Egln1 (egl-9 family hypoxia-inducible factor 1) - Rat Genome Database

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Gene: Egln1 (egl-9 family hypoxia-inducible factor 1) Rattus norvegicus
Analyze
Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
RGD ID: 631375
Description: Enables enzyme binding activity and peptidyl-proline dioxygenase activity. Involved in negative regulation of CAMKK-AMPK signaling cascade; positive regulation of neuron apoptotic process; and response to hypoxia. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in glutamatergic synapse and postsynaptic density. Used to study hypertension. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1); PARTICIPATES IN hypoxia inducible factor pathway; vascular endothelial growth factor signaling pathway; renal cell carcinoma pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: egl nine homolog 1; EGL nine homolog 1 (C. elegans); HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; PHD-2; PHD2; prolyl hydroxylase domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,867,900 - 52,907,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,869,486 - 52,907,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,652,672 - 59,692,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,503,724 - 60,543,214 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,579,139 - 62,618,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,660,194 - 57,701,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,662,278 - 57,699,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,373,433 - 68,412,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,080,670 - 55,118,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,086,125 - 55,122,813 (-)NCBI
Celera1952,235,066 - 52,273,829 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,10-phenanthroline  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
andrographolide  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
astemizole  (EXP)
atrazine  (ISO)
Azaspiracid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
formaldehyde  (ISO)
genistein  (ISO)
gentamycin  (EXP)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
minocycline  (ISO)
motexafin gadolinium  (ISO)
Muraglitazar  (EXP)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rutin  (EXP)
SB 431542  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Tesaglitazar  (EXP)
thimerosal  (ISO)
torcetrapib  (ISO)
triphenyl phosphate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Isolated erythrocytosis: study of 67 patients and identification of three novel germ-line mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. Albiero E, etal., Haematologica. 2012 Jan;97(1):123-7. doi: 10.3324/haematol.2010.039545. Epub 2011 Aug 9.
2. A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism. Arsenault PR, etal., J Biol Chem. 2013 Nov 22;288(47):33571-84. doi: 10.1074/jbc.M113.482364. Epub 2013 Oct 11.
3. Molecular study of congenital erythrocytosis in 70 unrelated patients revealed a potential causal mutation in less than half of the cases (Where is/are the missing gene(s)?). Bento C, etal., Eur J Haematol. 2013 Oct;91(4):361-8. doi: 10.1111/ejh.12170. Epub 2013 Aug 20.
4. Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Bruick RK Genes Dev 2003 Nov 1;17(21):2614-23.
5. Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure. Charchar FJ, etal., Hypertension. 2010 May;55(5):1231-8. doi: 10.1161/HYPERTENSIONAHA.109.141663. Epub 2010 Mar 15.
6. Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension. Chen YR, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):423-34.
7. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. D'Angelo G, etal., J Biol Chem 2003 Oct 3;278(40):38183-7.
8. Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion. Fallon MJ and MacDonald MJ, Metabolism. 2008 Aug;57(8):1148-54.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Han WQ, etal., Biochim Biophys Acta. 2013 Jun;1833(6):1454-62. doi: 10.1016/j.bbamcr.2013.02.029. Epub 2013 Mar 1.
12. Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D. Huo Z, etal., Biochem Biophys Res Commun. 2012 Oct 12;427(1):73-9. doi: 10.1016/j.bbrc.2012.09.005. Epub 2012 Sep 10.
13. Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury. Hyvarinen J, etal., J Biol Chem. 2010 Apr 30;285(18):13646-57. doi: 10.1074/jbc.M109.084855. Epub 2010 Feb 25.
14. Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia. Ladroue C, etal., Haematologica. 2012 Jan;97(1):9-14. doi: 10.3324/haematol.2011.044644. Epub 2011 Sep 20.
15. Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. Lipscomb EA, etal., J Neurochem. 1999 Jul;73(1):429-32.
16. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
17. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Minamishima YA, etal., Blood. 2008 Mar 15;111(6):3236-44. Epub 2007 Dec 20.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Percy MJ, etal., Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):654-9. Epub 2006 Jan 9.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis. Rahtu-Korpela L, etal., Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):608-17. doi: 10.1161/ATVBAHA.115.307136. Epub 2016 Feb 4.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schodel J, etal., Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
27. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Semenza GL Physiology (Bethesda). 2009 Apr;24:97-106.
