Rwdd1 (RWD domain containing 1) - Rat Genome Database

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Gene: Rwdd1 (RWD domain containing 1) Rattus norvegicus
Analyze
Symbol: Rwdd1
Name: RWD domain containing 1
RGD ID: 631337
Description: Predicted to be involved in several processes, including androgen receptor signaling pathway; cellular response to testosterone stimulus; and positive regulation of androgen receptor activity. Predicted to be located in cytoplasm. Orthologous to human RWDD1 (RWD domain containing 1); INTERACTS WITH 2,6-dinitrotoluene; aconitine; (1->4)-beta-D-glucan (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: RWD domain-containing protein 1; sarip; small androgen receptor-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82026,493,664 - 26,510,282 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2026,493,672 - 26,510,295 (-)EnsemblGRCr8
mRatBN7.22025,949,723 - 25,967,147 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,941,966 - 25,967,193 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2026,952,610 - 26,969,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02026,338,944 - 26,355,536 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02027,087,328 - 27,103,938 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02027,534,361 - 27,552,225 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,535,324 - 27,552,349 (-)Ensemblrn6Rnor6.0
Rnor_5.02029,363,288 - 29,379,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42037,810,012 - 37,817,545 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2027,404,835 - 27,421,422 (-)NCBICelera
RGSC_v3.12037,833,022 - 37,840,554 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:18761815  


Genomics

Comparative Map Data
Rwdd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82026,493,664 - 26,510,282 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2026,493,672 - 26,510,295 (-)EnsemblGRCr8
mRatBN7.22025,949,723 - 25,967,147 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,941,966 - 25,967,193 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2026,952,610 - 26,969,202 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02026,338,944 - 26,355,536 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02027,087,328 - 27,103,938 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02027,534,361 - 27,552,225 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2027,535,324 - 27,552,349 (-)Ensemblrn6Rnor6.0
Rnor_5.02029,363,288 - 29,379,902 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42037,810,012 - 37,817,545 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2027,404,835 - 27,421,422 (-)NCBICelera
RGSC_v3.12037,833,022 - 37,840,554 (+)NCBI
Cytogenetic Map20q11NCBI
RWDD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386116,571,504 - 116,597,675 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6116,571,409 - 116,597,675 (+)Ensemblhg38GRCh38
GRCh376116,892,667 - 116,918,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366116,999,276 - 117,021,131 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346116,999,275 - 117,021,127NCBI
Celera6117,635,653 - 117,657,505 (+)NCBICelera
Cytogenetic Map6q22.1NCBI
HuRef6114,472,164 - 114,494,013 (+)NCBIHuRef
CHM1_16117,156,198 - 117,178,045 (+)NCBICHM1_1
T2T-CHM13v2.06117,755,215 - 117,781,381 (+)NCBIT2T-CHM13v2.0
Rwdd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391033,872,551 - 33,895,612 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1033,872,551 - 33,895,620 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381033,996,555 - 34,019,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1033,996,555 - 34,019,624 (-)Ensemblmm10GRCm38
MGSCv371033,716,361 - 33,739,422 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361033,685,971 - 33,709,032 (-)NCBIMGSCv36mm8
Celera1034,906,841 - 34,929,903 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1018.85NCBI
Rwdd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495552694,518 - 120,421 (-)Ensembl
ChiLan1.0NW_00495552694,518 - 120,421 (-)NCBIChiLan1.0ChiLan1.0
RWDD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25136,585,174 - 136,607,130 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16134,478,228 - 134,506,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06114,379,178 - 114,401,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16118,524,052 - 118,546,383 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6118,524,052 - 118,546,373 (+)EnsemblpanPan2panpan1.1
RWDD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,986,809 - 57,008,720 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,987,202 - 57,007,037 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha157,781,962 - 57,804,848 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0157,168,700 - 57,191,579 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,168,998 - 57,190,562 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1157,063,107 - 57,085,979 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,911,254 - 56,934,130 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0157,539,766 - 57,562,648 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101972545
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946107,392,882 - 107,411,991 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368241,118,020 - 1,136,804 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368241,117,865 - 1,136,974 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RWDD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,161,741 - 82,182,177 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1182,161,371 - 82,180,325 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2192,384,856 - 92,403,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RWDD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11357,215,415 - 57,238,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1357,215,152 - 57,238,570 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604029,548,823 - 29,571,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rwdd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248561,818,374 - 1,838,368 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rwdd1
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000068777
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000068777   ⟹   ENSRNOP00000062656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2026,493,672 - 26,510,295 (-)Ensembl
mRatBN7.2 Ensembl2025,950,529 - 25,967,167 (-)Ensembl
Rnor_6.0 Ensembl2027,535,324 - 27,552,349 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095504   ⟹   ENSRNOP00000085613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2026,493,672 - 26,510,151 (-)Ensembl
mRatBN7.2 Ensembl2025,941,966 - 25,967,046 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098026   ⟹   ENSRNOP00000091822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2026,493,672 - 26,504,454 (-)Ensembl
mRatBN7.2 Ensembl2025,941,966 - 25,967,193 (-)Ensembl
RefSeq Acc Id: NM_147146   ⟹   NP_671487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82026,493,672 - 26,510,282 (-)NCBI
mRatBN7.22025,950,537 - 25,967,147 (-)NCBI
Rnor_6.02027,535,324 - 27,552,225 (-)NCBI
Rnor_5.02029,363,288 - 29,379,902 (-)NCBI
RGSC_v3.42037,810,012 - 37,817,545 (+)RGD
Celera2027,404,835 - 27,421,422 (-)RGD
Sequence:
RefSeq Acc Id: XM_008772869   ⟹   XP_008771091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82026,493,664 - 26,510,085 (-)NCBI
mRatBN7.22025,949,723 - 25,966,833 (-)NCBI
Rnor_6.02027,534,361 - 27,552,009 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_671487 (Get FASTA)   NCBI Sequence Viewer  
  XP_008771091 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93099 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062656
  ENSRNOP00000085613.1
GenBank Protein Q99ND9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_671487   ⟸   NM_147146
- UniProtKB: Q99ND9 (UniProtKB/Swiss-Prot),   A6K3S3 (UniProtKB/TrEMBL),   A0A8I6ACH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771091   ⟸   XM_008772869
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000062656   ⟸   ENSRNOT00000068777
Ensembl Acc Id: ENSRNOP00000091822   ⟸   ENSRNOT00000098026
Ensembl Acc Id: ENSRNOP00000085613   ⟸   ENSRNOT00000095504
Protein Domains
RWD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99ND9-F1-model_v2 AlphaFold Q99ND9 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701573
Promoter ID:EPDNEW_R12097
Type:initiation region
Name:Rwdd1_1
Description:RWD domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02027,552,129 - 27,552,189EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631337 AgrOrtholog
BioCyc Gene G2FUF-3796 BioCyc
Ensembl Genes ENSRNOG00000042916 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068777 ENTREZGENE
  ENSRNOT00000095504.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
  6.20.400.10 UniProtKB/Swiss-Prot
InterPro GIR2-like UniProtKB/Swiss-Prot
  RWD-domain UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
  ZC3H15/TMA46_C UniProtKB/Swiss-Prot
KEGG Report rno:259218 UniProtKB/Swiss-Prot
NCBI Gene 259218 ENTREZGENE
PANTHER PTHR12292 UniProtKB/Swiss-Prot
Pfam DFRP_C UniProtKB/Swiss-Prot
  RWD UniProtKB/Swiss-Prot
PhenoGen Rwdd1 PhenoGen
PROSITE RWD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042916 RatGTEx
SMART RWD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
UniProt A0A8I6ACH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QX02_RAT UniProtKB/TrEMBL
  A6K3S3 ENTREZGENE, UniProtKB/TrEMBL
  Q99ND9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Rwdd1  RWD domain containing 1  sarip  small androgen receptor-interacting protein  Symbol and Name updated 1299863 APPROVED