Lrp2 (LDL receptor related protein 2) - Rat Genome Database

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Gene: Lrp2 (LDL receptor related protein 2) Rattus norvegicus
Analyze
Symbol: Lrp2
Name: LDL receptor related protein 2
RGD ID: 68407
Description: Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including positive regulation of transport; protein transport; and response to vitamin D. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; pancreatic cancer pathway; INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycoprotein 330; gp330; low density lipoprotein receptor-related protein 2; low density lipoprotein-related protein 2; low-density lipoprotein receptor-related protein 2; LRP-2; megalin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
afimoxifene  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amitrole  (EXP)
aspartame  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
carbamazepine  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
cholic acid  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diiodine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
guggulsterone  (ISO)
hydrogen peroxide  (ISO)
lithocholic acid  (ISO)
manganese(II) chloride  (EXP)
methimazole  (EXP,ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
O-methyleugenol  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phosgene  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IMP)
anatomical structure development  (IEA)
animal organ regeneration  (IEP)
aorta development  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to growth factor stimulus  (IMP)
chemoattraction of axon  (IMP)
coronary artery morphogenesis  (IEA,ISO,ISS)
coronary vasculature development  (ISO)
diol metabolic process  (IEA,ISO)
endocytic hemoglobin import into cell  (IMP)
endocytosis  (IEA,IMP)
endosomal transport  (IMP)
folate import across plasma membrane  (IEA,ISO,ISS)
forebrain development  (IEA,ISO)
heart development  (ISO)
kidney development  (IEA,ISO)
male gonad development  (IEA,ISO,ISS)
metal ion transport  (IDA,IEA,ISO)
metanephric proximal tubule development  (IEP)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO,ISS)
neural tube closure  (IEA,ISO,ISS)
neuron projection arborization  (IEA,ISO,ISS)
outflow tract septum morphogenesis  (IEA,ISO,ISS)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of endocytosis  (IMP)
positive regulation of lipoprotein transport  (IMP)
positive regulation of lysosomal protein catabolic process  (ISO)
positive regulation of neurogenesis  (ISO,ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IEA,ISO,ISS)
protein import  (IMP)
protein transport  (IEA,ISO)
pulmonary artery morphogenesis  (IEA,ISO,ISS)
receptor-mediated endocytosis  (IBA,IDA,IEA,IMP,ISO)
response to leptin  (IEA,IMP,ISO)
response to retinoic acid  (IEP)
response to vitamin D  (IEP)
response to X-ray  (IDA)
response to xenobiotic stimulus  (IEP)
secondary heart field specification  (IEA,ISO,ISS)
sensory perception of sound  (IEA,ISO,ISS)
transcytosis  (IMP)
vagina development  (IEA,ISO,ISS)
ventricular compact myocardium morphogenesis  (IEA,ISO,ISS)
ventricular septum development  (IEA,ISO)
vitamin D metabolic process  (IEA,ISO)

Cellular Component
apical part of cell  (ISO)
apical plasma membrane  (IBA,IDA,IEA,ISO)
axon  (IEA,ISO,ISS)
axonal growth cone  (IDA)
brush border  (IDA,ISO)
brush border membrane  (IDA,IEA,ISO)
cell surface  (IDA)
clathrin-coated pit  (IEA,ISO)
dendrite  (IEA,ISO,ISS)
endocytic vesicle  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
endosome  (IDA,IEA,ISO)
endosome lumen  (IEA)
external side of plasma membrane  (IEA,ISO,ISS)
extracellular space  (IDA)
Golgi apparatus  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IBA,IDA,ISO)
protein-containing complex  (IDA)
receptor complex  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Megalin is a receptor for albumin in astrocytes and is required for the synthesis of the neurotrophic factor oleic acid. Bento-Abreu A, etal., J Neurochem. 2008 Aug;106(3):1149-59. doi: 10.1111/j.1471-4159.2008.05462.x. Epub 2008 May 5.
2. Megalin binds and mediates cellular internalization of folate binding protein. Birn H, etal., FEBS J. 2005 Sep;272(17):4423-30. doi: 10.1111/j.1742-4658.2005.04857.x.
3. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. Carro E, etal., J Neurosci. 2005 Nov 23;25(47):10884-93. doi: 10.1523/JNEUROSCI.2909-05.2005.
4. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
5. Megalin mediates the transport of leptin across the blood-CSF barrier. Dietrich MO, etal., Neurobiol Aging. 2008 Jun;29(6):902-12. Epub 2007 Feb 26.
6. Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Faber K, etal., Mol Endocrinol. 2006 Jan;20(1):212-8. Epub 2005 Aug 11.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Gburek J, etal., Am J Physiol Renal Physiol 2003 Sep;285(3):F451-8. Epub 2003 Apr 29.
9. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. Gburek J, etal., J Am Soc Nephrol. 2002 Feb;13(2):423-30.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Megalin binds and internalizes angiotensin II. Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2005 Feb;288(2):F420-7. Epub 2004 Oct 5.
12. Megalin binds and internalizes angiotensin-(1-7). Gonzalez-Villalobos R, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5. Epub 2005 Dec 27.
13. Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Hama H, etal., Endocrinology. 2004 Aug;145(8):3935-40. Epub 2004 May 6.
14. Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. Hammad SM, etal., J Biol Chem. 2000 Apr 21;275(16):12003-8.
15. Role of endocytosis in cellular uptake of sex steroids. Hammes A, etal., Cell. 2005 Sep 9;122(5):751-62.
16. Gentamicin inhibits rat renal cortical homotypic endosomal fusion: role of megalin. Hammond TG, etal., Am J Physiol. 1997 Jan;272(1 Pt 2):F117-23.
17. Megalin and nonmuscle myosin heavy chain IIA interact with the adaptor protein Disabled-2 in proximal tubule cells. Hosaka K, etal., Kidney Int. 2009 Jun;75(12):1308-15. Epub 2009 Apr 1.
18. The interaction between megalin and ClC-5 is scaffolded by the Na(+)-H(+) exchanger regulatory factor 2 (NHERF2) in proximal tubule cells. Hryciw DH, etal., Int J Biochem Cell Biol. 2012 May;44(5):815-23. doi: 10.1016/j.biocel.2012.02.007. Epub 2012 Feb 13.
19. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. Hvidberg V, etal., FEBS Lett. 2005 Jan 31;579(3):773-7.
20. Soluble megalin is accumulated in the lumen of the rat endolymphatic sac. Ishida T, etal., Cell Struct Funct. 2006;31(2):77-85. Epub 2006 Oct 23.
21. Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Johanns M, etal., Sci Rep. 2017 Jun 28;7(1):4328. doi: 10.1038/s41598-017-04648-y.
22. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
23. Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Kaseda R, etal., Biochem Biophys Res Commun. 2007 Jun 15;357(4):1130-4. Epub 2007 Apr 19.
24. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Kerjaschki D and Farquhar MG, Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61.
25. Megalin mediates renal uptake of heavy metal metallothionein complexes. Klassen RB, etal., Am J Physiol Renal Physiol. 2004 Sep;287(3):F393-403. Epub 2004 May 4.
26. Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
27. Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration. Landowski LM, etal., J Biol Chem. 2016 Jan 15;291(3):1092-102. doi: 10.1074/jbc.M115.668996. Epub 2015 Nov 23.
28. Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone release. Lisi S, etal., Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14858-63. Epub 2003 Dec 1.
29. Regulation of gp330/megalin expression by vitamins A and D. Liu W, etal., Eur J Clin Invest. 1998 Feb;28(2):100-7.
30. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. Lou X, etal., J Am Soc Nephrol. 2002 Apr;13(4):918-27.
31. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Magyar CE, etal., Am J Physiol Renal Physiol. 2000 Aug;279(2):F358-69.
32. Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis. Marino M, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2468-74.
33. Megalin functions as an endocytic sonic hedgehog receptor. McCarthy RA, etal., J Biol Chem. 2002 Jul 12;277(28):25660-7. Epub 2002 Apr 18.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
36. Epithelial trafficking of Sonic hedgehog by megalin. Morales CR, etal., J Histochem Cytochem. 2006 Oct;54(10):1115-27. Epub 2006 Jun 26.
37. The adaptor protein ARH escorts megalin to and through endosomes. Nagai M, etal., Mol Biol Cell. 2003 Dec;14(12):4984-96. Epub 2003 Oct 3.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Age-related change of endocytic receptors megalin and cubilin in the kidney in rats. Odera K, etal., Biogerontology. 2007 Apr 24;.
40. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Oleinikov AV, etal., Biochem J. 2000 May 1;347 Pt 3:613-21.
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. GOA pipeline RGD automated data pipeline
45. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Saito A, etal., Proc Natl Acad Sci U S A 1994 Oct 11;91(21):9725-9.
48. Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11.
49. Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. Stefansson S, etal., J Biol Chem. 1996 Apr 5;271(14):8215-20.
50. Identification of an apical sorting determinant in the cytoplasmic tail of megalin. Takeda T, etal., Am J Physiol Cell Physiol. 2003 May;284(5):C1105-13. Epub 2003 Jan 8.
51. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
52. Cubilin and megalin co-localize in the neonatal inner ear. Tauris J, etal., Audiol Neurootol. 2009;14(4):267-78. doi: 10.1159/000199446. Epub 2009 Feb 6.
53. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
54. Reduced albumin reabsorption in the proximal tubule of early-stage diabetic rats. Tojo A, etal., Histochem Cell Biol. 2001 Sep;116(3):269-76.
55. Modulation of gene expression by moxonidine in rats with chronic renal failure. Vonend O, etal., Nephrol Dial Transplant. 2004 Sep;19(9):2217-22. Epub 2004 Jul 20.
56. Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease. Witzgall R, etal., Kidney Int. 2002 Jan;61(1 Suppl):132-7.
57. Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock. Xu C, etal., Sci Signal. 2012 May 29;5(226):ra39. doi: 10.1126/scisignal.2002979.
58. Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy. Yammani RR, etal., Am J Physiol Endocrinol Metab 2001 Nov;281(5):E900-7.
59. Loss of albumin and megalin binding to renal cubilin in rats results in albuminuria after total body irradiation. Yammani RR, etal., Am J Physiol Regul Integr Comp Physiol. 2002 Aug;283(2):R339-46.
60. Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation. Zhao J, etal., Gene 2001 Mar 7;265(1-2):123-31.
Additional References at PubMed
PMID:7510321   PMID:7544804   PMID:9228033   PMID:10052453   PMID:10662735   PMID:12707383   PMID:12809172   PMID:12815097   PMID:12846736   PMID:14764706   PMID:15082773   PMID:15286052  
PMID:15342463   PMID:15616221   PMID:15623804   PMID:16027047   PMID:17228368   PMID:17245526   PMID:17457373   PMID:17846082   PMID:17897319   PMID:17990981   PMID:18174160   PMID:18927221  
PMID:19056867   PMID:20460439   PMID:20637285   PMID:20966072   PMID:21938401   PMID:22354480   PMID:23275343   PMID:23376485   PMID:23382219   PMID:23533145   PMID:23677864   PMID:23825075  
PMID:23836931   PMID:24586199   PMID:24639464   PMID:25807483   PMID:26025362   PMID:26173747   PMID:26248135   PMID:26822476   PMID:27241555   PMID:28289043   PMID:29187367   PMID:29286200  
PMID:29949391   PMID:32200675   PMID:36922642  


Genomics

Comparative Map Data
Lrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,189,305 - 54,346,769 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,588,938 - 57,746,695 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,172,509 - 66,330,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,935,221 - 64,092,679 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,665,153 - 55,822,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,271,279 - 62,434,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4351,563,764 - 51,724,478 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1351,460,135 - 51,620,850 (-)NCBI
Celera353,751,431 - 53,907,374 (-)NCBICelera
Cytogenetic Map3q21NCBI
LRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382169,127,109 - 169,362,534 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2169,127,109 - 169,362,534 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,983,619 - 170,219,044 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,691,865 - 169,927,368 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,810,367 - 170,044,520NCBI
Celera2163,608,960 - 163,839,028 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,880,497 - 162,110,457 (-)NCBIHuRef
CHM1_12169,989,632 - 170,225,372 (-)NCBICHM1_1
T2T-CHM13v2.02169,602,803 - 169,838,534 (-)NCBIT2T-CHM13v2.0
Lrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,254,679 - 69,416,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,254,684 - 69,416,409 (-)EnsemblGRCm39 Ensembl
GRCm38269,424,335 - 69,586,029 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,424,340 - 69,586,065 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,262,392 - 69,424,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,225,174 - 69,386,906 (-)NCBIMGSCv36mm8
Celera271,089,849 - 71,251,632 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map240.74NCBI
Lrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,160,946 - 5,314,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,155,109 - 5,314,886 (+)NCBIChiLan1.0ChiLan1.0
LRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12B71,806,164 - 72,043,965 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,407,871 - 56,640,471 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,873,454 - 174,103,911 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,873,767 - 174,103,697 (-)Ensemblpanpan1.1panPan2
LRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,910,450 - 14,107,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,911,865 - 14,107,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,921,313 - 14,118,067 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03614,026,860 - 14,223,177 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3614,025,608 - 14,223,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13614,111,272 - 14,307,564 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03614,099,044 - 14,295,347 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,212,187 - 14,408,758 (-)NCBIUU_Cfam_GSD_1.0
Lrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,178,787 - 131,372,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,244,881 - 10,438,935 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,245,001 - 10,438,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,565,303 - 75,716,694 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,565,299 - 75,754,604 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,725,590 - 84,788,031 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,672,876 - 54,889,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,711,517 - 54,889,208 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,669,443 - 144,856,881 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,798,938 - 6,998,697 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,797,462 - 6,998,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp2
895 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582249Bw77Body weight QTL 773.20.0025epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)35318459364655484Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat

Markers in Region
D3Rat239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2354,319,500 - 54,319,800 (+)MAPPERmRatBN7.2
Rnor_6.0355,795,318 - 55,795,617NCBIRnor6.0
Rnor_5.0362,407,260 - 62,407,559UniSTSRnor5.0
RGSC_v3.4351,697,009 - 51,697,309RGDRGSC3.4
RGSC_v3.4351,697,010 - 51,697,309UniSTSRGSC3.4
RGSC_v3.1351,593,353 - 51,593,777RGD
Celera353,880,411 - 53,880,710UniSTS
FHH x ACI Map339.47UniSTS
FHH x ACI Map339.47RGD
Cytogenetic Map3q21UniSTS
RH140983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2354,190,634 - 54,190,983 (+)MAPPERmRatBN7.2
Rnor_6.0355,666,480 - 55,666,828NCBIRnor6.0
Rnor_5.0362,272,606 - 62,272,954UniSTSRnor5.0
RGSC_v3.4351,565,091 - 51,565,439UniSTSRGSC3.4
Celera353,752,758 - 53,753,106UniSTS
Cytogenetic Map3q21UniSTS
UniSTS:485602  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22024,385,485 - 24,385,544 (+)MAPPERmRatBN7.2
mRatBN7.2354,309,254 - 54,309,840 (+)MAPPERmRatBN7.2
Rnor_6.0355,785,073 - 55,785,657NCBIRnor6.0
Rnor_6.02025,862,227 - 25,862,285NCBIRnor6.0
Rnor_5.0362,397,014 - 62,397,599UniSTSRnor5.0
Rnor_5.02027,932,273 - 27,932,331UniSTSRnor5.0
RGSC_v3.4351,686,764 - 51,687,349UniSTSRGSC3.4
Celera353,870,165 - 53,870,750UniSTS
Celera2025,718,227 - 25,718,285UniSTS
Cytogenetic Map20p11-q11UniSTS
Cytogenetic Map3q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 4
Medium 1 1 1 14 29 5 11
Low 22 40 24 19 24 7 7 58 2 36 7
Below cutoff 2 18 16 16 16 1 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082624   ⟹   ENSRNOP00000075159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl354,189,308 - 54,346,708 (-)Ensembl
Rnor_6.0 Ensembl355,665,145 - 55,822,551 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113902   ⟹   ENSRNOP00000080818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl354,189,308 - 54,339,408 (-)Ensembl
RefSeq Acc Id: NM_030827   ⟹   NP_110454
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2354,189,308 - 54,346,708 (-)NCBI
Rnor_6.0355,665,153 - 55,822,484 (-)NCBI
Rnor_5.0362,271,279 - 62,434,959 (-)NCBI
RGSC_v3.4351,563,764 - 51,724,478 (-)RGD
Celera353,751,431 - 53,907,374 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104427   ⟹   XP_038960355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2354,189,305 - 54,346,769 (-)NCBI
Protein Sequences
Protein RefSeqs NP_110454 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960355 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA51369 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075159
  ENSRNOP00000075159.1
  ENSRNOP00000080818.1
GenBank Protein P98158 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_110454   ⟸   NM_030827
- Peptide Label: precursor
- UniProtKB: P98158 (UniProtKB/Swiss-Prot),   A0A0G2K9W7 (UniProtKB/TrEMBL),   A6HM07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075159   ⟸   ENSRNOT00000082624
RefSeq Acc Id: XP_038960355   ⟸   XM_039104427
- Peptide Label: isoform X1
- UniProtKB: P98158 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000080818   ⟸   ENSRNOT00000113902
Protein Domains
EGF-like   LDL-receptor class A

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692114
Promoter ID:EPDNEW_R2639
Type:multiple initiation site
Name:Lrp2_1
Description:LDL receptor related protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0355,822,498 - 55,822,558EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68407 AgrOrtholog
BIND 133316
BioCyc Gene G2FUF-49510 BioCyc
Ensembl Genes ENSRNOG00000056184 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082624 ENTREZGENE
  ENSRNOT00000082624.2 UniProtKB/TrEMBL
  ENSRNOT00000113902.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29216 UniProtKB/Swiss-Prot
NCBI Gene 29216 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LRP2 RGD
PhenoGen Lrp2 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056184 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229506
UniProt A0A0G2K9W7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRK6_RAT UniProtKB/TrEMBL
  A6HM07 ENTREZGENE, UniProtKB/TrEMBL
  LRP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp2  LDL receptor related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Lrp2  low density lipoprotein receptor-related protein 2  Lrp2  low density lipoprotein-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrp2  low density lipoprotein-related protein 2  Lrp2  low density lipoprotein receptor-related protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lrp2  low density lipoprotein receptor-related protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the rat yolk sac carcinoma cells and in the distal intestine 628443
gene_physical_interaction binds with cubilin to bring about endocytosis and cobalamin transportation through the endoplasmic reticulum 628443
gene_process may be involved in the process of receptor-mediated endocytosis 68274
gene_process may be involved in the process of receptor-mediated endocytosis 68711