi Y, etal., Hum Pathol. 2017 Aug;66:67-78. doi: 10.1016/j.humpath.2017.05.022. Epub 2017 Jun 7.
14. Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Driver KE, etal., Carcinogenesis. 2008 Feb;29(2):333-41. Epub 2008 Jan 3.
15. Association of single-nucleotide polymorphisms in the Cell Cycle genes with breast cancer in the British population. Driver KE, etal., Carcinogenesis. 2008 Jan 3;.
16. Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice. Eto I Metabolism. 2013 Jun;62(6):873-87. doi: 10.1016/j.metabol.2013.01.001. Epub 2013 Jan 26.
17. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression. Ferri N, etal., Mol Pharmacol. 2008 Jul;74(1):144-53. Epub 2008 Apr 15.
18. Recessive transmission of a multiple endocrine neoplasia syndrome in the rat. Fritz A, etal., Cancer Res 2002 Jun 1;62(11):3048-51.
19. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine Fu Q, etal., Zhong Xi Yi Jie He Xue Bao. 2006 Jul;4(4):408-12.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences Ge JR, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Sep;36(5):483-7.
22. MIB-1 (KI-67) proliferation index and cyclin-dependent kinase inhibitor p27(Kip1) protein expression in nephroblastoma. Ghanem MA, etal., Clin Cancer Res. 2004 Jan 15;10(2):591-7.
23. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
24. Increased P27KIP1 protein expression in the dentate gyrus of chronically stressed rats indicates G1 arrest involvement. Heine VM, etal., Neuroscience. 2004;129(3):593-601.
25. PTEN and p27Kip1 are not downregulated in the majority of renal cell carcinomas--implications for Akt activation. Hennenlotter J, etal., Oncol Rep. 2008 May;19(5):1141-7.
26. Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation. Hikosaka A, etal., Int J Cancer. 2008 Mar 15;122(6):1222-8.
27. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Homsi E, etal., Kidney Int. 2006 Apr;69(8):1385-92.
28. Hypoxia-inducible factor 1 alpha is essential for hypoxic p27 induction in endometrioid endometrial carcinoma. Horree N, etal., J Pathol. 2008 Jan;214(1):38-45.
29. Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-beta pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice. Hussein N, etal., Endocr Relat Cancer. 2008 Mar;15(1):217-27.
30. Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Jiang W, etal., Cancer Res. 2012 Aug 1;72(15):3795-806. doi: 10.1158/0008-5472.CAN-12-1047. Epub 2012 May 31.
31. Prognostic significance of p27Kip1 and Ki-67 expression in carcinoma of the renal pelvis and ureter. Kamai T, etal., BJU Int. 2000 Jul;86(1):14-9.
32. Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Karlas A, etal., Nature. 2010 Feb 11;463(7282):818-22. doi: 10.1038/nature08760. Epub 2010 Jan 17.
33. Post-myocardial infarct p27 fusion protein intravenous delivery averts adverse remodelling and improves heart function and survival in rodents. Konecny F, etal., Cardiovasc Res. 2012 Jun 1;94(3):492-500. doi: 10.1093/cvr/cvs138. Epub 2012 Apr 4.
34. High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas: relation to E-cadherin alterations, proliferative activity, and ploidy of the tumors. Kouvaraki M, etal., Cancer. 2002 May 1;94(9):2454-65.
35. 17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Lahm T, etal., Am J Respir Crit Care Med. 2012 May 1;185(9):965-80. doi: 10.1164/rccm.201107-1293OC. Epub 2012 Mar 1.
36. Dynamic changes of PIRH2 and p27kip1 expression in injured rat sciatic nerve. Li H, etal., Neurol Sci. 2012 Aug;33(4):749-57. doi: 10.1007/s10072-011-0809-8. Epub 2011 Sep 30.
37. Downregulation of cyclin-dependent kinase inhibitors p21 and p27 in pressure-overload hypertrophy. Li JM and Brooks G, Am J Physiol. 1997 Sep;273(3 Pt 2):H1358-67.
38. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Liang J, etal., Nat Med 2002 Oct;8(10):1153-60.
39. Connective tissue growth factor is associated with the early renal hypertrophy in uninephrectomized diabetic rats. Liu BC, etal., Chin Med J (Engl). 2006 Jun 20;119(12):1010-6.
40. Epigenetic silencing of cell cycle regulatory genes during 3-methylcholanthrene and diethylnitrosamine-induced multistep rat lung cancer. Liu WB, etal., Mol Carcinog. 2010 Jun;49(6):556-65. doi: 10.1002/mc.20621.
41. A relationship between p27kip1 and Skp2 following adult brain injury: implications for glial proliferation. Liu Y, etal., J Neurotrauma. 2009 Oct 23.
42. UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. Lohmann F, etal., Biochim Biophys Acta. 2014 Jul;1842(7):945-58. doi: 10.1016/j.bbadis.2014.02.011. Epub 2014 Feb 28.
43. p27Kip1 knockdown induces proliferation in the organ of Corti in culture after efficient shRNA lentiviral transduction. Maass JC, etal., J Assoc Res Otolaryngol. 2013 Aug;14(4):495-508. doi: 10.1007/s10162-013-0383-2. Epub 2013 Apr 24.
44. A Prostatic Intraepithelial Neoplasia-Dependent p27(Kip1) Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression. Majumder PK, etal., Cancer Cell. 2008 Aug 12;14(2):146-55.
45. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
46. Successive phosphorylation of p27(KIP1) protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2. Mohanty AR, etal., J Biol Chem. 2012 Jun 22;287(26):21757-64. doi: 10.1074/jbc.M112.346254. Epub 2012 May 14.
47. Increased expression of MDM2, cyclin D1, and p27Kip1 in carcinogen-induced rat mammary tumors. Murray SA, etal., J Cell Biochem. 2005 Aug 1;95(5):875-84.
48. 73-kDa heat shock cognate protein interacts directly with P27Kip1, a cyclin-dependent kinase inhibitor, during G1/S transition. Nakamura S, etal., Biochem Biophys Res Commun. 1999 Apr 13;257(2):340-3.
49. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
50. Interaction of p27 with E1A and its effect on CDK kinase activity. Nomura H, etal., Biochem Biophys Res Commun. 1998 Jul 20;248(2):228-34.
51. Cloning and characterization of rat p27Kip1, a cyclin-dependent kinase inhibitor. Nomura H, etal., Gene 1997 Jun 3;191(2):211-8.
52. HER-2/neu and p27Kip1 in progression of Fallopian tube carcinoma: an immunohistochemical and array comparative genomic hybridization study. Nowee ME, etal., Histopathology. 2007 Nov;51(5):666-73.
53. The Proto-oncogene c-myc Acts through the Cyclin-dependent Kinase (Cdk) Inhibitor p27Kip1 to Facilitate the Activation of Cdk4/6 and Early G1 Phase Progression. Obaya AJ, etal., J Biol Chem 2002 Aug 23;277(34):31263-9.
54. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
55. Significantly decreased P27 expression in endometrial carcinoma compared to complex hyperplasia with atypia (correlation with p53 expression). Ozkara SK and Corakci A, Pathol Oncol Res. 2004;10(2):89-97. Epub 2004 Jun 9.
56. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Pellegata NS, etal., Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15558-63. Epub 2006 Oct 9.
57. Inhaled NO prevents hyperoxia-induced white matter damage in neonatal rats. Pham H, etal., Exp Neurol. 2014 Feb;252:114-23. doi: 10.1016/j.expneurol.2013.11.025. Epub 2013 Dec 7.
58. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
59. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
60. Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration. Pujol MJ, etal., J Hepatol. 2000 Aug;33(2):266-74.
61. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Raina K, etal., Cancer Res. 2007 Nov 15;67(22):11083-91.
62. GOA pipeline RGD automated data pipeline
63. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
64. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
65. Combined estrogen and ghrelin administration decreases expression of p27(kip1) and proportion of isomyosin type I in the striated urethral and anal sphincters and levator ani of old ovariectomized rats. Rizk DE, etal., Int Urogynecol J Pelvic Floor Dysfunct. 2008 May 22;.
66. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. Rodier G, etal., EMBO J 2001 Dec 3;20(23):6672-82.
67. Expression of p21(waf1/cip1), p27 (kip1), p63 and Androgen Receptor in Low and High Gleason Score Prostate Cancer. Romics I, etal., Pathol Oncol Res. 2008 Apr 16;.
68. Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Rosen DG, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):632-7.
69. The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures. SantamarĂ­a CG, etal., Toxicol Lett. 2019 Mar 15;303:48-54. doi: 10.1016/j.toxlet.2018.12.016. Epub 2018 Dec 30.
70. Adenovirus expressing mutant p27kip1 enhanced apoptosis and inhibited the growth of xenografted human breast cancer. Sasaki T, etal., Surg Today. 2007;37(12):1073-82. Epub 2007 Nov 26.
71. Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation. Shen A, etal., Neurochem Int. 2008 May;52(6):1266-75. Epub 2008 Jan 31.
72. The Pezcoller lecture: cancer cell cycles revisited. Sherr CJ Cancer Res. 2000 Jul 15;60(14):3689-95.
73. P21, p27, bax, cathepsin and survivin pathways in macular dystrophy corneas. Szentmary N, etal., Histol Histopathol. 2010 Mar;25(3):287-90.
74. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
75. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Tao LJ, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Feb;29(1):58-60.
76. Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation. Tokumoto YM, etal., Dev Biol 2002 May 1;245(1):224-34.
77. Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation. Uranbileg B, etal., J Biol Chem. 2012 Feb 24;287(9):6275-83. doi: 10.1074/jbc.M111.318295. Epub 2012 Jan 5.
78. [Protective effects of 15-methyl-lipoxin A4 on mesangioproliferative nephritis in rats] Wu SH, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):225-30.
79. Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats. Wu X, etal., J Mol Neurosci. 2012 Jan;46(1):184-91. doi: 10.1007/s12031-011-9572-9. Epub 2011 Jul 5.
80. Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase. Xie J and Shaikh ZA, Toxicology. 2006 Jul 5;224(1-2):56-65. Epub 2006 Apr 27.
81. MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3. Xu Y, etal., Cell Physiol Biochem. 2017;43(1):282-292. doi: 10.1159/000480371. Epub 2017 Aug 30.
82. Angiotensin II receptor blocker inhibits p27Kip1 expression in glucose-stimulated podocytes and in diabetic glomeruli. Xu ZG, etal., Kidney Int. 2005 Mar;67(3):944-52.
83. [Detection of Skp2 and p27(kip1) expression in human renal cell carcinoma using tissue chip technique.] Yao C, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Apr;28(4):642-5.
84. p27KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. Yatabe Y, etal., Cancer Res. 1998 Mar 1;58(5):1042-7.
85. Genistein inhibits rat aortic smooth muscle cell proliferation through the induction of p27kip1. Yu JY, etal., J Pharmacol Sci. 2008 May;107(1):90-8.
86. A rat model of glaucoma induced by episcleral vein ligation. Yu S, etal., Exp Eye Res. 2006 Oct;83(4):758-70. Epub 2006 May 16.
87. Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans. Zheng T and Lu Y, Curr Eye Res. 2011 May;36(5):449-55. doi: 10.3109/02713683.2011.559301.
Additional References at PubMed
PMID:8033212   PMID:8033213   PMID:8534916   PMID:8684460   PMID:8973354   PMID:9190208   PMID:9264403   PMID:9784491   PMID:9811456   PMID:10079221   PMID:10208428   PMID:10827137  
PMID:10918569   PMID:11751454   PMID:11800646   PMID:12093740   PMID:12130539   PMID:12421491   PMID:12698196   PMID:12759355   PMID:12773549   PMID:12823546   PMID:12891709   PMID:15024385  
PMID:15213258   PMID:15220466   PMID:15355997   PMID:15564458   PMID:15568022   PMID:15647380   PMID:15652749   PMID:15665120   PMID:15701816   PMID:15879300   PMID:15894805   PMID:15964824  
PMID:16014817   PMID:16188652   PMID:16195383   PMID:16288221   PMID:16393152   PMID:16532026   PMID:16790529   PMID:16839413   PMID:16953280   PMID:17031475   PMID:17205219   PMID:17438373  
PMID:17569667   PMID:17647103   PMID:17852410   PMID:17873289   PMID:18076013   PMID:18182390   PMID:18311148   PMID:18513991   PMID:18604603   PMID:18687224   PMID:18787071   PMID:18802749  
PMID:18927218   PMID:19056892   PMID:19088079   PMID:19170105   PMID:19224154   PMID:19266349   PMID:19587222   PMID:19838216   PMID:20016102   PMID:20492666   PMID:21141556   PMID:21182801  
PMID:21229311   PMID:21300049   PMID:21452304   PMID:21484444   PMID:21628527   PMID:21693435   PMID:22344541   PMID:22524684   PMID:22930444   PMID:23370976   PMID:23762493   PMID:23800691  
PMID:23939805   PMID:24380855   PMID:24479887   PMID:24772447   PMID:25093615   PMID:25099287   PMID:25535395   PMID:25596037   PMID:25655933   PMID:25932965   PMID:26009842   PMID:26086369  
PMID:26130252   PMID:26151495   PMID:26323483   PMID:26562163   PMID:26917264   PMID:26920732   PMID:27011052   PMID:27434733   PMID:28666995   PMID:29024678   PMID:29436581   PMID:29742504  
