AKR1A1 Human (1->4)-beta-D-glucan multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1A1 mRNA CTD PMID:36331819 AKR1A1 Human (S)-nicotine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 AKR1A1 Human 1,2-dimethylhydrazine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of AKR1A1 mRNA] CTD PMID:22206623 AKR1A1 Human 1,2-dimethylhydrazine increases expression ISO Akr1a1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of AKR1A1 mRNA CTD PMID:22206623 AKR1A1 Human 1,2-naphthoquinone increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 1 and 2-naphthoquinone CTD PMID:10510318 AKR1A1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO Akr1a1 (Mus musculus) 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 AKR1A1 Human 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 AKR1A1 Human 13-dihydrodaunorubicin multiple interactions EXP 6480464 [AKR1A1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol CTD PMID:18276838 AKR1A1 Human 16-Ketoestrone increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 16-ketoestrone CTD PMID:10510318 AKR1A1 Human 17alpha-ethynylestradiol increases expression ISO Akr1a1 (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of AKR1A1 mRNA CTD PMID:17942748 AKR1A1 Human 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression EXP 6480464 Metribolone results in increased expression of AKR1A1 protein CTD PMID:17152098 AKR1A1 Human 1H-pyrazole multiple interactions ISO Akr1a1 (Mus musculus) 6480464 pyrazole inhibits the reaction [AKR1A1 protein results in increased reduction of muconaldehyde] CTD PMID:16289176 AKR1A1 Human 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:31675489 AKR1A1 Human 2,2,2-tetramine multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein] CTD PMID:19634143 AKR1A1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of AKR1A1 mRNA CTD PMID:16214954 AKR1A1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of AKR1A1 mRNA CTD PMID:33387578 AKR1A1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1A1 mRNA CTD PMID:32109520 AKR1A1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Akr1a1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1A1 mRNA CTD PMID:21570461 AKR1A1 Human 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Akr1a1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of AKR1A1 mRNA CTD PMID:18796159 AKR1A1 Human 2,4,6-trinitrotoluene affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Trinitrotoluene affects the expression of AKR1A1 mRNA CTD PMID:21346803 AKR1A1 Human 2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:19954255 AKR1A1 Human 2,4-dinitrotoluene affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 2 and 4-dinitrotoluene affects the expression of AKR1A1 mRNA CTD PMID:21346803 AKR1A1 Human 2,6-dimethoxyphenol multiple interactions EXP 6480464 [pyrogallol 1 more ... CTD PMID:38598786 AKR1A1 Human 2,6-dinitrotoluene affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 2 and 6-dinitrotoluene affects the expression of AKR1A1 mRNA CTD PMID:21346803 AKR1A1 Human 3-chloropropane-1,2-diol decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin analog results in decreased expression of AKR1A1 protein and alpha-Chlorohydrin results in decreased expression of AKR1A1 protein CTD PMID:26597043 AKR1A1 Human 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKR1A1 mRNA CTD PMID:28628672 AKR1A1 Human 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of AKR1A1 mRNA CTD PMID:9973208 AKR1A1 Human 3-nitrobenzaldehyde increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 3-nitrobenzaldehyde CTD PMID:10510318 AKR1A1 Human 3H-1,2-dithiole-3-thione increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in increased expression of AKR1A1 mRNA CTD PMID:19162173 AKR1A1 Human 4,4'-sulfonyldiphenol increases expression EXP 6480464 bisphenol S results in increased expression of AKR1A1 protein CTD PMID:34186270 AKR1A1 Human 4-formylbenzoic acid increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 4-carboxybenzaladehyde CTD PMID:10510318 AKR1A1 Human 4-hydroxynon-2-enal increases expression ISO Akr1a1 (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA CTD PMID:19191707 AKR1A1 Human 4-hydroxynon-2-enal increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal CTD PMID:10510318 AKR1A1 Human 4-nitrobenzaldehyde increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 AKR1A1 