Kcnj16<sup>em1Mcwi</sup> (potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin)

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Gene: Kcnj16^em1Mcwi (potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus

Analyze

Symbol:

Kcnj16^em1Mcwi

Name:

potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin

RGD ID:

6893423

Description:

This allele was made by ZFN mutagenesis. The resulting allele is a 18-bp deletion in exon 1 (del 529-546)
ASSOCIATED WITH decreased body weight; decreased circulating aldosterone level; decreased circulating bicarbonate level; ASSOCIATED WITH hypokalemia; metabolic acidosis; Respiratory Underresponsiveness to Hypoxia and Hypercapnia

Type:

allele of Kcnj16

Previously known as:

Kcnj16em1Mcwi

Is Marker For:

Strains: SS-Kcnj16^em1Mcwi-/-

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	10		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypokalemia (IMP)

metabolic acidosis (IMP)

Respiratory Underresponsiveness to Hypoxia and Hypercapnia (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IMP)

decreased circulating aldosterone level (IMP)

decreased circulating bicarbonate level (IMP)

decreased circulating potassium level (IMP)

decreased heart rate (IMP)

decreased renal glomerular filtration rate (IMP)

decreased systemic arterial blood pressure (IMP)

decreased urine microalbumin level (IMP)

hypercapnia (IMP)

hyperventilation (IMP)

hypokalemia (IMP)

increased blood urea nitrogen level (IMP)

increased circulating chloride level (IMP)

increased circulating magnesium level (IMP)

increased sensitivity to induced morbidity/mortality (IMP)

metabolic acidosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2.	Essential role of Kir5.1 channels in renal salt handling and blood pressure control.	Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis.	Puissant MM, etal., FASEB J. 2019 Apr;33(4):5067-5075. doi: 10.1096/fj.201802257R. Epub 2019 Jan 3.

Genomics

Related Rat Strains

The following Strains have been annotated to Kcnj16^em1Mcwi

SS-Kcnj16^em1Mcwi-/-

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype