Dlg4 (discs large MAGUK scaffold protein 4) - Rat Genome Database

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Gene: Dlg4 (discs large MAGUK scaffold protein 4) Rattus norvegicus
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Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
RGD ID: 68424
Description: Enables several functions, including PDZ domain binding activity; enzyme binding activity; and signaling receptor binding activity. A structural constituent of postsynaptic density. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of cellular component organization; and postsynapse organization. Located in several cellular components, including dendrite; juxtaparanode region of axon; and postsynaptic membrane. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of Parkinson's disease and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 62. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4); PARTICIPATES IN glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: discs large homolog 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlgh4; postsynaptic density protein 95; PSD-95; PSD95; SAP-90; Sap90; synapse-associated protein 90; synapse-associated protein SAP90
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,239,397 - 55,267,780 (+)NCBIGRCr8
GRCr8 Ensembl1055,236,869 - 55,265,839 (+)EnsemblGRCr8 Ensembl
mRatBN7.21054,740,700 - 54,769,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,739,470 - 54,767,153 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,403,247 - 59,429,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,891,827 - 58,917,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,399,117 - 54,425,128 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,625,845 - 56,655,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,627,411 - 56,653,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,369,703 - 56,400,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,864,459 - 56,890,626 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1053,894,685 - 53,920,691 (+)NCBICelera
RGSC_v3.11056,878,081 - 56,904,246 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-methylcholine  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
agomelatine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Solamarine  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
azithromycin  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP,ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlordecone  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
citric acid  (EXP)
cocaine  (EXP,ISO)
corticosterone  (ISO)
curcumin  (EXP)
cyhalothrin  (EXP,ISO)
DDE  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fisetin  (ISO)
fluoranthene  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gabapentin  (ISO)
glutathione  (ISO)
hexachlorophene  (ISO)
Honokiol  (EXP)
ibuprofen  (EXP)
indometacin  (ISO)
iron dichloride  (ISO)
isoflurane  (EXP)
ivermectin  (ISO)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
linuron  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (ISO)
melittin  (ISO)
memantine  (EXP,ISO)
methamphetamine  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
Monobutylphthalate  (ISO)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (ISO)
PF-4708671  (EXP)
phencyclidine  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
poly(vinylpyrrolidone)  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propofol  (EXP)
resveratrol  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 415286  (EXP)
SB 431542  (ISO)
sevoflurane  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
U-73122  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
AMPA glutamate receptor clustering  (IBA,IMP)
cell-cell adhesion  (IBA)
cellular response to potassium ion  (IEA,ISO)
cerebral cortex development  (IEP)
chemical synaptic transmission  (IBA,IEA)
dendritic spine morphogenesis  (IEA,IMP,ISO)
dendritic spine organization  (IMP)
developmental maturation  (IEA)
establishment of protein localization  (IEA,ISO,ISS)
locomotory exploration behavior  (IEA,ISO,ISS)
maintenance of postsynaptic density structure  (IEA)
negative regulation of receptor internalization  (IDA)
nervous system development  (IBA)
neuromuscular process controlling balance  (IEA,ISO,ISS)
neuronal ion channel clustering  (TAS)
neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA,ISO)
NMDA selective glutamate receptor signaling pathway  (IDA)
positive regulation of AMPA glutamate receptor clustering  (IMP)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of excitatory postsynaptic potential  (IDA,IMP)
positive regulation of neuron projection arborization  (IGI)
positive regulation of synapse assembly  (IMP)
positive regulation of synaptic transmission  (IDA,IEA,ISO)
protein localization to membrane  (IEA)
protein localization to synapse  (IBA,IEA,IMP,ISO)
protein-containing complex assembly  (IEA,ISO,ISS)
receptor localization to synapse  (IBA,IEA,IMP)
