Cldn5 (claudin 5) - Rat Genome Database

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Gene: Cldn5 (claudin 5) Rattus norvegicus
Analyze
Symbol: Cldn5
Name: claudin 5
RGD ID: 68431
Description: Predicted to enable identical protein binding activity. Involved in myelination and response to ethanol. Located in Schmidt-Lanterman incisure; lateral plasma membrane; and paranode region of axon. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CLDN5 (claudin 5); PARTICIPATES IN hepatitis C pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: claudin-5; MGC95240
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,717,172 - 95,718,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,717,176 - 95,719,322 (-)EnsemblGRCr8
mRatBN7.21182,212,822 - 82,214,248 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,211,475 - 82,214,992 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,944,303 - 90,945,729 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,605,524 - 83,606,950 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,659,043 - 82,660,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,356,292 - 86,357,718 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,356,294 - 86,357,718 (-)Ensemblrn6Rnor6.0
Rnor_5.01189,458,258 - 89,459,684 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1180,993,136 - 80,994,562 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
8-Br-cAMP  (ISO)
9,10-phenanthroquinone  (ISO)
acrolein  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
aripiprazole  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cordycepin  (ISO)
cypermethrin  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP,ISO)
diiodine  (ISO)
dioxygen  (ISO)
dipyridamole  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
fenthion  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glycine  (ISO)
glyphosate  (ISO)
hydrogen sulfide  (EXP,ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
linsidomine  (ISO)
lipopolysaccharide  (ISO)
loxoprofen  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
malaoxon  (EXP)
malathion  (EXP)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methylmercury chloride  (EXP)
metronidazole  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nickel atom  (ISO)
obeticholic acid  (ISO)
octhilinone  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-tert-Amylphenol  (EXP)
palmitoyl ethanolamide  (ISO)
papaverine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium iodide  (EXP)
progesterone  (ISO)
Pyridostigmine bromide  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium sulfide (anhydrous)  (ISO)
testosterone  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protective effect of naringenin in experimental ischemic stroke: down-regulated NOD2, RIP2, NF-¿B, MMP-9 and up-regulated claudin-5 expression. Bai X, etal., Neurochem Res. 2014 Aug;39(8):1405-15. doi: 10.1007/s11064-014-1326-y. Epub 2014 May 20.
2. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Fernandez AL, etal., Alcohol. 2007 Aug;41(5):371-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Protective Effect of 4-Methoxy Benzyl Alcohol on the Blood-Brain Barrier after Cerebral Ischemia Reperfusion Injury. He F, etal., J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1258-1265. doi: 10.1016/j.jstrokecerebrovasdis.2017.01.018. Epub 2017 Apr 7.
5. Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats. Li Q, etal., J Cell Mol Med. 2009 Sep;13(9B):4061-76. Epub 2009 Nov 19.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. Nitta T, etal., J Cell Biol 2003 May 12;161(3):653-60.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. Poliak S, etal., J Cell Biol 2002 Oct 28;159(2):361-72.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. The CLDN5 locus may be involved in the vulnerability to schizophrenia. Sun ZY, etal., Eur Psychiatry 2004 Sep;19(6):354-7.
14. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
Additional References at PubMed
PMID:8889548   PMID:9892664   PMID:12477932   PMID:12734665   PMID:15383327   PMID:15489334   PMID:16763778   PMID:16998798   PMID:17899156   PMID:18036336   PMID:18065521   PMID:20043889  
PMID:20473716   PMID:20967520   PMID:20970449   PMID:21168935   PMID:21271259   PMID:21318404   PMID:21626096   PMID:21717368   PMID:22275141   PMID:22378877   PMID:22946046   PMID:23288152  
PMID:23376485   PMID:23626836   PMID:23653089   PMID:24280217   PMID:25323998   PMID:25753039   PMID:25816133   PMID:25978380   PMID:27038183   PMID:27164415   PMID:27452368   PMID:28741371  
PMID:28961379   PMID:30452951   PMID:30734065   PMID:31151084   PMID:33417957   PMID:34359845   PMID:35318077   PMID:37992974  


Genomics

Comparative Map Data
Cldn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81195,717,172 - 95,718,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1195,717,176 - 95,719,322 (-)EnsemblGRCr8
mRatBN7.21182,212,822 - 82,214,248 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,211,475 - 82,214,992 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,944,303 - 90,945,729 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01183,605,524 - 83,606,950 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01182,659,043 - 82,660,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01186,356,292 - 86,357,718 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,356,294 - 86,357,718 (-)Ensemblrn6Rnor6.0
Rnor_5.01189,458,258 - 89,459,684 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera1180,993,136 - 80,994,562 (-)NCBICelera
Cytogenetic Map11q23NCBI
CLDN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,523,024 - 19,525,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,523,024 - 19,527,545 (-)Ensemblhg38GRCh38
GRCh372219,510,547 - 19,512,860 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,890,550 - 17,892,860 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342217,885,103 - 17,887,414NCBI
Celera223,362,807 - 3,365,120 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef223,131,378 - 3,133,692 (-)NCBIHuRef
CHM1_12219,510,114 - 19,512,427 (-)NCBICHM1_1
T2T-CHM13v2.02219,899,865 - 19,902,178 (-)NCBIT2T-CHM13v2.0
Cldn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,595,597 - 18,597,012 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1618,595,597 - 18,597,012 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381618,776,847 - 18,778,262 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,776,847 - 18,778,262 (+)Ensemblmm10GRCm38
MGSCv371618,776,940 - 18,778,353 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361618,690,410 - 18,691,823 (+)NCBIMGSCv36mm8
Celera1619,350,901 - 19,352,314 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.63NCBI
Cldn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,509,676 - 18,510,332 (+)Ensembl
ChiLan1.0NW_00495544218,509,501 - 18,511,267 (+)NCBIChiLan1.0ChiLan1.0
CLDN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22329,148,325 - 29,150,156 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,696,053 - 31,697,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,282,215 - 2,286,724 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,957,605 - 17,962,121 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2217,958,182 - 17,959,093 (-)EnsemblpanPan2panpan1.1
CLDN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,702,464 - 29,704,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,703,683 - 29,704,339 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2629,657,506 - 29,659,994 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02631,103,894 - 31,106,387 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2631,104,951 - 31,106,379 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12629,151,222 - 29,153,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,776,939 - 28,779,430 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,862,380 - 29,864,535 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cldn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,296,955 - 139,298,554 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366193,456,166 - 3,456,822 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366193,455,508 - 3,457,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,161,042 - 51,163,482 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11451,161,490 - 51,162,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21454,778,542 - 54,779,434 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLDN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,227,881 - 6,230,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,228,965 - 6,229,621 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666085703,479 - 705,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624747164,761 - 165,417 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624747164,113 - 166,502 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cldn5
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:83
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000071806
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat

Markers in Region
RH141529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,212,888 - 82,213,084 (+)MAPPERmRatBN7.2
Rnor_6.01186,356,359 - 86,356,554NCBIRnor6.0
Rnor_5.01189,458,325 - 89,458,520UniSTSRnor5.0
Celera1180,993,203 - 80,993,398UniSTS
RH 3.4 Map11700.2UniSTS
Cytogenetic Map11p12UniSTS
UniSTS:465379  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,213,466 - 82,214,106 (+)MAPPERmRatBN7.2
Rnor_6.01186,356,937 - 86,357,576NCBIRnor6.0
Rnor_5.01189,458,903 - 89,459,542UniSTSRnor5.0
Celera1180,993,781 - 80,994,420UniSTS
Cytogenetic Map11p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 56 140 64 60 48 43 48 6 252 121 11 123 70 81 12 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000071806   ⟹   ENSRNOP00000064048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1186,356,294 - 86,357,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072027   ⟹   ENSRNOP00000066206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,211,475 - 82,214,992 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139530   ⟹   ENSRNOP00000099076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1195,717,176 - 95,719,322 (-)Ensembl
RefSeq Acc Id: NM_031701   ⟹   NP_113889
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81195,717,172 - 95,718,598 (-)NCBI
mRatBN7.21182,212,822 - 82,214,248 (-)NCBI
Rnor_6.01186,356,292 - 86,357,718 (-)NCBI
Rnor_5.01189,458,258 - 89,459,684 (-)NCBI
Celera1180,993,136 - 80,994,562 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113889 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF73425 (Get FASTA)   NCBI Sequence Viewer  
  AAH82073 (Get FASTA)   NCBI Sequence Viewer  
  EDL77958 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066206.2
  ENSRNOP00000099076
GenBank Protein Q9JKD6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113889   ⟸   NM_031701
- UniProtKB: Q66H22 (UniProtKB/Swiss-Prot),   Q9JKD6 (UniProtKB/Swiss-Prot),   A6JSE9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064048   ⟸   ENSRNOT00000071806
Ensembl Acc Id: ENSRNOP00000066206   ⟸   ENSRNOT00000072027
Ensembl Acc Id: ENSRNOP00000099076   ⟸   ENSRNOT00000139530

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKD6-F1-model_v2 AlphaFold Q9JKD6 1-218 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698298
Promoter ID:EPDNEW_R8821
Type:single initiation site
Name:Cldn5_1
Description:claudin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01186,357,730 - 86,357,790EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68431 AgrOrtholog
BioCyc Gene G2FUF-20671 BioCyc
Ensembl Genes ENSRNOG00000045811 Ensembl
  ENSRNOG00000050071 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000077978 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000072027.3 UniProtKB/Swiss-Prot
  ENSRNOT00000139530 ENTREZGENE
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133096 IMAGE-MGC_LOAD
InterPro Claudin UniProtKB/Swiss-Prot
  Claudin5 UniProtKB/Swiss-Prot
  Claudin_CS UniProtKB/Swiss-Prot
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot
KEGG Report rno:65131 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95240 IMAGE-MGC_LOAD
NCBI Gene 65131 ENTREZGENE
PANTHER PTHR12002 UniProtKB/Swiss-Prot
Pfam PMP22_Claudin UniProtKB/Swiss-Prot
PhenoGen Cldn5 PhenoGen
PRINTS CLAUDIN UniProtKB/Swiss-Prot
  CLAUDIN5 UniProtKB/Swiss-Prot
PROSITE CLAUDIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045811 RatGTEx
  ENSRNOG00000050071 RatGTEx
  ENSRNOG00000077978 RatGTEx
UniProt A6JSE9 ENTREZGENE, UniProtKB/TrEMBL
  CLD5_RAT UniProtKB/Swiss-Prot
  Q66H22 ENTREZGENE
  Q9JKD6 ENTREZGENE
UniProt Secondary Q66H22 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cldn5  claudin 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane at tight junctions 634852
gene_physical_interaction COOH-terminal region interacts with Mupp1 634852