PMID:30322885   PMID:30478251   PMID:30578960   PMID:30987681   PMID:32841050   PMID:33216476   PMID:33313941   PMID:34737126   PMID:37270133  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr84169,491,273 - 169,496,500 (+)NCBIGRCr8
mRatBN7.24167,760,067 - 167,765,177 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4167,760,181 - 167,764,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4174,053,581 - 174,058,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04169,836,661 - 169,841,462 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04168,460,545 - 168,465,348 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04168,689,043 - 168,694,159 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4168,689,163 - 168,693,964 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04232,962,218 - 232,967,323 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44171,841,705 - 171,846,506 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14172,086,631 - 172,091,508 (+)NCBI
Celera4156,357,827 - 156,362,628 (+)NCBICelera
Cytogenetic Map4q43NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381212,717,368 - 12,722,369 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,685,498 - 12,722,369 (+)EnsemblGRCh38hg38GRCh38
GRCh371212,870,302 - 12,875,303 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,761,576 - 12,766,570 (+)NCBINCBI36Build 36hg18NCBI36
Build 341212,761,575 - 12,766,569NCBI
Celera1218,018,828 - 18,023,831 (+)NCBICelera
Cytogenetic Map12p13.1NCBI
HuRef1212,639,893 - 12,644,900 (+)NCBIHuRef
CHM1_11212,835,677 - 12,840,684 (+)NCBICHM1_1
T2T-CHM13v2.01212,590,905 - 12,595,906 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm396134,897,364 - 134,902,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6134,897,364 - 134,902,476 (+)EnsemblGRCm39 Ensembl
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6134,920,401 - 134,925,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBIMGSCv36mm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554139,615,542 - 9,620,542 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554139,615,542 - 9,620,542 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21018,185,665 - 18,190,870 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11218,182,491 - 18,187,630 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01212,742,258 - 12,747,404 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11213,120,306 - 13,125,541 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1213,120,306 - 13,125,541 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12733,609,154 - 33,613,558 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2733,611,760 - 33,612,906 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2712,832,036 - 12,833,182 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02733,916,284 - 33,921,570 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2733,916,288 - 33,921,501 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12733,812,098 - 33,813,242 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02733,762,117 - 33,763,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02712,566,389 - 12,567,535 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494594,845,531 - 94,850,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365874,572,728 - 4,578,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365874,573,166 - 4,578,480 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl559,731,206 - 59,735,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1559,731,224 - 59,735,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11112,612,064 - 12,617,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1112,612,079 - 12,617,531 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606922,701,998 - 22,707,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475225,203,474 - 25,207,114 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475225,202,474 - 25,207,107 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cdkn1b
11 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir222rno-miR-222-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19150885
Mir221rno-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19150885

Predicted Target Of
Summary Value
Count of predictions:618
Count of miRNA genes:263
Interacting mature miRNAs:330
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,761,026 - 167,761,632 (+)MAPPERmRatBN7.2
Rnor_6.04168,690,009 - 168,690,614NCBIRnor6.0
Rnor_5.04232,963,173 - 232,963,778UniSTSRnor5.0
RGSC_v3.44171,842,551 - 171,843,156UniSTSRGSC3.4
Celera4156,358,673 - 156,359,278UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,764,989 - 167,765,083 (+)MAPPERmRatBN7.2
Rnor_6.04168,693,972 - 168,694,065NCBIRnor6.0
Rnor_5.04232,967,136 - 232,967,229UniSTSRnor5.0
RGSC_v3.44171,846,514 - 171,846,607UniSTSRGSC3.4
Celera4156,362,636 - 156,362,729UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,759,858 - 167,760,106 (+)MAPPERmRatBN7.2
Rnor_6.04168,688,841 - 168,689,088NCBIRnor6.0
Rnor_5.04232,962,005 - 232,962,252UniSTSRnor5.0
RGSC_v3.44171,841,383 - 171,841,630UniSTSRGSC3.4
Celera4156,357,505 - 156,357,752UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,760,599 - 167,760,737 (+)MAPPERmRatBN7.2
Rnor_6.04168,689,582 - 168,689,719NCBIRnor6.0
Rnor_5.04232,962,746 - 232,962,883UniSTSRnor5.0
RGSC_v3.44171,842,124 - 171,842,261UniSTSRGSC3.4
Celera4156,358,246 - 156,358,383UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,760,846 - 167,761,003 (+)MAPPERmRatBN7.2
Rnor_6.04168,689,829 - 168,689,985NCBIRnor6.0
Rnor_5.04232,962,993 - 232,963,149UniSTSRnor5.0
RGSC_v3.44171,842,371 - 171,842,527UniSTSRGSC3.4
Celera4156,358,493 - 156,358,649UniSTS
Cytogenetic Map4q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24167,760,580 - 167,760,777 (+)MAPPERmRatBN7.2
Rnor_6.04168,689,563 - 168,689,759NCBIRnor6.0
Rnor_5.04232,962,727 - 232,962,923UniSTSRnor5.0
RGSC_v3.44171,842,105 - 171,842,301UniSTSRGSC3.4
Celera4156,358,227 - 156,358,423UniSTS
Cytogenetic Map4q43UniSTS

Genetic Models
This gene Cdkn1b is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 56 40 19 40 8 10 74 35 36 11 8
Low 1 1 1 1 5
Below cutoff


RefSeq Acc Id: ENSRNOT00000049848   ⟹   ENSRNOP00000050173
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4167,760,181 - 167,764,982 (+)Ensembl
Rnor_6.0 Ensembl4168,689,163 - 168,693,964 (+)Ensembl
RefSeq Acc Id: NM_031762   ⟹   NP_113950
Rat AssemblyChrPosition (strand)Source
GRCr84169,491,504 - 169,496,305 (+)NCBI
mRatBN7.24167,760,181 - 167,764,982 (+)NCBI
Rnor_6.04168,689,163 - 168,693,964 (+)NCBI
Rnor_5.04232,962,218 - 232,967,323 (+)NCBI
RGSC_v3.44171,841,705 - 171,846,506 (+)RGD
Celera4156,357,827 - 156,362,628 (+)RGD
RefSeq Acc Id: XM_006237539   ⟹   XP_006237601
Rat AssemblyChrPosition (strand)Source
GRCr84169,491,273 - 169,496,500 (+)NCBI
mRatBN7.24167,760,067 - 167,765,177 (+)NCBI
Rnor_6.04168,689,043 - 168,694,159 (+)NCBI
Rnor_5.04232,962,218 - 232,967,323 (+)NCBI
RefSeq Acc Id: NP_113950   ⟸   NM_031762
- UniProtKB: O08769 (UniProtKB/TrEMBL),   F7EXK3 (UniProtKB/TrEMBL),   O35792 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237601   ⟸   XM_006237539
- Peptide Label: isoform X1
- UniProtKB: O08769 (UniProtKB/TrEMBL),   F7EXK3 (UniProtKB/TrEMBL),   O35792 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050173   ⟸   ENSRNOT00000049848
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08769-F1-model_v2 AlphaFold O08769 1-197 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693453
Promoter ID:EPDNEW_R3978
Type:multiple initiation site
Description:cyclin-dependent kinase inhibitor 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.04168,689,071 - 168,689,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69062 AgrOrtholog
BioCyc Gene G2FUF-42643 BioCyc
Ensembl Genes ENSRNOG00000007249 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049848 ENTREZGENE
  ENSRNOT00000049848.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.365.10 UniProtKB/TrEMBL
InterPro CDI UniProtKB/TrEMBL
  CDI_dom_sf UniProtKB/TrEMBL
KEGG Report rno:83571 UniProtKB/TrEMBL
  PTHR10265:SF9 UniProtKB/TrEMBL
PhenoGen Cdkn1b PhenoGen
RatGTEx ENSRNOG00000007249 RatGTEx

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cdkn1b  cyclin-dependent kinase inhibitor 1B       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function inhibits the activity of cyclin-CDK complexes 625485
gene_process regulates cell cycle progression at G1 stage through specific interactions with different cyclins 625485
gene_process involved in the timing of the exit from the cell cycle and the terminal differentiation of oligodendrocyte precursor cells 1298749