regulation of grooming behavior  (IEA,ISO,ISS)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO,ISS)
regulation of neuronal synaptic plasticity  (IEA,IMP)
regulation of NMDA receptor activity  (IMP)
regulation of postsynaptic membrane neurotransmitter receptor levels  (IBA)
social behavior  (IEA,ISO,ISS)
synaptic vesicle maturation  (IEA,ISO,ISS)
vocalization behavior  (IEA,ISO,ISS)

Cellular Component
AMPA glutamate receptor complex  (IEA,ISO,ISS)
axon  (IEA)
cell junction  (IEA,ISO,ISS)
cell periphery  (IEA,ISO)
cell projection  (IEA)
cell-cell junction  (IDA)
cerebellar mossy fiber  (IEA,ISO)
cortical cytoskeleton  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
cytosol  (TAS)
dendrite  (IDA,IEA,ISO)
dendrite cytoplasm  (IDA)
dendritic branch  (IDA)
dendritic spine  (IDA,IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO,ISS)
excitatory synapse  (IDA,IEA,ISO)
glutamatergic synapse  (IDA,IEA,IMP,ISO)
juxtaparanode region of axon  (IDA,IEA,ISO)
membrane  (IDA,IEA,ISO)
neuromuscular junction  (IBA,IEA)
neuron projection  (IBA,IEA)
neuron projection terminus  (IEA,ISO,ISS)
neuron spine  (IEA,ISO,ISS)
organelle  (IEA)
plasma membrane  (IDA,IEA,ISO,TAS)
postsynapse  (IEA,ISO)
postsynaptic density  (IDA,IEA,ISO)
postsynaptic density membrane  (IBA,IDA)
postsynaptic membrane  (IDA,IEA,ISO)
presynapse  (IEA)
proximal dendrite  (IDA)
synapse  (IDA,IEA,IMP,ISO)
synaptic membrane  (IDA,IEA,ISO)
synaptic vesicle  (IEA,ISO,ISS)
voltage-gated potassium channel complex  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Bassand P, etal., Eur J Neurosci. 1999 Jun;11(6):2031-43.
2. The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Bats C, etal., Neuron. 2007 Mar 1;53(5):719-34.
3. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
4. Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression. Bolliger MF, etal., Biochem J. 2001 Jun 1;356(Pt 2):581-8.
5. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
6. Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors. Cai C, etal., J Biol Chem. 2006 Feb 17;281(7):4267-73. Epub 2005 Dec 6.
7. Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. Chen BS, etal., J Biol Chem. 2006 Jun 16;281(24):16583-90. Epub 2006 Apr 10.
8. Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Chen M, etal., Neurosci Lett. 2003 Mar 13;339(1):29-32.
9. Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia. Chen WF, etal., Exp Neurol. 2007 Mar;204(1):400-10. Epub 2007 Jan 30.
10. PSD-95 is required to sustain the molecular organization of the postsynaptic density. Chen X, etal., J Neurosci. 2011 Apr 27;31(17):6329-38. doi: 10.1523/JNEUROSCI.5968-10.2011.
11. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. Chen Y and Li M, Neuropharmacology. 2005 Dec;49(7):1026-41. Epub 2005 Jul 28.
12. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. Chen Z, etal., J Biol Chem. 2006 May 5;281(18):12414-20. doi: 10.1074/jbc.M508651200. Epub 2006 Mar 13.
13. Control of excitatory and inhibitory synapse formation by neuroligins. Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
14. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Cho KO, etal., Neuron 1992 Nov;9(5):929-42.
15. Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. Choi J, etal., J Neurosci. 2005 Jan 26;25(4):869-79.
16. Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. Christenn M, etal., FEBS Lett. 2007 Nov 13;581(27):5173-7. Epub 2007 Oct 12.
17. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Colledge M, etal., Neuron. 2000 Jul;27(1):107-19.
18. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Colledge M, etal., Neuron. 2003 Oct 30;40(3):595-607.
19. Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. Cousins SL and Stephenson FA, J Biol Chem. 2012 Apr 13;287(16):13465-76. doi: 10.1074/jbc.M111.292862. Epub 2012 Feb 28.
20. The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization. Cubelos B, etal., J Neurochem. 2005 Nov;95(4):1047-58.
21. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. Deguchi M, etal., J Biol Chem 1998 Oct 9;273(41):26269-72.
22. Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. DeMarco SJ and Strehler EE, J Biol Chem. 2001 Jun 15;276(24):21594-600. Epub 2001 Mar 26.
23. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. Dong E, etal., Neuropharmacology. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4.
24. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Evers DM, etal., Nat Neurosci. 2010 Oct;13(10):1199-207. doi: 10.1038/nn.2624. Epub 2010 Aug 29.
25. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
26. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Fukata Y, etal., Science. 2006 Sep 22;313(5794):1792-5.
27. SAP90 binds and clusters kainate receptors causing incomplete desensitization. Garcia EP, etal., Neuron. 1998 Oct;21(4):727-39.
28. Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1beta and NMDA stimulation. Gardoni F, etal., J Neuroinflammation. 2011 Feb 11;8(1):14.
29. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. Gardoni F, etal., J Neurosci. 2001 Mar 1;21(5):1501-9.
30. A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia. Gardoni F, etal., J Neurosci. 2006 Mar 15;26(11):2914-22.
31. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
33. PMCA2 via PSD-95 controls calcium signaling by alpha7-containing nicotinic acetylcholine receptors on aspiny interneurons. Gomez-Varela D, etal., J Neurosci. 2012 May 16;32(20):6894-905. doi: 10.1523/JNEUROSCI.5972-11.2012.
34. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Graf ER, etal., Cell. 2004 Dec 29;119(7):1013-26.
35. Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5-choice serial reaction time task. Guo H, etal., J Neurosci Res. 2019 Sep;97(9):1051-1065. doi: 10.1002/jnr.24427. Epub 2019 May 12.
36. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization. Ha CM, etal., J Biol Chem. 2012 Sep 14;287(38):31813-22. doi: 10.1074/jbc.M112.370601. Epub 2012 Jul 26.
37. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Hayashi-Takagi A, etal., Nat Neurosci. 2010 Mar;13(3):327-32. Epub 2010 Feb 7.
38. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. He J, etal., J Biol Chem. 2006 Feb 3;281(5):2820-7. Epub 2005 Nov 29.
39. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. Hirao K, etal., J Biol Chem 1998 Aug 14;273(33):21105-10.
40. Three isoforms of synaptic scaffolding molecule and their characterization. Multimerization between the isoforms and their interaction with N-methyl-D-aspartate receptors and SAP90/PSD-95-associated protein. Hirao K, etal., J Biol Chem 2000 Jan 28;275(4):2966-72.
41. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
42. Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons. Horresh I, etal., J Neurosci. 2008 Dec 24;28(52):14213-22. doi: 10.1523/JNEUROSCI.3398-08.2008.
43. Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Hou XY, etal., Brain Res 2002 Nov 15;955(1-2):123-32.
44. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. Hu LA, etal., J Biol Chem. 2000 Dec 8;275(49):38659-66.
45. Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. Inagaki S, etal., J Biol Chem. 2001 Mar 23;276(12):9174-81. Epub 2000 Dec 27.
46. Binding of neuroligins to PSD-95. Irie M, etal., Science. 1997 Sep 5;277(5331):1511-5.
47. Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein gamma-8 with calcineurin. Itakura M, etal., FEBS J. 2014 Mar;281(5):1366-78. doi: 10.1111/febs.12708. Epub 2014 Jan 27.
48. Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity. Jang S, etal., Nat Neurosci. 2016 Jan;19(1):84-93. doi: 10.1038/nn.4176. Epub 2015 Nov 23.
49. Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. Jo K, etal., J Neurosci. 1999 Jun 1;19(11):4189-99.
50. Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling. Joiner ML, etal., EMBO J. 2010 Jan 20;29(2):482-95. Epub 2009 Nov 26.
51. Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons. Jourdi H, etal., Dev Biol. 2003 Nov 15;263(2):216-30. doi: 10.1016/j.ydbio.2003.07.008.
52. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. Jurado S, etal., EMBO J. 2010 Aug 18;29(16):2827-40. Epub 2010 Jul 13.
53. PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex. Kalia LV, etal., EMBO J. 2006 Oct 18;25(20):4971-82. Epub 2006 Sep 21.
54. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
55. Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
56. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. Kistner U, etal., J Biol Chem 1993 Mar 5;268(7):4580-3.
57. Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association. Kitano J, etal., J Biol Chem 2003 Apr 25;278(17):14762-8. Epub 2003 Feb 13.
58. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Klezovitch O, etal., Genes Dev 2004 Mar 1;18(5):559-71.
59. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Ko J, etal., EMBO J. 2009 Oct 21;28(20):3244-55. doi: 10.1038/emboj.2009.249. Epub 2009 Sep 3.
60. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Kornau HC, etal., Science. 1995 Sep 22;269(5231):1737-40.
61. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. Kravchick DO, etal., EMBO J. 2016 Sep 1;35(17):1923-34. doi: 10.15252/embj.201593070. Epub 2016 Jul 25.
62. The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic. Lee HW, etal., J Neurosci. 2010 Apr 21;30(16):5508-18. doi: 10.1523/JNEUROSCI.4283-09.2010.
63. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21.
64. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15.
65. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, etal., Curr Alzheimer Res. 2014 Jan;11(1):86-96.
66. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. Lim IA, etal., J Biol Chem. 2002 Jun 14;277(24):21697-711. Epub 2002 Apr 5.
67. Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Lim S, etal., Mol Cell Neurosci 2001 Feb;17(2):385-97.
68. Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. Long JF, etal., J Mol Biol 2003 Mar 14;327(1):203-14.
69. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Marco EM, etal., Pharmacol Biochem Behav. 2017 Jan;152:68-80. doi: 10.1016/j.pbb.2016.11.005. Epub 2016 Nov 25.
70. The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus. Marcora E and Kennedy MB, Hum Mol Genet. 2010 Nov 15;19(22):4373-84. Epub 2010 Aug 25.
71. Identification and characterization of the BRI2 interactome in the brain. Martins F, etal., Sci Rep. 2018 Feb 23;8(1):3548. doi: 10.1038/s41598-018-21453-3.
72. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
73. Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins. Mok H, etal., J Neurosci. 2002 Jul 1;22(13):5253-8.
74. Altered sensory experience exacerbates stable dendritic spine and synapse loss in a mouse model of Huntington's disease. Murmu RP, etal., J Neurosci. 2015 Jan 7;35(1):287-98. doi: 10.1523/JNEUROSCI.0244-14.2015.
75. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Naisbitt S, etal., Neuron 1999 Jul;23(3):569-82.
76. Subcellular redistribution of the synapse-associated proteins PSD-95 and SAP97 in animal models of Parkinson's disease and L-DOPA-induced dyskinesia. Nash JE, etal., FASEB J. 2005 Apr;19(6):583-5. Epub 2005 Feb 9.
77. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
78. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. Niethammer M, etal., J Neurosci. 1996 Apr 1;16(7):2157-63.
79. Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. Noritake J, etal., J Cell Biol. 2009 Jul 13;186(1):147-60. doi: 10.1083/jcb.200903101.
80. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. Ogawa Y, etal., J Neurosci. 2010 Jan 20;30(3):1038-48. doi: 10.1523/JNEUROSCI.4661-09.2010.
81. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. Oh D, etal., J Neurosci. 2010 Oct 20;30(42):14134-44. doi: 10.1523/JNEUROSCI.1711-10.2010.
82. Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. Ohtakara K, etal., Genes Cells. 2002 Nov;7(11):1149-60.
83. Functional analysis of the nucleotide binding domain of membrane-associated guanylate kinases. Olsen O and Bredt DS, J Biol Chem 2003 Feb 28;278(9):6873-8.
84. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. Osterweil E, etal., J Cell Biol. 2005 Jan 17;168(2):329-38.
85. Targeted protein degradation and synapse remodeling by an inducible protein kinase. Pak DT and Sheng M, Science 2003 Nov 21;302(5649):1368-73. Epub 2003 Oct 23.
86. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Pak DT, etal., Neuron. 2001 Aug 2;31(2):289-303.
87. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. Perez de Arce K, etal., J Neurosci. 2010 Mar 10;30(10):3728-38. doi: 10.1523/JNEUROSCI.2024-09.2010.
88. Disrupting 5-HT(2A) receptor/PDZ protein interactions reduces hyperalgesia and enhances SSRI efficacy in neuropathic pain. Pichon X, etal., Mol Ther. 2010 Aug;18(8):1462-70. doi: 10.1038/mt.2010.101. Epub 2010 Jun 8.
89. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
90. PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. Porras G, etal., J Clin Invest. 2012 Nov 1;122(11):3977-89. doi: 10.1172/JCI59426. Epub 2012 Oct 8.
91. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Rademacher N, etal., Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283.
92. The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. Reese ML, etal., Nat Struct Mol Biol. 2007 Feb;14(2):155-63. Epub 2007 Jan 14.
93. Molecular characterization of MARTA1, a protein interacting with the dendritic targeting element of MAP2 mRNAs. Rehbein M, etal., J Neurochem 2002 Sep;82(5):1039-46.
94. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
95. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
96. Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses. Ruiz A, etal., J Neurosci. 2005 Dec 14;25(50):11710-8.
97. Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. Russwurm M, etal., J Biol Chem 2001 Nov 30;276(48):44647-52.
98. Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Sabio G, etal., Biochem J 2004 May 15;380(Pt 1):19-30.
99. Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. Savinainen A, etal., J Biol Chem. 2001 Apr 6;276(14):11382-6. Epub 2001 Jan 10.
100. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Schnell E, etal., Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13902-7. Epub 2002 Oct 1.
101. Semaphorin4F interacts with the synapse-associated protein SAP90/PSD-95. Schultze W, etal., J Neurochem. 2001 Aug;78(3):482-9.
102. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, etal., Nat Neurosci. 2007 Mar;10(3):301-10. Epub 2007 Feb 18.
103. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Siow NL, etal., Mol Pharmacol. 2010 Dec;78(6):1059-71. doi: 10.1124/mol.110.066506. Epub 2010 Sep 16.
104. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Smith GA, etal., Hum Mol Genet. 2014 Sep 1;23(17):4510-27. doi: 10.1093/hmg/ddu166. Epub 2014 Apr 12.
105. Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a. Spinelli M, etal., Nat Commun. 2017 Dec 8;8(1):2009. doi: 10.1038/s41467-017-02221-9.
106. Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex. Stanic J, etal., Nat Commun. 2015 Dec 18;6:10181. doi: 10.1038/ncomms10181.
107. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, etal., Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.
108. Pursuit auditory tracking of dichotically presented tonal amplitudes. Sussman HM, etal., J Speech Hear Res. 1975 Mar;18(1):74-81.
109. SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. Takeuchi M, etal., J Biol Chem 1997 May 2;272(18):11943-51.
110. Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats. Tao F, etal., Neuroscience 2003;117(3):731-9.
111. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
112. Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II. Tian QB, etal., Eur J Neurosci. 2006 Jun;23(11):2864-76.
113. The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family. Tobaben S, etal., J Biol Chem 2000 Nov 17;275(46):36204-10.
114. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, etal., Cell Rep. 2014 Mar 27;6(6):1096-109. doi: 10.1016/j.celrep.2014.02.010. Epub 2014 Mar 6.
115. A novel family of adhesion-like molecules that interacts with the NMDA receptor. Wang CY, etal., J Neurosci. 2006 Feb 22;26(8):2174-83.
116. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. Wang D, etal., FASEB J. 2010 Sep;24(9):3511-21. doi: 10.1096/fj.10-156661. Epub 2010 Apr 15.
117. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, etal., Brain Res. 2010 Apr 30;1328:162-70. Epub 2010 Mar 1.
118. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Watanabe T, etal., Cancer Sci. 2005 Aug;96(8):498-506. doi: 10.1111/j.1349-7006.2005.00073.x.
119. Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. Wu HY, etal., J Biol Chem. 2007 Jul 13;282(28):20075-87. doi: 10.1074/jbc.M700624200. Epub 2007 May 25.
120. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
121. Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo. Wyszynski M, etal., J Neurosci 1999 Aug 1;19(15):6528-37.
122. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Wyszynski M, etal., Neuron 2002 Mar 28;34(1):39-52.
123. beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. Xu J, etal., J Biol Chem. 2001 Nov 2;276(44):41310-7. Epub 2001 Aug 28.
124. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
125. MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. Yao I, etal., J Biol Chem 1999 Apr 23;274(17):11889-96.
126. Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein. Yao I, etal., J Neurosci. 2002 Jul 1;22(13):5354-64.
127. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, etal., J Neurosci. 2016 Jun 15;36(24):6431-44. doi: 10.1523/JNEUROSCI.0419-16.2016.
128. Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons. Yoshii A, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1334-9.
129. Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 . Yoshioka T, etal., FEBS Lett. 2013 May 21;587(10):1453-9. doi: 10.1016/j.febslet.2013.03.030. Epub 2013 Apr 6.
130. SAP102 is a highly mobile MAGUK in spines. Zheng CY, etal., J Neurosci. 2010 Mar 31;30(13):4757-66. doi: 10.1523/JNEUROSCI.6108-09.2010.
131. Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. Zhu J, etal., Cell Res. 2014 Apr;24(4):451-63. doi: 10.1038/cr.2014.16. Epub 2014 Feb 11.
132. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. Zhu YC, etal., Proc Natl Acad Sci U S A. 2013 May 28;110(22):9118-23. doi: 10.1073/pnas.1300003110. Epub 2013 May 13.
Additional References at PubMed
PMID:7477295   PMID:9286858   PMID:9395480   PMID:9581761   PMID:9581762   PMID:9620694   PMID:9892651   PMID:10318831   PMID:10521485   PMID:11122378   PMID:11487731   PMID:12063253  
PMID:12065411   PMID:12115694   PMID:12151521   PMID:12427827   PMID:12563010   PMID:12576494   PMID:12675619   PMID:12682061   PMID:12972605   PMID:14529711   PMID:14529712   PMID:14610362  
PMID:14622577   PMID:14645471   PMID:14732465   PMID:14749436   PMID:14760703   PMID:15044063   PMID:15071120   PMID:15082773   PMID:15207857   PMID:15317856   PMID:15458844   PMID:15458847  
PMID:15458848   PMID:15483135   PMID:15496675   PMID:15574735   PMID:15603741   PMID:15629447   PMID:15665879   PMID:15673434   PMID:15723836   PMID:15729360   PMID:15748150   PMID:15883194  
PMID:15978582   PMID:16520334   PMID:16606358   PMID:16791853   PMID:16814779   PMID:16815335   PMID:16818724   PMID:16828986   PMID:16980967   PMID:17018287   PMID:17021172   PMID:17046693  
PMID:17093100   PMID:17114649   PMID:17118964   PMID:17237775   PMID:17348686   PMID:17360496   PMID:17437338   PMID:17459877   PMID:17486105   PMID:17646177   PMID:17670980   PMID:17904695  
PMID:17938206   PMID:17988632   PMID:18053028   PMID:18093743   PMID:18095156   PMID:18215622   PMID:18248606   PMID:18272690   PMID:18279309   PMID:18307989   PMID:18392731   PMID:18579798  
PMID:18617669   PMID:18678878   PMID:18700282   PMID:18721130   PMID:18723686   PMID:19041927   PMID:19075115   PMID:19098102   PMID:19104036   PMID:19166515   PMID:19169250   PMID:19332546  
PMID:19428647   PMID:19449206   PMID:19457061   PMID:19629758   PMID:19632332   PMID:19726645   PMID:19828436   PMID:20623763   PMID:20831617   PMID:20842722   PMID:20865734   PMID:20886623  
PMID:20952458   PMID:21144999   PMID:21185848   PMID:21324980   PMID:21645852   PMID:21668967   PMID:21719075   PMID:21865455   PMID:21911612   PMID:21920314   PMID:21927888   PMID:22022532  
PMID:22114157   PMID:22233891   PMID:22632720   PMID:22807451   PMID:22871113   PMID:23001297   PMID:23038781   PMID:23049922   PMID:23183381   PMID:23239444   PMID:23267080   PMID:23300088  
PMID:23321072   PMID:23342049   PMID:23395180   PMID:23395379   PMID:23424281   PMID:23516288   PMID:23595732   PMID:23719161   PMID:23791195   PMID:23800465   PMID:23891900   PMID:23946397  
PMID:23986251   PMID:24035762   PMID:24058620   PMID:24069373   PMID:24298137   PMID:24350898   PMID:24464040   PMID:24491052   PMID:24608243   PMID:24705401   PMID:24705785   PMID:24794856  
PMID:24981431   PMID:25393018   PMID:25399920   PMID:25565773   PMID:25966954   PMID:26147235   PMID:26223010   PMID:26257100   PMID:26365118   PMID:26479588   PMID:26604311   PMID:26609151  
PMID:27321669   PMID:27330081   PMID:27457929   PMID:27653801   PMID:27759003   PMID:28553222   PMID:28698933   PMID:28701415   PMID:28790172   PMID:28823933   PMID:29082919   PMID:29118110  
PMID:29281827   PMID:29490264   PMID:29577884   PMID:29592780   PMID:30053369   PMID:30108200   PMID:30193808   PMID:30214057   PMID:30605082   PMID:31745231   PMID:31989159   PMID:32029829  
PMID:32157575   PMID:32197489   PMID:32386416   PMID:32454040   PMID:33990590   PMID:34077732   PMID:34818135   PMID:35243702   PMID:35257794   PMID:35609859   PMID:35725243   PMID:37525090  


Genomics

Comparative Map Data
Dlg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,239,397 - 55,267,780 (+)NCBIGRCr8
GRCr8 Ensembl1055,236,869 - 55,265,839 (+)EnsemblGRCr8 Ensembl
mRatBN7.21054,740,700 - 54,769,097 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,739,470 - 54,767,153 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,403,247 - 59,429,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,891,827 - 58,917,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,399,117 - 54,425,128 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,625,845 - 56,655,543 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,627,411 - 56,653,599 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,369,703 - 56,400,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,864,459 - 56,890,626 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1053,894,685 - 53,920,691 (+)NCBICelera
RGSC_v3.11056,878,081 - 56,904,246 (+)NCBI
Cytogenetic Map10q24NCBI
DLG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,187,187 - 7,220,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,187,187 - 7,219,836 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,090,506 - 7,123,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,033,933 - 7,063,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,033,935 - 7,063,745NCBI
Celera177,117,875 - 7,148,003 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,984,911 - 7,015,359 (-)NCBIHuRef
CHM1_1177,102,006 - 7,132,134 (-)NCBICHM1_1
T2T-CHM13v2.0177,088,092 - 7,120,961 (-)NCBIT2T-CHM13v2.0
Dlg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,908,029 - 69,938,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,907,768 - 69,938,348 (+)EnsemblGRCm39 Ensembl
GRCm381170,017,203 - 70,045,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,016,942 - 70,047,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,832,107 - 69,859,034 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,835,059 - 69,860,963 (+)NCBIMGSCv36mm8
Celera1177,566,529 - 77,594,216 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
Dlg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,690,469 - 9,715,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,691,733 - 9,715,872 (+)NCBIChiLan1.0ChiLan1.0
DLG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,782,686 - 14,812,487 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,748,876 - 16,776,272 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,219,911 - 7,247,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,207,483 - 7,236,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,207,483 - 7,235,985 (-)Ensemblpanpan1.1panPan2
DLG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,165,399 - 32,175,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,163,594 - 32,188,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,303,501 - 32,327,281 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,271,402 - 32,294,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,272,047 - 32,293,737 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,236,680 - 32,259,896 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,195,151 - 32,218,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,372,643 - 32,395,864 (-)NCBIUU_Cfam_GSD_1.0
Dlg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,013,899 - 47,039,640 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595485,554 - 513,815 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595487,918 - 513,843 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,550,141 - 52,575,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,550,138 - 52,574,021 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,824,633 - 139,849,233 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,562,953 - 6,592,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,562,691 - 6,590,867 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,818,727 - 14,848,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dlg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,811,780 - 9,837,100 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,811,201 - 9,835,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dlg4
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:75
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000068493
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
UniSTS:224404  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,750,265 - 54,750,409 (+)MAPPERmRatBN7.2
Rnor_6.01056,636,712 - 56,636,855NCBIRnor6.0
Rnor_5.01056,381,831 - 56,381,974UniSTSRnor5.0
RGSC_v3.41056,873,736 - 56,873,879UniSTSRGSC3.4
Celera1053,903,797 - 53,903,940UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000068493   ⟹   ENSRNOP00000059045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,236,869 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,739,470 - 54,767,153 (+)Ensembl
Rnor_6.0 Ensembl1056,627,547 - 56,653,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089108   ⟹   ENSRNOP00000074184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,239,648 - 55,264,360 (+)Ensembl
mRatBN7.2 Ensembl1054,740,746 - 54,767,153 (+)Ensembl
Rnor_6.0 Ensembl1056,627,411 - 56,652,819 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095923   ⟹   ENSRNOP00000079351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,239,641 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,740,746 - 54,767,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096075   ⟹   ENSRNOP00000080177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,245,018 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,746,405 - 54,767,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096932   ⟹   ENSRNOP00000079890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,751,770 - 54,767,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099685   ⟹   ENSRNOP00000080495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,250,784 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,748,872 - 54,767,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111048   ⟹   ENSRNOP00000085178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,236,869 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,751,925 - 54,767,153 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117232   ⟹   ENSRNOP00000085005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,251,389 - 55,265,839 (+)Ensembl
mRatBN7.2 Ensembl1054,752,706 - 54,767,153 (+)Ensembl
RefSeq Acc Id: NM_019621   ⟹   NP_062567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,239,784 - 55,265,839 (+)NCBI
mRatBN7.21054,741,101 - 54,767,156 (+)NCBI
Rnor_6.01056,627,547 - 56,653,602 (+)NCBI
Rnor_5.01056,369,703 - 56,400,662 (+)NCBI
RGSC_v3.41056,864,459 - 56,890,626 (+)RGD
Celera1053,894,685 - 53,920,691 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246687   ⟹   XP_006246749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,239,397 - 55,267,780 (+)NCBI
mRatBN7.21054,740,700 - 54,769,097 (+)NCBI
Rnor_6.01056,627,172 - 56,655,543 (+)NCBI
Rnor_5.01056,369,703 - 56,400,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008767809   ⟹   XP_008766031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,248,267 - 55,267,780 (+)NCBI
mRatBN7.21054,749,604 - 54,769,097 (+)NCBI
Rnor_6.01056,625,895 - 56,655,543 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085766   ⟹   XP_038941694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,248,300 - 55,267,780 (+)NCBI
mRatBN7.21054,749,604 - 54,769,097 (+)NCBI
RefSeq Acc Id: XM_039085767   ⟹   XP_038941695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,245,240 - 55,267,780 (+)NCBI
mRatBN7.21054,746,556 - 54,769,097 (+)NCBI
RefSeq Acc Id: XM_039085768   ⟹   XP_038941696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,250,859 - 55,267,780 (+)NCBI
mRatBN7.21054,752,176 - 54,769,097 (+)NCBI
RefSeq Acc Id: XR_005489771
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,248,297 - 55,264,932 (+)NCBI
mRatBN7.21054,749,603 - 54,769,097 (+)NCBI
RefSeq Acc Id: NP_062567   ⟸   NM_019621
- UniProtKB: P97631 (UniProtKB/Swiss-Prot),   P31016 (UniProtKB/Swiss-Prot),   A0A0G2K7F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246749   ⟸   XM_006246687
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K7F5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766031   ⟸   XM_008767809
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMM3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074184   ⟸   ENSRNOT00000089108
Ensembl Acc Id: ENSRNOP00000059045   ⟸   ENSRNOT00000068493
RefSeq Acc Id: XP_038941695   ⟸   XM_039085767
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K7F5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941694   ⟸   XM_039085766
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941696   ⟸   XM_039085768
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K7F5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080177   ⟸   ENSRNOT00000096075
Ensembl Acc Id: ENSRNOP00000079351   ⟸   ENSRNOT00000095923
Ensembl Acc Id: ENSRNOP00000085005   ⟸   ENSRNOT00000117232
Ensembl Acc Id: ENSRNOP00000079890   ⟸   ENSRNOT00000096932
Ensembl Acc Id: ENSRNOP00000080495   ⟸   ENSRNOT00000099685
Ensembl Acc Id: ENSRNOP00000085178   ⟸   ENSRNOT00000111048
Protein Domains
Guanylate kinase-like   PDZ   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31016-F1-model_v2 AlphaFold P31016 1-724 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68424 AgrOrtholog
BioCyc Gene G2FUF-24485 BioCyc
Ensembl Genes ENSRNOG00000018526 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089108 ENTREZGENE
  ENSRNOT00000095923 ENTREZGENE
  ENSRNOT00000096075 ENTREZGENE
  ENSRNOT00000099685 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
  Guanylate Kinase phosphate binding domain UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro DLG1-like UniProtKB/Swiss-Prot
  DLG1_PEST_dom UniProtKB/Swiss-Prot
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot
  Guanylate_kin-like_dom UniProtKB/Swiss-Prot
  Guanylate_kinase_CS UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
  Synaptic_Scaffolding_LAP-MAGUK UniProtKB/Swiss-Prot
KEGG Report rno:29495 UniProtKB/Swiss-Prot
NCBI Gene 29495 ENTREZGENE
PANTHER DISCS LARGE UniProtKB/Swiss-Prot
  DISKS LARGE HOMOLOG 4 UniProtKB/Swiss-Prot
Pfam Guanylate_kin UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_assoc UniProtKB/Swiss-Prot
  SH3_1 UniProtKB/Swiss-Prot
PhenoGen Dlg4 PhenoGen
PIRSF MAGUK_DLGH UniProtKB/Swiss-Prot
PROSITE GUANYLATE_KINASE_1 UniProtKB/Swiss-Prot
  GUANYLATE_KINASE_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018526 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot
  MAGUK_N_PEST UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF52540 UniProtKB/Swiss-Prot
TIGR TC229371
UniProt A0A0G2K7F5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZMM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNM8_RAT UniProtKB/TrEMBL
  A0A8I5ZP61_RAT UniProtKB/TrEMBL
  A0A8I5ZQU2_RAT UniProtKB/TrEMBL
  A0A8I6A2E3_RAT UniProtKB/TrEMBL
  A0A8I6GC37_RAT UniProtKB/TrEMBL
  A0A8L2QSM4_RAT UniProtKB/TrEMBL
  DLG4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97631 ENTREZGENE
UniProt Secondary P97631 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-01 Dlg4  discs large MAGUK scaffold protein 4  Dlg4  discs large homolog 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Dlg4  discs large homolog 4  Dlg4  discs, large homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Dlg4  discs, large homolog 4 (Drosophila)  Dlgh4  discs, large homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Dlgh4  discs, large homolog 4 (Drosophila)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the postsynaptic density 68239
gene_domains contains a potential cytoskeletal region consisting of three repeats of 90 amino acids in length, a domain with similarity to SH3 and a carboxyl-terminal domain homologous to yeast guanylate kinase 68239