Cacng4 (calcium voltage-gated channel auxiliary subunit gamma 4) - Rat Genome Database

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Gene: Cacng4 (calcium voltage-gated channel auxiliary subunit gamma 4) Rattus norvegicus
Analyze
Symbol: Cacng4
Name: calcium voltage-gated channel auxiliary subunit gamma 4
RGD ID: 628804
Description: Enables ionotropic glutamate receptor binding activity. Involved in positive regulation of AMPA receptor activity and response to cocaine. Located in cell body and cell surface. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcium channel, voltage-dependent, gamma subunit 4; neuronal voltage-gated calcium channel gamma-4 subunit; TARP gamma-4; transmembrane AMPAR regulatory protein gamma-4; voltage-dependent calcium channel gamma-4 subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,183,410 - 93,245,470 (-)NCBIGRCr8
mRatBN7.21092,683,778 - 92,745,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,683,761 - 92,746,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,744,195 - 97,803,686 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,207,217 - 97,266,710 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,615,988 - 92,675,416 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,954,160 - 96,015,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,951,234 - 96,015,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,688,305 - 95,746,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,139,397 - 97,214,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,153,766 - 97,228,814 (-)NCBI
Celera1091,351,585 - 91,410,600 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Identification of Transcription Factor-Gene Regulatory Network in Acute Myocardial Infarction. Cao Y, etal., Heart Lung Circ. 2017 Apr;26(4):343-353. doi: 10.1016/j.hlc.2016.06.1209. Epub 2016 Jul 26.
2. Calcium channel gamma subunits provide insights into the evolution of this gene family. Chu PJ, etal., Gene 2001 Dec 12;280(1-2):37-48.
3. Different Profile of mRNA Expression in Sinoatrial Node from Streptozotocin-Induced Diabetic Rat. Ferdous Z, etal., PLoS One. 2016 Apr 20;11(4):e0153934. doi: 10.1371/journal.pone.0153934. eCollection 2016.
4. Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²¿-permeable AMPA receptors during the incubation of cocaine craving. Ferrario CR, etal., Neuropharmacology. 2011 Dec;61(7):1141-51. doi: 10.1016/j.neuropharm.2011.01.021. Epub 2011 Jan 27.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Distribution of transmembrane AMPA receptor regulatory protein (TARP) isoforms in the rat spinal cord. Larsson M, etal., Neuroscience. 2013 Sep 17;248:180-93. doi: 10.1016/j.neuroscience.2013.05.060. Epub 2013 Jun 7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating. Milstein AD, etal., Neuron. 2007 Sep 20;55(6):905-18.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, etal., Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
15. Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Soto D, etal., Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
16. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. Tomita S, etal., J Cell Biol. 2003 May 26;161(4):805-16. doi: 10.1083/jcb.200212116.
Additional References at PubMed
PMID:15677329   PMID:17670991   PMID:17880893   PMID:18341993   PMID:21127204   PMID:21172611   PMID:22632720  


