Nr1d1 (nuclear receptor subfamily 1, group D, member 1) - Rat Genome Database

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Gene: Nr1d1 (nuclear receptor subfamily 1, group D, member 1) Rattus norvegicus
Analyze
Symbol: Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
RGD ID: 628827
Description: Enables transcription cis-regulatory region binding activity. Involved in several processes, including photoperiodism; positive regulation of circadian rhythm; and regulation of hepatic stellate cell activation. Located in dendrite and neuronal cell body. Biomarker of hyperthyroidism; hypothyroidism; portal hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in brain small vessel disease. Orthologous to human NR1D1 (nuclear receptor subfamily 1 group D member 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EAR-1; nuclear receptor subfamily 1 group D member 1; rev-erb alpha; rev-erbA-alpha; REV-ERBAALPHA; V-erbA-related protein 1; V-erbA-related protein EAR-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,728,348 - 83,735,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,728,318 - 83,735,705 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,672,225 - 88,679,439 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01088,170,300 - 88,177,514 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01083,563,001 - 83,570,215 (-)NCBIRnor_WKY
Rnor_6.01086,683,875 - 86,690,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,683,875 - 86,690,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,479,868 - 86,486,808 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,541,246 - 87,548,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,555,629 - 87,560,471 (-)NCBI
Celera1082,476,555 - 82,483,495 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-m-cresol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
clofibrate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glyphosate  (EXP)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hyaluronic acid  (ISO)
hypochlorous acid  (ISO)
imidacloprid  (EXP)
indole-3-methanol  (EXP)
ketamine  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
luteolin  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
methotrexate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
naphthalenes  (EXP)
nevirapine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP)
propiconazole  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SCH-351591  (EXP)
scopolamine  (EXP)
senecionine  (ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
styrene  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
trametinib  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IBA)
cellular response to interleukin-1  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
cholesterol homeostasis  (IEA,ISO,ISS)
circadian regulation of gene expression  (IEA,ISO,ISS)
circadian rhythm  (IEP,ISO)
circadian temperature homeostasis  (IEA,ISO,ISS)
DNA-templated transcription  (IEA)
glycogen biosynthetic process  (IEA,ISO,ISS)
hormone-mediated signaling pathway  (IBA)
intracellular glucose homeostasis  (IEA,ISO,ISS)
intracellular receptor signaling pathway  (IEA)
negative regulation of astrocyte activation  (IEA,ISO,ISS)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO,ISS)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of microglial cell activation  (IEA,ISO,ISS)
negative regulation of neuroinflammatory response  (ISO,ISS)
negative regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
photoperiodism  (IEP)
positive regulation of bile acid biosynthetic process  (IEA,ISO,ISS)
positive regulation of circadian rhythm  (IDA)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA)
proteasomal protein catabolic process  (IEA,ISO,ISS)
protein destabilization  (IEA,ISO,ISS)
regulation of circadian rhythm  (IDA,ISO)
regulation of circadian sleep/wake cycle  (IEA,ISO,ISS)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of fat cell differentiation  (IEA,ISO,ISS)
regulation of hepatic stellate cell activation  (IDA)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO,ISS)
regulation of lipid metabolic process  (ISO,ISS)
regulation of type B pancreatic cell proliferation  (IEA,ISO,ISS)
response to leptin  (IBA,IEA,ISO,ISS)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
dendrite  (IDA,ISO,ISS)
dendritic spine  (IEA,ISO,ISS)
neuronal cell body  (IDA)
nuclear body  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Rev-erbalpha regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112. Chen H, etal., Biochem Biophys Res Commun. 2012 Apr 6;420(2):374-9. doi: 10.1016/j.bbrc.2012.02.164. Epub 2012 Mar 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The nuclear receptor Rev-erba controls circadian thermogenic plasticity. Gerhart-Hines Z, etal., Nature. 2013 Nov 21;503(7476):410-413. doi: 10.1038/nature12642. Epub 2013 Oct 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The orphan receptor Rev-ErbA alpha activates transcription via a novel response element. Harding HP and Lazar MA, Mol Cell Biol. 1993 May;13(5):3113-21.
6. [Pulmonary expression of Nr1d1 in rats with ventilation-induced lung injury]. Hu J and Wang C, Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1544-6.
7. Developmental expression of mRNAs from a rat C-erbA genomic locus. Jannini EA, etal., Biochem Biophys Res Commun. 1992 Apr 30;184(2):739-45.
8. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Lazar MA, etal., Mol Cell Biol 1989 Mar;9(3):1128-36.
9. Novel role of nuclear receptor Rev-erbalpha in hepatic stellate cell activation: potential therapeutic target for liver injury. Li T, etal., Hepatology. 2014 Jun;59(6):2383-96. doi: 10.1002/hep.27049. Epub 2014 Apr 29.
10. The thyroid hormone receptor alpha locus and white matter lesions: a role for the clock gene REV-ERBalpha. Medici M, etal., Thyroid. 2012 Nov;22(11):1181-6. doi: 10.1089/thy.2012.0198. Epub 2012 Oct 19.
11. Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner. Meng QJ, etal., J Cell Sci. 2008 Nov 1;121(Pt 21):3629-35. doi: 10.1242/jcs.035048.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements. Spanjaard RA, etal., Mol Endocrinol. 1994 Mar;8(3):286-95.
17. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
18. Effect of phase delay lighting rotation schedule on daily expression of per2, bmal1, rev-erbalpha, pparalpha, and pdk4 genes in the heart and liver of Wistar rats. Szantoova K, etal., Mol Cell Biochem. 2011 Feb;348(1-2):53-60. doi: 10.1007/s11010-010-0636-x. Epub 2010 Nov 14.
19. A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha. Valnegri P, etal., Nat Neurosci. 2011 Aug 28;14(10):1293-301. doi: 10.1038/nn.2911.
20. Association of Rev-erbalpha in adipose tissues with Type 2 diabetes mellitus amelioration after gastric bypass surgery in Goto-Kakizaki rats. Zhang R, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15;305(2):R134-46. doi: 10.1152/ajpregu.00520.2012. Epub 2013 May 1.
Additional References at PubMed
PMID:7838158   PMID:8622974   PMID:12150932   PMID:12821652   PMID:14645221   PMID:15761026   PMID:18006707   PMID:18227153   PMID:18511497   PMID:18565334   PMID:19721697   PMID:19955433  
PMID:20070857   PMID:20159955   PMID:20424134   PMID:21628546   PMID:21952132   PMID:22166979   PMID:23398316   PMID:24030830   PMID:24355794   PMID:24794873   PMID:25588874   PMID:25648833  
PMID:26102301   PMID:26811051   PMID:27686098   PMID:29508494   PMID:29533925   PMID:29653076   PMID:30096135   PMID:30555544   PMID:30792350   PMID:31957097   PMID:36077427  


Genomics

Comparative Map Data
Nr1d1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21083,728,348 - 83,735,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,728,318 - 83,735,705 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1088,672,225 - 88,679,439 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01088,170,300 - 88,177,514 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01083,563,001 - 83,570,215 (-)NCBIRnor_WKY
Rnor_6.01086,683,875 - 86,690,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,683,875 - 86,690,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,479,868 - 86,486,808 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,541,246 - 87,548,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11087,555,629 - 87,560,471 (-)NCBI
Celera1082,476,555 - 82,483,495 (-)NCBICelera
Cytogenetic Map10q31NCBI
NR1D1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,092,793 - 40,100,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1740,092,793 - 40,100,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,249,046 - 38,256,842 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,502,567 - 35,510,499 (-)NCBINCBI36Build 36hg18NCBI36
Build 341735,502,566 - 35,510,499NCBI
Celera1734,909,147 - 34,917,084 (-)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,042,773 - 34,050,715 (-)NCBIHuRef
CHM1_11738,484,740 - 38,492,682 (-)NCBICHM1_1
T2T-CHM13v2.01740,956,678 - 40,964,476 (-)NCBIT2T-CHM13v2.0
Nr1d1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,658,758 - 98,666,233 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,658,758 - 98,666,159 (-)EnsemblGRCm39 Ensembl
GRCm381198,767,932 - 98,775,377 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,767,932 - 98,775,333 (-)EnsemblGRCm38mm10GRCm38
MGSCv371198,629,249 - 98,636,556 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,584,022 - 98,590,912 (-)NCBIMGSCv36mm8
Celera11108,422,591 - 108,429,908 (-)NCBICelera
