Rcan1 (regulator of calcineurin 1) - Rat Genome Database

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Gene: Rcan1 (regulator of calcineurin 1) Rattus norvegicus
Analyze
Symbol: Rcan1
Name: regulator of calcineurin 1
RGD ID: 631338
Description: Predicted to enable calcium-dependent protein serine/threonine phosphatase regulator activity; identical protein binding activity; and protein phosphatase inhibitor activity. Involved in several processes, including negative regulation of smooth muscle cell differentiation; response to estrogen; and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN1 (regulator of calcineurin 1); PARTICIPATES IN calcineurin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcipressin-1; Down syndrome critical region gene 1; Down syndrome critical region homolog 1; Down syndrome critical region homolog 1 (human); down syndrome critical region protein 1 homolog; Dscr1; Mcip1; myocyte-enriched calcineurin-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,108,123 - 45,188,065 (-)NCBIGRCr8
GRCr8 Ensembl1145,108,124 - 45,118,236 (-)EnsemblGRCr8 Ensembl
mRatBN7.21131,622,208 - 31,702,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,622,210 - 31,702,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,316,701 - 40,326,773 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,988,158 - 32,998,230 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,146,929 - 32,157,070 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,539,689 - 32,620,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,539,683 - 32,550,539 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,145,269 - 36,224,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,386,576 - 32,408,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1131,275,905 - 31,284,458 (-)NCBICelera
RGSC_v3.11132,442,819 - 32,465,093 (-)NCBI
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
dipyridamole  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
etoposide  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
furan  (EXP,ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lithium chloride  (ISO)
maneb  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
peroxynitrous acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. Abbasi S, etal., J Biol Chem. 2006 Mar 24;281(12):7717-26. Epub 2006 Jan 16.
2. A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway. Bush E, etal., Proc Natl Acad Sci U S A 2004 Mar 2;101(9):2870-5. Epub 2004 Feb 19.
3. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. Ermak G, etal., J Biol Chem. 2001 Oct 19;276(42):38787-94. Epub 2001 Aug 1.
4. The calcineurin activity and MCIP1.4 mRNA levels are increased by innervation in regenerating soleus muscle. Fenyvesi R, etal., Biochem Biophys Res Commun 2004 Jul 23;320(2):599-605.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Calcineurin initiates smooth muscle differentiation in neural crest stem cells. Mann KM, etal., J Cell Biol. 2004 May 24;165(4):483-91. Epub 2004 May 17.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Estrogen inhibits cardiomyocyte hypertrophy in vitro. Antagonism of calcineurin-related hypertrophy through induction of MCIP1. Pedram A, etal., J Biol Chem. 2005 Jul 15;280(28):26339-48. Epub 2005 May 16.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. Wang Y, etal., Am J Physiol Heart Circ Physiol 2002 Aug;283(2):H533-9.
Additional References at PubMed
PMID:10722714   PMID:12809556   PMID:15975916   PMID:16024798   PMID:16648267   PMID:18056702   PMID:18319259   PMID:19270310   PMID:19926569   PMID:21216952   PMID:21890628   PMID:22389495  
PMID:23150431   PMID:23825664   PMID:24021800   PMID:25589755   PMID:26122706   PMID:27339639   PMID:28064310   PMID:32467610   PMID:37098739  


Genomics

Comparative Map Data
Rcan1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81145,108,123 - 45,188,065 (-)NCBIGRCr8
GRCr8 Ensembl1145,108,124 - 45,118,236 (-)EnsemblGRCr8 Ensembl
mRatBN7.21131,622,208 - 31,702,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1131,622,210 - 31,702,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,316,701 - 40,326,773 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01132,988,158 - 32,998,230 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01132,146,929 - 32,157,070 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01132,539,689 - 32,620,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1132,539,683 - 32,550,539 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01136,145,269 - 36,224,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41132,386,576 - 32,408,850 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1131,275,905 - 31,284,458 (-)NCBICelera
RGSC_v3.11132,442,819 - 32,465,093 (-)NCBI
Cytogenetic Map11q11NCBI
RCAN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382134,516,442 - 34,615,113 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2134,513,142 - 34,615,113 (-)EnsemblGRCh38hg38GRCh38
GRCh372135,888,740 - 35,987,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362134,810,652 - 34,909,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 342134,810,655 - 34,821,131NCBI
Celera2121,088,350 - 21,186,950 (-)NCBICelera
Cytogenetic Map21q22.12ENTREZGENE
HuRef2121,367,653 - 21,466,258 (-)NCBIHuRef
CHM1_12135,451,030 - 35,549,660 (-)NCBICHM1_1
T2T-CHM13v2.02132,899,007 - 32,997,690 (-)NCBIT2T-CHM13v2.0
Rcan1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391692,188,839 - 92,263,057 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1692,188,841 - 92,267,755 (-)EnsemblGRCm39 Ensembl
GRCm381692,391,951 - 92,466,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1692,391,953 - 92,470,867 (-)EnsemblGRCm38mm10GRCm38
MGSCv371692,392,198 - 92,466,391 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361692,280,814 - 92,288,917 (-)NCBIMGSCv36mm8
Celera1693,474,521 - 93,548,716 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1653.6NCBI
Rcan1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540733,873,383 - 33,951,498 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540733,873,427 - 33,951,762 (-)NCBIChiLan1.0ChiLan1.0
RCAN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22230,639,624 - 30,738,449 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12125,476,531 - 25,596,275 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02120,889,123 - 20,987,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12134,256,757 - 34,266,895 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2134,258,355 - 34,267,025 (-)Ensemblpanpan1.1panPan2
RCAN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13129,908,046 - 30,002,412 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3129,909,388 - 30,002,418 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3129,007,504 - 29,101,691 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03129,209,212 - 29,303,372 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3129,209,217 - 29,303,378 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13129,075,502 - 29,169,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03129,089,892 - 29,184,228 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03129,580,718 - 29,674,857 (-)NCBIUU_Cfam_GSD_1.0
Rcan1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497129,517,567 - 29,599,664 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365007,942,133 - 7,950,271 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365007,942,099 - 7,950,256 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RCAN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13198,102,098 - 198,205,629 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113198,106,256 - 198,205,727 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213207,934,802 - 208,034,246 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RCAN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1278,561,212 - 78,658,023 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl278,562,795 - 78,571,498 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660546,377,519 - 6,475,296 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rcan1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474522,683,016 - 22,764,720 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474522,683,600 - 22,764,735 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rcan1
536 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:123
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000002715
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH130128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,622,213 - 31,622,385 (+)MAPPERmRatBN7.2
Rnor_6.01132,539,695 - 32,539,866NCBIRnor6.0
Rnor_5.01136,145,275 - 36,145,446UniSTSRnor5.0
RGSC_v3.41132,386,582 - 32,386,753UniSTSRGSC3.4
Celera1131,275,911 - 31,276,082UniSTS
RH 3.4 Map11207.3UniSTS
Cytogenetic Map11q11UniSTS
RH130538  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21131,622,876 - 31,623,092 (+)MAPPERmRatBN7.2
Rnor_6.01132,540,358 - 32,540,573NCBIRnor6.0
Rnor_5.01136,145,938 - 36,146,153UniSTSRnor5.0
RGSC_v3.41132,387,245 - 32,387,460UniSTSRGSC3.4
Celera1131,276,574 - 31,276,789UniSTS
RH 3.4 Map11205.6UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002715   ⟹   ENSRNOP00000002715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1145,108,124 - 45,118,236 (-)Ensembl
mRatBN7.2 Ensembl1131,622,210 - 31,632,350 (-)Ensembl
Rnor_6.0 Ensembl1132,539,683 - 32,550,539 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097807   ⟹   ENSRNOP00000092573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,622,743 - 31,702,045 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106646   ⟹   ENSRNOP00000084872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1131,622,723 - 31,632,350 (-)Ensembl
RefSeq Acc Id: NM_153724   ⟹   NP_714946
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,108,123 - 45,118,236 (-)NCBI
mRatBN7.21131,622,208 - 31,632,321 (-)NCBI
Rnor_6.01132,539,689 - 32,550,523 (-)NCBI
Rnor_5.01136,145,269 - 36,224,657 (-)NCBI
RGSC_v3.41132,386,576 - 32,408,850 (-)RGD
Celera1131,275,905 - 31,284,458 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248041   ⟹   XP_006248103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81145,108,123 - 45,188,065 (-)NCBI
mRatBN7.21131,622,208 - 31,702,150 (-)NCBI
Rnor_6.01132,539,689 - 32,620,274 (-)NCBI
Rnor_5.01136,145,269 - 36,224,657 (-)NCBI
Sequence:
RefSeq Acc Id: NP_714946   ⟸   NM_153724
- UniProtKB: Q8K4S2 (UniProtKB/Swiss-Prot),   Q6IN33 (UniProtKB/Swiss-Prot),   A6JLK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248103   ⟸   XM_006248041
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000002715   ⟸   ENSRNOT00000002715
Ensembl Acc Id: ENSRNOP00000092573   ⟸   ENSRNOT00000097807
Ensembl Acc Id: ENSRNOP00000084872   ⟸   ENSRNOT00000106646

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IN33-F1-model_v2 AlphaFold Q6IN33 1-199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698069
Promoter ID:EPDNEW_R8592
Type:single initiation site
Name:Rcan1_1
Description:regulator of calcineurin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01132,550,552 - 32,550,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631338 AgrOrtholog
BioCyc Gene G2FUF-21834 BioCyc
Ensembl Genes ENSRNOG00000001979 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002715 ENTREZGENE
  ENSRNOT00000002715.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103498 IMAGE-MGC_LOAD
InterPro Calcipressin UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RCAN1_RRM UniProtKB/Swiss-Prot
KEGG Report rno:266766 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91448 IMAGE-MGC_LOAD
NCBI Gene 266766 ENTREZGENE
PANTHER PTHR10300 UniProtKB/Swiss-Prot
  PTHR10300:SF4 UniProtKB/Swiss-Prot
Pfam Calcipressin UniProtKB/Swiss-Prot
PhenoGen Rcan1 PhenoGen
RatGTEx ENSRNOG00000001979 RatGTEx
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8I6A2T8_RAT UniProtKB/TrEMBL
  A0A8I6AFT2 ENTREZGENE, UniProtKB/TrEMBL
  A6JLJ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JLK0 ENTREZGENE, UniProtKB/TrEMBL
  A6JLK1 ENTREZGENE, UniProtKB/TrEMBL
  Q6IN33 ENTREZGENE
  Q8K4S2 ENTREZGENE
  RCAN1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4S2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Rcan1  regulator of calcineurin 1  Dscr1  Down syndrome critical region homolog 1 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Slc1a7  Down syndrome critical region homolog 1 (human)  Dscr1  Down syndrome critical region gene 1  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA induced by mechanical strain in a time- and amplitude-dependent manner 625605