Genomics

Comparative Map Data
Cacng4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,183,410 - 93,245,470 (-)NCBIGRCr8
mRatBN7.21092,683,778 - 92,745,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,683,761 - 92,746,126 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,744,195 - 97,803,686 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,207,217 - 97,266,710 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,615,988 - 92,675,416 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,954,160 - 96,015,484 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,951,234 - 96,015,499 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,688,305 - 95,746,619 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,139,397 - 97,214,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,153,766 - 97,228,814 (-)NCBI
Celera1091,351,585 - 91,410,600 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
CACNG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381766,964,707 - 67,033,398 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1766,964,707 - 67,033,398 (+)EnsemblGRCh38hg38GRCh38
GRCh371764,960,823 - 65,029,514 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361762,391,475 - 62,459,980 (+)NCBINCBI36Build 36hg18NCBI36
Build 341762,391,474 - 62,459,980NCBI
Celera1761,533,692 - 61,602,193 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1760,402,967 - 60,418,125 (+)NCBIHuRef
CHM1_11765,024,942 - 65,093,343 (+)NCBICHM1_1
T2T-CHM13v2.01767,840,502 - 67,909,206 (+)NCBIT2T-CHM13v2.0
Cacng4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,623,183 - 107,685,532 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,623,183 - 107,685,383 (-)EnsemblGRCm39 Ensembl
GRCm3811107,732,357 - 107,794,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,732,357 - 107,794,557 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,596,094 - 107,655,778 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611107,550,870 - 107,610,554 (-)NCBIMGSCv36mm8
Celera11119,469,632 - 119,528,904 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.29NCBI
Cacng4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554786,219,631 - 6,280,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554786,219,637 - 6,278,759 (+)NCBIChiLan1.0ChiLan1.0
CACNG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21982,993,902 - 83,062,365 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,813,199 - 87,882,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,900,645 - 60,969,659 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11766,159,571 - 66,176,442 (+)NCBIpanpan1.1PanPan1.1panPan2
CACNG4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1913,449,465 - 13,464,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl913,449,450 - 13,462,645 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,344,165 - 14,404,358 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0915,112,749 - 15,172,995 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,112,694 - 15,173,656 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,060,134 - 14,120,341 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0913,413,810 - 13,473,970 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0913,415,469 - 13,475,483 (+)NCBIUU_Cfam_GSD_1.0
Cacng4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,107,963 - 13,143,585 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,053,391 - 6,059,505 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,051,021 - 6,062,275 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1213,391,079 - 13,452,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11213,391,080 - 13,454,542 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,761,277 - 13,824,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11654,413,981 - 54,482,707 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1654,413,965 - 54,482,561 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607725,452,813 - 25,522,456 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacng4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248701,359,806 - 1,419,443 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248701,359,937 - 1,419,458 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacng4
349 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:53
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000004383
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Rat14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,732,621 - 92,732,793 (+)MAPPERmRatBN7.2
Rnor_6.01096,002,695 - 96,002,866NCBIRnor6.0
Rnor_5.01095,733,830 - 95,734,001UniSTSRnor5.0
RGSC_v3.41097,201,655 - 97,201,826UniSTSRGSC3.4
RGSC_v3.41097,201,654 - 97,201,826RGDRGSC3.4
RGSC_v3.11097,216,025 - 97,216,196RGD
Celera1091,397,815 - 91,397,986UniSTS
RH 3.4 Map101027.0RGD
RH 3.4 Map101027.0UniSTS
RH 2.0 Map101129.7RGD
SHRSP x BN Map1073.37RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
D10Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,698,959 - 92,699,242 (+)MAPPERmRatBN7.2
Rnor_6.01095,967,019 - 95,967,298NCBIRnor6.0
Rnor_5.01095,701,164 - 95,701,443UniSTSRnor5.0
RGSC_v3.41097,152,256 - 97,152,538UniSTSRGSC3.4
RGSC_v3.41097,152,234 - 97,152,587RGDRGSC3.4
RGSC_v3.11097,166,626 - 97,166,908RGD
Celera1091,364,444 - 91,364,676UniSTS
RH 3.4 Map101030.5RGD
RH 3.4 Map101030.5UniSTS
RH 2.0 Map101136.8RGD
SHRSP x BN Map1073.35RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
Cacng4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,686,589 - 92,688,050 (+)MAPPERmRatBN7.2
Rnor_6.01095,954,650 - 95,956,110NCBIRnor6.0
Rnor_5.01095,688,795 - 95,690,255UniSTSRnor5.0
RGSC_v3.41097,139,887 - 97,141,347UniSTSRGSC3.4
Celera1091,352,075 - 91,353,535UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 110 79 81 52 23 52 6 206 92 93 45 60 29

Sequence


Ensembl Acc Id: ENSRNOT00000004383   ⟹   ENSRNOP00000004383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,683,761 - 92,746,126 (-)Ensembl
Rnor_6.0 Ensembl1095,951,234 - 96,015,499 (-)Ensembl
RefSeq Acc Id: NM_080692   ⟹   NP_542423
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,183,410 - 93,245,470 (-)NCBI
mRatBN7.21092,683,778 - 92,745,842 (-)NCBI
Rnor_6.01095,954,160 - 96,015,484 (-)NCBI
Rnor_5.01095,688,305 - 95,746,619 (-)NCBI
RGSC_v3.41097,139,397 - 97,214,444 (-)RGD
Celera1091,351,585 - 91,410,600 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_542423 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL50036 (Get FASTA)   NCBI Sequence Viewer  
  EDM06441 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004383.1
  ENSRNOP00055040161
  ENSRNOP00060018424
  ENSRNOP00065025486
GenBank Protein Q8VHW9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_542423   ⟸   NM_080692
- UniProtKB: Q8VHW9 (UniProtKB/Swiss-Prot),   A6HK86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004383   ⟸   ENSRNOT00000004383

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VHW9-F1-model_v2 AlphaFold Q8VHW9 1-327 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628804 AgrOrtholog
BioCyc Gene G2FUF-22888 BioCyc
Ensembl Genes ENSRNOG00000003262 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055028237 UniProtKB/Swiss-Prot
  ENSRNOG00060013608 UniProtKB/Swiss-Prot
  ENSRNOG00065018983 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004383.4 UniProtKB/Swiss-Prot
  ENSRNOT00055048850 UniProtKB/Swiss-Prot
  ENSRNOT00060023225 UniProtKB/Swiss-Prot
  ENSRNOT00065031932 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CACNG_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_g4su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_gsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140725 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 140725 ENTREZGENE
PANTHER PTHR12107:SF7 UniProtKB/Swiss-Prot
  VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacng4 PhenoGen
PRINTS VDCCGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCGAMMA4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003262 RatGTEx
  ENSRNOG00055028237 RatGTEx
  ENSRNOG00060013608 RatGTEx
  ENSRNOG00065018983 RatGTEx
UniProt A6HK86 ENTREZGENE, UniProtKB/TrEMBL
  CCG4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacng4  calcium voltage-gated channel auxiliary subunit gamma 4  Cacng4  calcium channel, voltage-dependent, gamma subunit 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Cacng4  calcium channel, voltage-dependent, gamma subunit 4    voltage-dependent calcium channel gamma-4 subunit  Name updated 1299863 APPROVED
2003-02-27 Cacng4  voltage-dependent calcium channel gamma-4 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL