Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pde1a | Rat | 1,1-dichloroethene | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of PDE1A mRNA | CTD | PMID:26682919 | Pde1a | Rat | 1,2-dichloroethane | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of PDE1A mRNA | CTD | PMID:28189721 and PMID:28960355 | Pde1a | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE1A mRNA | CTD | PMID:17942748 | Pde1a | Rat | 17beta-estradiol | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PDE1A mRNA | CTD | PMID:31614463 | Pde1a | Rat | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | Pde1a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDE1A mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of PDE1A mRNA | CTD | PMID:17942748 and PMID:25975270 | Pde1a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDE1A mRNA | CTD | PMID:32553695 | Pde1a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDE1A mRNA | CTD | PMID:28922406 | Pde1a | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:26705709 | Pde1a | Rat | 3',5'-cyclic GMP | multiple interactions | EXP | | 6480464 | PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP] | CTD | PMID:11696475 | Pde1a | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of PDE1A mRNA | CTD | PMID:28522335 | Pde1a | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE1A mRNA | CTD | PMID:28628672 | Pde1a | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | bisphenol S results in increased expression of PDE1A mRNA | CTD | PMID:30951980 | Pde1a | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PDE1A mRNA | CTD | PMID:28973697 | Pde1a | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PDE1A mRNA | CTD | PMID:30047161 | Pde1a | Rat | 7,12-dimethyltetraphene | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | 9 more ... | CTD | PMID:32553695 | Pde1a | Rat | 8-Br-cAMP | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PDE1A mRNA | CTD | PMID:20147733 | Pde1a | Rat | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of PDE1A mRNA | CTD | PMID:28959563 | Pde1a | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of PDE1A mRNA | CTD | PMID:30047161 | Pde1a | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PDE1A mRNA | CTD | PMID:16483693 | Pde1a | Rat | amphotericin B | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Amphotericin B analog results in decreased expression of PDE1A mRNA | CTD | PMID:28534445 | Pde1a | Rat | arotinoid acid | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [4-(2-(5 more ... | CTD | PMID:34480604 | Pde1a | Rat | arsenite(3-) | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | arsenite results in increased expression of PDE1A mRNA | CTD | PMID:33053406 | Pde1a | Rat | arsenous acid | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PDE1A mRNA | CTD | PMID:26705709 | Pde1a | Rat | benzo[a]pyrene | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PDE1A mRNA | CTD | PMID:17879257 | Pde1a | Rat | benzo[a]pyrene | affects methylation | ISO | PDE1A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PDE1A exon and Benzo(a)pyrene affects the methylation of PDE1A promoter | CTD | PMID:27901495 | Pde1a | Rat | benzo[a]pyrene | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PDE1A mRNA | CTD | PMID:22228805 | Pde1a | Rat | benzo[a]pyrene | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Benzo(a)pyrene metabolite results in decreased expression of PDE1A mRNA | CTD | PMID:32553695 | Pde1a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDE1A mRNA | CTD | PMID:25181051 more ... | Pde1a | Rat | bisphenol A | decreases methylation | ISO | PDE1A (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of PDE1A gene | CTD | PMID:31601247 | Pde1a | Rat | bisphenol A | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PDE1A protein | CTD | PMID:33376534 | Pde1a | Rat | bisphenol A | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | bisphenol A results in increased expression of PDE1A mRNA | CTD | PMID:30951980 | Pde1a | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PDE1A gene | CTD | PMID:28505145 | Pde1a | Rat | bisphenol A | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE1A mRNA | CTD | PMID:28628672 | Pde1a | Rat | bisphenol F | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | bisphenol F results in increased expression of PDE1A mRNA | CTD | PMID:30951980 | Pde1a | Rat | carbon nanotube | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Pde1a | Rat | CGP 52608 | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PDE1A gene] | CTD | PMID:28238834 | Pde1a | Rat | CHIR 99021 | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [4-(2-(5 more ... | CTD | PMID:34480604 | Pde1a | Rat | chlorpyrifos | affects expression | ISO | Pde1a (Mus musculus) | 6480464 | Chlorpyrifos affects the expression of PDE1A mRNA | CTD | PMID:32715474 | Pde1a | Rat | choline | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDE1A mRNA | CTD | PMID:20938992 | Pde1a | Rat | cortisol | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [4-(2-(5 more ... | CTD | PMID:34480604 | Pde1a | Rat | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PDE1A mRNA | CTD | PMID:26577399 | Pde1a | Rat | cytarabine | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Cytarabine results in increased expression of PDE1A mRNA | CTD | PMID:21198554 | Pde1a | Rat | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of PDE1A mRNA | CTD | PMID:23640034 and PMID:23914054 | Pde1a | Rat | deguelin | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | deguelin results in decreased expression of PDE1A mRNA | CTD | PMID:33512557 | Pde1a | Rat | dexamethasone | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE1A mRNA | CTD | PMID:28628672 | Pde1a | Rat | dextran sulfate | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PDE1A mRNA | CTD | PMID:29950665 | Pde1a | Rat | diarsenic trioxide | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PDE1A mRNA | CTD | PMID:26705709 | Pde1a | Rat | diazinon | decreases expression | EXP | | 6480464 | Diazinon results in decreased expression of PDE1A mRNA | CTD | PMID:17452286 | Pde1a | Rat | dioxygen | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of PDE1A mRNA | CTD | PMID:26516004 | Pde1a | Rat | dorsomorphin | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE1A mRNA | CTD | PMID:27188386 | Pde1a | Rat | entinostat | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | entinostat results in decreased expression of PDE1A mRNA | CTD | PMID:27188386 | Pde1a | Rat | ethanol | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PDE1A mRNA | CTD | PMID:30517762 | Pde1a | Rat | flavonoids | decreases expression | EXP | | 6480464 | Flavonoids results in decreased expression of PDE1A mRNA | CTD | PMID:18035473 | Pde1a | Rat | folic acid | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDE1A mRNA | CTD | PMID:20938992 | Pde1a | Rat | fosinopril | affects expression | EXP | | 6480464 | Fosinopril affects the expression of PDE1A mRNA and Fosinopril affects the expression of PDE1A protein | CTD | PMID:18209565 | Pde1a | Rat | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of PDE1A mRNA | CTD | PMID:25539665 | Pde1a | Rat | indometacin | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDE1A mRNA | CTD | PMID:28628672 | Pde1a | Rat | ivermectin | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PDE1A protein | CTD | PMID:32959892 | Pde1a | Rat | L-ascorbic acid | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of PDE1A mRNA | CTD | PMID:34480604 | Pde1a | Rat | L-ascorbic acid 2-phosphate | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of PDE1A mRNA | CTD | PMID:34480604 | Pde1a | Rat | L-methionine | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDE1A mRNA | CTD | PMID:20938992 | Pde1a | Rat | mercury atom | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Mercury results in decreased expression of PDE1A mRNA | CTD | PMID:22008530 | Pde1a | Rat | mercury(0) | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Mercury results in decreased expression of PDE1A mRNA | CTD | PMID:22008530 | Pde1a | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of PDE1A mRNA | CTD | PMID:30047161 | Pde1a | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of PDE1A gene | CTD | PMID:35440735 | Pde1a | Rat | methylmercury chloride | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PDE1A mRNA | CTD | PMID:23179753 | Pde1a | Rat | Muraglitazar | decreases expression | EXP | | 6480464 | muraglitazar results in decreased expression of PDE1A mRNA | CTD | PMID:21515302 | Pde1a | Rat | nickel atom | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Nickel results in decreased expression of PDE1A mRNA | CTD | PMID:24768652 and PMID:25583101 | Pde1a | Rat | nitroglycerin | increases expression | EXP | | 6480464 | Nitroglycerin results in increased expression of PDE1A mRNA and Nitroglycerin results in increased expression of PDE1A protein | CTD | PMID:11696475 | Pde1a | Rat | nitroglycerin | multiple interactions | EXP | | 6480464 | PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP] | CTD | PMID:11696475 | Pde1a | Rat | O-methyleugenol | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of PDE1A mRNA | CTD | PMID:32234424 | Pde1a | Rat | olanzapine | increases expression | EXP | | 6480464 | olanzapine results in increased expression of PDE1A mRNA | CTD | PMID:20222156 | Pde1a | Rat | ozone | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in increased expression of PDE1A mRNA | CTD | PMID:34911549 | Pde1a | Rat | paracetamol | affects expression | ISO | Pde1a (Mus musculus) | 6480464 | Acetaminophen affects the expression of PDE1A mRNA | CTD | PMID:17562736 | Pde1a | Rat | paracetamol | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PDE1A mRNA | CTD | PMID:26690555 | Pde1a | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of PDE1A mRNA | CTD | PMID:32680482 | Pde1a | Rat | phenylephrine | multiple interactions | EXP | | 6480464 | PDE1A protein promotes the reaction [Phenylephrine results in decreased activity of PRKG1 protein] | CTD | PMID:19797176 | Pde1a | Rat | phenylmercury acetate | increases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of PDE1A mRNA | CTD | PMID:26272509 | Pde1a | Rat | phenylmercury acetate | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE1A mRNA | CTD | PMID:27188386 | Pde1a | Rat | picoxystrobin | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | picoxystrobin results in decreased expression of PDE1A mRNA | CTD | PMID:33512557 | Pde1a | Rat | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of PDE1A mRNA | CTD | PMID:30047161 | Pde1a | Rat | rotenone | affects expression | ISO | PDE1A (Homo sapiens) | 6480464 | Rotenone affects the expression of PDE1A mRNA | CTD | PMID:29428530 | Pde1a | Rat | rotenone | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Rotenone results in decreased expression of PDE1A mRNA | CTD | PMID:33512557 | Pde1a | Rat | SB 431542 | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:34480604 | Pde1a | Rat | silicon dioxide | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PDE1A mRNA | CTD | PMID:25895662 | Pde1a | Rat | silver atom | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Silver results in decreased expression of PDE1A mRNA | CTD | PMID:26551752 | Pde1a | Rat | silver atom | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Silver results in decreased expression of PDE1A mRNA | CTD | PMID:27131904 | Pde1a | Rat | silver(0) | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Silver results in decreased expression of PDE1A mRNA | CTD | PMID:26551752 | Pde1a | Rat | silver(0) | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | Silver results in decreased expression of PDE1A mRNA | CTD | PMID:27131904 | Pde1a | Rat | sodium arsenite | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PDE1A mRNA | CTD | PMID:34032870 | Pde1a | Rat | succimer | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE1A mRNA | CTD | PMID:26378955 | Pde1a | Rat | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of PDE1A mRNA | CTD | PMID:30047161 | Pde1a | Rat | sulforaphane | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of PDE1A mRNA | CTD | PMID:31838189 | Pde1a | Rat | Tesaglitazar | decreases expression | EXP | | 6480464 | tesaglitazar results in decreased expression of PDE1A mRNA | CTD | PMID:21515302 | Pde1a | Rat | tetrachloromethane | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of PDE1A mRNA | CTD | PMID:30517762 | Pde1a | Rat | titanium dioxide | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | titanium dioxide results in increased expression of PDE1A mRNA | CTD | PMID:23557971 | Pde1a | Rat | titanium dioxide | multiple interactions | ISO | Pde1a (Mus musculus) | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of PDE1A mRNA | CTD | PMID:29950665 | Pde1a | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of PDE1A gene | CTD | PMID:27618143 | Pde1a | Rat | trimellitic anhydride | decreases expression | ISO | Pde1a (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of PDE1A mRNA | CTD | PMID:19042947 | Pde1a | Rat | troglitazone | affects expression | EXP | | 6480464 | troglitazone affects the expression of PDE1A mRNA | CTD | PMID:21515302 | Pde1a | Rat | uranium atom | affects expression | ISO | PDE1A (Homo sapiens) | 6480464 | Uranium affects the expression of PDE1A mRNA | CTD | PMID:15672453 | Pde1a | Rat | valproic acid | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PDE1A mRNA | CTD | PMID:23527032 | Pde1a | Rat | vancomycin | increases expression | ISO | Pde1a (Mus musculus) | 6480464 | Vancomycin results in increased expression of PDE1A mRNA | CTD | PMID:18930951 | Pde1a | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of PDE1A mRNA | CTD | PMID:23555832 | Pde1a | Rat | XAV939 | multiple interactions | ISO | PDE1A (Homo sapiens) | 6480464 | [[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of PDE1A mRNA and [[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein] co-treated with [INHBA protein binds to INHBA protein]] results in increased expression of PDE1A mRNA | CTD | PMID:34480604 | Pde1a | Rat | zoledronic acid | decreases expression | ISO | PDE1A (Homo sapiens) | 6480464 | zoledronic acid results in decreased expression of PDE1A mRNA | CTD | PMID:24714768 | |