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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Itprip | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ITPRIP mRNA | CTD | PMID:22079256 | Itprip | Rat | 17beta-estradiol | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Estradiol results in increased expression of ITPRIP mRNA | CTD | PMID:19153601 | Itprip | Rat | 17beta-estradiol | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of ITPRIP mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of ITPRIP mRNA | CTD | PMID:22217510 and PMID:30165855 | Itprip | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ITPRIP promoter] | CTD | PMID:19654925 | Itprip | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Itprip (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ITPRIP mRNA | CTD | PMID:21570461 | Itprip | Rat | 2-hydroxypropanoic acid | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of ITPRIP mRNA | CTD | PMID:30851411 | Itprip | Rat | 3,3',5,5'-tetrabromobisphenol A | increases expression | ISO | Itprip (Mus musculus) | 6480464 | tetrabromobisphenol A results in increased expression of ITPRIP mRNA | CTD | PMID:25172293 | Itprip | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of ITPRIP mRNA | CTD | PMID:28522335 | Itprip | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITPRIP mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPRIP mRNA | CTD | PMID:28628672 | Itprip | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ITPRIP mRNA | CTD | PMID:36843608 | Itprip | Rat | acrolein | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPRIP mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPRIP mRNA | CTD | PMID:32699268 | Itprip | Rat | afimoxifene | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | GPER1 protein affects the reaction [afimoxifene results in increased expression of ITPRIP mRNA] | CTD | PMID:19153601 | Itprip | Rat | afimoxifene | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | afimoxifene results in increased expression of ITPRIP mRNA | CTD | PMID:19153601 | Itprip | Rat | aflatoxin B1 | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of ITPRIP mRNA | CTD | PMID:22100608 | Itprip | Rat | aflatoxin B1 | increases methylation | ISO | ITPRIP (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ITPRIP gene | CTD | PMID:27153756 | Itprip | Rat | all-trans-retinoic acid | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Tretinoin results in increased expression of ITPRIP mRNA | CTD | PMID:33167477 | Itprip | Rat | alpha-pinene | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPRIP mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of ITPRIP mRNA | CTD | PMID:32699268 | Itprip | Rat | antirheumatic drug | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of ITPRIP mRNA | CTD | PMID:24449571 | Itprip | Rat | aristolochic acid A | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of ITPRIP mRNA | CTD | PMID:33212167 | Itprip | Rat | azathioprine | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Azathioprine results in increased expression of ITPRIP mRNA | CTD | PMID:22623647 | Itprip | Rat | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA | CTD | PMID:33854195 | Itprip | Rat | benzo[a]pyrene | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of ITPRIP mRNA | CTD | PMID:26238291 | Itprip | Rat | benzo[a]pyrene | affects methylation | ISO | ITPRIP (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ITPRIP 5' UTR and Benzo(a)pyrene affects the methylation of ITPRIP promoter | CTD | PMID:27901495 | Itprip | Rat | benzo[a]pyrene | increases methylation | ISO | ITPRIP (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ITPRIP exon | CTD | PMID:27901495 | Itprip | Rat | beta-lapachone | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of ITPRIP mRNA | CTD | PMID:38218311 | Itprip | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ITPRIP mRNA | CTD | PMID:25181051 | Itprip | Rat | bisphenol A | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ITPRIP mRNA | CTD | PMID:29275510 | Itprip | Rat | bisphenol A | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [[ginger extract results in increased abundance of Oils more ... | CTD | PMID:28628672 more ... | Itprip | Rat | bisphenol F | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPRIP mRNA | CTD | PMID:28628672 | Itprip | Rat | Butylbenzyl phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | carbon nanotube | decreases expression | ISO | Itprip (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of ITPRIP mRNA | CTD | PMID:25554681 | Itprip | Rat | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA | CTD | PMID:33854195 | Itprip | Rat | chromium(6+) | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | chromium hexavalent ion affects the expression of ITPRIP mRNA | CTD | PMID:30690063 | Itprip | Rat | cisplatin | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Cisplatin results in increased expression of ITPRIP mRNA | CTD | PMID:27594783 | Itprip | Rat | cobalt dichloride | decreases expression | ISO | Itprip (Mus musculus) | 6480464 | cobaltous chloride results in decreased expression of ITPRIP mRNA | CTD | PMID:21139344 | Itprip | Rat | copper(II) sulfate | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of ITPRIP mRNA | CTD | PMID:19549813 | Itprip | Rat | crocidolite asbestos | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Asbestos and Crocidolite affects the expression of ITPRIP mRNA | CTD | PMID:24160326 and PMID:25757056 | Itprip | Rat | cyclosporin A | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of ITPRIP mRNA | CTD | PMID:20106945 and PMID:25562108 | Itprip | Rat | DDE | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of ITPRIP mRNA | CTD | PMID:38568856 | Itprip | Rat | dexamethasone | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITPRIP mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPRIP mRNA | CTD | PMID:28628672 | Itprip | Rat | Dibutyl phosphate | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of ITPRIP mRNA | CTD | PMID:37042841 | Itprip | Rat | dibutyl phthalate | increases expression | ISO | Itprip (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of ITPRIP mRNA | CTD | PMID:17361019 and PMID:21266533 | Itprip | Rat | dibutyl phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | diethyl phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | diisobutyl phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | diisononyl phthalate | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the expression of ITPRIP mRNA | CTD | PMID:39150890 | Itprip | Rat | dorsomorphin | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPRIP mRNA | CTD | PMID:27188386 | Itprip | Rat | doxorubicin | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ITPRIP mRNA | CTD | PMID:29803840 | Itprip | Rat | fluoranthene | multiple interactions | ISO | Itprip (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of ITPRIP mRNA | CTD | PMID:28329830 | Itprip | Rat | fulvestrant | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of ITPRIP gene | CTD | PMID:31601247 | Itprip | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ITPRIP mRNA | CTD | PMID:33387578 | Itprip | Rat | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA | CTD | PMID:33854195 | Itprip | Rat | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA | CTD | PMID:33854195 | Itprip | Rat | indometacin | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ITPRIP mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ITPRIP mRNA | CTD | PMID:28628672 | Itprip | Rat | leflunomide | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | leflunomide results in increased expression of ITPRIP mRNA | CTD | PMID:28988120 | Itprip | Rat | methylmercury chloride | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of ITPRIP mRNA | CTD | PMID:28001369 | Itprip | Rat | ozone | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of ITPRIP mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | Itprip | Rat | paracetamol | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of ITPRIP mRNA | CTD | PMID:29067470 | Itprip | Rat | potassium chromate | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of ITPRIP mRNA | CTD | PMID:22714537 | Itprip | Rat | potassium chromate | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of ITPRIP mRNA | CTD | PMID:22079256 | Itprip | Rat | potassium chromate | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ITPRIP mRNA | CTD | PMID:22079256 | Itprip | Rat | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Itprip (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of ITPRIP mRNA | CTD | PMID:28903501 | Itprip | Rat | quercetin | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Quercetin results in increased expression of ITPRIP mRNA | CTD | PMID:21632981 | Itprip | Rat | rac-lactic acid | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of ITPRIP mRNA | CTD | PMID:30851411 | Itprip | Rat | SB 431542 | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPRIP mRNA | CTD | PMID:27188386 | Itprip | Rat | serpentine asbestos | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Asbestos and Serpentine affects the expression of ITPRIP mRNA | CTD | PMID:24160326 | Itprip | Rat | silicon dioxide | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of ITPRIP mRNA | CTD | PMID:25895662 | Itprip | Rat | sodium arsenite | increases expression | ISO | Itprip (Mus musculus) | 6480464 | sodium arsenite results in increased expression of ITPRIP mRNA | CTD | PMID:36209798 | Itprip | Rat | sulforaphane | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | sulforaphane results in increased expression of ITPRIP mRNA | CTD | PMID:26833863 | Itprip | Rat | sunitinib | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ITPRIP mRNA | CTD | PMID:31533062 | Itprip | Rat | temozolomide | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of ITPRIP mRNA | CTD | PMID:31758290 | Itprip | Rat | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of ITPRIP mRNA | CTD | PMID:33854195 | Itprip | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of ITPRIP mRNA | CTD | PMID:34492290 | Itprip | Rat | thiram | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Thiram results in increased expression of ITPRIP mRNA | CTD | PMID:38568856 | Itprip | Rat | titanium dioxide | decreases methylation | ISO | Itprip (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of ITPRIP gene | CTD | PMID:35295148 | Itprip | Rat | trichostatin A | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | trichostatin A results in increased expression of ITPRIP mRNA | CTD | PMID:24935251 | Itprip | Rat | triphenyl phosphate | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of ITPRIP mRNA | CTD | PMID:37042841 | Itprip | Rat | tris(2-butoxyethyl) phosphate | affects expression | ISO | ITPRIP (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of ITPRIP mRNA | CTD | PMID:29024780 | Itprip | Rat | valproic acid | increases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ITPRIP mRNA | CTD | PMID:23179753 and PMID:26272509 | Itprip | Rat | valproic acid | decreases expression | ISO | ITPRIP (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ITPRIP mRNA | CTD | PMID:28001369 | Itprip | Rat | valproic acid | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITPRIP mRNA | CTD | PMID:27188386 | Itprip | Rat | zinc atom | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ITPRIP mRNA | CTD | PMID:18593933 | Itprip | Rat | zinc(0) | multiple interactions | ISO | ITPRIP (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of ITPRIP mRNA | CTD | PMID:18593933 | |