Prss51 (serine protease 51) - Rat Genome Database

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Gene: Prss51 (serine protease 51) Rattus norvegicus
Analyze
Symbol: Prss51
Name: serine protease 51
RGD ID: 6498506
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human PRSS51 (serine protease 51).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910401; serine protease 55-like; serine protease-like protein 51
RGD Orthologs
Human
Mouse
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,507,450 - 42,513,776 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,509,974 - 42,513,781 (+)EnsemblGRCr8
mRatBN7.21538,331,545 - 38,337,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,333,963 - 38,337,883 (+)EnsemblmRatBN7.2
Rnor_6.01547,453,206 - 47,459,554 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,455,690 - 47,459,742 (+)Ensemblrn6Rnor6.0
Rnor_5.01551,211,488 - 51,215,348 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1538,011,914 - 38,018,219 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Comparative Map Data
Prss51
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,507,450 - 42,513,776 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,509,974 - 42,513,781 (+)EnsemblGRCr8
mRatBN7.21538,331,545 - 38,337,878 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,333,963 - 38,337,883 (+)EnsemblmRatBN7.2
Rnor_6.01547,453,206 - 47,459,554 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,455,690 - 47,459,742 (+)Ensemblrn6Rnor6.0
Rnor_5.01551,211,488 - 51,215,348 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1538,011,914 - 38,018,219 (+)NCBICelera
Cytogenetic Map15p12NCBI
PRSS51
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,481,293 - 10,547,723 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,482,878 - 10,547,624 (-)Ensemblhg38GRCh38
GRCh37810,353,836 - 10,405,089 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36810,391,246 - 10,442,499 (-)NCBIBuild 36Build 36hg18NCBI36
Celera89,480,982 - 9,532,298 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef89,284,362 - 9,335,643 (-)NCBIHuRef
T2T-CHM13v2.089,191,405 - 9,257,428 (+)NCBIT2T-CHM13v2.0
Prss51
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,322,974 - 64,335,123 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1464,323,683 - 64,335,127 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381464,085,525 - 64,097,674 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1464,086,234 - 64,097,678 (+)Ensemblmm10GRCm38
MGSCv371464,712,533 - 64,716,509 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361464,712,533 - 64,716,509 (+)NCBIMGSCv36mm8
Celera1461,871,212 - 61,875,201 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.35NCBI
PRSS51
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2726,928,472 - 27,000,973 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan182,961,143 - 3,033,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,662,908 - 8,733,912 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC102151341
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12527,447,669 - 27,459,137 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2527,447,659 - 27,459,121 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2528,107,329 - 28,118,536 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02527,605,308 - 27,616,527 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2527,605,275 - 27,616,518 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12527,559,967 - 27,571,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02527,455,244 - 27,465,433 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,608,451 - 27,619,900 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

Variants

.
Variants in Prss51
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000075276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 6 13 29 36 36 18 12 18 85 35 21 25 28 18 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000075276   ⟹   ENSRNOP00000064434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,509,974 - 42,513,781 (+)Ensembl
mRatBN7.2 Ensembl1538,333,963 - 38,337,883 (+)Ensembl
Rnor_6.0 Ensembl1547,455,690 - 47,459,742 (+)Ensembl
RefSeq Acc Id: XM_003751502   ⟹   XP_003751550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,510,044 - 42,513,776 (+)NCBI
mRatBN7.21538,334,057 - 38,337,878 (+)NCBI
Rnor_6.01547,455,038 - 47,459,554 (+)NCBI
Rnor_5.01551,211,488 - 51,215,348 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599903   ⟹   XP_017455392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,507,459 - 42,513,776 (+)NCBI
mRatBN7.21538,331,545 - 38,337,878 (+)NCBI
Rnor_6.01547,453,206 - 47,459,554 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093922   ⟹   XP_038949850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,509,955 - 42,513,776 (+)NCBI
mRatBN7.21538,334,006 - 38,337,878 (+)NCBI
RefSeq Acc Id: XM_039093923   ⟹   XP_038949851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,510,044 - 42,513,776 (+)NCBI
mRatBN7.21538,334,146 - 38,337,878 (+)NCBI
RefSeq Acc Id: XM_039093924   ⟹   XP_038949852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,509,955 - 42,513,281 (+)NCBI
mRatBN7.21538,333,984 - 38,337,383 (+)NCBI
RefSeq Acc Id: XM_063274879   ⟹   XP_063130949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,507,450 - 42,513,776 (+)NCBI
RefSeq Acc Id: XP_003751550   ⟸   XM_003751502
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017455392   ⟸   XM_017599903
- Peptide Label: isoform X3
- UniProtKB: M0R4Y2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064434   ⟸   ENSRNOT00000075276
RefSeq Acc Id: XP_038949852   ⟸   XM_039093924
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949850   ⟸   XM_039093922
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949851   ⟸   XM_039093923
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130949   ⟸   XM_063274879
- Peptide Label: isoform X2
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4Y2-F1-model_v2 AlphaFold M0R4Y2 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699786
Promoter ID:EPDNEW_R10307
Type:initiation region
Name:LOC100910401_1
Description:serine protease 55-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,455,750 - 47,455,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6498506 AgrOrtholog
BioCyc Gene G2FUF-13388 BioCyc
Ensembl Genes ENSRNOG00000047637 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075276 ENTREZGENE
  ENSRNOT00000075276.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
KEGG Report rno:100910401 UniProtKB/TrEMBL
NCBI Gene LOC100910401 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1 UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss51 PhenoGen
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047637 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt M0R4Y2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-05 Prss51  serine protease 51  LOC100910401  serine protease 55-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910401  serine protease 55-like      Symbol and Name status set to provisional 70820 PROVISIONAL