Serpinf1 (serpin family F member 1) - Rat Genome Database

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Gene: Serpinf1 (serpin family F member 1) Rattus norvegicus
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Symbol: Serpinf1
Name: serpin family F member 1
RGD ID: 631369
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to cobalt ion; cellular response to dexamethasone stimulus; and short-term memory. Located in several cellular components, including axon hillock; basement membrane; and perinuclear region of cytoplasm. Used to study Alzheimer's disease; middle cerebral artery infarction; and type 2 diabetes mellitus. Biomarker of endometriosis; liver disease (multiple); obesity; retinal disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-2 antiplasmin; Dmrs91; Pedf; pigment epithelium-derived factor; serine (or cysteine) peptidase inhibitor, clade F, member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; sserpin family F member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,748,504 - 60,760,898 (-)NCBIGRCr8
mRatBN7.21060,250,198 - 60,262,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,249,708 - 60,262,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,896,641 - 64,909,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,402,235 - 64,415,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,864,629 - 59,877,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,241,750 - 62,254,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,241,756 - 62,254,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,954,919 - 61,969,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,713,441 - 62,739,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,727,065 - 62,753,067 (-)NCBI
Celera1059,279,849 - 59,291,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IEP)
adenoid cystic carcinoma  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (IDA,ISO)
amyotrophic lateral sclerosis  (ISO)
anogenital venereal wart  (ISO)
Arterial Thrombosis  (ISO)
brain edema  (ISO)
Brain Injuries  (IEP,ISO)
Carotid Artery Injuries  (ISO)
central retinal vein occlusion  (IEP)
Choroidal Neovascularization  (IEP,ISO)
chronic fatigue syndrome  (ISO)
colorectal cancer  (ISO)
corneal neovascularization  (ISO)
corneal ulcer  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IEP,ISO)
endometriosis  (IEP,ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hepatosplenic schistosomiasis  (ISO)
Hirschsprung's disease  (ISO)
Hypoxia  (IEP)
Inflammation  (ISO)
Insulin Resistance  (IDA,ISO)
Keloid  (ISO)
kidney failure  (ISO)
leukostasis  (ISO)
lung non-small cell carcinoma  (ISO)
macular degeneration  (IEP,ISO)
macular retinal edema  (ISO)
melioidosis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatohepatitis  (ISO)
middle cerebral artery infarction  (IDA)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (IEP)
neovascular inflammatory vitreoretinopathy  (ISO)
nephroblastoma  (ISO)
obesity  (IEP,ISO)
Olfaction Disorders  (IEP)
Osteoarthritis, Experimental  (ISO)
osteogenesis imperfecta  (ISO)
osteogenesis imperfecta type 3  (ISO)
osteogenesis imperfecta type 6  (ISO,ISS)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Oxygen-Induced Retinopathy  (IEP,ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (IEP)
portal hypertension  (IEP)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinal vein occlusion  (ISO)
retinitis pigmentosa  (ISO)
retinoblastoma  (ISO)
retinopathy of prematurity  (IEP)
Salivary Gland Neoplasms  (ISO)
sciatic neuropathy  (ISO)
Septic Peritonitis  (ISO)
Sickle Cell Retinopathy  (ISO)
Staphylococcal Skin Infections  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,IMP,ISO)
uveal melanoma  (ISO)
uveitis  (ISO)
venous tributary occlusion of retina  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Nornicotine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (EXP)
adrenaline  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
ceruletide  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
flusilazole  (EXP)
fructose  (ISO)
furosemide  (EXP)
gefitinib  (ISO)
glafenine  (EXP)
glucose  (ISO)
indometacin  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP,ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenethyl caffeate  (EXP)
pinostrobin  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
propofol  (ISO)
propranolol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor. Abramson LP, etal., J Pediatr Surg. 2006 Aug;41(8):1351-6.
2. Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Amaral J and Becerra SP, Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1318-26. doi: 10.1167/iovs.09-4455. Epub 2009 Oct 22.
3. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. Awad AS, etal., Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F891-900. doi: 10.1152/ajprenal.00149.2013. Epub 2013 Jul 24.
4. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. Baraniuk JN, etal., BMC Neurol. 2005 Dec 1;5:22. doi: 10.1186/1471-2377-5-22.
5. Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Bhutto IA, etal., Exp Eye Res. 2006 Jan;82(1):99-110. Epub 2005 Jul 12.
6. Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. Bilak MM, etal., J Neuropathol Exp Neurol. 1999 Jul;58(7):719-28.
7. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. Calenda G, etal., BJU Int. 2012 May;109(10):1552-64. doi: 10.1111/j.1464-410X.2011.10705.x. Epub 2012 Feb 2.
8. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Cayouette M, etal., Neurobiol Dis. 1999 Dec;6(6):523-32.
9. Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor. Chavan SS, etal., Mol Med. 2012 Oct 24;18:1161-8. doi: 10.2119/molmed.2012.00156.
10. A physiological approach for treating endometriosis by recombinant pigment epithelium-derived factor (PEDF). Chuderland D, etal., Hum Reprod. 2013 Jun;28(6):1626-34. doi: 10.1093/humrep/det027. Epub 2013 Mar 6.
11. The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. Chuderland D, etal., J Clin Endocrinol Metab. 2013 Feb;98(2):E258-66. doi: 10.1210/jc.2012-3037. Epub 2013 Jan 7.
12. Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Chung C, etal., Gastroenterology. 2009 Jan;136(1):331-340.e2. Epub 2008 Oct 7.
13. Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy. Cohen MP, etal., Ophthalmic Res. 2008;40(1):5-9. Epub 2007 Nov 20.
14. Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity. Crawford SE, etal., J Cell Sci. 2001 Dec;114(Pt 24):4421-8.
15. Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis). de Jong HK, etal., J Thromb Haemost. 2015 Jan;13(1):41-6. doi: 10.1111/jth.12776. Epub 2014 Dec 6.
16. Downregulation of pigment epithelium-derived factor in condyloma acuminatum. Dong YH, etal., J Int Med Res. 2013 Apr;41(2):365-70. doi: 10.1177/0300060513476584. Epub 2013 Mar 14.
17. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Duh EJ, etal., Am J Ophthalmol. 2004 Apr;137(4):668-74.
18. Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Duh EJ, etal., Invest Ophthalmol Vis Sci. 2002 Mar;43(3):821-9.
19. Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis. Ek ET, etal., Cancer Gene Ther. 2007 Jul;14(7):616-26. Epub 2007 May 4.
20. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Ek ET, etal., Clin Exp Metastasis. 2007;24(2):93-106. Epub 2007 Apr 18.
21. Hyperfibrinolysis in hepatosplenic schistosomiasis. el-Bassiouni NE, etal., J Clin Pathol. 1996 Dec;49(12):990-3. doi: 10.1136/jcp.49.12.990.
22. Pigment epithelium-derived factor (PEDF) attenuated capsaicin-induced neurotrophic keratouveitis. Feher J, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5173-80. doi: 10.1167/iovs.08-1852. Epub 2009 Jun 24.
23. Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis. Fu G, etal., Acta Histochem. 2013 May;115(4):301-7. doi: 10.1016/j.acthis.2012.08.006. Epub 2012 Sep 10.
24. Plasminogen concentrations and functional activities and concentrations of plasmin inhibitors in plasma samples from normal subjects and patients with septic shock. Gallimore MJ, etal., Thromb Res. 1980 Jun 1;18(5):601-8. doi: 10.1016/0049-3848(80)90214-5.
25. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Gao G, etal., Diabetes. 2002 Apr;51(4):1218-25.
26. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
27. Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. Halin S, etal., Cancer Res. 2004 Aug 15;64(16):5664-71.
28. Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. Halin S, etal., Neoplasia. 2010 Apr;12(4):336-45.
29. Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Hartmann JS, etal., Mol Vis. 2011;17:1577-87. Epub 2011 Jun 10.
30. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. Houenou LJ, etal., J Comp Neurol. 1999 Sep 27;412(3):506-14.
31. Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy. Iizuka H, etal., Biochem Biophys Res Commun. 2007 Sep 21;361(2):421-6. Epub 2007 Jul 16.
32. Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Jenkins A, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):e5-7. Epub 2008 Aug 19.
33. Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes. Jenkins AJ, etal., Diabet Med. 2007 Dec;24(12):1345-51. Epub 2007 Oct 29.
34. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. Ji D, etal., Carcinogenesis. 2013 Jun;34(6):1265-72. doi: 10.1093/carcin/bgt056. Epub 2013 Feb 7.
35. Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease. Jiang R, etal., Medicine (Baltimore). 2019 Oct;98(41):e17478. doi: 10.1097/MD.0000000000017478.
36. Pharmacodynamics of active site-inhibited factor VIIa in endotoxin-induced coagulation in humans. Jilma B, etal., Clin Pharmacol Ther. 2002 Oct;72(4):403-10. doi: 10.1067/mcp.2002.127740.
37. Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice. Jinnouchi Y, etal., Brain Res. 2007 Sep 5;1167:92-100. Epub 2007 Jul 10.
38. Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis). Kager LM, etal., Am J Respir Crit Care Med. 2013 Oct 15;188(8):967-75. doi: 10.1164/rccm.201307-1344OC.
39. Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy. Katakami N, etal., Diabetes Res Clin Pract. 2008 Jul;81(1):e4-7. Epub 2008 May 2.
40. Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid. Kim SY, etal., Exp Eye Res. 2003 Oct;77(4):433-45.
41. Visceral obesity and hemostatic profile in patients with type 2 diabetes: the effect of gender and metabolic compensation. Kozek E, etal., Rev Diabet Stud. 2004 Fall;1(3):122-8. Epub 2004 Nov 10.
42. Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis. Kozlowska J, etal., Saudi J Gastroenterol. 2016 Sep-Oct;22(5):375-379. doi: 10.4103/1319-3767.191143.
43. Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
44. Proteases and protease inhibitors in cerulein-induced acute pancreatitis in rats. Kruse P, etal., J Surg Res. 1999 Aug;85(2):294-300.
45. Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis. Kuncl RW, etal., J Neurochem. 2002 Apr;81(1):178-84.
46. Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis. Kuo CN, etal., Exp Eye Res. 2009 Nov;89(5):678-85. doi: 10.1016/j.exer.2009.06.021. Epub 2009 Jul 9.
47. Alzheimer's disease: Elevated pigment epithelium-derived factor in the cerebrospinal fluid is mostly of systemic origin. Lang V, etal., J Neurol Sci. 2017 Apr 15;375:123-128. doi: 10.1016/j.jns.2017.01.051. Epub 2017 Jan 17.
48. Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. Lattier JM, etal., Clin Exp Metastasis. 2013 Dec;30(8):969-76. doi: 10.1007/s10585-013-9596-3. Epub 2013 Jun 22.
49. A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Li H, etal., Exp Eye Res. 2006 Oct;83(4):824-33. Epub 2006 Jul 5.
50. Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor. Maik-Rachline G, etal., Blood. 2005 Jan 15;105(2):670-8. Epub 2004 Sep 16.
51. Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats. Markovets AM, etal., Aging (Albany NY). 2011 Jan;3(1):44-54.
52. Pigment epithelium-derived factor improves metabolic derangements and ameliorates dysregulation of adipocytokines in obese type 2 diabetic rats. Matsui T, etal., Am J Pathol. 2014 Apr;184(4):1094-103. doi: 10.1016/j.ajpath.2013.12.032. Epub 2014 Feb 13.
53. Lack of alpha 2-antiplasmin promotes re-endothelialization via over-release of VEGF after vascular injury in mice. Matsuno H, etal., Blood 2003 Nov 15;102(10):3621-8. Epub 2003 Jul 31.
54. High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes. Matsuoka M, etal., Exp Eye Res. 2006 Jan;82(1):172-8. Epub 2005 Jul 27.
55. Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. Matsuoka M, etal., Mol Vis. 2007 Jun 29;13:1058-65.
56. Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy. Matsuyama K, etal., Mol Vis. 2008 May 28;14:992-6.
57. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
58. Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa. Miyazaki M, etal., J Gene Med. 2008 Dec;10(12):1273-81. doi: 10.1002/jgm.1257.
59. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Mori K, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1994-2000.
60. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. Mori K, etal., J Cell Physiol. 2001 Aug;188(2):253-63.
61. Effect of high glucose concentration on VEGF and PEDF expression in cultured retinal Muller cells. Mu H, etal., Mol Biol Rep. 2009 Nov;36(8):2147-51. doi: 10.1007/s11033-008-9428-8. Epub 2008 Dec 24.
62. Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins. Murakami Y, etal., Hum Gene Ther. 2010 Feb;21(2):199-209. doi: 10.1089/hum.2009.102.
63. Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. Nakamura DS, etal., BMC Musculoskelet Disord. 2017 Jan 25;18(1):39. doi: 10.1186/s12891-017-1410-y.
64. Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation. Nakamura K, etal., Am J Pathol. 2007 Jun;170(6):2159-70.
65. Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension. Nakamura K, etal., Int J Cardiol. 2008 Dec 13.
66. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. Noma H, etal., Curr Eye Res. 2011 Mar;36(3):256-63. doi: 10.3109/02713683.2010.513090. Epub 2011 Jan 28.
67. Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema. Noma H, etal., Graefes Arch Clin Exp Ophthalmol. 2010 Nov;248(11):1559-65. doi: 10.1007/s00417-010-1486-7. Epub 2010 Aug 17.
68. Coagulation and fibrinolysis factors in dialysis patients with and without ischemic heart disease. Oda H, etal., Adv Perit Dial. 2000;16:152-5.
69. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
70. Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization. Omri S, etal., Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4632-4642. doi: 10.1167/iovs.18-25502.
71. Comparative proteomic analysis between normal skin and keloid scar. Ong CT, etal., Br J Dermatol. 2010 Jun;162(6):1302-15. doi: 10.1111/j.1365-2133.2010.09660.x. Epub 2010 Feb 1.
72. The expression of PEDF and VEGF in the gastric wall of prehepatic portal hypertensive rats. Pan WD, etal., Hepatogastroenterology. 2011 Nov-Dec;58(112):2152-5. doi: 10.5754/hge11227.
73. Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. Park K, etal., Am J Pathol. 2011 Feb;178(2):688-98. doi: 10.1016/j.ajpath.2010.10.014.
74. Excess soluble urokinase-type plasminogen activator receptor in the plasma of dialysis patients correlates with increased fibrinolytic activity. Pawlak K, etal., Thromb Res. 2007;119(4):475-80. doi: 10.1016/j.thromres.2006.03.011. Epub 2006 Jul 7.
75. Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections. Peetermans M, etal., BMC Microbiol. 2014 Dec 17;14:310. doi: 10.1186/s12866-014-0310-7.
76. Expression of pigment-epithelium-derived factor during kidney development and aging. Pina AL, etal., Cell Tissue Res. 2007 Aug;329(2):329-38. Epub 2007 May 12.
77. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
78. GOA pipeline RGD automated data pipeline
79. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
80. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
81. Comprehensive gene review and curation RGD comprehensive gene curation
82. On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. Rodríguez-Piñeiro AM, etal., J Proteomics. 2010 Jun 16;73(8):1511-22. doi: 10.1016/j.jprot.2010.03.005. Epub 2010 Mar 15.
83. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
84. Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model. Sanagi T, etal., J Neurochem. 2008 Aug;106(4):1841-54. doi: 10.1111/j.1471-4159.2008.05529.x. Epub 2008 Jul 4.
85. Adenoviral gene delivery of pigment epithelium-derived factor protects striatal neurons from quinolinic acid-induced excitotoxicity. Sanagi T, etal., J Neuropathol Exp Neurol. 2010 Mar;69(3):224-33. doi: 10.1097/NEN.0b013e3181cfc46f.
86. Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat. Sanagi T, etal., Neurosci Lett. 2007 Aug 31;424(1):66-71. Epub 2007 Aug 1.
87. [Expression and signification of pigment epithelium-derived factor in experimental choroidal neovascularization of rat] Shi XH, etal., Zhonghua Yan Ke Za Zhi. 2004 Jun;40(6):404-8.
88. Changes in growth factor expression in normal aging of the rat retina. Smith CP and Steinle JJ, Exp Eye Res. 2007 Dec;85(6):817-24. Epub 2007 Aug 29.
89. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Spranger J, etal., Diabetes. 2001 Dec;50(12):2641-5.
90. Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35). Storozheva ZI, etal., Bull Exp Biol Med. 2006 Mar;141(3):319-22.
91. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
92. Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes. Takenaka K, etal., Atherosclerosis. 2008 Mar;197(1):25-33. Epub 2007 Sep 11.
93. Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells. Tombran-Tink J, etal., Exp Eye Res. 2004 May;78(5):945-55.
94. Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Tong JP, etal., Am J Ophthalmol. 2006 Mar;141(3):456-62.
95. Components of the fibrinolytic system in the vitreous body in patients with vitreoretinal disorders. Ulrich JN, etal., Clin Exp Ophthalmol. 2008 Jul;36(5):431-6.
96. Pigment epithelium-derived factor released by Muller glial cells exerts neuroprotective effects on retinal ganglion cells. Unterlauft JD, etal., Neurochem Res. 2012 Jul;37(7):1524-33. doi: 10.1007/s11064-012-0747-8. Epub 2012 Mar 13.
97. Epinephrine exerts anticoagulant effects during human endotoxemia. van der Poll T, etal., J Exp Med. 1997 Mar 17;185(6):1143-8.
98. Coagulation and fibrinolytic responses of human peritoneal fluid and plasma to bacterial peritonitis. van Goor H, etal., Br J Surg. 1996 Aug;83(8):1133-5. doi: 10.1002/bjs.1800830833.
99. Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. Wang JJ, etal., Am J Physiol Renal Physiol. 2008 May;294(5):F1166-73. Epub 2008 Mar 5.
100. Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy. Wang JJ, etal., Diabetes 2005 Jan;54(1):243-50.
101. Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Wang JJ, etal., Diabetes. 2006 Jun;55(6):1678-85.
102. Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes. Wang S, etal., Arch Ophthalmol. 2009 Apr;127(4):507-13.
103. Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kappa B and CREB. Yabe T, etal., Glia. 2005 May;50(3):223-34.
104. Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. Yamagishi S, etal., Microvasc Res. 2006 Jul-Sep;72(1-2):86-90. Epub 2006 Jun 22.
105. Pigment epithelium-derived factor (PEDF) inhibits diabetes- or advanced glycation end product (AGE)-induced platelet CD40 ligand overexpression in rats. Yamagishi SI, etal., Int J Cardiol. 2009 Feb 21.
106. PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. Yang H, etal., Cancer Sci. 2009 Dec;100(12):2419-25. doi: 10.1111/j.1349-7006.2009.01332.x. Epub 2009 Aug 27.
107. Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis. Yang M, etal., PLoS One. 2015 Jun 29;10(6):e0131664. doi: 10.1371/journal.pone.0131664. eCollection 2015.
108. Rosiglitazone inhibits expression and secretion of PEDF in adipose tissue and liver of male SD rats via a PPAR-gamma independent mechanism. Yang S, etal., Endocrinology. 2014 Mar;155(3):941-50. doi: 10.1210/en.2013-1813. Epub 2014 Jan 1.
109. Metformin inhibits expression and secretion of PEDF in adipocyte and hepatocyte via promoting AMPK phosphorylation. Yang S, etal., Mediators Inflamm. 2013;2013:429207. doi: 10.1155/2013/429207. Epub 2013 Oct 31.
110. Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (Muller) cells. Yang XM, etal., J Neurosci Res. 2012 Jan;90(1):257-66. doi: 10.1002/jnr.22732. Epub 2011 Sep 15.
111. Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. Yoshida T, etal., Dig Dis Sci. 2017 Jun;62(6):1527-1536. doi: 10.1007/s10620-017-4550-x. Epub 2017 Apr 1.
112. Increased levels of pigment epithelium-derived factor in aqueous humor of patients with uveitis. Yoshida Y, etal., Br J Ophthalmol. 2007 Feb;91(2):149-50. Epub 2006 Sep 14.
113. Administration of pigment epithelium-derived factor delivered by adeno-associated virus inhibits blood-retinal barrier breakdown in diabetic rats. Yu H, etal., Mol Vis. 2010 Nov 15;16:2384-94.
114. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. Zhang SX, etal., FASEB J. 2006 Feb;20(2):323-5. Epub 2005 Dec 20.