28. Induction of SM-20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase-dependent cell death. Straub JA, etal., J Neurochem. 2003 Apr;85(2):318-28.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla. Wang Z, etal., Hypertension. 2010 May;55(5):1129-36. Epub 2010 Mar 22.
31. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Willam C, etal., J Mol Cell Cardiol. 2006 Jul;41(1):68-77.
32. Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes. Yan H, etal., J Cell Mol Med. 2012 Sep;16(9):2049-59. doi: 10.1111/j.1582-4934.2011.01500.x.
33. von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas. Yi Y, etal., Clin Cancer Res. 2010 Nov 1;16(21):5142-52. doi: 10.1158/1078-0432.CCR-09-3416. Epub 2010 Oct 26.
34. Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension. Zhu Q, etal., J Cell Mol Med. 2012 Nov;16(11):2701-7. doi: 10.1111/j.1582-4934.2012.01590.x.
Additional References at PubMed
PMID:8889548   PMID:11598268   PMID:12615973   PMID:12788921   PMID:16956324   PMID:16966370   PMID:17129494   PMID:18500250   PMID:18651560   PMID:19420289   PMID:21601578   PMID:21825224  
PMID:22286099   PMID:22955912   PMID:24190904   PMID:24695462   PMID:25635047   PMID:25975603   PMID:26681021   PMID:26765925   PMID:26818499   PMID:26972007   PMID:28594552   PMID:29158549  
PMID:29355756   PMID:29471019   PMID:31998438   PMID:32179740   PMID:32308762   PMID:34205318  


Genomics

Comparative Map Data
Egln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21952,867,900 - 52,907,308 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,869,486 - 52,907,777 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,652,672 - 59,692,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,503,724 - 60,543,214 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,579,139 - 62,618,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,660,194 - 57,701,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,662,278 - 57,699,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,373,433 - 68,412,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41955,080,670 - 55,118,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11955,086,125 - 55,122,813 (-)NCBI
Celera1952,235,066 - 52,273,829 (-)NCBICelera
Cytogenetic Map19q12NCBI
EGLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,363,756 - 231,422,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,363,751 - 231,422,287 (-)EnsemblGRCh38hg38GRCh38
GRCh371231,499,502 - 231,558,033 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,568,054 - 229,627,413 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,808,165 - 227,867,525NCBI
Celera1204,764,347 - 204,825,640 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,982,787 - 202,043,989 (-)NCBIHuRef
CHM1_11232,773,121 - 232,834,670 (-)NCBICHM1_1
T2T-CHM13v2.01230,746,985 - 230,805,510 (-)NCBIT2T-CHM13v2.0
Egln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,635,325 - 125,676,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,635,326 - 125,676,063 (-)EnsemblGRCm39 Ensembl
GRCm388124,908,587 - 124,949,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,908,587 - 124,949,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,432,487 - 127,473,154 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,794,676 - 127,801,870 (-)NCBIMGSCv36mm8
Celera8129,217,254 - 129,257,497 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.86NCBI
Egln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,407,800 - 7,454,842 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,407,800 - 7,454,851 (+)NCBIChiLan1.0ChiLan1.0
EGLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1117,977,718 - 18,036,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,915,541 - 206,976,656 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,939,543 - 211,997,325 (-)NCBIpanpan1.1PanPan1.1panPan2
EGLN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,053,486 - 8,110,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,053,837 - 8,109,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,045,638 - 8,103,130 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,078,966 - 8,136,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,078,996 - 8,136,236 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,082,361 - 8,139,616 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,204,144 - 8,261,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,432,143 - 8,489,997 (+)NCBIUU_Cfam_GSD_1.0
Egln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,178,544 - 43,220,861 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648419,343,770 - 19,386,087 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,113,844 - 59,168,395 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,113,527 - 59,168,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,786,901 - 63,840,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EGLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,624,754 - 68,685,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,625,260 - 68,682,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605570,533,202 - 70,596,876 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Egln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477518,325,135 - 18,369,504 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egln1
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:216
Count of miRNA genes:145
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000026767
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat

Markers in Region
AI503754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21754,345,171 - 54,345,273 (+)MAPPERmRatBN7.2
Rnor_6.01757,130,351 - 57,130,452NCBIRnor6.0
Rnor_5.01755,162,176 - 55,162,277UniSTSRnor5.0
RGSC_v3.41762,878,179 - 62,878,280UniSTSRGSC3.4
Celera1750,325,356 - 50,325,457UniSTS
Cytogenetic Map19q12UniSTS
RH129177  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1750,325,270 - 50,325,419UniSTS
Celera1952,236,817 - 52,236,966UniSTS
Cytogenetic Map19q12UniSTS
RH143878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,874,004 - 52,874,111 (+)MAPPERmRatBN7.2
Rnor_6.01957,666,299 - 57,666,405NCBIRnor6.0
Rnor_5.01968,379,538 - 68,379,644UniSTSRnor5.0
RGSC_v3.41955,085,266 - 55,085,372UniSTSRGSC3.4
Celera1952,241,171 - 52,241,277UniSTS
RH 3.4 Map19723.4UniSTS
Cytogenetic Map19q12UniSTS
RH143920  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0628,669,343 - 28,669,528UniSTSRnor5.0
RGSC_v3.47194,033 - 194,218UniSTSRGSC3.4
Celera6380,891 - 381,076UniSTS
RH 3.4 Map3209.72UniSTS
Cytogenetic Map19q12UniSTS
AI178936  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,903,444 - 52,903,639 (+)MAPPERmRatBN7.2
Rnor_6.01957,696,057 - 57,696,251NCBIRnor6.0
Rnor_5.01968,409,429 - 68,409,623UniSTSRnor5.0
RGSC_v3.41955,114,876 - 55,115,070UniSTSRGSC3.4
Celera1952,270,425 - 52,270,619UniSTS
RH 3.4 Map19727.8UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000026767   ⟹   ENSRNOP00000026767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1957,662,278 - 57,699,113 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115777   ⟹   ENSRNOP00000077063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1952,869,486 - 52,907,777 (-)Ensembl
RefSeq Acc Id: NM_178334   ⟹   NP_848017
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21952,867,900 - 52,907,308 (-)NCBI
Protein Sequences
Protein RefSeqs NP_848017 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH81694 (Get FASTA)   NCBI Sequence Viewer  
  AAO34711 (Get FASTA)   NCBI Sequence Viewer  
  EDL96749 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077063
  ENSRNOP00000077063.1
GenBank Protein P59722 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000026767   ⟸   ENSRNOT00000026767
RefSeq Acc Id: ENSRNOP00000077063   ⟸   ENSRNOT00000115777
RefSeq Acc Id: NP_848017   ⟸   NM_178334
- UniProtKB: Q642G6 (UniProtKB/Swiss-Prot),   P59722 (UniProtKB/Swiss-Prot),   A0A8I5Y5B5 (UniProtKB/TrEMBL)
Protein Domains
Fe2OG dioxygenase   MYND-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59722-F1-model_v2 AlphaFold P59722 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631375 AgrOrtholog
BioCyc Gene G2FUF-5225 BioCyc
Ensembl Genes ENSRNOG00000019773 Ensembl
  ENSRNOG00000063609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115777 ENTREZGENE
  ENSRNOT00000115777.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.2220 UniProtKB/TrEMBL
  q2cbj1_9rhob like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189949 IMAGE-MGC_LOAD
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_MYND UniProtKB/TrEMBL
MGC_CLONE MGC:93066 IMAGE-MGC_LOAD
NCBI Gene 308913 ENTREZGENE
PANTHER EGL NINE HOMOLOG 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGL NINE HOMOLOG-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-MYND UniProtKB/TrEMBL
PhenoGen Egln1 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_MYND_1 UniProtKB/TrEMBL
  ZF_MYND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019773 RatGTEx
  ENSRNOG00000063609 RatGTEx
SMART P4Hc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HIT/MYND zinc finger-like UniProtKB/TrEMBL
UniProt A0A8I5Y5B5 ENTREZGENE, UniProtKB/TrEMBL
  A6KJ27_RAT UniProtKB/TrEMBL
  EGLN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q642G6 ENTREZGENE
UniProt Secondary Q642G6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Egln1  egl-9 family hypoxia-inducible factor 1  Egln1  EGL nine homolog 1 (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Elgn1  EGL nine homolog 1 (C. elegans)      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression increased by hypoxia 727754