Fstl1 (follistatin-like 1) - Rat Genome Database

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Gene: Fstl1 (follistatin-like 1) Rattus norvegicus
Analyze
Symbol: Fstl1
Name: follistatin-like 1
RGD ID: 68955
Description: Predicted to enable calcium ion binding activity and heparin binding activity. Predicted to be involved in several processes, including endothelial cell differentiation; endothelial cell migration; and regulation of BMP signaling pathway. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in extracellular region. Orthologous to human FSTL1 (follistatin like 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: follistatin-like; follistatin-like protein 1; follistatin-related protein; follistatin-related protein 1; follistatin-related protein precursor; Frp; Fstl; MGC93410
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,400,870 - 76,454,053 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,391,315 - 76,455,126 (-)EnsemblGRCr8
mRatBN7.21162,895,391 - 62,948,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,707,886 - 71,761,075 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,370,096 - 64,423,283 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,420,096 - 63,473,181 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,791,196 - 65,845,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,782,567 - 65,845,418 (-)Ensemblrn6Rnor6.0
Rnor_5.01168,884,410 - 68,938,352 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,681,814 - 64,735,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,393,441 - 62,446,724 (-)NCBICelera
RGSC_v3.11164,739,417 - 64,793,262 (-)NCBI
Cytogenetic Map11q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
3,4-dichloroaniline  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dimethylarsinic acid  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
indometacin  (ISO)
inulin  (ISO)
L-methionine  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naproxen  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of rat follistatin-related gene: effects of estrous cycle stage and pregnancy on its messenger RNA expression in rat reproductive tissues. Arai KY, etal., Biol Reprod 2003 Jan;68(1):199-206.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Regulation of FLRG expression in rat primary astroglial cells and injured brain tissue by transforming growth factor-beta 1 (TGF-beta 1). Zhang G, etal., J Neurosci Res 2003 Apr 1;72(1):33-45.
11. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. Zwijsen A, etal., Eur J Biochem 1994 Nov 1;225(3):937-46.
Additional References at PubMed
PMID:12477932   PMID:12591166   PMID:15489334   PMID:16502470   PMID:18925901   PMID:20054002   PMID:23533145   PMID:24006456   PMID:25139876   PMID:26687945   PMID:27561749   PMID:28188034  
PMID:31139662   PMID:35585770   PMID:35766911   PMID:38436106  


Genomics

Comparative Map Data
Fstl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,400,870 - 76,454,053 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1176,391,315 - 76,455,126 (-)EnsemblGRCr8
mRatBN7.21162,895,391 - 62,948,581 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1171,707,886 - 71,761,075 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01164,370,096 - 64,423,283 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,420,096 - 63,473,181 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,791,196 - 65,845,721 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,782,567 - 65,845,418 (-)Ensemblrn6Rnor6.0
Rnor_5.01168,884,410 - 68,938,352 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41164,681,814 - 64,735,673 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1162,393,441 - 62,446,724 (-)NCBICelera
RGSC_v3.11164,739,417 - 64,793,262 (-)NCBI
Cytogenetic Map11q21NCBI
FSTL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383120,392,293 - 120,450,992 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3120,392,293 - 120,451,241 (-)Ensemblhg38GRCh38
GRCh373120,111,140 - 120,169,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,595,816 - 121,652,515 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343121,595,816 - 121,652,515NCBI
Celera3118,522,464 - 118,579,350 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3117,488,896 - 117,545,793 (-)NCBIHuRef
CHM1_13120,076,707 - 120,133,627 (-)NCBICHM1_1
T2T-CHM13v2.03123,111,839 - 123,170,569 (-)NCBIT2T-CHM13v2.0
Fstl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,597,417 - 37,656,878 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,597,235 - 37,656,876 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381637,777,055 - 37,836,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1637,776,873 - 37,836,514 (+)Ensemblmm10GRCm38
