Sh2b3 (SH2B adaptor protein 3) - Rat Genome Database

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Gene: Sh2b3 (SH2B adaptor protein 3) Mus musculus
Analyze
Symbol: Sh2b3
Name: SH2B adaptor protein 3
RGD ID: 68608
MGI Page MGI
Description: Enables protein tyrosine kinase binding activity; signaling receptor complex adaptor activity; and stem cell factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; megakaryocyte development; and negative regulation of signal transduction. Acts upstream of or within with a negative effect on cellular response to chemokine. Acts upstream of or within embryonic hemopoiesis; hematopoietic stem cell differentiation; and intracellular signal transduction. Predicted to be active in plasma membrane. Is expressed in aorta-gonad-mesonephros; dorsal aorta; liver; lower jaw molar; and upper jaw molar. Used to study chronic myeloid leukemia. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to human SH2B3 (SH2B adaptor protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI429800; L; linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,953,544 - 121,975,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,953,551 - 121,975,709 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,815,488 - 121,837,646 (-)Ensemblmm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBIMGSCv36mm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (EXP)
FR900359  (ISO)
gentamycin  (ISO)
hexachlorobenzene  (ISO)
indometacin  (ISO)
inulin  (EXP)
isobutanol  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
methimazole  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrates  (EXP)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Flister MJ, etal., Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.
2. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. LNK protein: Low expression in human colorectal carcinoma and relationship with tumor invasion. Pan J, etal., Biomed Pharmacother. 2020 Jan;121:109467. doi: 10.1016/j.biopha.2019.109467. Epub 2019 Nov 6.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. Plagnol V, etal., PLoS Genet. 2011 Aug;7(8):e1002216. doi: 10.1371/journal.pgen.1002216. Epub 2011 Aug 4.
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Rudemiller NP, etal., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.
15. Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. Timofeeva MN, etal., Sci Rep. 2015 Nov 10;5:16286. doi: 10.1038/srep16286.
16. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
Additional References at PubMed
PMID:9169414   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11114373   PMID:11217851   PMID:11805142   PMID:12070287   PMID:12477932   PMID:12517931   PMID:12518435  
PMID:14612394   PMID:14766215   PMID:15337790   PMID:15489334   PMID:15705783   PMID:15747579   PMID:15782199   PMID:15935779   PMID:16141072   PMID:16141073   PMID:16332975   PMID:16882979  
PMID:17284614   PMID:17693582   PMID:18456388   PMID:18618018   PMID:18753636   PMID:19293402   PMID:19325148   PMID:19859984   PMID:20038804   PMID:20458146   PMID:20571037   PMID:20855498  
PMID:20870899   PMID:21113129   PMID:21267068   PMID:21310211   PMID:21677750   PMID:21873635   PMID:22101255   PMID:22496561   PMID:22546852   PMID:22614355   PMID:22812478   PMID:22942183  
PMID:23590807   PMID:23897412   PMID:23908464   PMID:24091439   PMID:24297922   PMID:24536025   PMID:25024389   PMID:25664851   PMID:25882670   PMID:26101343   PMID:26974155   PMID:27430239  
PMID:27793180   PMID:28067429   PMID:28526415   PMID:28611190   PMID:30110639   PMID:30254368   PMID:30333305   PMID:30755420   PMID:31110180   PMID:31301301   PMID:32629392   PMID:33495419  
PMID:34341450   PMID:34464969   PMID:34740959   PMID:34846914   PMID:38096361   PMID:38417019  


Genomics

Comparative Map Data
Sh2b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,953,544 - 121,975,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,953,551 - 121,975,709 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,815,488 - 121,837,646 (-)Ensemblmm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBIMGSCv36mm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
SH2B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,404,730 - 111,451,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,405,923 - 111,451,623 (+)Ensemblhg38GRCh38
GRCh3712111,843,727 - 111,889,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,328,135 - 110,373,810 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412110,306,471 - 110,352,146NCBI
Celera12111,470,186 - 111,515,861 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12108,858,506 - 108,903,968 (+)NCBIHuRef
CHM1_112111,811,712 - 111,857,391 (+)NCBICHM1_1
T2T-CHM13v2.012111,385,588 - 111,432,181 (+)NCBIT2T-CHM13v2.0
Sh2b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,391,755 - 40,414,336 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,392,633 - 40,414,335 (+)EnsemblGRCr8
mRatBN7.21234,731,934 - 34,753,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,904,822 - 35,926,500 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,516,036 - 36,537,714 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,568,505 - 35,590,183 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)Ensemblrn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,414,671 - 36,418,438 (+)NCBICelera
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Cytogenetic Map12q16NCBI
Sh2b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,096,160 - 8,097,765 (+)Ensembl
ChiLan1.0NW_0049554828,079,905 - 8,100,791 (+)NCBIChiLan1.0ChiLan1.0
SH2B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,471,325 - 119,518,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,467,715 - 119,514,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,977,344 - 109,024,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,371,797 - 112,418,746 (+)NCBIPanPan1.1PanPan1.1panPan2
SH2B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,033,851 - 9,073,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,005,281 - 9,070,204 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha269,206,973 - 9,235,670 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0269,303,831 - 9,332,542 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,292,891 - 9,329,651 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,259,823 - 9,288,511 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,322,052 - 9,350,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,275,536 - 9,304,251 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh2b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,352,543 - 155,375,181 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,104,534 - 4,123,869 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,103,898 - 4,126,883 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,623,286 - 32,664,606 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11432,623,286 - 32,664,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,618,865 - 34,660,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH2B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,657,601 - 106,703,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,670,685 - 106,700,619 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037138,394,084 - 138,440,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,730,751 - 20,759,625 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474720,729,142 - 20,759,631 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh2b3
809 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:2746
Count of miRNA genes:684
Interacting mature miRNAs:834
Transcripts:ENSMUST00000040308, ENSMUST00000086310, ENSMUST00000118580, ENSMUST00000122426, ENSMUST00000136960, ENSMUST00000137682
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1301974Chab7_mcholesterol absorption 7 (mouse)Not determined595233214129233330Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357662Lprq4_mlipoprotein QTL 4 (mouse)Not determined5114021753129632606Mouse
14746986Manh58_mmandible shape 58 (mouse)5102446283136446283Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
10412239Alpq7_malcohol preference QTL 7 (mouse)Not determined5104705939138705939Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
1357644Egrd1_mearly growth rate, direct effect 1 (mouse)Not determined595434580129434786Mouse
12859290Criq2_mCitrobacter rodentium infection QTL 2 (mouse)5101332579135332579Mouse
1300940Actd3_mactivity-distance traveled 3 (mouse)Not determined596320385130320533Mouse
1300659Pcd8ts1_mp-glycoprotein positive CD8 T cell subset 1 (mouse)Not determined597021753131021986Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
1558774Lith17_mlithogenic gene 17 (mouse)Not determined595465549129465722Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
10402486Dipa1_mdrug induced psychomotor activation 1 (mouse)Not determined595465549129465722Mouse
1301624Aevm2_mautoimmune extremity vasculitis in MRL mice 2 (mouse)Not determined5101863832135864028Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
4141139Hmtb4_mhemostasis and thrombosis rebleeding time 4 (mouse)Not determined108762509126882944Mouse
11532736Sluc33b_msusceptibility to lung cancer 33b (mouse)5102945037136945196Mouse
