CLU (clusterin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: CLU (clusterin) Homo sapiens
Analyze
Symbol: CLU
Name: clusterin
RGD ID: 68978
HGNC Page HGNC:2095
Description: Enables several functions, including amyloid-beta binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cellular component organization; regulation of intrinsic apoptotic signaling pathway; and regulation of macromolecule metabolic process. Located in several cellular components, including apical dendrite; neurofibrillary tangle; and perinuclear endoplasmic reticulum lumen. Part of spherical high-density lipoprotein particle. Is active in extracellular space. Implicated in artery disease (multiple); breast cancer; diabetic retinopathy; exfoliation syndrome; and muscular disease (multiple). Biomarker of several diseases, including Kawasaki disease; Stevens-Johnson syndrome; autoimmune disease of musculoskeletal system (multiple); eye disease (multiple); and invasive ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AAG4; aging-associated protein 4; APO-J; APOJ; apolipoprotein J; CLI; CLU1; CLU2; complement cytolysis inhibitor; complement lysis inhibitor; complement-associated protein SP-40,40; ku70-binding protein 1; KUB1; MGC24903; NA1/NA2; SGP-2; SGP2; SP-40; sulfated glycoprotein 2; testosterone-repressed prostate message 2; TRPM-2; TRPM2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)Ensemblhg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP,ISO)
Alzheimer's disease  (EXP,IAGP,IEP)
amyotrophic lateral sclerosis type 1  (EXP)
anti-basement membrane glomerulonephritis  (ISO)
atherosclerosis  (IDA)
Atrophy  (EXP)
autosomal dominant nocturnal frontal lobe epilepsy  (IAGP)
brain ischemia  (ISO)
breast cancer  (IAGP)
Breast Neoplasms  (IEP,IMP)
Chemical and Drug Induced Liver Injury  (EXP)
Chronic Allograft Nephropathy  (ISO)
chronic kidney disease  (ISO)
cicatricial pemphigoid  (IEP)
Cognitive Dysfunction  (EXP)
conjunctival disease  (IEP)
coronary artery disease  (IEP)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IDA)
Drug-Related Side Effects and Adverse Reactions  (EXP)
exfoliation syndrome  (IAGP,IEP)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (IMP)
Facial Nerve Injuries  (ISO)
Fuchs' endothelial dystrophy  (IEP,ISO)
gelatinous drop-like corneal dystrophy  (IEP)
Hyperplasia  (IEP)
hypertension  (IAGP)
inclusion body myositis  (IDA)
invasive ductal carcinoma  (IEP)
iron metabolism disease  (ISO)
juvenile rheumatoid arthritis  (EXP)
Kawasaki disease  (IEP)
kidney disease  (EXP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (IAGP)
macular retinal edema  (IEP)
melanoma  (EXP)
muscular disease  (IDA)
mycosis fungoides  (IEP)
myocardial infarction  (IDA)
nasal cavity adenocarcinoma  (IEP)
Neointima  (ISO)
Neoplasm Metastasis  (IMP)
Neovascularization, Pathologic  (EXP)
Optic Nerve Injuries  (ISO)
osteoarthritis  (EXP)
Pituitary Neoplasms  (ISO)
pre-eclampsia  (IAGP)
prostate adenocarcinoma  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (EXP)
proteinuria  (ISO)
psoriasis  (IEP)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
skin papilloma  (ISO)
squamous cell carcinoma  (ISO)
Stevens-Johnson syndrome  (IEP)
systemic lupus erythematosus  (EXP,IEP)
systemic scleroderma  (IEP)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
(S)-ropivacaine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-Dichlorobenzophenone  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
aluminium oxide  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP,ISO)
amphotericin B  (EXP,ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
bacitracin  (ISO)
bathocuproine disulfonic acid  (EXP)
belinostat  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-lapachone  (EXP)
beta-naphthoflavone  (EXP)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
cannabidiol  (EXP,ISO)
carbendazim  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carnosic acid  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (EXP)
cumene  (ISO)
Cuprizon  (ISO)
cyanuric acid  (ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
D-penicillamine  (EXP)
dacarbazine  (EXP)
daidzein  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deferasirox  (ISO)
deoxynivalenol  (EXP)
depsipeptide  (EXP)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenzoylmethane  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP,ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP)
dioxygen  (EXP)
dobutamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enalapril  (ISO)
Enterolactone  (EXP)
entinostat  (EXP)
ethanol  (EXP,ISO)
etomoxir  (ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
graphite  (ISO)
Hexachloro-1,3-butadiene  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
imidacloprid  (ISO)
iron dichloride  (EXP)
isocyanuric acid  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-glutamic acid  (ISO)
lead(0)  (EXP)
levamisole  (EXP)
Licochalcone B  (EXP)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
m-xylene  (ISO)
maneb  (ISO)
Meclizine  (EXP)
megestrol  (EXP)
melamine  (ISO)
mercury dichloride  (ISO)
metaproterenol  (ISO)
Methazolamide  (EXP)
methimazole  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (EXP)
methylseleninic acid  (EXP)
mitoxantrone  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
natamycin  (ISO)
nickel atom  (EXP,ISO)
nifedipine  (ISO)
nimodipine  (ISO)
nitrates  (ISO)
nitroglycerin  (ISO)
Nonylphenol  (ISO)
nystatin  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
olanzapine  (EXP)
omega-conotoxin GVIA  (ISO)
orciprenaline  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (ISO)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP,ISO)
razoxane  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rotenone  (EXP,ISO)
sarin  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
styrene  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetramethylpyrazine  (ISO)
thallium atom  (ISO)
thallium sulfate  (ISO)
theophylline  (ISO)
thiabendazole  (ISO)
thimerosal  (EXP)
thiram  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
triazines  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (ISO)
valproic acid  (EXP)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
verapamil  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IDA)
apoptotic process  (IEA)
cell morphogenesis  (IDA)
cellular response to growth factor stimulus  (ISO)
central nervous system myelin maintenance  (IMP)
chaperone-mediated protein complex assembly  (IDA)
complement activation  (IDA,TAS)
complement activation, classical pathway  (IEA)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
immune complex clearance  (IEA,ISS)
immune system process  (IEA)
innate immune response  (IEA)
intrinsic apoptotic signaling pathway  (IDA)
lipid metabolic process  (NAS)
microglial cell activation  (IDA)
microglial cell proliferation  (IDA)
negative regulation of activation of membrane attack complex  (IDA)
negative regulation of amyloid fibril formation  (IDA,IEA,TAS)
negative regulation of amyloid-beta formation  (IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of complement activation  (IDA)
negative regulation of complement-dependent cytotoxicity  (IDA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (IMP)
negative regulation of neuron apoptotic process  (ISS)
negative regulation of protein-containing complex assembly  (IDA,IMP)
negative regulation of release of cytochrome c from mitochondria  (TAS)
negative regulation of response to endoplasmic reticulum stress  (IMP)
neuron projection morphogenesis  (ISO)
positive regulation of amyloid fibril formation  (TAS)
positive regulation of amyloid-beta formation  (IEA,ISS)
positive regulation of apoptotic process  (IEA,IMP,ISS)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IMP)
positive regulation of neurofibrillary tangle assembly  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of nitric oxide biosynthetic process  (IDA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,IMP)
positive regulation of protein-containing complex assembly  (IDA)
positive regulation of receptor-mediated endocytosis  (IGI,ISS)
positive regulation of tumor necrosis factor production  (IDA)
positive regulation of ubiquitin-dependent protein catabolic process  (IMP)
protein folding  (IDA)
protein import  (IDA)
protein stabilization  (IDA)
protein targeting to lysosome involved in chaperone-mediated autophagy  (IDA)
regulation of amyloid-beta clearance  (IDA)
regulation of apoptotic process  (IBA)
regulation of cell population proliferation  (IMP)
regulation of neuronal signal transduction  (IMP)
release of cytochrome c from mitochondria  (IC)
response to axon injury  (ISO)
response to light stimulus  (ISO)
response to misfolded protein  (IDA)
response to potassium ion  (ISO)
response to virus  (IEP)
reverse cholesterol transport  (TAS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genetic analysis of the clusterin gene in pseudoexfoliation syndrome. Burdon KP, etal., Mol Vis. 2008 Sep 22;14:1727-36.
2. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Carlson ES, etal., Brain Res. 2008 Aug 7.
3. Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension. Chen M, etal., Gynecol Obstet Invest. 2005;60(3):133-8. Epub 2005 May 27.
4. Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth. Chesnokova V, etal., Mol Endocrinol. 2012 Dec;26(12):2092-103. doi: 10.1210/me.2012-1158. Epub 2012 Oct 9.
5. Involvement of clusterin and the aggresome in abnormal protein deposits in myofibrillar myopathies and inclusion body myositis. Ferrer I, etal., Brain Pathol. 2005 Apr;15(2):101-8.
6. Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene. Fink TM, etal., Genomics 1993 May;16(2):526-8.
7. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. Flanagan L, etal., BMC Cancer. 2010 Mar 22;10:107. doi: 10.1186/1471-2407-10-107.
8. Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model. Franquesa M, etal., Stem Cells Dev. 2012 Nov 20;21(17):3125-35. doi: 10.1089/scd.2012.0096. Epub 2012 May 18.
9. Decreased plasma levels of clusterin in patients with psoriasis. Garcia-Rodriguez S, etal., Actas Dermosifiliogr. 2013 Jul-Aug;104(6):497-503. doi: 10.1016/j.ad.2012.11.019. Epub 2013 Mar 21.
10. Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Giannakopoulos P, etal., Acta Neuropathol. 1998 Apr;95(4):387-94.
11. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
12. Expression of clusterin in Muller cells of the rat retina after pressure-induced ischemia. Gwon JS, etal., Glia. 2004 Jul;47(1):35-45.
13. Identification of new pathogenic candidates for diabetic macular edema using fluorescence-based difference gel electrophoresis analysis. Hernandez C, etal., Diabetes Metab Res Rev. 2013 Sep;29(6):499-506. doi: 10.1002/dmrr.2419.
14. Clusterin attenuates the development of renal fibrosis. Jung GS, etal., J Am Soc Nephrol. 2012 Jan;23(1):73-85. doi: 10.1681/ASN.2011010048. Epub 2011 Nov 3.
15. Increased clusterin expression in Fuchs' endothelial dystrophy. Jurkunas UV, etal., Invest Ophthalmol Vis Sci. 2008 Jul;49(7):2946-55. doi: 10.1167/iovs.07-1405. Epub 2008 Mar 31.
16. Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Kalka K, etal., Cancer Res. 2000 Nov 1;60(21):5984-7.
17. The role of clusterin on pancreatic beta cell regeneration after exendin-4 treatment in neonatal streptozotocin administrated rats. Kaya-Dagistanli F and Ozturk M, Acta Histochem. 2013 Jul;115(6):577-86. doi: 10.1016/j.acthis.2012.12.007. Epub 2013 Jan 23.
18. Protective role of clusterin/apolipoprotein J against neointimal hyperplasia via antiproliferative effect on vascular smooth muscle cells and cytoprotective effect on endothelial cells. Kim HJ, etal., Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1558-64. doi: 10.1161/ATVBAHA.109.190058. Epub 2009 Aug 20.
19. A signaling network in phenylephrine-induced benign prostatic hyperplasia. Kim J, etal., Endocrinology. 2009 Aug;150(8):3576-83. doi: 10.1210/en.2008-1782. Epub 2009 May 14.
20. Protective effect of clusterin on blood-retinal barrier breakdown in diabetic retinopathy. Kim JH, etal., Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1659-65. doi: 10.1167/iovs.09-3615. Epub 2009 Oct 29.
21. Retinal expression of clusterin in the streptozotocin-induced diabetic rat. Kim YS, etal., Brain Res. 2003 Jun 20;976(1):53-9.
22. Prognostic significance of clusterin immunoreactivity in breast cancer. Kruger S, etal., Neoplasma. 2007;54(1):46-50.
23. Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Krumbiegel M, etal., Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2796-801. doi: 10.1167/iovs.08-2339. Epub 2009 Jan 31.
24. Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis. Li J, etal., J Int Med Res. 2012;40(2):545-55.
25. Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Liu X, etal., Acta Physiol (Oxf). 2014 Jul 29. doi: 10.1111/apha.12352.
26. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Matthaei M, etal., Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.
27. Tubular up-regulation of clusterin mRNA in murine lupus-like nephritis. Moll S, etal., Am J Pathol. 1998 Apr;152(4):953-62.
28. Changes in conjunctival clusterin expression in severe ocular surface disease. Nakamura T, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1702-7.
29. [Molecular mechanism of pathological keratinization in severe ocular surface diseases]. Nakamura T, Nippon Ganka Gakkai Zasshi. 2004 Nov;108(11):654-64.
30. An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Navab M, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1932-7. Epub 2005 Jun 16.
31. Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein. Newkirk MM, etal., J Rheumatol. 1999 Mar;26(3):597-603.
32. Apolipoproteins J and E co-localise with amyloid in gelatinous drop-like and lattice type I corneal dystrophies. Nishida K, etal., Br J Ophthalmol. 1999 Oct;83(10):1178-82.
33. Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer. Niu Z, etal., Acta Biochim Biophys Sin (Shanghai). 2012 Dec;44(12):991-8. doi: 10.1093/abbs/gms091. Epub 2012 Oct 25.
34. Complement activation following optic nerve crush in the adult rat. Ohlsson M, etal., J Neurotrauma. 2003 Sep;20(9):895-904.
35. Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease. Ou-Yang MC, etal., ScientificWorldJournal. 2013 Jul 15;2013:382523. doi: 10.1155/2013/382523. eCollection 2013.
36. Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Padhy B, etal., Exp Eye Res. 2014 Jul 21;127C:69-76. doi: 10.1016/j.exer.2014.07.005.
37. Citicoline reduces upregulated clusterin following kainic acid injection in the rat retina. Park CH, etal., Curr Eye Res. 2007 Dec;32(12):1055-63.
38. Overexpression of clusterin in human breast carcinoma. Redondo M, etal., Am J Pathol. 2000 Aug;157(2):393-9.
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancer. Shi H, etal., Breast Cancer Res Treat. 2012 Feb;131(3):1039-47. doi: 10.1007/s10549-011-1826-2. Epub 2011 Oct 26.
42. Deficiency of clusterin inhibits neointimal hyperplasia after vascular injury. Shirasawa T, etal., J Atheroscler Thromb. 2009;16(6):772-81. Epub 2009 Dec 22.
43. Photoreceptor cells in the vitiligo mouse die by apoptosis. TRPM-2/clusterin expression is increased in the neural retina and in the retinal pigment epithelium. Smith SB, etal., Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2193-201.
44. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis. Suzuki S, etal., Cancer Sci. 2013 Dec;104(12):1711-7. doi: 10.1111/cas.12292. Epub 2013 Oct 28.
45. NF-kappaB-dependent genes induced by proteinuria and identified using DNA microarrays. Takase O, etal., Clin Exp Nephrol. 2008 Jun;12(3):181-8. doi: 10.1007/s10157-008-0038-5. Epub 2008 Feb 15.
46. Glial cell responses, complement and apolipoprotein J expression following axon injury in the neonatal rat. Tao R and Aldskogius H, J Neurocytol. 1999 Jul;28(7):559-70. doi: 10.1023/a:1007067305837.
47. Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo. Thomas-Tikhonenko A, etal., Cancer Res. 2004 May 1;64(9):3126-36.
48. Prognostic factors in 105 Japanese cases of mycosis fungoides and Sezary syndrome: clusterin expression as a novel prognostic factor. Tobisawa S, etal., J Dermatol Sci. 2013 Sep;71(3):160-6. doi: 10.1016/j.jdermsci.2013.04.020. Epub 2013 May 2.
49. Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats. Togashi Y, etal., Exp Toxicol Pathol. 2013 Nov;65(7-8):1137-43. doi: 10.1016/j.etp.2013.05.005. Epub 2013 Jun 21.
50. Gene expression profiling in sinonasal adenocarcinoma. Tripodi D, etal., BMC Med Genomics. 2009 Nov 10;2:65. doi: 10.1186/1755-8794-2-65.
51. The effects of ACE inhibitor and angiotensin receptor blocker on clusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. Tuncdemir M and Ozturk M, J Mol Histol. 2008 Dec;39(6):605-16. doi: 10.1007/s10735-008-9201-2. Epub 2008 Oct 24.
52. Intravenous clusterin administration reduces myocardial infarct size in rats. Van Dijk A, etal., Eur J Clin Invest. 2010 Oct;40(10):893-902. doi: 10.1111/j.1365-2362.2010.02345.x.
53. Tissue Kim-1 and urinary clusterin as early indicators of cisplatin-induced acute kidney injury in rats. Vinken P, etal., Toxicol Pathol. 2012 Oct;40(7):1049-62. Epub 2012 May 11.
54. Delayed, but prolonged increases in astrocytic clusterin (ApoJ) mRNA expression following acute cortical spreading depression in the rat: evidence for a role of clusterin in ischemic tolerance. Wiggins AK, etal., Brain Res Mol Brain Res 2003 May 26;114(1):20-30.
55. A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis. Yanaba K, etal., Arch Dermatol Res. 2012 Aug;304(6):459-63. doi: 10.1007/s00403-012-1219-3. Epub 2012 Feb 17.
56. Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease. Yu HR, etal., Pediatr Cardiol. 2010 Nov;31(8):1151-6. doi: 10.1007/s00246-010-9769-7. Epub 2010 Aug 15.
57. Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material. Zenkel M, etal., Invest Ophthalmol Vis Sci. 2006 May;47(5):1982-90.
58. Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. Zhang Q, etal., Biomark Med. 2014 Jan;8(1):85-94. doi: 10.2217/bmm.13.106.
Additional References at PubMed
PMID:1424805   PMID:1491011   PMID:1551440   PMID:1585460   PMID:1903064   PMID:1924317   PMID:1974459   PMID:2185274   PMID:2387851   PMID:2454950   PMID:2601725   PMID:2721499  
PMID:2780565   PMID:2780570   PMID:3154963   PMID:3167096   PMID:7615015   PMID:7626703   PMID:7768901   PMID:7802646   PMID:8181474   PMID:8292612   PMID:8328966   PMID:8345200  
PMID:8387101   PMID:8555189   PMID:8634259   PMID:8752142   PMID:8759347   PMID:8843912   PMID:8889548   PMID:9200695   PMID:9228033   PMID:9336835   PMID:9537999   PMID:10066740  
PMID:10219089   PMID:10329371   PMID:10694874   PMID:11123922   PMID:11186422   PMID:11570883   PMID:11714447   PMID:11795992   PMID:11813210   PMID:11892985   PMID:11904161   PMID:11906815  
PMID:12047389   PMID:12082621   PMID:12172907   PMID:12176985   PMID:12200037   PMID:12393179   PMID:12427144   PMID:12429802   PMID:12470829   PMID:12477932   PMID:12551933   PMID:12679903  
PMID:12754519   PMID:12824284   PMID:12860995   PMID:12867999   PMID:12882985   PMID:14618611   PMID:14630798   PMID:14702039   PMID:14718574   PMID:14760718   PMID:15033782   PMID:15133840  
PMID:15146195   PMID:15158456   PMID:15174051   PMID:15247015   PMID:15252304   PMID:15304052   PMID:15342556   PMID:15389725   PMID:15480429   PMID:15489334   PMID:15492264   PMID:15499376  
PMID:15538973   PMID:15591223   PMID:15649646   PMID:15689620   PMID:15791650   PMID:15809754   PMID:15857407   PMID:15883054   PMID:15897157   PMID:15929184   PMID:15955107   PMID:16038965  
PMID:16113678   PMID:16179938   PMID:16263699   PMID:16335952   PMID:16421571   PMID:16464517   PMID:16490286   PMID:16502470   PMID:16548883   PMID:16675913   PMID:16682745   PMID:16709604  
PMID:16709934   PMID:16740002   PMID:16775601   PMID:16806233   PMID:16955214   PMID:17043677   PMID:17048076   PMID:17056579   PMID:17080454   PMID:17148459   PMID:17170699   PMID:17224269  
PMID:17260971   PMID:17322305   PMID:17407782   PMID:17412999   PMID:17420006   PMID:17451556   PMID:17512083   PMID:17534116   PMID:17535098   PMID:17567961   PMID:17689225   PMID:17855704  
PMID:17872975   PMID:17974975   PMID:18079682   PMID:18082619   PMID:18097679   PMID:18239862   PMID:18458059   PMID:18514801   PMID:18542050   PMID:18612545   PMID:18624398   PMID:18649357  
PMID:18709641   PMID:18712185   PMID:18714397   PMID:18786636   PMID:18813793   PMID:18842294   PMID:19056867   PMID:19118032   PMID:19137541   PMID:19165232   PMID:19166932   PMID:19177010  
PMID:19199708   PMID:19220628   PMID:19264665   PMID:19289586   PMID:19344414   PMID:19353783   PMID:19357365   PMID:19391138   PMID:19413638   PMID:19446882   PMID:19535339   PMID:19542874  
PMID:19651157   PMID:19664600   PMID:19734902   PMID:19734903   PMID:19757199   PMID:19793084   PMID:19814590   PMID:19878569   PMID:19878770   PMID:19878774   PMID:19879420   PMID:19879421  
PMID:19879422   PMID:19879423   PMID:19903745   PMID:19935703   PMID:19940549   PMID:19996109   PMID:20000738   PMID:20005821   PMID:20007348   PMID:20009887   PMID:20019877   PMID:20028970  
PMID:20057494   PMID:20058210   PMID:20068069   PMID:20096688   PMID:20195357   PMID:20209083   PMID:20353268   PMID:20360068   PMID:20410100   PMID:20460622   PMID:20497247   PMID:20534741  
PMID:20551380   PMID:20554627   PMID:20570404   PMID:20599866   PMID:20603455   PMID:20614220   PMID:20674675   PMID:20697030   PMID:20738160   PMID:20739100   PMID:20842452   PMID:20847305  
PMID:20850846   PMID:20855565   PMID:20873220   PMID:20930273   PMID:21042904   PMID:21043527   PMID:21059989   PMID:21135756   PMID:21163940   PMID:21224044   PMID:21240462   PMID:21242307  
PMID:21280673   PMID:21300948   PMID:21347408   PMID:21349332   PMID:21379329   PMID:21397462   PMID:21420681   PMID:21422520   PMID:21447104   PMID:21460841   PMID:21460853   PMID:21467232  
PMID:21467285   PMID:21505792   PMID:21508640   PMID:21525168   PMID:21527247   PMID:21543606   PMID:21567405   PMID:21573492   PMID:21627779   PMID:21630085   PMID:21633299   PMID:21653829  
PMID:21732348   PMID:21761117   PMID:21803450   PMID:21824521   PMID:21873635   PMID:21892414   PMID:21899841   PMID:21900379   PMID:21912625   PMID:21953030   PMID:21953454   PMID:21980627  
PMID:21987172   PMID:21988832   PMID:21998749   PMID:22012253   PMID:22013110   PMID:22015308   PMID:22016805   PMID:22068036   PMID:22082661   PMID:22122982   PMID:22130675   PMID:22145905  
PMID:22159129   PMID:22166956   PMID:22179788   PMID:22232000   PMID:22234156   PMID:22236192   PMID:22248099   PMID:22258514   PMID:22266332   PMID:22268729   PMID:22274961   PMID:22296908  
PMID:22391565   PMID:22402018   PMID:22465014   PMID:22506010   PMID:22516433   PMID:22528093   PMID:22532874   PMID:22539578   PMID:22545109   PMID:22569264   PMID:22617144   PMID:22647452  
PMID:22689054   PMID:22701550   PMID:22795969   PMID:22810586   PMID:22863883   PMID:22889670   PMID:22896337   PMID:22902018   PMID:22906254   PMID:22949882   PMID:22952074   PMID:22975582  
PMID:22981431   PMID:22990118   PMID:23010347   PMID:23106396   PMID:23164821   PMID:23174100   PMID:23201481   PMID:23208459   PMID:23209684   PMID:23276503   PMID:23279642   PMID:23376485  
PMID:23411014   PMID:23416242   PMID:23457489   PMID:23521156   PMID:23533145   PMID:23538443   PMID:23573206   PMID:23589125   PMID:23602568   PMID:23621580   PMID:23643458   PMID:23650005  
PMID:23658023   PMID:23673647   PMID:23769013   PMID:23770713   PMID:23786771   PMID:23805218   PMID:23816822   PMID:23892938   PMID:23896217   PMID:24008723   PMID:24073260   PMID:24085287  
PMID:24117116   PMID:24162737   PMID:24217652   PMID:24244428   PMID:24327270   PMID:24334140   PMID:24378367   PMID:24388797   PMID:24407433   PMID:24428970   PMID:24446231   PMID:24477687  
PMID:24491388   PMID:24578178   PMID:24599003   PMID:24660791   PMID:24696417   PMID:24743338   PMID:24758255   PMID:24797263   PMID:24806679   PMID:24937130   PMID:24947876   PMID:24958191  
PMID:24967550   PMID:24981860   PMID:24996046   PMID:25051234   PMID:25056061   PMID:25071085   PMID:25076422   PMID:25083615   PMID:25343293   PMID:25402950   PMID:25451228   PMID:25464035  
PMID:25478940   PMID:25496871   PMID:25503391   PMID:25574066   PMID:25600802   PMID:25609201   PMID:25633098   PMID:25703218   PMID:25849827   PMID:25855029   PMID:25884309   PMID:25884382  
PMID:25917404   PMID:25934174   PMID:25940137   PMID:25963833   PMID:26062444   PMID:26081122   PMID:26159041   PMID:26167880   PMID:26179372   PMID:26186194   PMID:26264614   PMID:26293319  
PMID:26343804   PMID:26352072   PMID:26368530   PMID:26399194   PMID:26434199   PMID:26449541   PMID:26482819   PMID:26488311   PMID:26496610   PMID:26545630   PMID:26661731   PMID:26673020  
PMID:26683597   PMID:26716898   PMID:26738351   PMID:26757186   PMID:26781643   PMID:26795031   PMID:26810527   PMID:26826245   PMID:26884339   PMID:26899953   PMID:26939938   PMID:26988917  
PMID:27017968   PMID:27068509   PMID:27070750   PMID:27071964   PMID:27076484   PMID:27079858   PMID:27143425   PMID:27148688   PMID:27197790   PMID:27221710   PMID:27229352   PMID:27233433  
PMID:27248362   PMID:27365216   PMID:27378688   PMID:27396407   PMID:27477018   PMID:27543695   PMID:27559042   PMID:27576135   PMID:27684187   PMID:27773727   PMID:27781389   PMID:27806672  
PMID:27928700   PMID:27983983   PMID:28064403   PMID:28120874   PMID:28168383   PMID:28233427   PMID:28391884   PMID:28411179   PMID:28428074   PMID:28514442   PMID:28558900   PMID:28631188  
PMID:28803177   PMID:28843803   PMID:28849249   PMID:28887769   PMID:28887822   PMID:28890185   PMID:28902428   PMID:28954633   PMID:28958138   PMID:28972394   PMID:28973302   PMID:28986164  
PMID:29133960   PMID:29169407   PMID:29200898   PMID:29253572   PMID:29279586   PMID:29324756   PMID:29396813   PMID:29400663   PMID:29436591   PMID:29463595   PMID:29504051   PMID:29507755  
PMID:29509190   PMID:29509794   PMID:29511261   PMID:29511890   PMID:29628342   PMID:29665645   PMID:29717106   PMID:29970704   PMID:30002194   PMID:30038359   PMID:30053814   PMID:30097533  
PMID:30333625   PMID:30465328   PMID:30552328   PMID:30560405   PMID:30565691   PMID:30659075   PMID:30659732   PMID:30669930   PMID:30691533   PMID:30833792   PMID:30884312   PMID:30952532  
PMID:30967152   PMID:31029938   PMID:31077261   PMID:31180492   PMID:31270237   PMID:31273033   PMID:31343316   PMID:31343317   PMID:31406108   PMID:31413325   PMID:31489966   PMID:31586073  
PMID:31614179   PMID:31739636   PMID:31753913   PMID:31833103   PMID:31930747   PMID:32059741   PMID:32062451   PMID:32149426   PMID:32222009   PMID:32332780   PMID:32409323   PMID:32454375  
PMID:32457219   PMID:32516132   PMID:32707033   PMID:32764517   PMID:32814053   PMID:32882505   PMID:32913257   PMID:32917098   PMID:32929329   PMID:32991610   PMID:32992916   PMID:33003328  
PMID:33052230   PMID:33060605   PMID:33078455   PMID:33124569   PMID:33141553   PMID:33152068   PMID:33155695   PMID:33160989   PMID:33184463   PMID:33206315   PMID:33251792   PMID:33261653  
PMID:33295114   PMID:33385484   PMID:33484131   PMID:33506054   PMID:33545068   PMID:33567341   PMID:33618749   PMID:33649289   PMID:33666516   PMID:33682707   PMID:33742100   PMID:33744871  
PMID:33766124   PMID:33804666   PMID:33845483   PMID:33874952   PMID:33957083   PMID:33961781   PMID:33975532   PMID:33980978   PMID:34036481   PMID:34043937   PMID:34147956   PMID:34290294  
PMID:34298087   PMID:34381050   PMID:34580705   PMID:34650147   PMID:34667172   PMID:34672135   PMID:34686405   PMID:34709727   PMID:34732716   PMID:34741558   PMID:35062233   PMID:35135450  
PMID:35191419   PMID:35271311   PMID:35384245   PMID:35436052   PMID:35439851   PMID:35546756   PMID:35696571   PMID:35787989   PMID:35914814   PMID:35944360   PMID:36180527   PMID:36215168  
PMID:36225252   PMID:36426859   PMID:36736316   PMID:36880596   PMID:36959561   PMID:37047762   PMID:37211336   PMID:37343697   PMID:37378824   PMID:37479568   PMID:37494190   PMID:37652361  
PMID:37685987   PMID:37686218   PMID:37717073   PMID:38125724   PMID:38319453   PMID:38416702   PMID:38447939   PMID:38777146   PMID:38851158   PMID:38857696   PMID:39242637   PMID:40437099  


Genomics

Comparative Map Data
CLU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,596,917 - 27,614,700 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)Ensemblhg38GRCh38
GRCh37827,454,434 - 27,472,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,510,368 - 27,528,244 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34827,510,367 - 27,524,855NCBI
Celera826,414,541 - 26,432,416 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,999,468 - 26,017,387 (-)NCBIHuRef
CHM1_1827,656,307 - 27,674,217 (-)NCBICHM1_1
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBIT2T-CHM13v2.0
Clu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,206,093 - 66,218,992 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,205,932 - 66,218,996 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381465,968,483 - 65,981,548 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,968,483 - 65,981,547 (+)Ensemblmm10GRCm38
MGSCv371466,587,320 - 66,600,382 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361464,922,735 - 64,935,658 (+)NCBIMGSCv36mm8
Celera1451,264,543 - 51,272,775 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Clu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,336,619 - 44,375,861 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1544,359,914 - 44,375,860 (+)EnsemblGRCr8
mRatBN7.21540,161,068 - 40,200,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,174,617 - 40,200,315 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1542,026,339 - 42,065,337 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,176,537 - 43,215,535 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,621,373 - 41,660,612 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,626,612 - 42,665,858 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,640,146 - 42,665,857 (+)Ensemblrn6Rnor6.0
Rnor_5.01548,926,511 - 48,965,757 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41545,365,779 - 45,405,314 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1539,832,711 - 39,871,901 (+)NCBICelera
RGSC_v3.11545,381,558 - 45,421,094 (+)NCBI
Cytogenetic Map15p12NCBI
Clu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,160,598 - 50,175,876 (-)Ensembl
ChiLan1.0NW_00495540350,160,598 - 50,175,876 (-)NCBIChiLan1.0ChiLan1.0
CLU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,128,456 - 46,145,344 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1821,842,687 - 21,859,551 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0826,867,973 - 26,884,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,070,053 - 24,086,934 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,070,053 - 24,083,523 (-)EnsemblpanPan2panpan1.1
CLU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,982,811 - 29,999,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,982,811 - 29,999,563 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2530,569,577 - 30,586,344 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02530,173,217 - 30,190,014 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2530,173,100 - 30,195,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12530,103,442 - 30,120,185 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,984,486 - 30,001,273 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02530,150,889 - 30,167,668 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Clu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049438,072,565 - 8,086,406 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675499,199 - 513,836 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936675499,745 - 513,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,336,595 - 11,349,764 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11411,336,585 - 11,352,569 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,516,644 - 12,527,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,704,441 - 25,721,789 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,703,257 - 25,721,789 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605216,420,009 - 16,437,520 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,426,918 - 22,444,357 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475822,431,331 - 22,444,185 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in CLU
31 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-q11.21(chr8:25832130-48521849)x3 copy number gain See cases [RCV000050904] Chr8:25832130..48521849 [GRCh38]
Chr8:25689646..49434409 [GRCh37]
Chr8:25745563..49596962 [NCBI36]
Chr8:8p21.2-q11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12		 pathogenic
NM_001831.3(CLU):c.1017G>A (p.Arg339=) single nucleotide variant Malignant melanoma [RCV000068271] Chr8:27599927 [GRCh38]
Chr8:27457444 [GRCh37]
Chr8:27513361 [NCBI36]
Chr8:8p21.1		 not provided
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31196357)x1 copy number loss See cases [RCV000136120] Chr8:24910364..31196357 [GRCh38]
Chr8:24767877..31053873 [GRCh37]
Chr8:24823781..31173415 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:25171103-31750600)x1 copy number loss See cases [RCV000138081] Chr8:25171103..31750600 [GRCh38]
Chr8:25028618..31608116 [GRCh37]
Chr8:25084535..31727658 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12		 pathogenic
GRCh37/hg19 8p21.2-q12.1(chr8:24772064-24813176)x3 copy number gain See cases [RCV000446588] Chr8:24772064..24813176 [GRCh37]
Chr8:8p21.2-q12.1		 uncertain significance
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p21.2-12(chr8:24514488-34808438) copy number gain See cases [RCV000448582] Chr8:24514488..34808438 [GRCh37]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12		 not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_001831.4(CLU):c.608C>T (p.Thr203Ile) single nucleotide variant Alzheimer disease [RCV000590968]|not provided [RCV000955185] Chr8:27605145 [GRCh38]
Chr8:27462662 [GRCh37]
Chr8:8p21.1		 likely benign
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_001831.4(CLU):c.756C>T (p.His252=) single nucleotide variant not provided [RCV000904406] Chr8:27604997 [GRCh38]
Chr8:27462514 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.382G>A (p.Val128Ile) single nucleotide variant CLU-related disorder [RCV003922962]|not provided [RCV000901031] Chr8:27606389 [GRCh38]
Chr8:27463906 [GRCh37]
Chr8:8p21.1		 benign|likely benign
NM_001831.4(CLU):c.705C>T (p.Tyr235=) single nucleotide variant not provided [RCV000983110] Chr8:27605048 [GRCh38]
Chr8:27462565 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.984C>T (p.Asp328=) single nucleotide variant not provided [RCV000971373] Chr8:27599960 [GRCh38]
Chr8:27457477 [GRCh37]
Chr8:8p21.1		 benign
GRCh37/hg19 8p21.2-21.1(chr8:24305969-28673405)x1 copy number loss not provided [RCV001006090] Chr8:24305969..28673405 [GRCh37]
Chr8:8p21.2-21.1		 pathogenic
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_001831.4(CLU):c.417+8G>C single nucleotide variant not provided [RCV000925508] Chr8:27606346 [GRCh38]
Chr8:27463863 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.564C>T (p.Asp188=) single nucleotide variant not provided [RCV000922206] Chr8:27605189 [GRCh38]
Chr8:27462706 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.999C>T (p.Val333=) single nucleotide variant not provided [RCV000915760] Chr8:27599945 [GRCh38]
Chr8:27457462 [GRCh37]
Chr8:8p21.1		 likely benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_001831.4(CLU):c.1314G>T (p.Ala438=) single nucleotide variant not provided [RCV000885211] Chr8:27598486 [GRCh38]
Chr8:27456003 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.1187C>T (p.Ser396Leu) single nucleotide variant not provided [RCV000888734] Chr8:27598613 [GRCh38]
Chr8:27456130 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.123C>T (p.Tyr41=) single nucleotide variant not provided [RCV000888113] Chr8:27609061 [GRCh38]
Chr8:27466578 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.75G>A (p.Thr25=) single nucleotide variant not provided [RCV000974218] Chr8:27610497 [GRCh38]
Chr8:27468014 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.1191C>T (p.Asp397=) single nucleotide variant not provided [RCV000910373] Chr8:27598609 [GRCh38]
Chr8:27456126 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.954C>G (p.Pro318=) single nucleotide variant not provided [RCV000956582] Chr8:27599990 [GRCh38]
Chr8:27457507 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.982G>A (p.Asp328Asn) single nucleotide variant not provided [RCV000956581] Chr8:27599962 [GRCh38]
Chr8:27457479 [GRCh37]
Chr8:8p21.1		 benign
GRCh37/hg19 8p21.2-12(chr8:27064033-28832392)x3 copy number gain not provided [RCV002472907] Chr8:27064033..28832392 [GRCh37]
Chr8:8p21.2-12		 uncertain significance
GRCh37/hg19 8p21.1(chr8:27417421-27643275)x3 copy number gain not provided [RCV001259473] Chr8:27417421..27643275 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NC_000008.10:g.(?_27319146)_(28608383_?)dup duplication Autosomal dominant nocturnal frontal lobe epilepsy [RCV003107941]|not provided [RCV002043387] Chr8:27319146..28608383 [GRCh37]
Chr8:8p21.2-21.1		 uncertain significance|no classifications from unflagged records
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30187456)x1 copy number loss See cases [RCV002286343] Chr8:158048..30187456 [GRCh37]
Chr8:8p23.3-12		 pathogenic
GRCh37/hg19 8p21.2-11.22(chr8:26808969-38346383)x1 copy number loss not provided [RCV002472596] Chr8:26808969..38346383 [GRCh37]
Chr8:8p21.2-11.22		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12721809-30183737)x1 copy number loss Microcephaly [RCV003327707] Chr8:12721809..30183737 [GRCh38]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21		 pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1		 pathogenic
GRCh37/hg19 8p21.1(chr8:27406843-27733562)x3 copy number gain not provided [RCV003484731] Chr8:27406843..27733562 [GRCh37]
Chr8:8p21.1		 uncertain significance
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23		 pathogenic
GRCh37/hg19 8p23.1-21.1(chr8:12490999-28150620)x1 copy number loss not provided [RCV003483018] Chr8:12490999..28150620 [GRCh37]
Chr8:8p23.1-21.1		 pathogenic
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
NM_001831.4(CLU):c.192C>T (p.Asn64=) single nucleotide variant CLU-related disorder [RCV003966429]|not provided [RCV003436829] Chr8:27608992 [GRCh38]
Chr8:27466509 [GRCh37]
Chr8:8p21.1		 likely benign
GRCh37/hg19 8p21.2-12(chr8:23754939-30219110)x1 copy number loss not specified [RCV003986748] Chr8:23754939..30219110 [GRCh37]
Chr8:8p21.2-12		 pathogenic
GRCh37/hg19 8p21.2-q21.3(chr8:27024288-89410121)x3 copy number gain not specified [RCV003986754] Chr8:27024288..89410121 [GRCh37]
Chr8:8p21.2-q21.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1		 pathogenic
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
NM_001831.4(CLU):c.*9T>C single nucleotide variant CLU-related disorder [RCV003944337] Chr8:27598232 [GRCh38]
Chr8:27455749 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.120G>A (p.Lys40=) single nucleotide variant CLU-related disorder [RCV003964623] Chr8:27609064 [GRCh38]
Chr8:27466581 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.789T>C (p.His263=) single nucleotide variant CLU-related disorder [RCV003982416] Chr8:27604964 [GRCh38]
Chr8:27462481 [GRCh37]
Chr8:8p21.1		 benign
NM_001831.4(CLU):c.60C>T (p.Val20=) single nucleotide variant CLU-related disorder [RCV003964194] Chr8:27610512 [GRCh38]
Chr8:27468029 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.1218C>T (p.Val406=) single nucleotide variant CLU-related disorder [RCV003934121] Chr8:27598582 [GRCh38]
Chr8:27456099 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.1192G>A (p.Val398Ile) single nucleotide variant not provided [RCV004809534] Chr8:27598608 [GRCh38]
Chr8:27456125 [GRCh37]
Chr8:8p21.1		 likely benign
NM_001831.4(CLU):c.545G>A (p.Arg182His) single nucleotide variant CLU-related disorder [RCV004759170] Chr8:27605208 [GRCh38]
Chr8:27462725 [GRCh37]
Chr8:8p21.1		 likely benign
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p21.2-12(chr8:24910364-31210737)x1 copy number loss See cases [RCV000054237] Chr8:24910364..31210737 [GRCh38]
Chr8:24767877..31068253 [GRCh37]
Chr8:24823781..31187795 [NCBI36]
Chr8:8p21.2-12		 pathogenic
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:6301
Count of miRNA genes:1166
Interacting mature miRNAs:1450
Transcripts:ENST00000316403, ENST00000405140, ENST00000518050, ENST00000519472, ENST00000519742, ENST00000520491, ENST00000520796, ENST00000521770, ENST00000522098, ENST00000522238, ENST00000522299, ENST00000522413, ENST00000522502, ENST00000523396, ENST00000523500, ENST00000523589, ENST00000546343, ENST00000560366, ENST00000560566
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597025430GWAS1121504_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS1121504 (human)7e-17Alzheimer disease, family history of Alzheimer’s disease82761016927610170Human
597032209GWAS1128283_HAlzheimer disease QTL GWAS1128283 (human)6e-15Alzheimer disease82761016927610170Human
597140433GWAS1236507_Hsmoking initiation QTL GWAS1236507 (human)4e-76behavior trait (VT:0010442)82760077727600778Human
407138563GWAS787539_HAlzheimer disease QTL GWAS787539 (human)3e-09Alzheimer disease82761016927610170Human
597078687GWAS1174761_HAlzheimer disease QTL GWAS1174761 (human)6e-20Alzheimer disease82760741227607413Human
597370449GWAS1466523_HAlzheimer disease QTL GWAS1466523 (human)8e-08Alzheimer disease82760879827608799Human
597415953GWAS1512027_Hlate-onset Alzheimers disease QTL GWAS1512027 (human)2e-22brain integrity trait (VT:0010579)82760879827608799Human
597462864GWAS1558938_HAlzheimer disease QTL GWAS1558938 (human)4e-16Alzheimer disease82760741227607413Human
597078747GWAS1174821_HAlzheimer disease QTL GWAS1174821 (human)1e-18Alzheimer disease82761016927610170Human
597342676GWAS1438750_HAlzheimer disease QTL GWAS1438750 (human)6e-34Alzheimer disease82760779527607796Human
597412500GWAS1508574_Hrefractive error, age at onset, Myopia QTL GWAS1508574 (human)1e-08refractive error, age at onset, Myopia82760879827608799Human
597463951GWAS1560025_HAlzheimer disease QTL GWAS1560025 (human)1e-10Alzheimer disease82760864027608641Human
597068096GWAS1164170_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS1164170 (human)5e-08Alzheimer disease, family history of Alzheimer’s disease82760610127606102Human
597423757GWAS1519831_HAlzheimer disease QTL GWAS1519831 (human)6e-13Alzheimer disease82760779527607796Human
597421634GWAS1517708_HAlzheimer disease QTL GWAS1517708 (human)1e-18Alzheimer disease82760741227607413Human
597468230GWAS1564304_Hfamily history of Alzheimer’s disease QTL GWAS1564304 (human)7e-09family history of Alzheimer’s disease82760879827608799Human
597067784GWAS1163858_Hfamily history of Alzheimer’s disease QTL GWAS1163858 (human)0.0000002family history of Alzheimer’s disease82761016927610170Human
597162120GWAS1258194_HAlzheimer disease, age at onset QTL GWAS1258194 (human)0.0000001Alzheimer disease, age at onset82760496427604965Human
407099107GWAS748083_HAlzheimer disease QTL GWAS748083 (human)9e-10Alzheimer disease82760700227607003Human
597386811GWAS1482885_Hlate-onset Alzheimers disease QTL GWAS1482885 (human)6e-10brain integrity trait (VT:0010579)82760879827608799Human
1298482BP2_HBlood pressure QTL 2 (human)1.8Blood pressurediastolic8695325632953256Human
597028406GWAS1124480_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS1124480 (human)3e-19Alzheimer disease, family history of Alzheimer’s disease82760741227607413Human
597357439GWAS1453513_HAlzheimer disease QTL GWAS1453513 (human)0.000002Alzheimer disease82759873627598737Human
597304060GWAS1400134_HAlzheimer disease QTL GWAS1400134 (human)2e-44Alzheimer disease82760779527607796Human
597068095GWAS1164169_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS1164169 (human)4e-25Alzheimer disease, family history of Alzheimer’s disease82760741227607413Human
407124270GWAS773246_HAlzheimer disease QTL GWAS773246 (human)3e-25Alzheimer disease82761016927610170Human
597068092GWAS1164166_Hfamily history of Alzheimer’s disease QTL GWAS1164166 (human)0.0000001family history of Alzheimer’s disease82760741227607413Human
597261237GWAS1357311_Hdementia QTL GWAS1357311 (human)0.000005dementia82760700227607003Human
597078009GWAS1174083_Hfamily history of Alzheimer’s disease QTL GWAS1174083 (human)6e-08family history of Alzheimer’s disease82761016927610170Human
597463660GWAS1559734_HAlzheimer's disease biomarker measurement QTL GWAS1559734 (human)9e-17Alzheimer's disease biomarker measurement82760879827608799Human
597017254GWAS1113328_HAlzheimer disease QTL GWAS1113328 (human)2e-37Alzheimer disease82760864027608641Human
597457193GWAS1553267_Hdementia QTL GWAS1553267 (human)6e-08dementia82760879827608799Human
597414254GWAS1510328_HAbnormality of refraction QTL GWAS1510328 (human)3e-16Abnormality of refraction82760864027608641Human
597067936GWAS1164010_Hfamily history of Alzheimer’s disease QTL GWAS1164010 (human)0.000001family history of Alzheimer’s disease82761016927610170Human
1558703SCL6_HSerum cholesterol level QTL 1 (human)1.2Lipid levelHDL cholesterol81246863538468635Human
597112175GWAS1208249_HAlzheimer disease, family history of Alzheimer’s disease QTL GWAS1208249 (human)8e-26Alzheimer disease, family history of Alzheimer’s disease82761098627610987Human
597371744GWAS1467818_HAlzheimer disease QTL GWAS1467818 (human)6e-10Alzheimer disease82760700227607003Human
596953320GWAS1072839_Hdementia QTL GWAS1072839 (human)6e-08dementia82760879827608799Human
597154026GWAS1250100_HAlzheimer disease, educational attainment QTL GWAS1250100 (human)3e-16Alzheimer disease, educational attainment82760496427604965Human
596969195GWAS1088714_HAlzheimer disease QTL GWAS1088714 (human)2e-37Alzheimer disease82760864027608641Human

Markers in Region
RH27907  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,455,543 - 27,455,673UniSTSGRCh37
Build 36827,511,460 - 27,511,590RGDNCBI36
Celera826,415,633 - 26,415,763RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,000,577 - 26,000,707UniSTS
PMC310777P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,455,614 - 27,456,150UniSTSGRCh37
Build 36827,511,531 - 27,512,067RGDNCBI36
Celera826,415,704 - 26,416,240RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,000,648 - 26,001,184UniSTS
RH11712  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,456,005 - 27,456,110UniSTSGRCh37
Build 36827,511,922 - 27,512,027RGDNCBI36
Celera826,416,095 - 26,416,200RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,001,039 - 26,001,144UniSTS
GeneMap99-GB4 RH Map8108.79UniSTS
NCBI RH Map8339.8UniSTS
STS-J02908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37827,456,012 - 27,456,150UniSTSGRCh37
Build 36827,511,929 - 27,512,067RGDNCBI36
Celera826,416,102 - 26,416,240RGD
Cytogenetic Map8p21-p12UniSTS
HuRef826,001,046 - 26,001,184UniSTS
GeneMap99-GB4 RH Map8108.09UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2433 2788 2245 4970 1724 2347 5 624 1846 465 2266 7200 6371 53 3734 1 852 1742 1612 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_038335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A21577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB839016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF311103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY172563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY184486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY341244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY513288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC019588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF528374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG819541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG914262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM682289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM723283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP193735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ181025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ181739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX418836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX459023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN990822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ004564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ006268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ012938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EB385800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI179164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L00974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000316403   ⟹   ENSP00000315130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,596,917 - 27,614,700 (-)Ensembl
Ensembl Acc Id: ENST00000405140   ⟹   ENSP00000385419
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,597,808 - 27,611,431 (-)Ensembl
Ensembl Acc Id: ENST00000518050
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,608,541 - 27,614,700 (-)Ensembl
Ensembl Acc Id: ENST00000519472   ⟹   ENSP00000427868
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,608,937 - 27,614,681 (-)Ensembl
Ensembl Acc Id: ENST00000519742   ⟹   ENSP00000431026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,606,354 - 27,611,966 (-)Ensembl
