Kcnj16<sup>em1Mcwi</sup> (potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Kcnj16em1Mcwi (potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin) Rattus norvegicus
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Symbol: Kcnj16em1Mcwi
Name: potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin
RGD ID: 6893423
Description: This allele was made by ZFN mutagenesis. The resulting allele is a 18-bp deletion in exon 1 (del 529-546)
ASSOCIATED WITH decreased body weight; decreased circulating aldosterone level; decreased circulating bicarbonate level; ASSOCIATED WITH hypokalemia; metabolic acidosis; Respiratory Underresponsiveness to Hypoxia and Hypercapnia
Type: allele  of Kcnj16  
Previously known as: Kcnj16em1Mcwi
Is Marker For: Strains:   SS-Kcnj16em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map10 RGD


References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Essential role of Kir5.1 channels in renal salt handling and blood pressure control. Palygin O, etal., JCI Insight. 2017 Sep 21;2(18). pii: 92331. doi: 10.1172/jci.insight.92331. eCollection 2017 Sep 21.
3. PhysGen Knockouts PhysGen Knockout strains
4. Genetic mutation of Kcnj16 identifies Kir5.1-containing channels as key regulators of acute and chronic pH homeostasis. Puissant MM, etal., FASEB J. 2019 Apr;33(4):5067-5075. doi: 10.1096/fj.201802257R. Epub 2019 Jan 3.

Genomics


Related Rat Strains
The following Strains have been annotated to Kcnj16em1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information