115. Role of pigment epithelium-derived factor (PEDF) in arsenic-induced cell apoptosis of liver and brain in a rat model. Zhang W, etal., Biol Trace Elem Res. 2013 Feb;151(2):269-76. doi: 10.1007/s12011-012-9558-7. Epub 2012 Dec 11.
116. [Pigment epithelium-derived factor expression in the retina in response to hypobaric hypoxia]. Zhang Y, etal., Zhonghua Yan Ke Za Zhi. 2007 Dec;43(12):1130-4.
117. The intrinsic PEDF is regulated by PPARgamma in permanent focal cerebral ischemia of rat. Zhu C, etal., Neurochem Res. 2012 Oct;37(10):2099-107. doi: 10.1007/s11064-012-0831-0. Epub 2012 Jun 20.
118. Regulation of vascular endothelial growth factor and pigment epithelium-derived factor in rat retinal explants under retinal acidification. Zhu D, etal., Eye (Lond). 2009 Nov;23(11):2105-11. doi: 10.1038/eye.2009.161. Epub 2009 Jul 3.
Additional References at PubMed
PMID:8226833   PMID:9614124   PMID:11562499   PMID:12632345   PMID:12737624   PMID:12740569   PMID:15020256   PMID:16901919   PMID:17261189   PMID:17943991   PMID:18418629   PMID:19042927  
PMID:19056867   PMID:19188429   PMID:19608741   PMID:20551380   PMID:21750722   PMID:22206666   PMID:22266516   PMID:22906018   PMID:22944728   PMID:23376485   PMID:23533145   PMID:24006456  
PMID:25337213   PMID:25673207   PMID:25890298   PMID:26277390   PMID:26519036   PMID:27214310   PMID:27413044   PMID:27973457   PMID:29210651   PMID:29568944   PMID:30142325   PMID:30180954  
PMID:30230261   PMID:30232174   PMID:30819588   PMID:30864707   PMID:31718448   PMID:32377760   PMID:36787348   PMID:37740176   PMID:39048917  


Genomics

Comparative Map Data
Serpinf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,748,504 - 60,760,898 (-)NCBIGRCr8
mRatBN7.21060,250,198 - 60,262,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,249,708 - 60,262,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,896,641 - 64,909,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,402,235 - 64,415,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,864,629 - 59,877,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,241,750 - 62,254,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,241,756 - 62,254,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,954,919 - 61,969,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,713,441 - 62,739,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,727,065 - 62,753,067 (-)NCBI
Celera1059,279,849 - 59,291,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
SERPINF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,762,060 - 1,777,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,762,029 - 1,777,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37171,665,354 - 1,680,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,612,009 - 1,627,618 (+)NCBINCBI36Build 36hg18NCBI36
Build 34171,612,008 - 1,627,618NCBI
Celera171,681,796 - 1,697,412 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,562,622 - 1,578,251 (+)NCBIHuRef
CHM1_1171,673,331 - 1,688,930 (+)NCBICHM1_1
T2T-CHM13v2.0171,650,754 - 1,666,265 (+)NCBIT2T-CHM13v2.0
Serpinf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,300,855 - 75,313,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,300,595 - 75,313,527 (-)EnsemblGRCm39 Ensembl
GRCm381175,410,029 - 75,422,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,409,769 - 75,422,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,223,531 - 75,236,125 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,225,964 - 75,238,707 (-)NCBIMGSCv36mm8
Celera1182,918,458 - 82,931,037 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.87NCBI
Serpinf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,414,930 - 1,426,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,414,930 - 1,426,436 (-)NCBIChiLan1.0ChiLan1.0
SERPINF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,333,350 - 9,349,052 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,299,810 - 11,315,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,745,597 - 1,761,399 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,638,479 - 1,653,568 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,638,556 - 1,653,568 (+)Ensemblpanpan1.1panPan2
SERPINF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,891,368 - 45,902,768 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,891,410 - 45,902,765 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha945,042,116 - 45,052,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,718,522 - 46,730,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,718,590 - 46,730,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,488,488 - 45,499,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,782,914 - 45,794,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,837,469 - 45,848,807 (+)NCBIUU_Cfam_GSD_1.0
Serpinf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,008,093 - 45,020,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,885,475 - 7,899,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,885,816 - 7,898,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,948,510 - 47,959,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,949,004 - 47,959,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,408,453 - 1,424,197 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,549,218 - 20,565,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,486,978 - 4,497,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,487,005 - 4,497,706 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpinf1
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000004313
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
RH127978  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81060,748,678 - 60,749,139 (+)Marker Load Pipeline
mRatBN7.21060,250,372 - 60,250,833 (+)MAPPERmRatBN7.2
Rnor_6.01062,241,925 - 62,242,385NCBIRnor6.0
Rnor_5.01061,955,094 - 61,955,554UniSTSRnor5.0
RGSC_v3.41062,713,616 - 62,714,076UniSTSRGSC3.4
Celera1059,280,024 - 59,280,484UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000004313   ⟹   ENSRNOP00000004313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,249,708 - 60,262,646 (-)Ensembl
Rnor_6.0 Ensembl1062,241,756 - 62,254,287 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112278   ⟹   ENSRNOP00000091165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,254,605 - 60,262,646 (-)Ensembl
RefSeq Acc Id: NM_177927   ⟹   NP_808788
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,748,504 - 60,760,898 (-)NCBI
mRatBN7.21060,250,198 - 60,262,593 (-)NCBI
Rnor_6.01062,241,750 - 62,254,145 (-)NCBI
Rnor_5.01061,954,919 - 61,969,094 (-)NCBI
RGSC_v3.41062,713,441 - 62,739,444 (-)RGD
Celera1059,279,849 - 59,291,539 (-)RGD
Sequence:
RefSeq Acc Id: NP_808788   ⟸   NM_177927
- Peptide Label: precursor
- UniProtKB: Q80ZA3 (UniProtKB/TrEMBL),   F1LSW0 (UniProtKB/TrEMBL),   Q68G45 (UniProtKB/TrEMBL),   A0A8J8XL70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004313   ⟸   ENSRNOT00000004313
Ensembl Acc Id: ENSRNOP00000091165   ⟸   ENSRNOT00000112278
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80ZA3-F1-model_v2 AlphaFold Q80ZA3 1-418 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697424
Promoter ID:EPDNEW_R7947
Type:initiation region
Name:Serpinf1_1
Description:serpin family F member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01062,254,145 - 62,254,205EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631369 AgrOrtholog
BioCyc Gene G2FUF-24213 BioCyc
Ensembl Genes ENSRNOG00000003172 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004313 ENTREZGENE
  ENSRNOT00000004313.6 UniProtKB/TrEMBL
  ENSRNOT00000112278.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110230 IMAGE-MGC_LOAD
InterPro PEDF UniProtKB/TrEMBL
  Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:287526 UniProtKB/TrEMBL
MGC_CLONE MGC:93051 IMAGE-MGC_LOAD
NCBI Gene 287526 ENTREZGENE
PANTHER PIGMENT EPITHELIUM-DERIVED FACTOR UniProtKB/TrEMBL
  Prot_inh_serpin UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinf1 PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003172 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I6GIT3_RAT UniProtKB/TrEMBL
  A0A8J8XL70 ENTREZGENE, UniProtKB/TrEMBL
  A6HGQ2_RAT UniProtKB/TrEMBL
  A6HGQ4_RAT UniProtKB/TrEMBL
  F1LSW0 ENTREZGENE
  Q68G45 ENTREZGENE, UniProtKB/TrEMBL
  Q80ZA3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LSW0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-20 Serpinf1  serpin family F member 1  Serpinf1  sserpin family F member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-13 Serpinf1  sserpin family F member 1  Serpinf1  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-01-19 Serpinf1  serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1  Serpinf1  serine (or cysteine) peptidase inhibitor, clade F, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Serpinf1  serine (or cysteine) peptidase inhibitor, clade F, member 1    serine (or cysteine) proteinase inhibitor, clade F), member 1  Name updated 1299863 APPROVED
2004-02-11 Serpinf1  serine (or cysteine) proteinase inhibitor, clade F), member 1  Dmrs91  alpha-2 antiplasmin  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED