LOC100911649 (ral guanine nucleotide dissociation stimulator-like) - Rat Genome Database

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Gene: LOC100911649 (ral guanine nucleotide dissociation stimulator-like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: LOC100911649
Name: ral guanine nucleotide dissociation stimulator-like
RGD ID: 6491640
Description: Predicted to enable guanyl-nucleotide exchange factor activity.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC685463; similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS); uncharacterized protein LOC100911649
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81611,455,658 - 11,458,517 (-)NCBIGRCr8
mRatBN7.21611,435,459 - 11,438,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1611,435,429 - 11,437,334 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1611,385,919 - 11,387,756 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01612,530,661 - 12,532,498 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01611,374,176 - 11,376,022 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01612,739,773 - 12,742,080 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1612,736,362 - 12,742,010 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01612,634,378 - 12,636,212 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41611,836,469 - 11,837,908 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1611,697,452 - 11,699,759 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in LOC100911649
44 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system integumental system musculoskeletal system reproductive system appendage
High
Medium 3
Low 4
Below cutoff 1 1 1 4 1

Sequence


RefSeq Acc Id: ENSRNOT00000029573   ⟹   ENSRNOP00000029548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,435,429 - 11,437,334 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077513   ⟹   ENSRNOP00000074828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,665,896 - 11,668,685 (+)Ensembl
Rnor_6.0 Ensembl1612,736,362 - 12,742,010 (-)Ensembl
RefSeq Acc Id: NM_001402507   ⟹   NP_001389436
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,455,743 - 11,457,587 (-)NCBI
mRatBN7.21611,435,459 - 11,437,303 (-)NCBI
RefSeq Acc Id: XM_039095061   ⟹   XP_038950989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,455,658 - 11,457,628 (-)NCBI
mRatBN7.21611,436,015 - 11,438,066 (-)NCBI
RefSeq Acc Id: XM_063274972   ⟹   XP_063131042
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,455,658 - 11,458,517 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389436 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950989 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131042 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029548
  ENSRNOP00000029548.6
RefSeq Acc Id: XP_038950989   ⟸   XM_039095061
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000074828   ⟸   ENSRNOT00000077513
RefSeq Acc Id: ENSRNOP00000029548   ⟸   ENSRNOT00000029573
RefSeq Acc Id: NP_001389436   ⟸   NM_001402507
- UniProtKB: D3ZE80 (UniProtKB/TrEMBL),   A6K9I2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131042   ⟸   XM_063274972
- Peptide Label: isoform X1
Protein Domains
N-terminal Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE80-F1-model_v2 AlphaFold D3ZE80 1-218 view protein structure
AF-A0A0G2K922-F1-model_v2 AlphaFold A0A0G2K922 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6491640 AgrOrtholog
BioCyc Gene G2FUF-12024 BioCyc
Ensembl Genes ENSRNOG00000022798 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000051457 Ensembl
Ensembl Transcript ENSRNOT00000029573 ENTREZGENE
  ENSRNOT00000029573.6 UniProtKB/TrEMBL
Gene3D-CATH Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
KEGG Report rno:100911649 UniProtKB/TrEMBL
NCBI Gene LOC100911649 ENTREZGENE
PANTHER 1700018F24RIK PROTEIN-RELATED-RELATED UniProtKB/TrEMBL
  RIKEN CDNA 4930474N05 GENE UniProtKB/TrEMBL
Pfam RasGEF_N UniProtKB/TrEMBL
PhenoGen LOC100911649 PhenoGen
PROSITE RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022798 RatGTEx
  ENSRNOG00000051457 RatGTEx
SMART RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
UniProt A6K9I2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZE80 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 LOC100911649  ral guanine nucleotide dissociation stimulator-like  LOC685463  similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS)  Data merged from RGD:1593794 737654 PROVISIONAL
2012-07-05 LOC100911649  ral guanine nucleotide dissociation stimulator-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC685463  similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS)      Symbol and Name status set to provisional 70820 PROVISIONAL