Epas1 (endothelial PAS domain protein 1) - Rat Genome Database

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Gene: Epas1 (endothelial PAS domain protein 1) Mus musculus
Analyze
Symbol: Epas1
Name: endothelial PAS domain protein 1
RGD ID: 68595
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in mRNA transcription by RNA polymerase II; myoblast fate commitment; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; norepinephrine metabolic process; and surfactant homeostasis. Located in cytoplasm and nuclear speck. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bHLHe7; bHLHe73; endothelial PAS domain-containing protein 1; EPAS-1; HIF; Hif like protein; HIF-1-alpha-like factor; HIF-2; HIF-2-alpha; HIF-2alpha; HIF-related factor; HIF1 alpha-like factor; HIF1alpha-like factor; HIF2-alpha; HIF2A; HL; HLF; HLF (HIF1alpha-like factor); HR; HRF; hypoxia inducible transcription factor 2alpha; hypoxia-inducible factor 2-alpha; mHLF; MO; MOP2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,061,292 - 87,140,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)EnsemblGRCm39 Ensembl
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBIMGSCv36mm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-benzimidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dihydroxybenzoate  (EXP)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroperoxycyclophosphamide  (EXP)
4-hydroxy-TEMPO  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP)
carbon nanotube  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
ciglitazone  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
DDT  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
desferrioxamine B  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl malate  (EXP)
diethylstilbestrol  (ISO)
diisononyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenamidone  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
galangin  (ISO)
glutathione  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indoxyl sulfate  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
ketoconazole  (ISO)
ketorolac  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
leflunomide  (ISO)
letrozole  (EXP)
LY294002  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
mithramycin  (ISO)
molibresib  (ISO)
myxothiazol  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitric oxide  (EXP)
nitrofen  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphane  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
protoporphyrin  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
sodium cyanide  (ISO)
sotorasib  (ISO)
squalene  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar lamellar body morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal heart morphology  (IEA)
abnormal heart right ventricle pressure  (IAGP)
abnormal hematopoietic system physiology  (IAGP)
abnormal lung development  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal physiological neovascularization  (IAGP)
abnormal physiological response to hypoxia  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal retina inner nuclear layer morphology  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
abnormal surfactant secretion  (IAGP)
abnormal type I cell of carotid body physiology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
anemia  (IAGP)
atelectasis  (IAGP)
congestive heart failure  (IAGP)
cyanosis  (IAGP)
decreased birth body size  (IAGP)
decreased bone trabecula number  (IAGP)
decreased circulating erythropoietin level  (IAGP)
decreased circulating iron level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased heart rate  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased trabecular bone volume  (IAGP)
decreased type II pneumocyte number  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enlarged spleen  (IAGP)
heart left ventricle hypertrophy  (IAGP)
heart vascular congestion  (IAGP)
hemorrhage  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased erythrocyte cell number  (IAGP)
increased heart weight  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
increased leukocyte cell number  (IAGP)
increased lymphocyte cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased spleen weight  (IAGP)
increased total body fat amount  (IEA)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
liver vascular congestion  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
pulmonary artery hypoplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
reticulocytopenia  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thick ventricular wall  (IAGP)
visceral vascular congestion  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Intestinal HIF2alpha promotes tissue-iron accumulation in disorders of iron overload with anemia. Anderson ER, etal., Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4922-30. doi: 10.1073/pnas.1314197110. Epub 2013 Nov 26.
2. Regional expression of the hypoxia-inducible factor (HIF) system and association with cardiomyocyte cell cycle re-entry after myocardial infarction in rats. Bai CG, etal., Heart Vessels. 2008 May;23(3):193-200. Epub 2008 May 17.
3. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Bernhardt WM, etal., Am J Pathol. 2007 Mar;170(3):830-42.
4. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. Bernhardt WM, etal., J Am Soc Nephrol. 2006 Jul;17(7):1970-8. Epub 2006 Jun 8.
5. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
6. Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation. Gale DP, etal., Blood. 2008 Aug 1;112(3):919-21. doi: 10.1182/blood-2008-04-153718.
7. Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Giatromanolaki A, etal., Arthritis Res Ther. 2003;5(4):R193-201. Epub 2003 Apr 29.
8. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
9. Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. Jurgensen JS, etal., FASEB J. 2004 Sep;18(12):1415-7. Epub 2004 Jul 9.
10. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Keith B, etal., Nat Rev Cancer. 2011 Dec 15;12(1):9-22. doi: 10.1038/nrc3183.
11. Differential expression of three hypoxia-inducible factor-alpha subunits in pulmonary arteries of rat with hypoxia-induced hypertension. Li QF and Dai AG, Acta Biochim Biophys Sin (Shanghai). 2005 Oct;37(10):665-72.
12. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Liu MY, etal., Cancer Res. 2003 May 15;63(10):2675-80.
13. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
14. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Luo B, etal., Biochim Biophys Acta. 2013 Aug;1832(8):1260-70. doi: 10.1016/j.bbadis.2013.04.015. Epub 2013 Apr 17.
15. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Int6 silencing causes induction of angiogenic factors in neuronal cells via accumulation of hypoxia-inducible factor 2alpha and decreases brain damage in rats. Miyashita R, etal., Neurosci Lett. 2012 Oct 18;528(1):83-8. doi: 10.1016/j.neulet.2012.08.033. Epub 2012 Aug 28.
19. A large-scale replication study for the association of rs17039192 in HIF-2alpha with knee osteoarthritis. Nakajima M, etal., J Orthop Res. 2012 Aug;30(8):1244-8. doi: 10.1002/jor.22063. Epub 2012 Jan 13.
20. Cobalt ameliorates renal injury in an obese, hypertensive type 2 diabetes rat model. Ohtomo S, etal., Nephrol Dial Transplant. 2008 Apr;23(4):1166-72. Epub 2007 Oct 28.
21. Silencing of int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease. Okamoto N, etal., Cardiovasc Res. 2011 Nov 1;92(2):209-17. doi: 10.1093/cvr/cvr203. Epub 2011 Jul 19.
22. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
23. Sildenafil alleviates bronchopulmonary dysplasia in neonatal rats by activating the hypoxia-inducible factor signaling pathway. Park HS, etal., Am J Respir Cell Mol Biol. 2013 Jan;48(1):105-13. doi: 10.1165/rcmb.2012-0043OC. Epub 2012 Oct 11.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Proper SP, etal., Toxicol Sci. 2014 Feb;137(2):447-57. doi: 10.1093/toxsci/kft253. Epub 2013 Nov 11.
27. Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia. Rajakumar A, etal., Biol Reprod. 2001 Feb;64(2):499-506.
28. Hepatic changes of erythropoietin gene expression in a rat model of acute-phase response. Ramadori P, etal., Liver Int. 2010 Jan;30(1):55-64. doi: 10.1111/j.1478-3231.2009.02131.x. Epub 2009 Oct 13.
29. Mouse MP Annotation Import Pipeline RGD automated import pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Upregulation of hypoxia-inducible factors in normal and psoriatic skin. Rosenberger C, etal., J Invest Dermatol. 2007 Oct;127(10):2445-52. Epub 2007 May 10.
33. Cellular responses to hypoxia after renal segmental infarction. Rosenberger C, etal., Kidney Int. 2003 Sep;64(3):874-86.
34. Adaptation to hypoxia in the diabetic rat kidney. Rosenberger C, etal., Kidney Int. 2008 Jan;73(1):34-42. Epub 2007 Oct 3.
35. Hypoxia-inducible factor-2alpha regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Ryu JH, etal., Cell Death Differ. 2012 Mar;19(3):440-50. doi: 10.1038/cdd.2011.111. Epub 2011 Aug 26.
36. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Saito T, etal., Nat Med. 2010 Jun;16(6):678-86. doi: 10.1038/nm.2146. Epub 2010 May 23.
37. Searching for novel molecular targets of chronic rejection in an orthotopic experimental lung transplantation model. Santana-Rodriguez N, etal., J Heart Lung Transplant. 2012 Feb;31(2):213-21. doi: 10.1016/j.healun.2011.11.011.
38. Renal tubular HIF-2alpha expression requires VHL inactivation and causes fibrosis and cysts. Schietke RE, etal., PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27.
39. The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Scortegagna M, etal., Blood. 2003 Sep 1;102(5):1634-40. Epub 2003 May 15.
40. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Scortegagna M, etal., Nat Genet 2003 Dec;35(4):331-40. Epub 2003 Nov 9.
41. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Tian H, etal., Genes Dev 1997 Jan 1;11(1):72-82.
42. EPAS1 Gene Polymorphisms Are Associated With High Altitude Polycythemia in Tibetans at the Qinghai-Tibetan Plateau. Xu J, etal., Wilderness Environ Med. 2015 Sep;26(3):288-94. doi: 10.1016/j.wem.2015.01.002. Epub 2015 Mar 16.
43. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Yang S, etal., Nat Med. 2010 Jun;16(6):687-93. doi: 10.1038/nm.2153. Epub 2010 May 23.
44. Long-term exposure to hypoxia inhibits tumor progression of lung cancer in rats and mice. Yu L and Hales CA, BMC Cancer. 2011 Aug 3;11:331. doi: 10.1186/1471-2407-11-331.
Additional References at PubMed
PMID:9113979   PMID:9178256   PMID:9398602   PMID:9545558   PMID:9576906   PMID:9704006   PMID:9808618   PMID:10349636   PMID:10395786   PMID:10580084   PMID:10813585   PMID:10880563  
PMID:11042159   PMID:11076861   PMID:11172053   PMID:11217851   PMID:11304494   PMID:11447259   PMID:11782478   PMID:11823643   PMID:11839666   PMID:11983697   PMID:12053176   PMID:12080085  
PMID:12464608   PMID:12466851   PMID:12477932   PMID:12606578   PMID:12750401   PMID:12832481   PMID:14610273   PMID:14691554   PMID:15117738   PMID:15190133   PMID:15258146   PMID:15369676  
PMID:15626745   PMID:15653678   PMID:15689487   PMID:15728559   PMID:15851592   PMID:16141072   PMID:16141073   PMID:16287860   PMID:16394508   PMID:16510872   PMID:16571862   PMID:16611993  
PMID:16787915   PMID:16899596   PMID:16966370   PMID:16971531   PMID:16977322   PMID:17170753   PMID:17220275   PMID:17284606   PMID:17322295   PMID:17342756   PMID:17404621   PMID:17418408  
PMID:17507435   PMID:17553906   PMID:17609113   PMID:17655754   PMID:17712557   PMID:17804822   PMID:17992257   PMID:18070924   PMID:18176562   PMID:18178798   PMID:18281611   PMID:18285456  
PMID:18287559   PMID:18332118   PMID:18347341   PMID:18356544   PMID:18367557   PMID:18434321   PMID:18439915   PMID:18442887   PMID:18451309   PMID:18490920   PMID:18557763   PMID:18635823  
PMID:18799693   PMID:18832080   PMID:19252526   PMID:19302442   PMID:19342889   PMID:19352007   PMID:19439736   PMID:19454749   PMID:19461047   PMID:19498162   PMID:19528226   PMID:19662677  
PMID:19809162   PMID:19899108   PMID:20005221   PMID:20059953   PMID:20140661   PMID:20181618   PMID:20185832   PMID:20194441   PMID:20197624   PMID:20211142   PMID:20388654   PMID:20412781  
PMID:20544853   PMID:20628150   PMID:20644254   PMID:20660313   PMID:20678473   PMID:20713899   PMID:20881124   PMID:20932939   PMID:20952691   PMID:21042733   PMID:21106753   PMID:21217667  
PMID:21257819   PMID:21267068   PMID:21288809   PMID:21419768   PMID:21447692   PMID:21498508   PMID:21517900   PMID:21546903   PMID:21742975   PMID:21765015   PMID:21814490   PMID:21856340  
PMID:21862448   PMID:21873635   PMID:22014577   PMID:22033266   PMID:22081627   PMID:22084310   PMID:22094019   PMID:22095691   PMID:22128145   PMID:22207682   PMID:22223045   PMID:22235342  
PMID:22264788   PMID:22295069   PMID:22298531   PMID:22318228   PMID:22407773   PMID:22419665   PMID:22426208   PMID:22464323   PMID:22490864   PMID:22547685   PMID:22556263   PMID:22627278  
PMID:22684009   PMID:22692279   PMID:22807441   PMID:22869521   PMID:22869907   PMID:22897855   PMID:22930750   PMID:22936665   PMID:22967998   PMID:22988430   PMID:23093773   PMID:23103253  
PMID:23114598   PMID:23250618   PMID:23264599   PMID:23384425   PMID:23395173   PMID:23395174   PMID:23437279   PMID:23447580   PMID:23451260   PMID:23520526   PMID:23555700   PMID:23563312  
PMID:23640890   PMID:23676498   PMID:23749643   PMID:23777768   PMID:23785149   PMID:23845627   PMID:23852473   PMID:23860500   PMID:23894152   PMID:23897427   PMID:23900840   PMID:23946285  
PMID:23981688   PMID:24025643   PMID:24030251   PMID:24037094   PMID:24037341   PMID:24054150   PMID:24076634   PMID:24101470   PMID:24121508   PMID:24146773   PMID:24194600   PMID:24196071  
PMID:24326162   PMID:24347567   PMID:24421394   PMID:24475033   PMID:24497508   PMID:24503013   PMID:24551189   PMID:24576667   PMID:24598112   PMID:24599965   PMID:24607765   PMID:24760996  
PMID:24785085   PMID:24789906   PMID:24828078   PMID:24891620   PMID:24914685   PMID:24947359   PMID:24952961   PMID:24972088   PMID:24999590   PMID:25015343   PMID:25018103   PMID:25023702  
PMID:25023703   PMID:25071089   PMID:25087887   PMID:25103499   PMID:25108527   PMID:25340332   PMID:25377876   PMID:25394489   PMID:25414188   PMID:25440060   PMID:25450522   PMID:25557133  
PMID:25565665   PMID:25574837   PMID:25587709   PMID:25750431   PMID:25751063   PMID:25758454   PMID:25796140   PMID:25833250   PMID:25855602   PMID:25889500   PMID:25915585   PMID:25921247  
PMID:25953833   PMID:26054543   PMID:26124130   PMID:26241779   PMID:26245371   PMID:26296885   PMID:26348575   PMID:26398496   PMID:26422241   PMID:26503986   PMID:26572826   PMID:26603154  
PMID:26642431   PMID:26642852   PMID:26649797   PMID:26731474   PMID:26746864   PMID:26759234   PMID:26837714   PMID:26853750   PMID:26856890   PMID:26927670   PMID:26976644   PMID:26978795  
PMID:27001147   PMID:27075652   PMID:27088801   PMID:27150457   PMID:27189088   PMID:27271565   PMID:27357444   PMID:27432976   PMID:27501247   PMID:27528422   PMID:27546461   PMID:27565342  
PMID:27600268   PMID:27626380   PMID:27671111   PMID:27683416   PMID:27798602   PMID:27930960   PMID:27956697   PMID:28067314   PMID:28112274   PMID:28232488   PMID:28527294   PMID:28555642  
PMID:28696319   PMID:28760743   PMID:28813675   PMID:28847650   PMID:28848049   PMID:28928136   PMID:29035368   PMID:29036334   PMID:29049022   PMID:29074488   PMID:29078383   PMID:29136509  
PMID:29190746   PMID:29307582   PMID:29339479   PMID:29343683   PMID:29422508   PMID:29480820   PMID:29483579   PMID:29533927   PMID:29615467   PMID:29666476   PMID:29671738   PMID:29688375  
PMID:29911998   PMID:29967068   PMID:29983349   PMID:29986746   PMID:30092219   PMID:30156910   PMID:30209343   PMID:30352047   PMID:30388216   PMID:30431439   PMID:30523118   PMID:30586708  
PMID:30635555   PMID:30709906   PMID:30718289   PMID:30761250   PMID:30818059   PMID:31105007   PMID:31118412   PMID:31241981   PMID:31281892   PMID:31357086   PMID:31403471   PMID:31436357  
PMID:31515405   PMID:31668872   PMID:31669249   PMID:31695081   PMID:31710666   PMID:31848220   PMID:31980651   PMID:31999648   PMID:32019729   PMID:32027825   PMID:32234487   PMID:32325033  
PMID:32332719   PMID:32513733   PMID:32515984   PMID:32534258   PMID:32659785   PMID:32673288   PMID:32681351   PMID:32733884   PMID:32807776   PMID:32938724   PMID:32940375   PMID:33024109  
PMID:33154420   PMID:33202783   PMID:33208471   PMID:33321829   PMID:33357457   PMID:33428604   PMID:33483479   PMID:33619535   PMID:33665549   PMID:33792560   PMID:33796838   PMID:33811248  
PMID:33819507   PMID:33850295   PMID:33914705   PMID:33960384   PMID:33966229   PMID:34128478   PMID:34251509   PMID:34321604   PMID:34325467   PMID:34329568   PMID:34433035   PMID:34455812  
PMID:34487578   PMID:34556788   PMID:34593646   PMID:34661337   PMID:34677125   PMID:34699114   PMID:34699385   PMID:34724959   PMID:34902628   PMID:35192456   PMID:35216965   PMID:35242281  
PMID:35247391   PMID:35313689   PMID:35472707   PMID:35532553   PMID:35584682   PMID:35672324   PMID:35724581   PMID:35802383   PMID:35839978   PMID:35912776   PMID:36117450   PMID:36185172  
PMID:36227697   PMID:36247475   PMID:36291563   PMID:36404595   PMID:36625299   PMID:36719147   PMID:37227777   PMID:37267915   PMID:37392019   PMID:37509073   PMID:37562670   PMID:37794190  
PMID:37933447   PMID:37948457   PMID:38019933   PMID:38077147   PMID:38243847   PMID:38333911   PMID:38355793   PMID:38363679   PMID:38422022   PMID:38501098   PMID:38509584   PMID:38627575  
PMID:38652538   PMID:39039245  


Genomics

Comparative Map Data
Epas1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391787,061,292 - 87,140,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)EnsemblGRCm39 Ensembl
GRCm381786,753,864 - 86,833,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv371787,153,204 - 87,232,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361786,662,228 - 86,739,908 (+)NCBIMGSCv36mm8
Celera1791,133,927 - 91,214,803 (+)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1756.9NCBI
EPAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38246,297,407 - 46,386,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl246,293,667 - 46,386,697 (+)EnsemblGRCh38hg38GRCh38
GRCh37246,524,546 - 46,613,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36246,378,067 - 46,467,340 (+)NCBINCBI36Build 36hg18NCBI36
Build 34246,436,213 - 46,525,486NCBI
Celera246,363,267 - 46,452,583 (+)NCBICelera
Cytogenetic Map2p21NCBI
HuRef246,262,570 - 46,351,445 (+)NCBIHuRef
CHM1_1246,455,122 - 46,544,416 (+)NCBICHM1_1
T2T-CHM13v2.0246,302,427 - 46,391,719 (+)NCBIT2T-CHM13v2.0
Epas1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8613,543,252 - 13,626,147 (-)NCBIGRCr8
mRatBN7.267,790,236 - 7,871,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl67,790,647 - 7,871,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx68,070,313 - 8,149,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.068,379,714 - 8,459,355 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.067,907,014 - 7,986,657 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0610,306,508 - 10,385,239 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl610,306,405 - 10,387,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0620,299,603 - 20,379,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4610,203,108 - 10,297,215 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1610,203,107 - 10,297,215 (+)NCBI
Celera67,526,511 - 7,605,382 (-)NCBICelera
Cytogenetic Map6q12NCBI
Epas1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544113,244,626 - 13,328,369 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544113,244,626 - 13,328,220 (+)NCBIChiLan1.0ChiLan1.0
EPAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21280,015,546 - 80,104,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A80,019,514 - 80,108,896 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A46,403,411 - 46,492,734 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A47,332,286 - 47,421,560 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A47,332,308 - 47,421,560 (+)Ensemblpanpan1.1panPan2
EPAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11048,550,836 - 48,636,776 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1048,551,410 - 48,634,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1048,405,643 - 48,491,569 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01049,422,114 - 49,508,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1049,422,316 - 49,508,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11049,131,051 - 49,216,377 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01049,421,043 - 49,506,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01049,603,605 - 49,689,524 (+)NCBIUU_Cfam_GSD_1.0
Epas1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629234,427,139 - 34,510,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365085,855,732 - 5,938,856 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365085,855,748 - 5,938,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl394,165,816 - 94,254,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1394,167,759 - 94,253,662 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23100,157,832 - 100,211,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPAS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11460,823,110 - 60,912,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1460,822,815 - 60,912,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604550,944,448 - 51,034,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epas1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473827,747,696 - 27,834,054 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473827,747,770 - 27,831,213 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epas1
2949 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:921
Count of miRNA genes:509
Interacting mature miRNAs:593
Transcripts:ENSMUST00000024954
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301107Scc4_mcolon tumor susceptibility 4 (mouse)Not determined176230101095294699Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
11039498Ltpr7b_mLeishmania tropica response 7b (mouse)177070119895294699Mouse
11039499Ltpr7a_mLeishmania tropica response 7a (mouse)177070119895294699Mouse
1357552Aaj4_manxiety in A/J 4 (mouse)Not determined177458908990395270Mouse
11039500Ltpr7c_mLeishmania tropica response 7c (mouse)177070119895294699Mouse
11528551Sluc32_msusceptibility to lung cancer 32 (mouse)176230101095294699Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1357528Nhdlq3_mnon-HDL QTL 3 (mouse)Not determined177339513295294699Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
14697708Stsl5_mSalmonella typhimurium susceptibility locus 5 (mouse)178080742991407428Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
4141040Hmtb9_mhemostasis and thrombosis rebleeding time 9 (mouse)Not determined5758908991589197Mouse
4142256Nilac12_mnicotine induced locomotor activity 12 (mouse)Not determined176894131995294699Mouse
4142414Pregq4_mpregnancy QTL 4 (mouse)Not determined175753444793507179Mouse
1302017Aliq3_macute lung injury QTL 3 (mouse)Not determined176388554895294699Mouse
11039514Ltpr7_mLeishmania tropica response 7 (mouse)177070119895294699Mouse
1301728Ffal1_mfree fatty acid level 1 (mouse)Not determined176521493895294699Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141195Nilac11_mnicotine induced locomotor activity 11 (mouse)Not determined177339513295294699Mouse
14928308Manh82_mmandible shape 82 (mouse)176631524395294699Mouse
1357646Axtq3_manxiety QTL 3 (mouse)Not determined177458908990395270Mouse
4141697Hbnr3_mHeligmosomoides bakeri nematode resistance 3 (mouse)Not determined7410765193507179Mouse

Markers in Region
RH129283  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381786,833,170 - 86,833,348UniSTSGRCm38
MGSCv371787,232,510 - 87,232,688UniSTSGRCm37
Celera1791,214,563 - 91,214,741UniSTS
Cytogenetic Map17E4UniSTS
D10Mit28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38109,413,375 - 9,413,521UniSTSGRCm38
MGSCv37109,133,173 - 9,133,319UniSTSGRCm37
Celera109,311,096 - 9,311,242UniSTS
cM Map104.0UniSTS
Whitehead Genetic102.2UniSTS
Whitehead_YAC10 UniSTS
D89787  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17E4UniSTS
Whitehead/MRC_RH171089.76UniSTS
Epas1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371787,196,455 - 87,196,642UniSTSGRCm37
MGSCv371787,204,582 - 87,204,676UniSTSGRCm37
Celera1791,177,312 - 91,177,499UniSTS
Celera1791,186,292 - 91,186,386UniSTS
Cytogenetic Map17E4UniSTS
cM Map17 UniSTS
PMC26957P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381786,805,220 - 86,805,793UniSTSGRCm38
MGSCv371787,204,560 - 87,205,133UniSTSGRCm37
Celera1791,186,270 - 91,186,841UniSTS
Cytogenetic Map17E4UniSTS
PMC26957P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381786,797,120 - 86,797,293UniSTSGRCm38
MGSCv371787,196,460 - 87,196,633UniSTSGRCm37
Celera1791,177,317 - 91,177,490UniSTS
Cytogenetic Map17E4UniSTS
Epas1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381786,797,115 - 86,797,302UniSTSGRCm38
MGSCv371787,196,455 - 87,196,642UniSTSGRCm37
Celera1791,177,312 - 91,177,499UniSTS
Cytogenetic Map17E4UniSTS
Epas1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381786,805,242 - 86,805,336UniSTSGRCm38
MGSCv371787,204,582 - 87,204,676UniSTSGRCm37
Celera1791,186,292 - 91,186,386UniSTS
Cytogenetic Map17E4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000024954   ⟹   ENSMUSP00000024954
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,061,128 - 87,140,838 (+)Ensembl
GRCm38.p6 Ensembl1786,753,700 - 86,833,410 (+)Ensembl
Ensembl Acc Id: ENSMUST00000234447
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1787,131,761 - 87,133,050 (+)Ensembl
GRCm38.p6 Ensembl1786,824,333 - 86,825,622 (+)Ensembl
RefSeq Acc Id: NM_010137   ⟹   NP_034267
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391787,061,292 - 87,140,838 (+)NCBI
GRCm381786,753,864 - 86,833,410 (+)ENTREZGENE
MGSCv371787,153,204 - 87,232,750 (+)RGD
Celera1791,133,927 - 91,214,803 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030249471   ⟹   XP_030105331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391787,093,612 - 87,139,602 (+)NCBI
GRCm381786,786,184 - 86,831,609 (+)NCBI
Sequence:
RefSeq Acc Id: NP_034267   ⟸   NM_010137
- UniProtKB: O08787 (UniProtKB/Swiss-Prot),   O55046 (UniProtKB/Swiss-Prot),   P97481 (UniProtKB/Swiss-Prot),   Q6PEU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030105331   ⟸   XM_030249471
- Peptide Label: isoform X1
- UniProtKB: Q6PEU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000024954   ⟸   ENSMUST00000024954
Protein Domains
bHLH   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97481-F1-model_v2 AlphaFold P97481 1-874 view protein structure

Promoters
RGD ID:13676926
Promoter ID:EPDNEW_M22612
Type:multiple initiation site
Name:Epas1_1
Description:Mus musculus endothelial PAS domain protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22613  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381786,753,908 - 86,753,968EPDNEW
RGD ID:13676928
Promoter ID:EPDNEW_M22613
Type:initiation region
Name:Epas1_2
Description:Mus musculus endothelial PAS domain protein 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22612  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381786,754,128 - 86,754,188EPDNEW
RGD ID:6828075
Promoter ID:MM_KWN:24377
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:NM_010137
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,152,691 - 87,153,652 (+)MPROMDB
RGD ID:6828074
Promoter ID:MM_KWN:24378
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000112273
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,194,101 - 87,195,152 (+)MPROMDB
RGD ID:6848685
Promoter ID:MM_TRO:4565
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung
Transcripts:MTR007163.17.2157.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,196,351 - 87,196,851 (+)MPROMDB
RGD ID:6847386
Promoter ID:MM_ACW:23839
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:EPAS1.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,208,676 - 87,209,176 (+)MPROMDB
RGD ID:6847385
Promoter ID:MM_ACW:23841
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung
Transcripts:EPAS1.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,222,801 - 87,223,967 (+)MPROMDB
RGD ID:6847388
Promoter ID:MM_ACW:23842
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:EPAS1.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361787,230,151 - 87,232,202 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109169 AgrOrtholog
Ensembl Genes ENSMUSG00000024140 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000024954 ENTREZGENE
  ENSMUST00000024954.11 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF-1_TAD_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF_alpha_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuc_translocat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13819 UniProtKB/Swiss-Prot
MGD MGI:109169 ENTREZGENE
NCBI Gene 13819 ENTREZGENE
PANTHER ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HYPOXIA-INDUCIBLE FACTOR 1 ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HIF-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIF-1a_CTAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epas1 PhenoGen
PRINTS NCTRNSLOCATR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EPAS1_MOUSE UniProtKB/Swiss-Prot
  O08787 ENTREZGENE
  O55046 ENTREZGENE
  P97481 ENTREZGENE
  Q6PEU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O08787 UniProtKB/Swiss-Prot
  O55046 UniProtKB/Swiss-Prot