4141519Hmtb5_mhemostasis and thrombosis bleeding time 5 (mouse)Not determined99949422126882944Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
1301858Smdq1_msegregation of mitochondrial DNA QTL 1 (mouse)Not determined597021753131021986Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412202Bbaa26_mB.burgdorferi-associated arthritis 26 (mouse)Not determined5104583688138555455Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
12904945Tammq2_mtibialis anterior muscle mass QTL 2 (mouse)5100665965134665965Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13464244Ahl19_mage related hearing loss, early onset 19 (mouse)595465549129465722Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
12904959Smmq1_msoleus muscle mass QTL 1 (mouse)5100665965134665965Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1301102Cia14_mcollagen induced arthritis 14 (mouse)Not determined5113320385138555455Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse

Markers in Region
AW476061  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,853,331 - 121,853,470UniSTSGRCm38
MGSCv375122,303,340 - 122,303,479UniSTSGRCm37
Celera5118,943,708 - 118,943,847UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Whitehead/MRC_RH51482.84UniSTS
AI429800  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,815,636 - 121,815,839UniSTSGRCm38
MGSCv375122,265,645 - 122,265,848UniSTSGRCm37
Celera5118,905,798 - 118,906,001UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Whitehead/MRC_RH51480.21UniSTS
UniSTS:235300  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385121,817,855 - 121,818,094UniSTSGRCm38
MGSCv375122,267,864 - 122,268,103UniSTSGRCm37
Celera5118,908,017 - 118,908,256UniSTS
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS
Lnk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5FUniSTS
cM Map565.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001306126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001306128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006530173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036164833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK156499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK157297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP762530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000040308   ⟹   ENSMUSP00000041611
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,955,279 - 121,974,913 (-)Ensembl
GRCm38.p6 Ensembl5121,817,216 - 121,836,850 (-)Ensembl
Ensembl Acc Id: ENSMUST00000086310   ⟹   ENSMUSP00000083490
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,953,711 - 121,974,922 (-)Ensembl
GRCm38.p6 Ensembl5121,815,648 - 121,836,859 (-)Ensembl
Ensembl Acc Id: ENSMUST00000118580   ⟹   ENSMUSP00000113808
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,955,353 - 121,974,880 (-)Ensembl
GRCm38.p6 Ensembl5121,817,290 - 121,836,817 (-)Ensembl
Ensembl Acc Id: ENSMUST00000122426   ⟹   ENSMUSP00000113926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,955,073 - 121,974,167 (-)Ensembl
GRCm38.p6 Ensembl5121,817,010 - 121,836,104 (-)Ensembl
Ensembl Acc Id: ENSMUST00000136960   ⟹   ENSMUSP00000119086
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,953,551 - 121,974,888 (-)Ensembl
GRCm38.p6 Ensembl5121,815,488 - 121,836,825 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137682   ⟹   ENSMUSP00000118523
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,966,631 - 121,974,327 (-)Ensembl
GRCm38.p6 Ensembl5121,828,568 - 121,836,264 (-)Ensembl
Ensembl Acc Id: ENSMUST00000197892   ⟹   ENSMUSP00000142666
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,957,170 - 121,975,709 (-)Ensembl
GRCm38.p6 Ensembl5121,819,107 - 121,837,646 (-)Ensembl
Ensembl Acc Id: ENSMUST00000198161   ⟹   ENSMUSP00000143505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5121,954,375 - 121,966,804 (-)Ensembl
GRCm38.p6 Ensembl5121,816,312 - 121,828,741 (-)Ensembl
RefSeq Acc Id: NM_001306126   ⟹   NP_001293055
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,329 (-)NCBI
GRCm385121,815,481 - 121,836,104 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001306127   ⟹   NP_001293056
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,890 (-)NCBI
GRCm385121,815,481 - 121,836,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001306128   ⟹   NP_001293057
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,890 (-)NCBI
GRCm385121,815,481 - 121,836,859 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008507   ⟹   NP_032533
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,890 (-)NCBI
GRCm385121,815,481 - 121,836,859 (-)NCBI
MGSCv375122,267,224 - 122,286,810 (-)RGD
Celera5118,907,377 - 118,942,299 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530170   ⟹   XP_006530233
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,206 (-)NCBI
GRCm385121,815,481 - 121,836,023 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530171   ⟹   XP_006530234
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,975,706 (-)NCBI
GRCm385121,815,481 - 121,837,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530172   ⟹   XP_006530235
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,322 (-)NCBI
GRCm385121,815,481 - 121,836,259 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006530173   ⟹   XP_006530236
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,974,561 (-)NCBI
GRCm385121,815,481 - 121,836,765 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164833   ⟹   XP_036020726
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395121,953,544 - 121,975,703 (-)NCBI
Sequence:
RefSeq Acc Id: NP_032533   ⟸   NM_008507
- Peptide Label: isoform 1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530234   ⟸   XM_006530171
- Peptide Label: isoform X1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530236   ⟸   XM_006530173
- Peptide Label: isoform X1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530235   ⟸   XM_006530172
- Peptide Label: isoform X1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530233   ⟸   XM_006530170
- Peptide Label: isoform X1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001293057   ⟸   NM_001306128
- Peptide Label: isoform 2
- UniProtKB: D3Z3Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001293056   ⟸   NM_001306127
- Peptide Label: isoform 1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001293055   ⟸   NM_001306126
- Peptide Label: isoform 1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000143505   ⟸   ENSMUST00000198161
Ensembl Acc Id: ENSMUSP00000083490   ⟸   ENSMUST00000086310
Ensembl Acc Id: ENSMUSP00000142666   ⟸   ENSMUST00000197892
Ensembl Acc Id: ENSMUSP00000113808   ⟸   ENSMUST00000118580
Ensembl Acc Id: ENSMUSP00000041611   ⟸   ENSMUST00000040308
Ensembl Acc Id: ENSMUSP00000118523   ⟸   ENSMUST00000137682
Ensembl Acc Id: ENSMUSP00000119086   ⟸   ENSMUST00000136960
Ensembl Acc Id: ENSMUSP00000113926   ⟸   ENSMUST00000122426
RefSeq Acc Id: XP_036020726   ⟸   XM_036164833
- Peptide Label: isoform X1
- UniProtKB: O09039 (UniProtKB/Swiss-Prot)
Protein Domains
PH   Phenylalanine zipper   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09039-F1-model_v2 AlphaFold O09039 1-548 view protein structure

Promoters
RGD ID:6887942
Promoter ID:EPDNEW_M7422
Type:initiation region
Name:Sh2b3_1
Description:Mus musculus SH2B adaptor protein 3 , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385121,836,827 - 121,836,887EPDNEW
RGD ID:6847952
Promoter ID:MM_ACW:39329
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   Spleen
Transcripts:SH2B3.ISEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,278,431 - 122,279,082 (-)MPROMDB
RGD ID:6838332
Promoter ID:MM_KWN:43912
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000086310,   ENSMUST00000122426,   OTTMUST00000073988,   OTTMUST00000073989,   OTTMUST00000073992,   UC008ZKI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365122,286,031 - 122,287,737 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:893598 AgrOrtholog
Ensembl Genes ENSMUSG00000042594 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040308 ENTREZGENE
  ENSMUST00000040308.14 UniProtKB/Swiss-Prot
  ENSMUST00000086310 ENTREZGENE
  ENSMUST00000086310.8 UniProtKB/Swiss-Prot
  ENSMUST00000118580 ENTREZGENE
  ENSMUST00000122426 ENTREZGENE
  ENSMUST00000122426.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  6.10.140.110 UniProtKB/Swiss-Prot
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot
  Phe_ZIP UniProtKB/Swiss-Prot
  Phe_ZIP_sf UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SH2B UniProtKB/Swiss-Prot
  SH2B3_SH2 UniProtKB/Swiss-Prot
KEGG Report mmu:16923 UniProtKB/Swiss-Prot
MGD MGI:893598 ENTREZGENE
NCBI Gene 16923 ENTREZGENE
PANTHER PTHR10872 UniProtKB/Swiss-Prot
  PTHR10872:SF1 UniProtKB/Swiss-Prot
Pfam Phe_ZIP UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Sh2b3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
SMART SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF109805 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
UniProt A0A0G2JE79_MOUSE UniProtKB/TrEMBL
  A0A0G2JGB8_MOUSE UniProtKB/TrEMBL
  D3Z0T9_MOUSE UniProtKB/TrEMBL
  D3Z3Y5 ENTREZGENE, UniProtKB/TrEMBL
  D6RCY9_MOUSE UniProtKB/TrEMBL
  O09039 ENTREZGENE, UniProtKB/Swiss-Prot