Gimap5 (GTPase, IMAP family member 5) - Rat Genome Database

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Gene: Gimap5 (GTPase, IMAP family member 5) Rattus norvegicus
Analyze
Symbol: Gimap5
Name: GTPase, IMAP family member 5
RGD ID: 628871
Description: Predicted to enable GTP binding activity. Involved in several processes, including mononuclear cell differentiation; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Located in mitochondrion. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to human GIMAP5 (GTPase, IMAP family member 5); INTERACTS WITH (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTPase IMAP family member 5; IAN-4; IAN4; Ian4l1; IAN5; immune associated nucleotide 4 like 1; immune associated nucleotide 4 like 1 (mouse); immunity-associated nucleotide 4 protein; immunity-associated nucleotide 4-like 1 protein; lymphopenia; lymphopenia gene; lyp
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Genes
More Info more info ...
Is Marker For: Strains:   BB.SHR-(D4Got41-Gimap5)/K   BBDP.BBDR-Gimap5/Sunn   BBDP.BBDR-Gimap5, WF-(D13Rat124-D13Mgh5)/Sunn  
Candidate Gene For: Bw52 Bw53 Iddm39
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2477,693,417 - 77,701,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,687,564 - 77,703,086 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,902,037 - 82,908,725 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0478,677,516 - 78,684,204 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0477,117,807 - 77,124,495 (+)NCBIRnor_WKY
Rnor_6.0478,377,228 - 78,386,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,378,144 - 78,385,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,066,311 - 143,073,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,836,521 - 76,843,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,112,650 - 77,119,327 (+)NCBI
Celera472,631,351 - 72,638,043 (+)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Decreased core temperature and increased beta(3)-adrenergic sensitivity in diabetes-prone BB rats. Akesson L, etal., Diabetes Technol Ther. 2007 Aug;9(4):354-62.
2. Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats. Akesson L, etal., Exp Clin Endocrinol Diabetes. 2008 May 9;.
3. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Bieg S, etal., Diabetologia 1997 Jul;40(7):786-92.
4. The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. Clark L, etal., FEMS Immunol Med Microbiol. 2002 Feb 18;32(3):205-9.
5. Expression of the Ian family of putative GTPases during T cell development and description of an Ian with three sets of GTP/GDP-binding motifs. Dion C, etal., Int Immunol. 2005 Sep;17(9):1257-68. Epub 2005 Aug 15.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Hornum L, etal., Diabetes 2002 Jun;51(6):1972-9.
8. Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes. Ilangumaran S, etal., Mol Immunol. 2008 Nov 11.
9. GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment. Keita M, etal., Biochem Biophys Res Commun. 2007 Sep 21;361(2):481-6. Epub 2007 Jul 23.
10. Loss of a gimap/ian gene leads to activation of NF-kappaB through a MAPK-dependent pathway. Kupfer R, etal., Mol Immunol. 2007 Jan;44(4):479-87. Epub 2006 Apr 11.
11. Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals. Lau A, etal., Diabetes. 1998 Feb;47(2):197-205.
12. Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene. MacMurray AJ, etal., Genome Res 2002 Jul;12(7):1029-39.
13. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Michalkiewicz M, etal., Physiol Genomics 2004 Oct 4;19(2):228-32. Epub 2004 Aug 24.
14. A diabetogenic gene prevents T cells from receiving costimulatory signals. Moore JK, etal., Cell Immunol. 1999 May 25;194(1):90-7.
15. Ian4 is required for mitochondrial integrity and T cell survival. Pandarpurkar M, etal., Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10382-7. Epub 2003 Aug 20.
16. Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. Poussier P, etal., J Immunol. 2005 Apr 1;174(7):4081-9.
17. Evidence for the extrathymic origin of intestinal TCRgammadelta(+) T cells in normal rats and for an impairment of this differentiation pathway in BB rats. Ramanathan S, etal., J Immunol 2002 Mar 1;168(5):2182-7.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Comprehensive gene review and curation RGD comprehensive gene curation
22. Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background. Sommandas V, etal., J Autoimmun. 2005 Aug;25(1):46-56.
23. Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat. Sommandas V, etal., J Leukoc Biol. 2007 Oct;82(4):869-76. Epub 2007 Jun 28.
24. Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. Todd DJ, etal., J Immunol. 2004 May 1;172(9):5356-62.
Additional References at PubMed
PMID:12477932   PMID:14624755   PMID:15307172   PMID:15474297   PMID:15489334   PMID:19351909   PMID:19424493   PMID:19996157   PMID:21925515   PMID:23098229   PMID:26740263   PMID:27023180  