Ensembl Acc Id: ENST00000520491   ⟹   ENSP00000429881
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,606,364 - 27,611,218 (-)Ensembl
Ensembl Acc Id: ENST00000520796   ⟹   ENSP00000429336
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,605,141 - 27,611,205 (-)Ensembl
Ensembl Acc Id: ENST00000521770   ⟹   ENSP00000428033
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,598,143 - 27,600,015 (-)Ensembl
Ensembl Acc Id: ENST00000522098   ⟹   ENSP00000430821
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,598,537 - 27,605,339 (-)Ensembl
Ensembl Acc Id: ENST00000522238   ⟹   ENSP00000429087
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,610,476 - 27,614,243 (-)Ensembl
Ensembl Acc Id: ENST00000522299
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,597,996 - 27,614,693 (-)Ensembl
Ensembl Acc Id: ENST00000522413   ⟹   ENSP00000428779
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,606,382 - 27,614,692 (-)Ensembl
Ensembl Acc Id: ENST00000522502
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,604,218 - 27,605,339 (-)Ensembl
Ensembl Acc Id: ENST00000523396   ⟹   ENSP00000428526
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,608,937 - 27,614,698 (-)Ensembl
Ensembl Acc Id: ENST00000523500   ⟹   ENSP00000429620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,597,996 - 27,611,357 (-)Ensembl
Ensembl Acc Id: ENST00000523589   ⟹   ENSP00000431070
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,604,310 - 27,614,690 (-)Ensembl
Ensembl Acc Id: ENST00000560566   ⟹   ENSP00000453247
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl827,604,366 - 27,611,751 (-)Ensembl
RefSeq Acc Id: NM_001831   ⟹   NP_001822
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,614,700 (-)NCBI
Build 36827,510,368 - 27,528,244 (-)NCBI Archive
HuRef825,999,468 - 26,017,387 (-)NCBI
CHM1_1827,656,307 - 27,674,217 (-)NCBI
T2T-CHM13v2.0827,874,264 - 27,892,057 (-)NCBI
Sequence:
RefSeq Acc Id: NR_038335
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,611,371 (-)NCBI
GRCh37827,454,434 - 27,472,328 (-)ENTREZGENE
HuRef825,999,468 - 26,017,387 (-)ENTREZGENE
CHM1_1827,656,307 - 27,670,835 (-)NCBI
T2T-CHM13v2.0827,874,264 - 27,888,729 (-)NCBI
Sequence:
RefSeq Acc Id: NR_045494
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,596,917 - 27,611,751 (-)NCBI
GRCh37827,454,434 - 27,472,328 (-)NCBI
HuRef825,999,468 - 26,017,387 (-)NCBI
CHM1_1827,656,307 - 27,671,149 (-)NCBI
T2T-CHM13v2.0827,874,264 - 27,889,109 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001822   ⟸   NM_001831
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q5HYC1 (UniProtKB/Swiss-Prot),   Q2TU75 (UniProtKB/Swiss-Prot),   P11381 (UniProtKB/Swiss-Prot),   P11380 (UniProtKB/Swiss-Prot),   B3KSE6 (UniProtKB/Swiss-Prot),   B2R9Q1 (UniProtKB/Swiss-Prot),   Q7Z5B9 (UniProtKB/Swiss-Prot),   P10909 (UniProtKB/Swiss-Prot),   A0A384NKS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000427868   ⟸   ENST00000519472
Ensembl Acc Id: ENSP00000431026   ⟸   ENST00000519742
Ensembl Acc Id: ENSP00000429881   ⟸   ENST00000520491
Ensembl Acc Id: ENSP00000429336   ⟸   ENST00000520796
Ensembl Acc Id: ENSP00000453247   ⟸   ENST00000560566
Ensembl Acc Id: ENSP00000428033   ⟸   ENST00000521770
Ensembl Acc Id: ENSP00000429087   ⟸   ENST00000522238
Ensembl Acc Id: ENSP00000430821   ⟸   ENST00000522098
Ensembl Acc Id: ENSP00000428779   ⟸   ENST00000522413
Ensembl Acc Id: ENSP00000385419   ⟸   ENST00000405140
Ensembl Acc Id: ENSP00000429620   ⟸   ENST00000523500
Ensembl Acc Id: ENSP00000431070   ⟸   ENST00000523589
Ensembl Acc Id: ENSP00000428526   ⟸   ENST00000523396
Ensembl Acc Id: ENSP00000315130   ⟸   ENST00000316403
Protein Domains
Clusterin C-terminal   Clusterin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10909-F1-model_v2 AlphaFold P10909 1-449 view protein structure

Promoters
RGD ID:6806474
Promoter ID:HG_KWN:60998
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:UC003XFW.1,   UC010LUX.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,523,726 - 27,524,226 (-)MPROMDB
RGD ID:6806570
Promoter ID:HG_KWN:60999
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:ENST00000405140,   NM_203339,   UC003XFY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,524,626 - 27,525,527 (-)MPROMDB
RGD ID:6806646
Promoter ID:HG_KWN:61000
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:ENST00000316403,   OTTHUMT00000219953
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,527,751 - 27,528,251 (-)MPROMDB
RGD ID:6850782
Promoter ID:EP73185
Type:single initiation site
Name:HS_CLU
Description:Clusterin (complement lysis inhibitor, SP-40,40, sulfatedglycoprotein 2, testosterone-repressed prostate message 2,apolipoprotein J).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36827,528,136 - 27,528,196EPD
RGD ID:7212957
Promoter ID:EPDNEW_H12224
Type:initiation region
Name:CLU_1
Description:clusterin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38827,614,700 - 27,614,760EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2095 AgrOrtholog
COSMIC CLU COSMIC
Ensembl Genes ENSG00000120885 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000316403 ENTREZGENE
  ENST00000316403.15 UniProtKB/Swiss-Prot
  ENST00000405140.7 UniProtKB/Swiss-Prot
  ENST00000523500.5 UniProtKB/Swiss-Prot
GTEx ENSG00000120885 GTEx
HGNC ID HGNC:2095 ENTREZGENE
Human Proteome Map CLU Human Proteome Map
InterPro Clusterin UniProtKB/Swiss-Prot
  Clusterin-like UniProtKB/Swiss-Prot
  Clusterin_C UniProtKB/Swiss-Prot
  Clusterin_CS UniProtKB/Swiss-Prot
  Clusterin_N UniProtKB/Swiss-Prot
KEGG Report hsa:1191 UniProtKB/Swiss-Prot
NCBI Gene 1191 ENTREZGENE
OMIM 185430 OMIM
PANTHER PTHR10970 UniProtKB/Swiss-Prot
  PTHR10970:SF1 UniProtKB/Swiss-Prot
Pfam Clusterin UniProtKB/Swiss-Prot
PharmGKB PA26620 PharmGKB
PIRSF Clusterin UniProtKB/Swiss-Prot
PROSITE CLUSTERIN_1 UniProtKB/Swiss-Prot
  CLUSTERIN_2 UniProtKB/Swiss-Prot
SMART CLa UniProtKB/Swiss-Prot
  CLb UniProtKB/Swiss-Prot
UniProt A0A384NKS6 ENTREZGENE, UniProtKB/TrEMBL
  B2R9Q1 ENTREZGENE
  B3KSE6 ENTREZGENE
  CLUS_HUMAN UniProtKB/Swiss-Prot
  E5RG36_HUMAN UniProtKB/TrEMBL
  E5RGB0_HUMAN UniProtKB/TrEMBL
  E5RH61_HUMAN UniProtKB/TrEMBL
  E5RJD6_HUMAN UniProtKB/TrEMBL
  E5RJZ5_HUMAN UniProtKB/TrEMBL
  E7ERK6_HUMAN UniProtKB/TrEMBL
  E7ETB4_HUMAN UniProtKB/TrEMBL
  H0YAS8_HUMAN UniProtKB/TrEMBL
  H0YC35_HUMAN UniProtKB/TrEMBL
  H0YLK8_HUMAN UniProtKB/TrEMBL
  P10909 ENTREZGENE
  P11380 ENTREZGENE
  P11381 ENTREZGENE
  Q2TU75 ENTREZGENE
  Q5HYC1 ENTREZGENE
  Q7Z5B9 ENTREZGENE
  Q8IWM0_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R9Q1 UniProtKB/Swiss-Prot
  B3KSE6 UniProtKB/Swiss-Prot
  P11380 UniProtKB/Swiss-Prot
  P11381 UniProtKB/Swiss-Prot
  Q2TU75 UniProtKB/Swiss-Prot
  Q5HYC1 UniProtKB/Swiss-Prot
  Q7Z5B9 UniProtKB/Swiss-Prot