Hvcn1<sup>em2Mcwi</sup> (hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Hvcn1em2Mcwi (hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Hvcn1em2Mcwi
Name: hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 6893419
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 8-bp deletion in exon 5 (del 313-320)
ASSOCIATED WITH cerebral edema; ASSOCIATED WITH middle cerebral artery infarction
Type: allele  of Hvcn1  
Previously known as: Hvcn1em2Mcwi
Is Marker For: Strains:   SS-Hvcn1em2Mcwi-/-  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map12 RGD


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Li W, etal., Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142.
3. PhysGen Knockouts PhysGen Knockout strains

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Hvcn1em2Mcwi-var1 chr12 39829788 39829795 AAGTCCAG - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Hvcn1em2Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001079575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information