Lepr<sup>em2Mcwi</sup> (leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) - Rat Genome Database

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Gene: Leprem2Mcwi (leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus
Symbol: Leprem2Mcwi
Name: leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
RGD ID: 6484701
Description: This allele was made by ZFN mutagenesis. The resulting mutation is a 16-bp deletion in exon 11 (del 2130-2145)
ASSOCIATED WITH abnormal glomerular filtration barrier morphology; glomerulosclerosis; impaired glucose tolerance; ASSOCIATED WITH chronic kidney disease; glucose intolerance; hypertension
Type: allele  of Lepr  
Previously known as: Leprem2Mcwi
Is Marker For: Strains:   SS-Leprem2Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Cytogenetic Map5 RGD


References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats. McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
3. PhysGen Knockouts PhysGen Knockout strains
4. Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats. Poudel B, etal., Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1489-F1499. doi: 10.1152/ajprenal.00100.2020. Epub 2020 May 11.


Related Rat Strains
The following Strains have been annotated to Leprem2Mcwi



Nucleotide Sequences
RefSeq Transcripts NM_012596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Additional Information