Insig2 (insulin induced gene 2) - Rat Genome Database

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Gene: Insig2 (insulin induced gene 2) Rattus norvegicus
Analyze
Symbol: Insig2
Name: insulin induced gene 2
RGD ID: 631417
Description: Predicted to enable oxysterol binding activity and protein sequestering activity. Involved in response to fatty acid and response to insulin. Predicted to be located in membrane. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Biomarker of end stage renal disease. Orthologous to human INSIG2 (insulin induced gene 2); PARTICIPATES IN sterol regulatory element-binding protein signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: INSIG-2; insulin-induced gene 2 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81335,025,160 - 35,052,937 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1335,025,164 - 35,047,658 (-)EnsemblGRCr8
mRatBN7.21332,472,390 - 32,500,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1332,473,742 - 32,494,923 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1335,042,312 - 35,055,633 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01336,330,238 - 36,343,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01333,604,703 - 33,618,041 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01337,264,818 - 37,292,718 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1337,266,312 - 37,287,458 (-)Ensemblrn6Rnor6.0
Rnor_5.01342,366,075 - 42,393,747 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41333,331,951 - 33,345,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1332,342,137 - 32,355,402 (-)NCBICelera
RGSC_v3.11333,333,183 - 33,355,516 (-)NCBI
Cytogenetic Map13q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (EXP)
bromuconazole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpromazine  (EXP)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fipronil  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
Ganoderic acid A  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hexaconazole  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
inulin  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
lovastatin  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nevirapine  (EXP)
nickel sulfate  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
ranitidine  (EXP)
resorcinol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vandetanib  (ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. Botolin D, etal., J Lipid Res. 2006 Jan;47(1):181-92. Epub 2005 Oct 12.
2. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Cho KH, etal., Biochim Biophys Acta. 2010 Jan;1800(1):6-15. Epub 2009 Oct 28.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver. Koch A, etal., J Nutr. 2007 Sep;137(9):2018-23.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Osborne TF and Espenshade PJ, Genes Dev. 2009 Nov 15;23(22):2578-91.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats. Takaishi K, etal., Proc Natl Acad Sci U S A. 2004 May 4;101(18):7106-11. Epub 2004 Apr 19.
10. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Yabe D, etal., Proc Natl Acad Sci U S A 2003 Mar 18;100(6):3155-60.
Additional References at PubMed
PMID:12242332   PMID:12354157   PMID:12477932   PMID:16100574   PMID:16955138   PMID:26007286  


Genomics

Comparative Map Data
Insig2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81335,025,160 - 35,052,937 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1335,025,164 - 35,047,658 (-)EnsemblGRCr8
mRatBN7.21332,472,390 - 32,500,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1332,473,742 - 32,494,923 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1335,042,312 - 35,055,633 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01336,330,238 - 36,343,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01333,604,703 - 33,618,041 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01337,264,818 - 37,292,718 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1337,266,312 - 37,287,458 (-)Ensemblrn6Rnor6.0
Rnor_5.01342,366,075 - 42,393,747 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41333,331,951 - 33,345,132 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1332,342,137 - 32,355,402 (-)NCBICelera
RGSC_v3.11333,333,183 - 33,355,516 (-)NCBI
Cytogenetic Map13q11NCBI
INSIG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,088,471 - 118,110,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,088,137 - 118,112,313 (+)Ensemblhg38GRCh38
GRCh372118,846,047 - 118,868,573 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362118,562,520 - 118,584,067 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342118,562,279 - 118,583,826NCBI
Celera2112,173,296 - 112,194,866 (+)NCBICelera
Cytogenetic Map2q14.1-q14.2NCBI
HuRef2111,173,146 - 111,193,705 (+)NCBIHuRef
CHM1_12118,849,883 - 118,871,052 (+)NCBICHM1_1
T2T-CHM13v2.02118,521,717 - 118,544,171 (+)NCBIT2T-CHM13v2.0
Insig2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391121,232,082 - 121,260,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1121,232,082 - 121,260,318 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381121,304,353 - 121,332,662 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1121,304,353 - 121,332,589 (-)Ensemblmm10GRCm38
MGSCv371123,200,930 - 123,229,157 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361123,131,899 - 123,160,126 (-)NCBIMGSCv36mm8
Celera1123,943,057 - 123,971,749 (-)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.91NCBI
Insig2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545911,571,145 - 11,592,146 (-)Ensembl
ChiLan1.0NW_00495545911,571,582 - 11,596,069 (-)NCBIChiLan1.0ChiLan1.0
INSIG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21320,115,269 - 20,137,088 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B20,130,316 - 20,152,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B5,046,971 - 5,068,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B118,632,105 - 118,652,650 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B118,632,402 - 118,652,647 (+)EnsemblpanPan2panpan1.1
INSIG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11931,796,984 - 31,811,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1931,791,710 - 31,811,386 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1932,063,758 - 32,083,699 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01933,190,437 - 33,210,363 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1933,190,674 - 33,210,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11931,864,844 - 31,884,780 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01932,033,058 - 32,052,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01933,222,123 - 33,242,041 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Insig2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530389,477,055 - 89,505,055 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646952,117,733 - 52,140,765 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646952,120,063 - 52,140,646 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSIG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1523,676,683 - 23,699,582 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11523,676,684 - 23,699,591 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
INSIG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11012,198,390 - 12,219,002 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1012,196,990 - 12,219,023 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606110,404,780 - 10,425,500 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insig2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473227,087,674 - 27,104,181 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473227,089,776 - 27,110,170 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Insig2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11013,896,099 - 13,918,607 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Insig2
273 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:600
Count of miRNA genes:297
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000003391
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13143736554Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13600200837088115Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
RH142395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21332,472,723 - 32,472,888 (+)MAPPERmRatBN7.2
Rnor_6.01337,265,152 - 37,265,316NCBIRnor6.0
Rnor_5.01342,366,409 - 42,366,573UniSTSRnor5.0
RGSC_v3.41333,330,690 - 33,330,854UniSTSRGSC3.4
Celera1332,340,876 - 32,341,040UniSTS
Cytogenetic Map13q11UniSTS
RH128587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21332,472,554 - 32,472,748 (+)MAPPERmRatBN7.2
Rnor_6.01337,264,983 - 37,265,176NCBIRnor6.0
Rnor_5.01342,366,240 - 42,366,433UniSTSRnor5.0
RGSC_v3.41333,330,521 - 33,330,714UniSTSRGSC3.4
Celera1332,340,707 - 32,340,900UniSTS
Cytogenetic Map13q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY152392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY156086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY156087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003391   ⟹   ENSRNOP00000003391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1335,025,164 - 35,047,658 (-)Ensembl
mRatBN7.2 Ensembl1332,473,742 - 32,494,923 (-)Ensembl
Rnor_6.0 Ensembl1337,266,312 - 37,287,458 (-)Ensembl
RefSeq Acc Id: NM_178091   ⟹   NP_835192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,026,755 - 35,040,098 (-)NCBI
mRatBN7.21332,473,985 - 32,487,328 (-)NCBI
Rnor_6.01337,266,413 - 37,279,866 (-)NCBI
Rnor_5.01342,366,075 - 42,393,747 (-)NCBI
RGSC_v3.41333,331,951 - 33,345,132 (-)RGD
Celera1332,342,137 - 32,355,402 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249667   ⟹   XP_006249729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,049,146 (-)NCBI
mRatBN7.21332,472,390 - 32,495,265 (-)NCBI
Rnor_6.01337,264,818 - 37,287,751 (-)NCBI
Rnor_5.01342,366,075 - 42,393,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249668   ⟹   XP_006249730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,052,937 (-)NCBI
mRatBN7.21332,472,390 - 32,500,138 (-)NCBI
Rnor_6.01337,264,818 - 37,292,718 (-)NCBI
Rnor_5.01342,366,075 - 42,393,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090419   ⟹   XP_038946347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,049,146 (-)NCBI
mRatBN7.21332,472,390 - 32,495,280 (-)NCBI
RefSeq Acc Id: XM_039090420   ⟹   XP_038946348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,052,910 (-)NCBI
mRatBN7.21332,472,390 - 32,500,139 (-)NCBI
RefSeq Acc Id: XM_039090421   ⟹   XP_038946349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,047,680 (-)NCBI
mRatBN7.21332,472,390 - 32,494,867 (-)NCBI
RefSeq Acc Id: XM_063272061   ⟹   XP_063128131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,047,695 (-)NCBI
RefSeq Acc Id: XM_063272062   ⟹   XP_063128132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81335,025,160 - 35,047,615 (-)NCBI
RefSeq Acc Id: NP_835192   ⟸   NM_178091
- UniProtKB: Q80UA9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249730   ⟸   XM_006249668
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006249729   ⟸   XM_006249667
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000003391   ⟸   ENSRNOT00000003391
RefSeq Acc Id: XP_038946348   ⟸   XM_039090420
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946347   ⟸   XM_039090419
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946349   ⟸   XM_039090421
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q1M5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128131   ⟸   XM_063272061
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128132   ⟸   XM_063272062
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80UA9-F1-model_v2 AlphaFold Q80UA9 1-225 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698770
Promoter ID:EPDNEW_R9294
Type:multiple initiation site
Name:Insig2_1
Description:insulin induced gene 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01337,287,466 - 37,287,526EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631417 AgrOrtholog
BioCyc Gene G2FUF-18499 BioCyc
Ensembl Genes ENSRNOG00000002478 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000003391 ENTREZGENE
IMAGE_CLONE IMAGE:7189822 IMAGE-MGC_LOAD
InterPro INSIG_fam UniProtKB/Swiss-Prot
KEGG Report rno:288985 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93054 IMAGE-MGC_LOAD
NCBI Gene 288985 ENTREZGENE
PANTHER INSULIN-INDUCED GENE 2 PROTEIN UniProtKB/Swiss-Prot
  PTHR15301 UniProtKB/Swiss-Prot
Pfam INSIG UniProtKB/Swiss-Prot
PhenoGen Insig2 PhenoGen
RatGTEx ENSRNOG00000002478 RatGTEx
UniProt A0A8L2Q1M5 ENTREZGENE, UniProtKB/TrEMBL
  A6K803_RAT UniProtKB/TrEMBL
  A6K805_RAT UniProtKB/TrEMBL
  INSI2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Insig2  insulin induced gene 2      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is downregulated by insulin 724448