Derl2 (derlin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Derl2 (derlin 2) Rattus norvegicus
Analyze
Symbol: Derl2
Name: derlin 2
RGD ID: 6496100
Description: Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Predicted to act upstream of or within retrograde protein transport, ER to cytosol and suckling behavior. Predicted to be located in early endosome; endoplasmic reticulum; and late endosome. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DERL2 (derlin 2); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; doxorubicin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Der1-like domain family, member 2; derlin-2; derlin-2-like; LOC100910823
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,226,340 - 56,238,038 (-)NCBIGRCr8
mRatBN7.21055,727,764 - 55,739,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,727,643 - 55,739,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,407,453 - 60,419,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,895,972 - 59,907,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,395,062 - 55,406,668 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,641,682 - 57,653,554 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,644,207 - 57,653,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,386,894 - 57,398,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1054,873,447 - 54,885,319 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11500051   PMID:15215855   PMID:16449189   PMID:19509052   PMID:19946888   PMID:21220515   PMID:23444373   PMID:25660456   PMID:26565908  


Genomics

Comparative Map Data
Derl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81056,226,340 - 56,238,038 (-)NCBIGRCr8
mRatBN7.21055,727,764 - 55,739,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,727,643 - 55,739,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1060,407,453 - 60,419,059 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,895,972 - 59,907,578 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01055,395,062 - 55,406,668 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,641,682 - 57,653,554 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,644,207 - 57,653,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01057,386,894 - 57,398,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1054,873,447 - 54,885,319 (-)NCBICelera
Cytogenetic Map10q24NCBI
DERL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,471,254 - 5,486,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,471,254 - 5,486,811 (-)EnsemblGRCh38hg38GRCh38
GRCh37175,374,574 - 5,389,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36175,318,337 - 5,330,221 (-)NCBINCBI36Build 36hg18NCBI36
Build 34175,318,336 - 5,330,218NCBI
Celera175,393,985 - 5,405,873 (-)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef175,268,081 - 5,279,745 (-)NCBIHuRef
CHM1_1175,387,294 - 5,399,165 (-)NCBICHM1_1
T2T-CHM13v2.0175,364,997 - 5,380,235 (-)NCBIT2T-CHM13v2.0
Derl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,898,266 - 70,910,667 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,897,990 - 70,910,667 (-)EnsemblGRCm39 Ensembl
GRCm381171,007,440 - 71,019,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,007,164 - 71,019,841 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,820,947 - 70,832,765 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,823,640 - 70,835,458 (-)NCBIMGSCv36mm8
Celera1178,561,860 - 78,573,678 (-)NCBICelera
Cytogenetic Map11B4NCBI
cM Map1143.21NCBI
Derl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,825,341 - 10,837,328 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,824,922 - 10,837,408 (-)NCBIChiLan1.0ChiLan1.0
DERL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21913,084,405 - 13,096,337 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11715,049,592 - 15,064,585 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,519,183 - 5,534,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1175,514,440 - 5,526,363 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl175,514,440 - 5,526,363 (-)Ensemblpanpan1.1panPan2
DERL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,319,660 - 31,330,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,319,717 - 31,330,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,457,816 - 31,468,997 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0531,424,427 - 31,435,599 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,424,475 - 31,435,594 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,389,973 - 31,401,157 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,348,892 - 31,360,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,525,284 - 31,536,488 (+)NCBIUU_Cfam_GSD_1.0
Derl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,558,913 - 53,572,084 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,328,904 - 2,342,080 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,328,783 - 2,342,068 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DERL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,507,996 - 51,524,793 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,508,138 - 51,524,799 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DERL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,882,296 - 4,897,799 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,881,876 - 4,898,078 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605916,689,748 - 16,705,481 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Derl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,274,302 - 9,285,288 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,274,302 - 9,285,645 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Derl2
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000009585, ENSRNOT00000067381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105220003059378278Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105379738558445852Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH132056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,727,854 - 55,728,051 (+)MAPPERmRatBN7.2
Rnor_6.01057,641,773 - 57,641,969NCBIRnor6.0
Rnor_5.01057,386,985 - 57,387,181UniSTSRnor5.0
RGSC_v3.41057,909,680 - 57,909,876UniSTSRGSC3.4
Celera1054,873,538 - 54,873,734UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000089638   ⟹   ENSRNOP00000068885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,730,291 - 55,739,420 (-)Ensembl
Rnor_6.0 Ensembl1057,644,207 - 57,653,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096117   ⟹   ENSRNOP00000095156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,727,643 - 55,739,412 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096118   ⟹   ENSRNOP00000090568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1055,727,816 - 55,739,518 (-)Ensembl
RefSeq Acc Id: NM_001399430   ⟹   NP_001386359
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,226,340 - 56,237,993 (-)NCBI
mRatBN7.21055,727,764 - 55,739,417 (-)NCBI
RefSeq Acc Id: XM_039087317   ⟹   XP_038943245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,228,857 - 56,238,016 (-)NCBI
mRatBN7.21055,727,764 - 55,739,442 (-)NCBI
RefSeq Acc Id: XM_063268246   ⟹   XP_063124316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81056,231,748 - 56,238,038 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386359 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943245 (Get FASTA)   NCBI Sequence Viewer  
  XP_063124316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05070 (Get FASTA)   NCBI Sequence Viewer  
  EDM05072 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068885.2
  ENSRNOP00000090568.1
  ENSRNOP00000095156.1
Ensembl Acc Id: ENSRNOP00000068885   ⟸   ENSRNOT00000089638
RefSeq Acc Id: XP_038943245   ⟸   XM_039087317
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GIB4 (UniProtKB/TrEMBL),   A0A8I6AMH0 (UniProtKB/TrEMBL),   A6HGB5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090568   ⟸   ENSRNOT00000096118
Ensembl Acc Id: ENSRNOP00000095156   ⟸   ENSRNOT00000096117
RefSeq Acc Id: NP_001386359   ⟸   NM_001399430
- UniProtKB: A6HGB7 (UniProtKB/TrEMBL),   A0A8I6AMH0 (UniProtKB/TrEMBL),   A6HGB5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124316   ⟸   XM_063268246
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTX9-F1-model_v2 AlphaFold A0A0G2JTX9 1-239 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697382
Promoter ID:EPDNEW_R7904
Type:multiple initiation site
Name:Derl2_1
Description:derlin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01057,653,330 - 57,653,390EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6496100 AgrOrtholog
BioCyc Gene G2FUF-24416 BioCyc
Ensembl Genes ENSRNOG00000055466 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089638.2 UniProtKB/TrEMBL
  ENSRNOT00000096117.1 UniProtKB/TrEMBL
  ENSRNOT00000096118.1 UniProtKB/TrEMBL
InterPro DER1 UniProtKB/TrEMBL
  Rhomboid-like_sf UniProtKB/TrEMBL
NCBI Gene LOC100910823 ENTREZGENE
PANTHER DER1-LIKE PROTEIN, DERLIN UniProtKB/TrEMBL
  DERLIN-2 UniProtKB/TrEMBL
Pfam DER1 UniProtKB/TrEMBL
PhenoGen Derl2 PhenoGen
RatGTEx ENSRNOG00000055466 RatGTEx
Superfamily-SCOP SSF144091 UniProtKB/TrEMBL
UniProt A0A0G2JTX9_RAT UniProtKB/TrEMBL
  A0A8I6AMH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIB4 ENTREZGENE, UniProtKB/TrEMBL
  A6HGB5 ENTREZGENE, UniProtKB/TrEMBL
  A6HGB7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-12 Derl2  derlin 2  LOC100910823  derlin-2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910823  derlin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL