Lepr<sup>em2Mcwi</sup> (leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin)

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Gene: Lepr^em2Mcwi (leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin) Rattus norvegicus

Analyze

Symbol:

Lepr^em2Mcwi

Name:

leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin

RGD ID:

6484701

Description:

This allele was made by ZFN mutagenesis. The resulting mutation is a 16-bp deletion in exon 11 (del 2130-2145)
ASSOCIATED WITH abnormal glomerular filtration barrier morphology; glomerulosclerosis; impaired glucose tolerance; ASSOCIATED WITH chronic kidney disease; glucose intolerance; hypertension

Type:

allele of Lepr

Previously known as:

Leprem2Mcwi

Is Marker For:

Strains: SS-Lepr^em2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	5		RGD

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chronic kidney disease (IMP)

glucose intolerance (IMP)

hypertension (IMP)

obesity (IMP)

proteinuria (IMP)

renal fibrosis (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal glomerular filtration barrier morphology (IMP)

glomerulosclerosis (IMP)

impaired glucose tolerance (IMP)

increased body weight (IMP)

increased circulating cholesterol level (IMP)

increased circulating creatinine level (IMP)

increased circulating insulin level (IMP)

increased circulating leptin level (IMP)

increased circulating triglyceride level (IMP)

increased systemic arterial systolic blood pressure (IMP)

increased urine protein level (IMP)

insulin resistance (IMP)

podocyte foot process effacement (IMP)

renal interstitial fibrosis (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Knockout rats via embryo microinjection of zinc-finger nucleases.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2.	Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.	McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
3.	PhysGen Knockouts	PhysGen Knockout strains
4.	Depletion of macrophages slows the early progression of renal injury in obese Dahl salt-sensitive leptin receptor mutant rats.	Poudel B, etal., Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1489-F1499. doi: 10.1152/ajprenal.00100.2020. Epub 2020 May 11.

Genomics

Related Rat Strains

The following Strains have been annotated to Lepr^em2Mcwi

SS-Lepr^em2Mcwi

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Mammalian Phenotype