Human 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human 6-propyl-2-thiouracil affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Propylthiouracil affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human 9,10-phenanthroquinone multiple interactions EXP 6480464 AKR1A1 protein results in increased reduction of and affects the activity of 9 and 10-phenanthrenequinone CTD PMID:21910479 AKR1A1 Human acrolein increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Acrolein CTD PMID:10510318 AKR1A1 Human acrolein affects reduction ISO Akr1a1 (Rattus norvegicus) 6480464 AKR1A1 protein affects the reduction of Acrolein CTD PMID:12604195 AKR1A1 Human actinomycin D multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased secretion of AKR1A1 protein CTD PMID:38460933 AKR1A1 Human aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of AKR1A1 mRNA CTD PMID:27153756 AKR1A1 Human aldehydo-D-glucose multiple interactions ISO Akr1a1 (Mus musculus) 6480464 fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 AKR1A1 Human aldehydo-D-glucose decreases expression ISO Akr1a1 (Mus musculus) 6480464 Glucose results in decreased expression of AKR1A1 mRNA CTD PMID:16805838 AKR1A1 Human amiodarone affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Amiodarone affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human ammonium chloride affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of AKR1A1 mRNA CTD PMID:16483693 AKR1A1 Human antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of AKR1A1 mRNA CTD PMID:24449571 AKR1A1 Human arecoline decreases expression EXP 6480464 Arecoline results in decreased expression of AKR1A1 mRNA CTD PMID:17682004 AKR1A1 Human aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of AKR1A1 protein CTD PMID:33212167 AKR1A1 Human arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1A1 protein] CTD PMID:26598702 AKR1A1 Human atrazine increases expression EXP 6480464 Atrazine results in increased expression of AKR1A1 mRNA CTD PMID:22378314 AKR1A1 Human benzbromarone affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Benzbromarone affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of AKR1A1 promoter CTD PMID:27901495 AKR1A1 Human benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of AKR1A1 mRNA CTD PMID:32234424 AKR1A1 Human benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:19150397 AKR1A1 Human Benzo[a]pyrene-7,8-diol multiple interactions EXP 6480464 [AKR1A1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:15720144 more ... AKR1A1 Human Benzo[a]pyrene-7,8-diol decreases response to substance EXP 6480464 AKR1A1 protein results in decreased susceptibility to benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:22053912 AKR1A1 Human benzo[a]pyrene-7,8-dione multiple interactions EXP 6480464 [AKR1A1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7 more ... CTD PMID:15720144 and PMID:21910479 AKR1A1 Human benzo[a]pyrene-7,8-dione increases expression EXP 6480464 benzo(a)pyrene-7 and 8-dione results in increased expression of AKR1A1 mRNA CTD PMID:9973208 AKR1A1 Human benzo[a]pyrene-7,8-dione increases chemical synthesis EXP 6480464 AKR1A1 protein results in increased chemical synthesis of benzo(a)pyrene-7 and 8-dione CTD PMID:16411658 AKR1A1 Human benzo[a]pyrene-7,8-dione affects chemical synthesis EXP 6480464 AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7 and 8-dione CTD PMID:15720144 AKR1A1 Human beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of AKR1A1 mRNA CTD PMID:9973208 AKR1A1 Human bisphenol A increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of AKR1A1 mRNA CTD PMID:25181051 more ... AKR1A1 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1A1 protein CTD PMID:37567409 AKR1A1 Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of AKR1A1 protein CTD PMID:34186270 AKR1A1 Human bisphenol A increases methylation ISO Akr1a1 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of AKR1A1 gene CTD PMID:28505145 AKR1A1 Human bisphenol AF increases expression EXP 6480464 bisphenol AF results in increased expression of AKR1A1 protein CTD PMID:34186270 AKR1A1 Human bisphenol F multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKR1A1 mRNA CTD PMID:28628672 AKR1A1 Human bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of AKR1A1 protein CTD PMID:34186270 AKR1A1 Human cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1A1 mRNA CTD PMID:35301059 AKR1A1 Human cadmium dichloride decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of AKR1A1 protein CTD PMID:21699967 AKR1A1 Human cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1A1 mRNA CTD PMID:35301059 AKR1A1 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of AKR1A1 mRNA CTD PMID:38568856 AKR1A1 Human cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of AKR1A1 protein CTD PMID:24527689 AKR1A1 Human caffeine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 AKR1A1 Human capsaicin multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 Capsaicin inhibits the reaction [Dietary Fats results in decreased expression of AKR1A1 protein] CTD PMID:20359164 AKR1A1 Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of AKR1A1 mRNA CTD PMID:25979313 AKR1A1 Human chenodeoxycholic acid multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human chlorpyrifos increases expression ISO Akr1a1 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of AKR1A1 mRNA CTD PMID:37019170 AKR1A1 Human cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of AKR1A1 mRNA CTD PMID:27392435 AKR1A1 Human clofibrate affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Clofibrate affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human clofibric acid multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of AKR1A1 mRNA CTD PMID:17602206 AKR1A1 Human cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of AKR1A1 mRNA CTD PMID:19376846 AKR1A1 Human copper atom decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Copper results in decreased expression of AKR1A1 mRNA CTD PMID:22465980 AKR1A1 Human copper atom affects binding EXP 6480464 AKR1A1 protein binds to Copper CTD PMID:15359738 AKR1A1 Human copper(0) decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Copper results in decreased expression of AKR1A1 mRNA CTD PMID:22465980 AKR1A1 Human copper(0) affects binding EXP 6480464 AKR1A1 protein binds to Copper CTD PMID:15359738 AKR1A1 Human copper(II) chloride increases expression ISO Akr1a1 (Mus musculus) 6480464 cupric chloride results in increased expression of AKR1A1 protein CTD PMID:29617964 AKR1A1 Human copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of AKR1A1 mRNA CTD PMID:19549813 AKR1A1 Human crotonaldehyde affects reduction ISO Akr1a1 (Rattus norvegicus) 6480464 AKR1A1 protein affects the reduction of 2-butenal CTD PMID:12604195 AKR1A1 Human cyclosporin A multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human D-glucose multiple interactions ISO Akr1a1 (Mus musculus) 6480464 fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 AKR1A1 Human D-glucose decreases expression ISO Akr1a1 (Mus musculus) 6480464 Glucose results in decreased expression of AKR1A1 mRNA CTD PMID:16805838 AKR1A1 Human D-glyceraldehyde decreases activity EXP 6480464 Glyceraldehyde results in decreased activity of AKR1A1 protein CTD PMID:30469331 AKR1A1 Human daunorubicin increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Daunorubicin CTD PMID:18322072 AKR1A1 Human daunorubicin affects metabolic processing EXP 6480464 AKR1A1 SNP affects the metabolism of Daunorubicin CTD PMID:18276838 AKR1A1 Human daunorubicin multiple interactions EXP 6480464 [AKR1A1 results in increased metabolism of Daunorubicin] which results in increased chemical synthesis of daunorubicinol CTD PMID:18276838 AKR1A1 Human daunorubicin increases metabolic processing EXP 6480464 AKR1A1 results in increased metabolism of Daunorubicin CTD PMID:18276838 AKR1A1 Human deoxycholic acid multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKR1A1 mRNA CTD PMID:28628672 AKR1A1 Human Diallyl sulfide affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 allyl sulfide affects the expression of AKR1A1 mRNA CTD PMID:19768707 AKR1A1 Human diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1A1 protein] CTD PMID:26598702 AKR1A1 Human Dibutyl phosphate affects expression EXP 6480464 di-n-butylphosphoric acid affects the expression of AKR1A1 mRNA CTD PMID:37042841 AKR1A1 Human dichlorine increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Chlorine results in increased expression of AKR1A1 mRNA CTD PMID:18636392 AKR1A1 Human dichlorine multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] results in decreased expression of AKR1A1 mRNA CTD PMID:18636392 AKR1A1 Human diethyl maleate increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 diethyl maleate results in increased expression of AKR1A1 protein CTD PMID:21161181 AKR1A1 Human diuron decreases expression EXP 6480464 Diuron results in decreased expression of AKR1A1 mRNA CTD PMID:35967413 AKR1A1 Human doxorubicin increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Doxorubicin CTD PMID:18322072 AKR1A1 Human doxorubicin affects metabolic processing EXP 6480464 AKR1A1 SNP affects the metabolism of Doxorubicin CTD PMID:18276838 AKR1A1 Human doxorubicin multiple interactions EXP 6480464 [AKR1A1 results in increased metabolism of Doxorubicin] which results in increased chemical synthesis of adriamycinol CTD PMID:18276838 AKR1A1 Human doxorubicin increases metabolic processing EXP 6480464 AKR1A1 results in increased metabolism of Doxorubicin CTD PMID:18276838 AKR1A1 Human endosulfan increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Endosulfan results in increased expression of AKR1A1 mRNA CTD PMID:29391264 AKR1A1 Human enzyme inhibitor multiple interactions EXP 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AKR1A1 protein CTD PMID:23301498 AKR1A1 Human ethanol affects splicing ISO Akr1a1 (Mus musculus) 6480464 Ethanol affects the splicing of AKR1A1 mRNA CTD PMID:30319688 AKR1A1 Human Fidarestat multiple interactions ISO Akr1a1 (Mus musculus) 6480464 fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 AKR1A1 Human flutamide increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Flutamide results in increased expression of AKR1A1 mRNA CTD PMID:24136188 AKR1A1 Human folic acid multiple interactions ISO Akr1a1 (Mus musculus) 6480464 Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of AKR1A1 mRNA] CTD PMID:22206623 AKR1A1 Human fumonisin B1 increases expression ISO Akr1a1 (Mus musculus) 6480464 fumonisin B1 results in increased expression of AKR1A1 mRNA CTD PMID:16221962 AKR1A1 Human furan increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 furan results in increased expression of AKR1A1 mRNA CTD PMID:25539665 and PMID:26194646 AKR1A1 Human furfural multiple interactions EXP 6480464 [pyrogallol 1 more ... CTD PMID:38598786 AKR1A1 Human gentamycin increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of AKR1A1 mRNA CTD PMID:22061828 AKR1A1 Human glafenine increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Glafenine results in increased expression of AKR1A1 mRNA CTD PMID:24136188 AKR1A1 Human glucose multiple interactions ISO Akr1a1 (Mus musculus) 6480464 fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] CTD PMID:16805838 AKR1A1 Human glucose decreases expression ISO Akr1a1 (Mus musculus) 6480464 Glucose results in decreased expression of AKR1A1 mRNA CTD PMID:16805838 AKR1A1 Human glucuronic acid increases reduction ISO Akr1a1 (Rattus norvegicus) 6480464 AKR1A1 protein results in increased reduction of Glucuronic Acid CTD PMID:29763686 AKR1A1 Human glucuronic acid increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Glucuronic Acid CTD PMID:10510318 AKR1A1 Human glyceraldehyde decreases activity EXP 6480464 Glyceraldehyde results in decreased activity of AKR1A1 protein CTD PMID:30469331 AKR1A1 Human glycidyl methacrylate decreases expression EXP 6480464 glycidyl methacrylate results in decreased expression of AKR1A1 protein CTD PMID:36641056 AKR1A1 Human glycochenodeoxycholic acid multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human glycocholic acid multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human glycodeoxycholic acid multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of AKR1A1 mRNA CTD PMID:32152650 AKR1A1 Human hexane-2,3-dione increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of 2 and 3-hexanedione CTD PMID:10510318 AKR1A1 Human hydralazine multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of AKR1A1 mRNA CTD PMID:17183730 AKR1A1 Human hypochlorous acid increases expression ISO Akr1a1 (Mus musculus) 6480464 Hypochlorous Acid results in increased expression of AKR1A1 mRNA CTD PMID:19376150 AKR1A1 Human indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of AKR1A1 mRNA CTD PMID:28628672 AKR1A1 Human indometacin decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Indomethacin results in decreased expression of AKR1A1 mRNA CTD PMID:36868495 AKR1A1 Human inulin multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of AKR1A1 mRNA CTD PMID:36331819 AKR1A1 Human isotretinoin decreases expression EXP 6480464 Isotretinoin results in decreased expression of AKR1A1 mRNA CTD PMID:20436886 AKR1A1 Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of AKR1A1 protein CTD PMID:32959892 AKR1A1 Human L-ascorbic acid decreases abundance ISO Akr1a1 (Mus musculus) 6480464 AKR1A1 gene mutant form results in decreased abundance of Ascorbic Acid CTD PMID:32805337 AKR1A1 Human L-ascorbic acid multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [AKR1A1 gene mutant form results in increased susceptibility to Diethylnitrosamine] which results in decreased abundance of Ascorbic Acid and AKR1A1 gene mutant form promotes the reaction [Diethylnitrosamine results in decreased abundance of Ascorbic Acid] CTD PMID:32805337 AKR1A1 Human L-ethionine affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Ethionine affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human methidathion increases expression ISO Akr1a1 (Mus musculus) 6480464 methidathion results in increased expression of AKR1A1 mRNA CTD PMID:34813904 AKR1A1 Human methylglyoxal increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Pyruvaldehyde CTD PMID:10510318 AKR1A1 Human methylglyoxal increases reduction ISO Akr1a1 (Rattus norvegicus) 6480464 AKR1A1 protein results in increased reduction of Pyruvaldehyde CTD PMID:29763686 AKR1A1 Human monosodium L-glutamate increases expression ISO Akr1a1 (Mus musculus) 6480464 Sodium Glutamate results in increased expression of AKR1A1 mRNA and Sodium Glutamate results in increased expression of AKR1A1 protein CTD PMID:25473020 AKR1A1 Human Muconic dialdehyde multiple interactions ISO Akr1a1 (Mus musculus) 6480464 pyrazole inhibits the reaction [AKR1A1 protein results in increased reduction of muconaldehyde] CTD PMID:16289176 AKR1A1 Human Muconic dialdehyde increases reduction ISO Akr1a1 (Mus musculus) 6480464 AKR1A1 protein results in increased reduction of muconaldehyde CTD PMID:16289176 AKR1A1 Human N-nitrosodiethylamine multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of AKR1A1 mRNA CTD PMID:17602206 AKR1A1 Human N-nitrosodiethylamine increases response to substance ISO Akr1a1 (Mus musculus) 6480464 AKR1A1 gene mutant form results in increased susceptibility to Diethylnitrosamine CTD PMID:32805337 AKR1A1 Human N-nitrosodiethylamine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [AKR1A1 gene mutant form results in increased susceptibility to Diethylnitrosamine] which results in decreased abundance of Ascorbic Acid and AKR1A1 gene mutant form promotes the reaction [Diethylnitrosamine results in decreased abundance of Ascorbic Acid] CTD PMID:32805337 AKR1A1 Human NAD zwitterion multiple interactions EXP 6480464 NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7 more ... CTD PMID:15720144 AKR1A1 Human NAD(+) multiple interactions EXP 6480464 NAD promotes the reaction [AKR1A1 protein affects the chemical synthesis of benzo(a)pyrene-7 more ... CTD PMID:15720144 AKR1A1 Human NADP zwitterion multiple interactions EXP 6480464 [AKR1A1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:15720144 and PMID:21910479 AKR1A1 Human NADP(+) multiple interactions EXP 6480464 [AKR1A1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:15720144 and PMID:21910479 AKR1A1 Human nefazodone increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 nefazodone results in increased expression of AKR1A1 mRNA CTD PMID:24136188 AKR1A1 Human nicotine multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... CTD PMID:20230807 AKR1A1 Human nimesulide increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 nimesulide results in increased expression of AKR1A1 mRNA CTD PMID:24136188 AKR1A1 Human Nutlin-3 multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased secretion of AKR1A1 protein CTD PMID:38460933 AKR1A1 Human ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of AKR1A1 mRNA CTD PMID:32905824 AKR1A1 Human omeprazole affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human ozone multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 [Ozone co-treated with Chlorine] results in decreased expression of AKR1A1 mRNA CTD PMID:18636392 AKR1A1 Human pentachlorophenol increases expression ISO Akr1a1 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of AKR1A1 mRNA CTD PMID:23892564 AKR1A1 Human perfluorooctane-1-sulfonic acid multiple interactions ISO Akr1a1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AKR1A1 mRNA more ... CTD PMID:36331819 AKR1A1 Human perfluorooctanoic acid affects expression ISO Akr1a1 (Mus musculus) 6480464 perfluorooctanoic acid affects the expression of AKR1A1 mRNA CTD PMID:18281256 AKR1A1 Human phenobarbital affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Phenobarbital affects the expression of AKR1A1 mRNA CTD PMID:19768707 AKR1A1 Human phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of AKR1A1 mRNA CTD PMID:19159669 AKR1A1 Human Phenylglyoxal increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of Phenylglyoxal CTD PMID:10510318 AKR1A1 Human phlorizin decreases expression ISO Akr1a1 (Mus musculus) 6480464 Phlorhizin results in decreased expression of AKR1A1 mRNA CTD PMID:22538082 AKR1A1 Human pirinixic acid affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 pirinixic acid affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human pyrogallol increases expression ISO Akr1a1 (Mus musculus) 6480464 Pyrogallol results in increased expression of AKR1A1 mRNA CTD PMID:20362636 AKR1A1 Human sodium arsenite decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 sodium arsenite results in decreased expression of AKR1A1 mRNA CTD PMID:19072884 AKR1A1 Human sodium arsenite increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of AKR1A1 protein CTD PMID:29459688 AKR1A1 Human sodium chloride multiple interactions EXP 6480464 [Sodium Chloride co-treated with Furaldehyde] results in increased expression of AKR1A1 protein more ... CTD PMID:38598786 AKR1A1 Human sodium dichromate increases expression ISO Akr1a1 (Mus musculus) 6480464 sodium bichromate results in increased expression of AKR1A1 mRNA CTD PMID:22155349 AKR1A1 Human sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of AKR1A1 mRNA CTD PMID:17685462 AKR1A1 Human sodium dichromate increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 sodium bichromate results in increased expression of AKR1A1 mRNA CTD PMID:22561333 AKR1A1 Human streptozocin increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of AKR1A1 protein CTD PMID:19634143 AKR1A1 Human streptozocin multiple interactions ISO Akr1a1 (Rattus norvegicus) 6480464 Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein] CTD PMID:19634143 AKR1A1 Human succinic semialdehyde increases reduction EXP 6480464 AKR1A1 protein results in increased reduction of succinic semialdehyde CTD PMID:10510318 and PMID:21276435 AKR1A1 Human tetrachloroethene decreases expression ISO Akr1a1 (Mus musculus) 6480464 Tetrachloroethylene results in decreased expression of AKR1A1 mRNA CTD PMID:28973375 AKR1A1 Human thioacetamide affects expression ISO Akr1a1 (Rattus norvegicus) 6480464 Thioacetamide affects the expression of AKR1A1 mRNA CTD PMID:19483382 AKR1A1 Human thioacetamide increases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of AKR1A1 mRNA CTD PMID:34492290 AKR1A1 Human thioacetamide multiple interactions ISO Akr1a1 (Mus musculus) 6480464 AKR1A1 protein affects the reaction [Thioacetamide results in increased activity of GPT protein] and AKR1A1 protein affects the reaction [Thioacetamide results in increased expression of DDIT3 protein] CTD PMID:29763686 AKR1A1 Human thioacetamide increases response to substance ISO Akr1a1 (Mus musculus) 6480464 AKR1A1 protein results in increased susceptibility to Thioacetamide CTD PMID:29763686 AKR1A1 Human urethane decreases expression EXP 6480464 Urethane results in decreased expression of AKR1A1 mRNA CTD PMID:28818685 AKR1A1 Human valproic acid multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of AKR1A1 mRNA CTD PMID:17183730 AKR1A1 Human valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of AKR1A1 mRNA CTD PMID:25979313 AKR1A1 Human valproic acid affects expression ISO Akr1a1 (Mus musculus) 6480464 Valproic Acid affects the expression of AKR1A1 mRNA CTD PMID:17292431 AKR1A1 Human Yessotoxin increases expression EXP 6480464 yessotoxin analog results in increased expression of AKR1A1 mRNA CTD PMID:30679557 AKR1A1 Human zinc atom decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of AKR1A1 mRNA CTD PMID:11717422 AKR1A1 Human zinc(0) decreases expression ISO Akr1a1 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of AKR1A1 mRNA CTD PMID:11717422 AKR1A1 Human zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of AKR1A1 mRNA CTD PMID:24714768
