Lrp2 (low density lipoprotein receptor-related protein 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Lrp2 (low density lipoprotein receptor-related protein 2) Mus musculus
Analyze
Symbol: Lrp2
Name: low density lipoprotein receptor-related protein 2
RGD ID: 68600
MGI Page MGI
Description: Predicted to enable several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including circulatory system development; nervous system development; and reproductive structure development. Acts upstream of or within several processes, including circulatory system development; cranial skeletal system development; and vitamin D metabolic process. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; heart and pericardium; metanephros; ureter; and ventricular layer. Used to study Donnai-Barrow syndrome; Fanconi syndrome; and degenerative myopia. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI315343; AW536255; b2b1625.2Clo; D230004K18Rik; glycoprotein 330; Gp33; Gp330; low-density lipoprotein receptor-related protein 2; LRP-2; Meg; Megalin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
afimoxifene  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
aspartame  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calciol  (EXP)
carbamazepine  (ISO)
chenodeoxycholic acid  (EXP)
chloroprene  (EXP)
cholic acid  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP)
clobetasol  (EXP)
cobalt dichloride  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (EXP)
diiodine  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
fenamidone  (EXP)
folic acid  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
guggulsterone  (EXP)
hydrogen peroxide  (ISO)
lithocholic acid  (EXP)
manganese(II) chloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
O-methyleugenol  (ISO)
ozone  (EXP)
panobinostat  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phosgene  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vitamin D  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (ISO)
animal organ regeneration  (ISO)
aorta development  (IMP)
cell population proliferation  (IMP)
cellular response to growth factor stimulus  (ISO)
chemoattraction of axon  (ISO)
coronary artery morphogenesis  (IMP)
coronary vasculature development  (IMP)
cranial skeletal system development  (IMP)
diol metabolic process  (IMP)
endocytic hemoglobin import into cell  (ISO)
endocytosis  (ISO)
endosomal transport  (ISO)
folate import across plasma membrane  (IMP)
forebrain development  (IMP)
gene expression  (IMP)
heart development  (IMP)
kidney development  (IMP)
male gonad development  (IMP)
metal ion transport  (ISO)
metanephric proximal tubule development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (IMP)
nervous system development  (IEA)
neural tube closure  (IMP)
neuron projection arborization  (IMP)
outflow tract morphogenesis  (IMP)
outflow tract septum morphogenesis  (IMP)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of lipoprotein transport  (ISO)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (IMP)
positive regulation of oligodendrocyte progenitor proliferation  (IMP)
protein import  (ISO)
protein transport  (IDA,ISO)
pulmonary artery morphogenesis  (IMP)
receptor-mediated endocytosis  (IBA,IDA,IMP,ISO)
response to leptin  (IDA,ISO)
response to retinoic acid  (ISO)
response to vitamin D  (ISO)
response to X-ray  (ISO)
response to xenobiotic stimulus  (ISO)
secondary heart field specification  (IMP)
sensory perception of sound  (IMP)
transcytosis  (ISO)
vagina development  (IMP)
ventricular compact myocardium morphogenesis  (IMP)
ventricular septum development  (IMP)
vitamin D metabolic process  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aortic arch morphology  (IEA)
abnormal bone mineralization  (IAGP)
abnormal bone remodeling  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cerebellum fissure morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal choroid plexus morphology  (IAGP)
abnormal circulating mineral level  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal ear physiology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal intraocular pressure  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal myocardium compact layer morphology  (IEA)
abnormal olfactory bulb morphology  (IAGP)
abnormal optic nerve morphology  (IAGP)
abnormal placement of pupils  (IAGP)
abnormal posterior eye segment morphology  (IAGP)
abnormal proximal convoluted tubule morphology  (IAGP)
abnormal renal reabsorption  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina pigment epithelium morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal sclera morphology  (IAGP)
abnormal selenium level  (IAGP)
abnormal strial marginal cell morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal testis development  (IAGP)
abnormal testis morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
abnormal viscerocranium morphology  (IAGP)
abnormal vitamin D level  (IAGP)
absent corpus callosum  (IAGP)
absent nasal septum  (IAGP)
absent olfactory bulb  (IAGP)
albuminuria  (IAGP)
anophthalmia  (IAGP)
atelectasis  (IAGP)
choroid plexus hyperplasia  (IAGP)
cleft palate  (IAGP)
cyanosis  (IAGP)
decreased bone mineral content  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating calcium level  (IAGP)
decreased embryo size  (IAGP)
decreased glutathione peroxidase activity  (IAGP)
decreased retina ganglion cell number  (IAGP)
decreased total retina thickness  (IAGP)
delayed neural tube closure  (IAGP)
dilated uterus  (IAGP)
emphysema  (IAGP)
exencephaly  (IAGP)
flat forehead  (IAGP)
heart left ventricle hypertrophy  (IEA)
heart right ventricle hypertrophy  (IEA)
high myopia  (IAGP)
holoprosencephaly  (IAGP)
hydronephrosis  (IEA)
impaired coordination  (IAGP)
impaired hearing  (IAGP)
increased apoptosis  (IAGP)
increased bone resorption  (IAGP)
increased circulating dihydrotestosterone level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased circulating testosterone level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased retina apoptosis  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
increased urine microglobulin level  (IAGP)
increased urine protein level  (IAGP)
increased urine selenium level  (IAGP)
kidney cyst  (IEA)
kinked tail  (IEA)
macrophthalmia  (IAGP)
micrognathia  (IEA)
microphthalmia  (IAGP)
muscular ventricular septal defect  (IEA)
neonatal lethality, incomplete penetrance  (IAGP)
ocular hypotelorism  (IAGP)
omphalocele  (IEA)
osteomalacia  (IAGP)
overexpanded pulmonary alveolus  (IAGP)
perimembraneous ventricular septal defect  (IEA)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
persistent truncus arteriosus  (IEA)
persistent truncus arteriosus type i  (IEA)
respiratory failure  (IAGP)
right aortic arch  (IEA)
round forehead  (IAGP)
sclera thinning  (IAGP)
short snout  (IAGP)
small embryonic telencephalon  (IAGP)
small olfactory bulb  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina inner plexiform layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thymus hypoplasia  (IEA)
umbilical hernia  (IEA)
unilateral cryptorchism  (IAGP)
vaginal septum  (IAGP)
vascular ring  (IEA)
ventricular septal defect  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
2. A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland. Jiang Y, etal., J Biol Chem 1996 May 3;271(18):10723-30.
3. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
4. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Magyar CE, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69.
5. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis. Marino M, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2468-74.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Tojo A, etal., Histochem Cell Biol. 2001 Sep;116(3):269-76.
17. Modulation of gene expression by moxonidine in rats with chronic renal failure. Vonend O, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2217-22. Epub 2004 Jul 20.
18. Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease. Witzgall R, etal., Kidney Int. 2002 Jan;61(1 Suppl):132-7.
19. Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. Yammani RR, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R339-46.
Additional References at PubMed
PMID:7656578   PMID:7720568   PMID:8244399   PMID:8710893   PMID:8827514   PMID:9457688   PMID:9546356   PMID:9616220   PMID:9727058   PMID:10052453   PMID:10073957   PMID:10203351  
PMID:10349636   PMID:10438476   PMID:10469351   PMID:10514418   PMID:10535319   PMID:10556425   PMID:10662735   PMID:10665926   PMID:10725249   PMID:10766831   PMID:10772929   PMID:10811843  
PMID:10827173   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11208732   PMID:11217851   PMID:11544199   PMID:11675412   PMID:11832420   PMID:12370429   PMID:12371967   PMID:12413896  
PMID:12475886   PMID:12477932   PMID:12508107   PMID:12520002   PMID:12724130   PMID:12748857   PMID:12815097   PMID:12904583   PMID:14610273   PMID:14657389   PMID:14983511   PMID:15005800  
PMID:15034091   PMID:15082773   PMID:15314648   PMID:15342463   PMID:15616221   PMID:15623804   PMID:15870384   PMID:15878230   PMID:15976002   PMID:16099815   PMID:16141072   PMID:16141073  
