Cyp26b1 (cytochrome P450, family 26, subfamily b, polypeptide 1) - Rat Genome Database

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Gene: Cyp26b1 (cytochrome P450, family 26, subfamily b, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
RGD ID: 631379
Description: Enables retinoic acid 4-hydroxylase activity. Involved in several processes, including response to retinoic acid; response to vitamin A; and retinoic acid catabolic process. Predicted to be located in cytoplasm. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1); PARTICIPATES IN retinoic acid metabolic pathway; retinol metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytochrome P450 26B1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84118,599,356 - 118,616,176 (-)NCBIGRCr8
mRatBN7.24117,041,808 - 117,058,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,041,808 - 117,058,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4122,523,010 - 122,539,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,298,178 - 118,314,997 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04116,911,101 - 116,927,919 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,261,796 - 116,278,615 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,261,796 - 116,278,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04180,848,037 - 180,865,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44118,734,786 - 118,751,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14118,979,266 - 118,996,087 (-)NCBI
Celera4106,028,365 - 106,045,185 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
ammonium chloride  (EXP)
arecoline  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
fipronil  (ISO)
fluconazole  (ISO)
fluoxetine  (EXP)
flusilazole  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nitrofen  (EXP)
oleic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
picoxystrobin  (ISO)
quercitrin  (ISO)
quinalphos  (ISO)
quinolines  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vinyl carbamate  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis. Chapman JS, etal., Arch Biochem Biophys. 2003 Nov 15;419(2):234-43.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Expression of retinoic acid-synthesizing and -metabolizing enzymes during nephrogenesis in the rat. Marlier A and Gilbert T, Gene Expr Patterns. 2004 Dec;5(2):179-85.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, etal., J Biol Chem. 2011 Feb 25;286(8):6542-53. Epub 2010 Dec 7.
14. Comprehensive Molecular Analyses of a Macrophage-Related Gene Signature With Regard to Prognosis, Immune Features, and Biomarkers for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and the LASSO Algorithm. Wang T, etal., Front Immunol. 2022 May 27;13:843408. doi: 10.3389/fimmu.2022.843408. eCollection 2022.
15. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. White JA, etal., Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6403-8.
16. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. Wu L and Ross AC, J Lipid Res. 2010 Feb;51(2):378-87. Epub 2009 Aug 20.
Additional References at PubMed
PMID:15030763   PMID:16554478   PMID:16574820   PMID:18816858   PMID:22019272   PMID:22020119   PMID:22366455   PMID:22899867   PMID:23554885   PMID:23991089   PMID:26937021  


Genomics

Comparative Map Data
Cyp26b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84118,599,356 - 118,616,176 (-)NCBIGRCr8
mRatBN7.24117,041,808 - 117,058,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,041,808 - 117,058,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4122,523,010 - 122,539,827 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04118,298,178 - 118,314,997 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04116,911,101 - 116,927,919 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04116,261,796 - 116,278,615 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4116,261,796 - 116,278,615 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04180,848,037 - 180,865,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44118,734,786 - 118,751,606 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14118,979,266 - 118,996,087 (-)NCBI
Celera4106,028,365 - 106,045,185 (-)NCBICelera
Cytogenetic Map4q34NCBI
CYP26B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38272,129,238 - 72,147,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl272,129,238 - 72,147,862 (-)EnsemblGRCh38hg38GRCh38
GRCh37272,356,367 - 72,374,991 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,209,875 - 72,228,471 (-)NCBINCBI36Build 36hg18NCBI36
Build 34272,268,021 - 72,286,618NCBI
Celera272,206,377 - 72,224,974 (-)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef272,092,551 - 72,111,176 (-)NCBIHuRef
CHM1_1272,285,791 - 72,304,416 (-)NCBICHM1_1
T2T-CHM13v2.0272,142,327 - 72,160,951 (-)NCBIT2T-CHM13v2.0
Cyp26b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39684,548,396 - 84,570,890 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl684,548,396 - 84,570,890 (-)EnsemblGRCm39 Ensembl
GRCm38684,571,414 - 84,593,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl684,571,414 - 84,593,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37684,521,408 - 84,543,902 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36684,537,602 - 84,559,404 (-)NCBIMGSCv36mm8
Celera686,552,442 - 86,574,953 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map636.45NCBI
LOC102023166
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542413,336,189 - 13,355,423 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542413,336,189 - 13,355,368 (+)NCBIChiLan1.0ChiLan1.0
CYP26B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21254,241,428 - 54,260,740 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A54,244,188 - 54,263,488 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A72,172,658 - 72,191,410 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A73,667,847 - 73,686,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A73,670,830 - 73,686,433 (-)Ensemblpanpan1.1panPan2
CYP26B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11750,633,397 - 50,653,882 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1750,633,413 - 50,653,894 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1750,280,509 - 50,301,422 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01751,501,857 - 51,522,773 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1751,503,195 - 51,522,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11750,510,776 - 50,531,647 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01750,576,538 - 50,597,422 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01751,150,622 - 51,171,524 (+)NCBIUU_Cfam_GSD_1.0
LOC101975674
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629212,541,815 - 12,561,209 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649116,010,070 - 16,028,895 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649116,010,394 - 16,028,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP26B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl370,572,197 - 70,593,408 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1370,573,551 - 70,593,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,914,357 - 73,934,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP26B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11435,030,011 - 35,057,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1435,038,654 - 35,057,176 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604577,009,329 - 77,029,165 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714280
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247621,456,440 - 1,472,381 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247621,455,828 - 1,474,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp26b1
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:648
Count of miRNA genes:293
Interacting mature miRNAs:353
Transcripts:ENSRNOT00000020505
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat

Markers in Region
D4Got92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,056,959 - 117,057,111 (+)MAPPERmRatBN7.2
Rnor_6.04116,276,947 - 116,277,098NCBIRnor6.0
Rnor_5.04180,863,189 - 180,863,340UniSTSRnor5.0
RGSC_v3.44118,749,937 - 118,750,089RGDRGSC3.4
RGSC_v3.44118,749,938 - 118,750,089UniSTSRGSC3.4
RGSC_v3.14118,994,419 - 118,994,570RGD
Celera4106,043,517 - 106,043,668UniSTS
RH 3.4 Map4683.3RGD
RH 3.4 Map4683.3UniSTS
Cytogenetic Map4q34UniSTS
BF398420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,042,935 - 117,043,143 (+)MAPPERmRatBN7.2
Rnor_6.04116,262,924 - 116,263,131NCBIRnor6.0
Rnor_5.04180,849,166 - 180,849,373UniSTSRnor5.0
RGSC_v3.44118,735,914 - 118,736,121UniSTSRGSC3.4
Celera4106,029,493 - 106,029,700UniSTS
RH 3.4 Map4684.3UniSTS
Cytogenetic Map4q34UniSTS
UniSTS:464663  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24117,054,705 - 117,054,821 (+)MAPPERmRatBN7.2
Rnor_6.04116,274,693 - 116,274,808NCBIRnor6.0
Rnor_5.04180,860,935 - 180,861,050UniSTSRnor5.0
RGSC_v3.44118,747,684 - 118,747,799UniSTSRGSC3.4
Celera4106,041,263 - 106,041,378UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 50 14 23 6
Low 2 42 34 18 8 18 8 10 24 21 18 5 8
Below cutoff 1 1 19 19 11 19 1

Sequence


RefSeq Acc Id: ENSRNOT00000020505   ⟹   ENSRNOP00000020505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4117,041,808 - 117,058,628 (-)Ensembl
Rnor_6.0 Ensembl4116,261,796 - 116,278,615 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114567   ⟹   ENSRNOP00000094593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4117,041,808 - 117,058,472 (-)Ensembl
RefSeq Acc Id: NM_181087   ⟹   NP_851601
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84118,599,356 - 118,616,176 (-)NCBI
mRatBN7.24117,041,808 - 117,058,628 (-)NCBI
Rnor_6.04116,261,796 - 116,278,615 (-)NCBI
Rnor_5.04180,848,037 - 180,865,444 (-)NCBI
RGSC_v3.44118,734,786 - 118,751,606 (-)RGD
Celera4106,028,365 - 106,045,185 (-)RGD
Sequence:
RefSeq Acc Id: XM_063286064   ⟹   XP_063142134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84118,599,356 - 118,615,696 (-)NCBI
RefSeq Acc Id: NP_851601   ⟸   NM_181087
- UniProtKB: G3V7X8 (UniProtKB/Swiss-Prot),   Q80YE5 (UniProtKB/Swiss-Prot),   A0A8I6AMJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020505   ⟸   ENSRNOT00000020505
RefSeq Acc Id: ENSRNOP00000094593   ⟸   ENSRNOT00000114567
RefSeq Acc Id: XP_063142134   ⟸   XM_063286064
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7X8-F1-model_v2 AlphaFold G3V7X8 1-512 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631379 AgrOrtholog
BioCyc Gene G2FUF-43977 BioCyc
Ensembl Genes ENSRNOG00000015076 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012560 UniProtKB/Swiss-Prot
  ENSRNOG00060003060 UniProtKB/Swiss-Prot
  ENSRNOG00065016235 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020505 ENTREZGENE
  ENSRNOT00000020505.4 UniProtKB/Swiss-Prot
  ENSRNOT00000114567.1 UniProtKB/TrEMBL
  ENSRNOT00055021424 UniProtKB/Swiss-Prot
  ENSRNOT00060005039 UniProtKB/Swiss-Prot
  ENSRNOT00065027041 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312495 UniProtKB/Swiss-Prot
NCBI Gene 312495 ENTREZGENE
PANTHER CYTOCHROME P450 26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 26B1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp26b1 PhenoGen
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015076 RatGTEx
  ENSRNOG00055012560 RatGTEx
  ENSRNOG00060003060 RatGTEx
  ENSRNOG00065016235 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AMJ8 ENTREZGENE, UniProtKB/TrEMBL
  CP26B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80YE5 ENTREZGENE
UniProt Secondary Q80YE5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Cyp26b1  cytochrome P450, family 26, subfamily b, polypeptide 1      Symbol and Name status set to approved 625702 APPROVED