Aard (alanine and arginine rich domain containing protein) - Rat Genome Database

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Gene: Aard (alanine and arginine rich domain containing protein) Rattus norvegicus
Analyze
Symbol: Aard
Name: alanine and arginine rich domain containing protein
RGD ID: 631378
Description: Involved in lung development. Orthologous to human AARD (alanine and arginine rich domain containing protein); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: A5D3; alanine and arginine-rich domain-containing protein; rA5D3
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,254,322 - 85,259,163 (+)NCBIGRCr8
mRatBN7.2783,364,478 - 83,369,319 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx785,266,568 - 85,271,407 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,467,779 - 87,472,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,288,152 - 87,292,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0791,588,458 - 91,593,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0792,232,534 - 92,237,375 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4788,346,189 - 88,351,030 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1788,366,918 - 88,371,758 (+)NCBI
Celera780,241,346 - 80,246,187 (+)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of a novel gene upregulated early during postnatal rat lung development. Blomberg LA, etal., Biochim Biophys Acta 2002 Apr 12;1574(3):391-8.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Aard
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8785,254,322 - 85,259,163 (+)NCBIGRCr8
mRatBN7.2783,364,478 - 83,369,319 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx785,266,568 - 85,271,407 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0787,467,779 - 87,472,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0787,288,152 - 87,292,993 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0791,588,458 - 91,593,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0792,232,534 - 92,237,375 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4788,346,189 - 88,351,030 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1788,366,918 - 88,371,758 (+)NCBI
Celera780,241,346 - 80,246,187 (+)NCBICelera
Cytogenetic Map7q31NCBI
AARD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388116,938,207 - 116,944,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8116,938,207 - 116,944,487 (+)EnsemblGRCh38hg38GRCh38
GRCh378117,950,446 - 117,956,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,019,664 - 118,024,403 (+)NCBINCBI36Build 36hg18NCBI36
Celera8114,139,154 - 114,144,929 (+)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8113,276,873 - 113,282,648 (+)NCBIHuRef
CHM1_18117,990,693 - 117,996,449 (+)NCBICHM1_1
T2T-CHM13v2.08118,066,378 - 118,072,658 (+)NCBIT2T-CHM13v2.0
Aard
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391551,903,503 - 51,909,118 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1551,903,503 - 51,909,118 (+)EnsemblGRCm39 Ensembl
GRCm381552,040,107 - 52,045,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1552,040,107 - 52,045,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv371551,871,653 - 51,877,269 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361551,870,181 - 51,875,795 (+)NCBIMGSCv36mm8
Celera1553,613,350 - 53,618,906 (+)NCBICelera
Cytogenetic Map15CNCBI
cM Map1519.55NCBI
AARD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27134,342,121 - 134,351,815 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18109,857,519 - 109,867,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08113,610,223 - 113,619,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18116,155,559 - 116,160,040 (+)NCBIpanpan1.1PanPan1.1panPan2
Aard
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530321,786,039 - 21,952,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647029,321,105 - 29,325,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647029,320,937 - 29,325,193 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl421,715,819 - 21,720,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1421,715,688 - 21,720,760 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2422,984,620 - 22,989,689 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18111,574,689 - 111,580,903 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8111,575,266 - 111,580,871 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603928,745,848 - 28,751,287 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Aard
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:242
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000006257
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat

Markers in Region
AI229720  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,368,425 - 83,368,592 (+)MAPPERmRatBN7.2
Rnor_6.0791,592,406 - 91,592,572NCBIRnor6.0
Rnor_5.0792,236,482 - 92,236,648UniSTSRnor5.0
RGSC_v3.4788,350,137 - 88,350,303UniSTSRGSC3.4
Celera780,245,294 - 80,245,460UniSTS
RH 3.4 Map7549.8UniSTS
Cytogenetic Map7q31UniSTS
AV328152  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2783,369,161 - 83,369,283 (+)MAPPERmRatBN7.2
Rnor_6.0791,593,142 - 91,593,263NCBIRnor6.0
Rnor_5.0792,237,218 - 92,237,339UniSTSRnor5.0
RGSC_v3.4788,350,873 - 88,350,994UniSTSRGSC3.4
Celera780,246,030 - 80,246,151UniSTS
Cytogenetic Map7q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 10 6 6 6 17 14 33
Low 2 24 20 19 2 19 4 5 57 15 3 3 4
Below cutoff 1 6 23 13 12 13 4 6 6 2 6 4

Sequence


RefSeq Acc Id: ENSRNOT00000006257   ⟹   ENSRNOP00000006257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl783,364,204 - 83,369,317 (+)Ensembl
Rnor_6.0 Ensembl791,588,458 - 91,593,297 (+)Ensembl
RefSeq Acc Id: NM_145093   ⟹   NP_659561
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8785,254,322 - 85,259,163 (+)NCBI
mRatBN7.2783,364,478 - 83,369,319 (+)NCBI
Rnor_6.0791,588,458 - 91,593,299 (+)NCBI
Rnor_5.0792,232,534 - 92,237,375 (+)NCBI
RGSC_v3.4788,346,189 - 88,351,030 (+)RGD
Celera780,241,346 - 80,246,187 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_659561 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG15560 (Get FASTA)   NCBI Sequence Viewer  
  EDM16274 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006257.3
GenBank Protein Q91ZF7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659561   ⟸   NM_145093
- UniProtKB: Q91ZF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006257   ⟸   ENSRNOT00000006257

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZF7-F1-model_v2 AlphaFold Q91ZF7 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695324
Promoter ID:EPDNEW_R5849
Type:single initiation site
Name:Aard_1
Description:alanine and arginine rich domain containing protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0791,588,435 - 91,588,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631378 AgrOrtholog
BioCyc Gene G2FUF-33424 BioCyc
Ensembl Genes ENSRNOG00000004708 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006257.4 UniProtKB/TrEMBL
KEGG Report rno:246323 UniProtKB/Swiss-Prot
NCBI Gene 246323 ENTREZGENE
PANTHER ALANINE AND ARGININE-RICH DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN FAM167A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aard PhenoGen
RatGTEx ENSRNOG00000004708 RatGTEx
UniProt A0A8L2Q2N6_RAT UniProtKB/TrEMBL
  A6HRE7_RAT UniProtKB/TrEMBL
  AARD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Aard  alanine and arginine rich domain containing protein    A5D3 protein  Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains potential leucine zipper motifs and phosphorylation sites 632257
gene_protein 165 amino acids 632257