Cytogenetic Map11DNCBI
Nr1d1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,742,735 - 14,750,999 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,743,763 - 14,750,903 (-)NCBIChiLan1.0ChiLan1.0
NR1D1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11726,748,938 - 26,756,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,188,390 - 17,196,315 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,409,669 - 17,417,600 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,409,669 - 17,417,600 (+)Ensemblpanpan1.1panPan2
NR1D1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,461,556 - 22,469,243 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,461,705 - 22,469,053 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,933,902 - 21,941,575 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,254,745 - 23,262,432 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,254,822 - 23,262,435 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,028,188 - 22,035,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,287,169 - 22,294,857 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,411,920 - 22,419,594 (+)NCBIUU_Cfam_GSD_1.0
Nr1d1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,861,286 - 21,868,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,206,191 - 15,213,867 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649015,206,194 - 15,213,858 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR1D1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,263,657 - 22,271,643 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,263,549 - 22,274,131 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NR1D1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,078,990 - 66,086,927 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,079,089 - 66,090,685 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,982,347 - 36,990,288 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr1d1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,102,439 - 3,109,497 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,102,424 - 3,109,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr1d1
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:187
Count of miRNA genes:98
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000012537, ENSRNOT00000055333
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat

Markers in Region
RH133144  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,729,162 - 83,729,353 (+)MAPPERmRatBN7.2
Rnor_6.01086,684,690 - 86,684,880NCBIRnor6.0
Rnor_5.01086,480,683 - 86,480,873UniSTSRnor5.0
RGSC_v3.41087,542,061 - 87,542,251UniSTSRGSC3.4
Celera1082,477,370 - 82,477,560UniSTS
RH 3.4 Map10858.6UniSTS
Cytogenetic Map10q31UniSTS
AW259572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,729,114 - 83,729,206 (+)MAPPERmRatBN7.2
Rnor_6.01086,684,642 - 86,684,733NCBIRnor6.0
Rnor_5.01086,480,635 - 86,480,726UniSTSRnor5.0
RGSC_v3.41087,542,013 - 87,542,104UniSTSRGSC3.4
Celera1082,477,322 - 82,477,413UniSTS
Cytogenetic Map10q31UniSTS
BF387429  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,732,373 - 83,732,559 (+)MAPPERmRatBN7.2
Rnor_6.01086,687,901 - 86,688,086NCBIRnor6.0
Rnor_5.01086,483,894 - 86,484,079UniSTSRnor5.0
RGSC_v3.41087,545,272 - 87,545,457UniSTSRGSC3.4
Celera1082,480,581 - 82,480,766UniSTS
RH 3.4 Map10876.09UniSTS
Cytogenetic Map10q31UniSTS
D17S1644E  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,729,253 - 83,729,324 (+)MAPPERmRatBN7.2
Rnor_6.01086,684,781 - 86,684,851NCBIRnor6.0
Rnor_5.01086,480,774 - 86,480,844UniSTSRnor5.0
RGSC_v3.41087,542,152 - 87,542,222UniSTSRGSC3.4
Celera1082,477,461 - 82,477,531UniSTS
Cytogenetic Map10q31UniSTS
MARC_5497-5498:996690469:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,728,799 - 83,729,539 (+)MAPPERmRatBN7.2
Rnor_6.01086,684,327 - 86,685,066NCBIRnor6.0
Rnor_5.01086,480,320 - 86,481,059UniSTSRnor5.0
RGSC_v3.41087,541,698 - 87,542,437UniSTSRGSC3.4
Celera1082,477,007 - 82,477,746UniSTS
Cytogenetic Map10q31UniSTS
RH125185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,728,377 - 83,728,548 (+)MAPPERmRatBN7.2
Rnor_6.01086,683,905 - 86,684,075NCBIRnor6.0
Rnor_5.01086,479,898 - 86,480,068UniSTSRnor5.0
RGSC_v3.41087,541,276 - 87,541,446UniSTSRGSC3.4
Celera1082,476,585 - 82,476,755UniSTS
Cytogenetic Map10q31UniSTS
NR1D1_2626  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,728,163 - 83,728,854 (+)MAPPERmRatBN7.2
Rnor_6.01086,683,691 - 86,684,381NCBIRnor6.0
Rnor_5.01086,479,684 - 86,480,374UniSTSRnor5.0
RGSC_v3.41087,541,062 - 87,541,752UniSTSRGSC3.4
Celera1082,476,371 - 82,477,061UniSTS
Cytogenetic Map10q31UniSTS
THRA_2263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,728,582 - 83,729,339 (+)MAPPERmRatBN7.2
Rnor_6.01086,684,110 - 86,684,866NCBIRnor6.0
Rnor_5.01086,480,103 - 86,480,859UniSTSRnor5.0
RGSC_v3.41087,541,481 - 87,542,237UniSTSRGSC3.4
Celera1082,476,790 - 82,477,546UniSTS
Cytogenetic Map10q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 17 15 5 6 5 7 10 29 15 14 11 7
Low 26 36 30 13 30 1 1 45 20 27 1
Below cutoff 6 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012537   ⟹   ENSRNOP00000012537
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,728,349 - 83,735,705 (-)Ensembl
Rnor_6.0 Ensembl1086,683,875 - 86,690,815 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000055333   ⟹   ENSRNOP00000052200
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,728,348 - 83,732,502 (-)Ensembl
Rnor_6.0 Ensembl1086,683,875 - 86,688,730 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117389   ⟹   ENSRNOP00000080936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1083,728,318 - 83,735,705 (-)Ensembl
RefSeq Acc Id: NM_001113422   ⟹   NP_001106893
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,728,348 - 83,735,562 (-)NCBI
Rnor_6.01086,683,875 - 86,690,815 (-)NCBI
Rnor_5.01086,479,868 - 86,486,808 (-)NCBI
RGSC_v3.41087,541,246 - 87,548,186 (-)RGD
Celera1082,476,555 - 82,483,495 (-)RGD
Sequence:
RefSeq Acc Id: NM_145775   ⟹   NP_665718
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,728,348 - 83,733,204 (-)NCBI
Rnor_6.01086,683,875 - 86,688,730 (-)NCBI
Rnor_5.01086,479,868 - 86,486,808 (-)NCBI
RGSC_v3.41087,541,246 - 87,548,186 (-)RGD
Celera1082,476,555 - 82,481,410 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_665718   ⟸   NM_145775
- Peptide Label: isoform 2
- UniProtKB: Q63503 (UniProtKB/Swiss-Prot),   G3V9L8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001106893   ⟸   NM_001113422
- Peptide Label: isoform 1
- UniProtKB: G3V770 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000052200   ⟸   ENSRNOT00000055333
RefSeq Acc Id: ENSRNOP00000012537   ⟸   ENSRNOT00000012537
RefSeq Acc Id: ENSRNOP00000080936   ⟸   ENSRNOT00000117389
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63503-F1-model_v2 AlphaFold Q63503 1-615 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697671
Promoter ID:EPDNEW_R8195
Type:single initiation site
Name:Nr1d1_1
Description:nuclear receptor subfamily 1, group D, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01086,690,773 - 86,690,833EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628827 AgrOrtholog
BioCyc Gene G2FUF-23344 BioCyc
Ensembl Genes ENSRNOG00000009329 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012537 ENTREZGENE
  ENSRNOP00000012537.5 UniProtKB/TrEMBL
  ENSRNOP00000052200 ENTREZGENE
  ENSRNOP00000052200.3 UniProtKB/TrEMBL
  ENSRNOP00000080936.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012537 ENTREZGENE
  ENSRNOT00000012537.8 UniProtKB/TrEMBL
  ENSRNOT00000055333 ENTREZGENE
  ENSRNOT00000055333.3 UniProtKB/TrEMBL
  ENSRNOT00000117389.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598020 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252917 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72288 IMAGE-MGC_LOAD
NCBI Gene 252917 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nr1d1 PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZRE2_RAT UniProtKB/TrEMBL
  G3V770 ENTREZGENE, UniProtKB/TrEMBL
  G3V9L8 ENTREZGENE, UniProtKB/TrEMBL
  NR1D1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6P6S7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Nr1d1  nuclear receptor subfamily 1, group D, member 1      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Nr1d1  nuclear receptor subfamily 1, group D, member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in skeletal muscle and brown fat 728950
gene_other gene overlaps with r-erbA alpha-2 gene 728950