MGSCv371637,777,141 - 37,836,602 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361637,696,294 - 37,755,755 (+)NCBIMGSCv36mm8
Celera1638,184,966 - 38,244,699 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.48NCBI
Fstl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,952,853 - 20,004,241 (-)Ensembl
ChiLan1.0NW_00495542719,952,823 - 20,003,832 (-)NCBIChiLan1.0ChiLan1.0
FSTL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,363,612 - 118,419,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13118,368,390 - 118,423,861 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03117,508,772 - 117,564,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl3124,422,968 - 124,475,431 (-)EnsemblpanPan2panpan1.1
FSTL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,892,317 - 23,914,406 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,894,573 - 23,933,779 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3323,919,531 - 23,972,261 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03324,129,955 - 24,182,735 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3324,129,947 - 24,183,502 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,930,929 - 23,983,640 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,971,619 - 24,024,230 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,535,350 - 24,588,071 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fstl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,335,041 - 130,388,800 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365367,126,966 - 7,187,269 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365367,132,369 - 7,186,951 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSTL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13139,847,438 - 139,901,965 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113139,847,246 - 139,901,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FSTL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,371,309 - 60,427,259 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,371,554 - 60,428,764 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041105,887,988 - 105,942,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fstl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473127,790,363 - 27,841,251 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473127,789,671 - 27,839,267 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fstl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1422,746,832 - 22,800,097 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fstl1
420 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:33
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000003721
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat

Markers in Region
RH138069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21162,909,268 - 62,909,484 (+)MAPPERmRatBN7.2
Rnor_6.01165,806,070 - 65,806,285NCBIRnor6.0
Rnor_5.01168,899,283 - 68,899,498UniSTSRnor5.0
RGSC_v3.41164,696,162 - 64,696,377UniSTSRGSC3.4
Celera1162,407,319 - 62,407,534UniSTS
RH 3.4 Map11492.9UniSTS
Cytogenetic Map11q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 49 59 6 313 149 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003721   ⟹   ENSRNOP00000003721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,885,835 - 62,917,459 (-)Ensembl
Rnor_6.0 Ensembl1165,782,567 - 65,814,601 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091057   ⟹   ENSRNOP00000072839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,895,378 - 62,948,575 (-)Ensembl
Rnor_6.0 Ensembl1165,792,207 - 65,845,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097784   ⟹   ENSRNOP00000077559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,779,783 - 62,948,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103472   ⟹   ENSRNOP00000095289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,400,888 - 76,454,571 (-)Ensembl
mRatBN7.2 Ensembl1162,894,395 - 62,948,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110627   ⟹   ENSRNOP00000077415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,779,783 - 62,914,411 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114285   ⟹   ENSRNOP00000080660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,894,395 - 62,948,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117870   ⟹   ENSRNOP00000076465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1162,898,199 - 62,948,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137764   ⟹   ENSRNOP00000103073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,403,678 - 76,453,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142374   ⟹   ENSRNOP00000099729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,400,888 - 76,455,126 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153323   ⟹   ENSRNOP00000107888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,400,888 - 76,454,379 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163869   ⟹   ENSRNOP00000109806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1176,391,315 - 76,422,935 (-)Ensembl
RefSeq Acc Id: NM_024369   ⟹   NP_077345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81176,400,870 - 76,454,053 (-)NCBI
mRatBN7.21162,895,391 - 62,948,581 (-)NCBI
Rnor_6.01165,792,192 - 65,845,375 (-)NCBI
Rnor_5.01168,884,410 - 68,938,352 (-)NCBI
RGSC_v3.41164,681,814 - 64,735,673 (-)RGD
Celera1162,393,441 - 62,446,724 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077345 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66063 (Get FASTA)   NCBI Sequence Viewer  
  AAH87014 (Get FASTA)   NCBI Sequence Viewer  
  AAP92604 (Get FASTA)   NCBI Sequence Viewer  
  EDM11239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095289
  ENSRNOP00000095289.1
GenBank Protein Q62632 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077345   ⟸   NM_024369
- Peptide Label: precursor
- UniProtKB: Q62632 (UniProtKB/Swiss-Prot),   A0A8I5Y6A3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072839   ⟸   ENSRNOT00000091057
Ensembl Acc Id: ENSRNOP00000003721   ⟸   ENSRNOT00000003721
Ensembl Acc Id: ENSRNOP00000076465   ⟸   ENSRNOT00000117870
Ensembl Acc Id: ENSRNOP00000077415   ⟸   ENSRNOT00000110627
Ensembl Acc Id: ENSRNOP00000077559   ⟸   ENSRNOT00000097784
Ensembl Acc Id: ENSRNOP00000095289   ⟸   ENSRNOT00000103472
Ensembl Acc Id: ENSRNOP00000080660   ⟸   ENSRNOT00000114285
Ensembl Acc Id: ENSRNOP00000103073   ⟸   ENSRNOT00000137764
Ensembl Acc Id: ENSRNOP00000109806   ⟸   ENSRNOT00000163869
Ensembl Acc Id: ENSRNOP00000099729   ⟸   ENSRNOT00000142374
Ensembl Acc Id: ENSRNOP00000107888   ⟸   ENSRNOT00000153323
Protein Domains
EF-hand   Follistatin-like   Kazal-like   VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62632-F1-model_v2 AlphaFold Q62632 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698172
Promoter ID:EPDNEW_R8697
Type:initiation region
Name:Fstl1_1
Description:follistatin-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,845,382 - 65,845,442EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68955 AgrOrtholog
BioCyc Gene G2FUF-21259 BioCyc
Ensembl Genes ENSRNOG00000002746 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000103472 ENTREZGENE
  ENSRNOT00000103472.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7189359 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF-hand_FSTL1 UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Fol_N UniProtKB/Swiss-Prot
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_Inhib_GrowthFact_Antg UniProtKB/Swiss-Prot
KEGG Report rno:79210 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93410 IMAGE-MGC_LOAD
NCBI Gene 79210 ENTREZGENE
PANTHER FOLLISTATIN-RELATED UniProtKB/Swiss-Prot
  FOLLISTATIN-RELATED PROTEIN 1 UniProtKB/Swiss-Prot
Pfam EF-hand_FSTL1 UniProtKB/Swiss-Prot
  FOLN UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
  VWF UniProtKB/Swiss-Prot
PhenoGen Fstl1 PhenoGen
PROSITE EF_HAND_2 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002746 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot
  KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
  SSF100895 UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8I5Y6A3 ENTREZGENE
  A0ABK0LE54_RAT UniProtKB/TrEMBL
  A0ABK0LM89_RAT UniProtKB/TrEMBL
  A0ABK0LRY0_RAT UniProtKB/TrEMBL
  A0ABK0LZP6_RAT UniProtKB/TrEMBL
  A6IR86_RAT UniProtKB/TrEMBL
  FSTL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Fstl1  follistatin-like 1  Fstl  follistatin-like  Symbol and Name updated 1299863 APPROVED
2003-04-09 Fstl  follistatin-like  Frp  follistatin-related protein  Symbol and Name updated 629477 APPROVED
2002-06-10 Frp  follistatin-related protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization may be secreted from astroglial cells 1299175
gene_expression expressed in the ovary, uterus, testis, lung, adrenal gland, pituitary, kidney, small intestine, placenta and heart 1299174
gene_function heparin-binding protein 1299173
gene_function binds to activins and bone morphogenetic proteins 1299174
gene_process may function as a negative regulator of cell growth 61515
gene_process may play a role in the regulation of reproductive processes 1299174
gene_process regulates activin A in brain wound healing in response to TGF-beta1 1299175
gene_protein native molecular mass of 55-75,000 Da 1299173