PMID:16143106   PMID:16177003   PMID:16196028   PMID:16251603   PMID:16263760   PMID:16306401   PMID:16319116   PMID:16380466   PMID:16602821   PMID:16787536   PMID:16901941   PMID:17063000  
PMID:17077144   PMID:17283184   PMID:17324488   PMID:17339320   PMID:17369355   PMID:17389516   PMID:17460141   PMID:17462596   PMID:17846082   PMID:18005667   PMID:18083160   PMID:18174160  
PMID:18287559   PMID:18322545   PMID:18388738   PMID:18400109   PMID:18769366   PMID:19047013   PMID:19177150   PMID:19279259   PMID:19367412   PMID:19416849   PMID:19521566   PMID:20048263  
PMID:20357188   PMID:20460439   PMID:20531455   PMID:20637285   PMID:20653565   PMID:20798259   PMID:20966072   PMID:21170526   PMID:21267068   PMID:21311715   PMID:21337463   PMID:21444625  
PMID:21818577   PMID:21873635   PMID:21926402   PMID:21938401   PMID:21939757   PMID:22340494   PMID:22354480   PMID:22496890   PMID:22555591   PMID:22999937   PMID:23048173   PMID:23362348  
PMID:23382219   PMID:23430977   PMID:23554936   PMID:23592779   PMID:23651543   PMID:23673647   PMID:23825075   PMID:23826131   PMID:23836931   PMID:23968836   PMID:24140060   PMID:24254699  
PMID:24277939   PMID:24434121   PMID:24586199   PMID:24639464   PMID:24740791   PMID:24760755   PMID:24825475   PMID:24950692   PMID:24980834   PMID:25270072   PMID:25807483   PMID:26107939  
PMID:26206087   PMID:26439398   PMID:26534923   PMID:26786190   PMID:26822476   PMID:27002738   PMID:27213360   PMID:27382987   PMID:27518433   PMID:27591083   PMID:27773703   PMID:27796299  
PMID:27820600   PMID:28087629   PMID:28143489   PMID:28167773   PMID:28190767   PMID:28226240   PMID:28289043   PMID:28331063   PMID:28351841   PMID:28366874   PMID:28527294   PMID:28575050  
PMID:28659595   PMID:28678521   PMID:28847650   PMID:29032953   PMID:29186471   PMID:29449453   PMID:29916093   PMID:30025861   PMID:30046000   PMID:30401801   PMID:30485812   PMID:30567480  
PMID:30665232   PMID:30940800   PMID:31308417   PMID:31548351   PMID:31740596   PMID:31923383   PMID:31937343   PMID:32179912   PMID:32200668   PMID:32290105   PMID:32325033   PMID:32504627  
PMID:32736701   PMID:32876567   PMID:32901292   PMID:33069809   PMID:33103447   PMID:33230847   PMID:33500317   PMID:33737325   PMID:34066779   PMID:34321999   PMID:34341182   PMID:34370295  
PMID:34445520   PMID:34463328   PMID:34511037   PMID:34709266   PMID:34747197   PMID:35055044   PMID:35230973   PMID:35341793   PMID:35716070   PMID:35781329   PMID:35833708   PMID:36325513  
PMID:36445780   PMID:36750096   PMID:36764939   PMID:36807241   PMID:37126375   PMID:37215091   PMID:37406929   PMID:37682076   PMID:37702891  


Genomics

Comparative Map Data
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,127,109 - 169,362,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
T2T-CHM13v2.02169,602,803 - 169,838,534 (-)NCBIT2T-CHM13v2.0
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,597,148 - 74,754,535 (-)NCBIGRCr8
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,791,193 - 72,028,996 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,025,608 - 14,223,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBIUU_Cfam_GSD_1.0
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,244,881 - 10,438,935 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,798,938 - 6,998,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp2
6314 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:861
Count of miRNA genes:501
Interacting mature miRNAs:604
Transcripts:ENSMUST00000080953, ENSMUST00000092551, ENSMUST00000100051, ENSMUST00000128742
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
13432174Actres5_mactivity response to ethanol/saline 5 (mouse)25989228769792287Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
13432184Actdes1_mactivity chamber total difference ethanol/saline 1 (mouse)25939228769292287Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
13432178Actres2_mactivity response to ethanol/saline 2 (mouse)26069228774092287Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26759194074964933Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse

Markers in Region
AW536255  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,755 - 69,424,873UniSTSGRCm38
MGSCv37269,262,812 - 69,262,930UniSTSGRCm37
Celera271,090,269 - 71,090,387UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Whitehead/MRC_RH21100.11UniSTS
MHAa84g10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,501,875 - 69,502,026UniSTSGRCm38
MGSCv37269,339,932 - 69,340,083UniSTSGRCm37
Celera271,167,623 - 71,167,774UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Whitehead_YAC2 UniSTS
D2Mit327  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,465,036 - 69,465,161UniSTSGRCm38
MGSCv37269,303,093 - 69,303,218UniSTSGRCm37
Celera271,130,458 - 71,130,585UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.4UniSTS
Whitehead Genetic240.4UniSTS
D2Mit524  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,570,569 - 69,570,665UniSTSGRCm38
MGSCv37269,408,626 - 69,408,722UniSTSGRCm37
Cytogenetic Map2C2UniSTS
cM Map240.4UniSTS
Whitehead Genetic240.4UniSTS
Whitehead/MRC_RH21097.19UniSTS
AI315343  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,485 - 69,424,646UniSTSGRCm38
MGSCv37269,262,542 - 69,262,703UniSTSGRCm37
Celera271,089,999 - 71,090,160UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Whitehead/MRC_RH21099.55UniSTS
UniSTS:234416  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,424,710 - 69,424,974UniSTSGRCm38
MGSCv37269,262,767 - 69,263,031UniSTSGRCm37
Celera271,090,224 - 71,090,488UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Lrp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,425,638 - 69,425,786UniSTSGRCm38
MGSCv37269,263,695 - 69,263,843UniSTSGRCm37
Celera271,091,152 - 71,091,300UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
RH126651  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,519,228 - 69,519,428UniSTSGRCm38
MGSCv37269,357,285 - 69,357,485UniSTSGRCm37
Celera271,184,947 - 71,185,147UniSTS
Cytogenetic Map2C2UniSTS
cM Map240.0UniSTS
Whitehead/MRC_RH21100.21UniSTS
Lrp2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2C2UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000080953   ⟹   ENSMUSP00000079752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,254,684 - 69,416,409 (-)Ensembl
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)Ensembl
Ensembl Acc Id: ENSMUST00000092551   ⟹   ENSMUSP00000090212
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,356,710 - 69,416,373 (-)Ensembl
GRCm38.p6 Ensembl269,526,366 - 69,586,029 (-)Ensembl
Ensembl Acc Id: ENSMUST00000100051   ⟹   ENSMUSP00000097628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,336,548 - 69,416,373 (-)Ensembl
GRCm38.p6 Ensembl269,506,204 - 69,586,029 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128742
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,337,967 - 69,339,489 (-)Ensembl
GRCm38.p6 Ensembl269,507,623 - 69,509,145 (-)Ensembl
RefSeq Acc Id: NM_001081088   ⟹   NP_001074557
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,254,679 - 69,416,373 (-)NCBI
GRCm38269,424,335 - 69,586,029 (-)NCBI
MGSCv37269,262,392 - 69,424,124 (-)RGD
Celera271,089,849 - 71,251,632 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001074557   ⟸   NM_001081088
- Peptide Label: precursor
- UniProtKB: Q3TL35 (UniProtKB/Swiss-Prot),   P70215 (UniProtKB/Swiss-Prot),   Q9JLB3 (UniProtKB/Swiss-Prot),   A2ARV4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000090212   ⟸   ENSMUST00000092551
Ensembl Acc Id: ENSMUSP00000097628   ⟸   ENSMUST00000100051
Ensembl Acc Id: ENSMUSP00000079752   ⟸   ENSMUST00000080953
Protein Domains
EGF-like   EGF-like calcium-binding   LDL-receptor class A

Promoters
RGD ID:6831731
Promoter ID:MM_KWN:29540
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000031296
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,346,871 - 69,347,371 (-)MPROMDB
RGD ID:6831730
Promoter ID:MM_KWN:29541
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Lung
Transcripts:NM_001081088,   OTTMUST00000031295,   UC008JYD.1,   UC008JYE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,423,726 - 69,424,226 (-)MPROMDB
RGD ID:6877498
Promoter ID:EPDNEW_M2199
Type:initiation region
Name:Lrp2_1
Description:Mus musculus low density lipoprotein receptor-related protein2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38269,586,029 - 69,586,089EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95794 AgrOrtholog
Ensembl Genes ENSMUSG00000027070 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSMUSG00000068892
Ensembl Transcript ENSMUST00000080953 ENTREZGENE
  ENSMUST00000080953.12 UniProtKB/Swiss-Prot
  ENSMUST00000092551.5 UniProtKB/TrEMBL
  ENSMUST00000100051.9 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report mmu:14725 UniProtKB/Swiss-Prot
MGD MGI:95794 ENTREZGENE
NCBI Gene 14725 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEGALIN, ISOFORM A UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LRP2 RGD
PhenoGen Lrp2 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ARV4 ENTREZGENE
  A2ARV5_MOUSE UniProtKB/TrEMBL
  LRP2_MOUSE UniProtKB/Swiss-Prot
  P70215 ENTREZGENE
  Q3TL35 ENTREZGENE
  Q3V346_MOUSE UniProtKB/TrEMBL
  Q9JLB3 ENTREZGENE
UniProt Secondary P70215 UniProtKB/Swiss-Prot
  Q3TL35 UniProtKB/Swiss-Prot
  Q9JLB3 UniProtKB/Swiss-Prot