Genomics

Comparative Map Data
Gimap5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2477,693,417 - 77,701,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,687,564 - 77,703,086 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx482,902,037 - 82,908,725 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0478,677,516 - 78,684,204 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0477,117,807 - 77,124,495 (+)NCBIRnor_WKY
Rnor_6.0478,377,228 - 78,386,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,378,144 - 78,385,577 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,066,311 - 143,073,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,836,521 - 76,843,214 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,112,650 - 77,119,327 (+)NCBI
Celera472,631,351 - 72,638,043 (+)NCBICelera
Cytogenetic Map4q24NCBI
GIMAP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,737,418 - 150,743,646 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7150,722,253 - 150,750,033 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,434,506 - 150,440,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,065,384 - 150,071,669 (+)NCBINCBI36Build 36hg18NCBI36
Build 347149,872,098 - 149,878,384NCBI
Celera7144,991,531 - 144,997,796 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,246,520 - 144,252,822 (+)NCBIHuRef
CHM1_17150,442,821 - 150,449,122 (+)NCBICHM1_1
T2T-CHM13v2.07151,910,326 - 151,916,554 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,763,721 - 149,770,022 (+)NCBI
Gimap5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,723,131 - 48,731,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,723,131 - 48,731,144 (+)EnsemblGRCm39 Ensembl
GRCm38648,746,197 - 48,754,200 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,746,197 - 48,754,210 (+)EnsemblGRCm38mm10GRCm38
MGSCv37648,696,196 - 48,704,199 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,675,783 - 48,683,786 (+)NCBIMGSCv36mm8
Celera649,257,051 - 49,265,008 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
LOC100984887
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17154,471,995 - 154,478,298 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v07142,319,479 - 142,326,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC100687459
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,887,308 - 14,895,522 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,495,620 - 15,503,788 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,602,613 - 16,610,785 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,602,557 - 16,610,761 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11614,981,879 - 14,990,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,563,361 - 15,571,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,613,881 - 15,622,077 (+)NCBIUU_Cfam_GSD_1.0
GIMAP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1186,363,443 - 6,371,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,671,945 - 6,676,690 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Gimap5
50 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000059156
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)457114432102114432Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat

Markers in Region
RH141689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,700,690 - 77,700,902 (+)MAPPERmRatBN7.2
Rnor_6.0478,384,502 - 78,384,713NCBIRnor6.0
Rnor_5.04143,072,669 - 143,072,880UniSTSRnor5.0
RGSC_v3.4476,842,880 - 76,843,091UniSTSRGSC3.4
Celera472,637,709 - 72,637,920UniSTS
RH 3.4 Map4499.81UniSTS
Cytogenetic Map4q24UniSTS
PMC186618P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,699,887 - 77,700,387 (+)MAPPERmRatBN7.2
Rnor_6.0478,383,699 - 78,384,198NCBIRnor6.0
Rnor_5.04143,071,866 - 143,072,365UniSTSRnor5.0
RGSC_v3.4476,842,077 - 76,842,576UniSTSRGSC3.4
Celera472,636,906 - 72,637,405UniSTS
Cytogenetic Map4q24UniSTS
PMC186618P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,700,048 - 77,700,387 (+)MAPPERmRatBN7.2
Rnor_6.0478,383,860 - 78,384,198NCBIRnor6.0
Rnor_5.04143,072,027 - 143,072,365UniSTSRnor5.0
RGSC_v3.4476,842,238 - 76,842,576UniSTSRGSC3.4
Celera472,637,067 - 72,637,405UniSTS
Cytogenetic Map4q24UniSTS
PMC186618P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,700,048 - 77,700,433 (+)MAPPERmRatBN7.2
Rnor_6.0478,383,860 - 78,384,244NCBIRnor6.0
Rnor_5.04143,072,027 - 143,072,411UniSTSRnor5.0
RGSC_v3.4476,842,238 - 76,842,622UniSTSRGSC3.4
Celera472,637,067 - 72,637,451UniSTS
Cytogenetic Map4q24UniSTS


Related Rat Strains
The following Strains have been annotated to Gimap5


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 8 19 2 3 11
Low 1 34 49 41 41 8 11 74 33 32 8
Below cutoff 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY055776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY055777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY550023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ125352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ125353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000059156   ⟹   ENSRNOP00000055929
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,687,564 - 77,701,004 (+)Ensembl
Rnor_6.0 Ensembl478,378,144 - 78,384,827 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083891   ⟹   ENSRNOP00000071587
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl478,378,313 - 78,384,783 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084927   ⟹   ENSRNOP00000072663
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,694,097 - 77,703,086 (+)Ensembl
Rnor_6.0 Ensembl478,382,287 - 78,385,577 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115571   ⟹   ENSRNOP00000078457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,694,262 - 77,703,086 (+)Ensembl
RefSeq Acc Id: NM_001033913   ⟹   NP_001029085
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,694,333 - 77,701,025 (+)NCBI
Rnor_6.0478,378,144 - 78,384,836 (+)NCBI
Rnor_5.04143,066,311 - 143,073,003 (+)NCBI
RGSC_v3.4476,836,521 - 76,843,214 (+)RGD
Celera472,631,351 - 72,638,043 (+)RGD
Sequence:
RefSeq Acc Id: NM_145680   ⟹   NP_663713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,694,333 - 77,701,025 (+)NCBI
Rnor_6.0478,378,144 - 78,384,836 (+)NCBI
Rnor_5.04143,066,311 - 143,073,003 (+)NCBI
RGSC_v3.4476,836,521 - 76,843,214 (+)RGD
Celera472,631,351 - 72,638,043 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236457   ⟹   XP_006236519
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,694,440 - 77,701,025 (+)NCBI
Rnor_6.0478,377,824 - 78,386,683 (+)NCBI
Rnor_5.04143,066,311 - 143,073,003 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236458   ⟹   XP_006236520
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,694,440 - 77,701,025 (+)NCBI
Rnor_6.0478,377,843 - 78,386,683 (+)NCBI
Rnor_5.04143,066,311 - 143,073,003 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762871   ⟹   XP_008761093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2477,693,417 - 77,701,025 (+)NCBI
Rnor_6.0478,377,228 - 78,386,683 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_663713   ⟸   NM_145680
- Peptide Label: isoform 2
- UniProtKB: Q8K3L6 (UniProtKB/Swiss-Prot),   Q0R3W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029085   ⟸   NM_001033913
- Peptide Label: isoform 1
- UniProtKB: Q8K3L7 (UniProtKB/Swiss-Prot),   Q8K3L6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236519   ⟸   XM_006236457
- Peptide Label: isoform X1
- UniProtKB: Q8K3L7 (UniProtKB/Swiss-Prot),   Q8K3L6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236520   ⟸   XM_006236458
- Peptide Label: isoform X2
- UniProtKB: Q8K3L6 (UniProtKB/Swiss-Prot),   Q0R3W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761093   ⟸   XM_008762871
- Peptide Label: isoform X2
- UniProtKB: Q8K3L6 (UniProtKB/Swiss-Prot),   Q0R3W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072663   ⟸   ENSRNOT00000084927
RefSeq Acc Id: ENSRNOP00000071587   ⟸   ENSRNOT00000083891
RefSeq Acc Id: ENSRNOP00000055929   ⟸   ENSRNOT00000059156
RefSeq Acc Id: ENSRNOP00000078457   ⟸   ENSRNOT00000115571
Protein Domains
AIG1-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3L6-F1-model_v2 AlphaFold Q8K3L6 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693032
Promoter ID:EPDNEW_R3555
Type:initiation region
Name:Gimap5_1
Description:GTPase, IMAP family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0478,378,191 - 78,378,251EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628871 AgrOrtholog
BioCyc Gene G2FUF-44941 BioCyc
Ensembl Genes ENSRNOG00000008416 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000055929 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072663 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000078457 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059156 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000084927 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000115571 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7106699 IMAGE-MGC_LOAD
  IMAGE:7130634 IMAGE-MGC_LOAD
InterPro G_AIG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GIMA/IAN/Toc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246774 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108516 IMAGE-MGC_LOAD
  MGC:93145 IMAGE-MGC_LOAD
NCBI Gene 246774 ENTREZGENE
PANTHER PTHR10903 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AIG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gimap5 PhenoGen
PROSITE G_AIG1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GIMA5_RAT UniProtKB/Swiss-Prot
  Q0R3W6_RAT UniProtKB/TrEMBL
  Q0R3W7 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3L6 ENTREZGENE
  Q8K3L7 ENTREZGENE
UniProt Secondary Q5YEJ2 UniProtKB/Swiss-Prot
  Q5YEJ3 UniProtKB/Swiss-Prot
  Q8K3L7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Gimap5  GTPase, IMAP family member 5      Symbol and Name status set to approved 1299863 APPROVED
2004-12-08 Gimap5  GTPase, IMAP family member 5  Ian4l1  immune associated nucleotide 4 like 1 (mouse)  Symbol and Name updated 1299863 PROVISIONAL
2003-02-27 Ian4l1  immune associated nucleotide 4 like 1 (mouse)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease frameshift mutation which resulted in a truncated protein was found in lymphopenic rats 633092
gene_expression mRNA expressed in spleen, thymus and lymph nodes 619544