Usp15 (ubiquitin specific peptidase 15) - Rat Genome Database

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Gene: Usp15 (ubiquitin specific peptidase 15) Rattus norvegicus
Analyze
Symbol: Usp15
Name: ubiquitin specific peptidase 15
RGD ID: 628795
Description: Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Located in cytoplasm and nucleus. Orthologous to human USP15 (ubiquitin specific peptidase 15); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deubiquitinating enzyme 15; deubiquitinating enzyme Ubp109; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin carboxyl-terminal hydrolase of 109 kDa; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15; Ubp109
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
GRCr8 Ensembl760,643,613 - 60,734,099 (-)EnsemblGRCr8 Ensembl
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera755,929,201 - 56,019,813 (-)NCBICelera
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetohydrazide  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-endorphin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
morphine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
streptozocin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IEA,ISO)
mitochondrion  (IEA)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. De-regulated STAT5A/miR-202-5p/USP15/Caspase-6 regulatory axis suppresses CML cell apoptosis and contributes to Imatinib resistance. Nie ZY, etal., J Exp Clin Cancer Res. 2020 Jan 17;39(1):17. doi: 10.1186/s13046-019-1502-7.
6. Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated. Park KC, etal., Biochem J 2000 Jul 15;349(Pt 2):443-53.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12532266   PMID:16005295   PMID:21947082   PMID:22001210   PMID:22344298   PMID:24399297   PMID:24526689   PMID:25002582   PMID:27368102   PMID:31933062   PMID:34088152   PMID:35478295  
PMID:36635430  


Genomics

Comparative Map Data
Usp15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8760,643,611 - 60,805,137 (-)NCBIGRCr8
GRCr8 Ensembl760,643,613 - 60,734,099 (-)EnsemblGRCr8 Ensembl
mRatBN7.2758,756,714 - 58,848,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl758,756,872 - 58,848,721 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx760,630,453 - 60,720,966 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0762,833,103 - 62,923,616 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0762,610,431 - 62,700,867 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0766,595,707 - 66,687,707 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl766,595,742 - 66,687,278 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0766,793,539 - 66,885,533 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4762,871,167 - 62,961,405 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera755,929,201 - 56,019,813 (-)NCBICelera
RGSC_v3.1762,891,896 - 62,982,135 (-)NCBI
Cytogenetic Map7q22NCBI
USP15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381262,260,404 - 62,416,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1262,260,338 - 62,417,431 (+)EnsemblGRCh38hg38GRCh38
GRCh371262,654,185 - 62,810,169 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361260,940,454 - 61,086,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 341260,940,453 - 61,086,165NCBI
Celera1262,323,221 - 62,468,927 (+)NCBICelera
Cytogenetic Map12q14.1NCBI
HuRef1259,705,057 - 59,854,661 (+)NCBIHuRef
CHM1_11262,622,031 - 62,771,333 (+)NCBICHM1_1
T2T-CHM13v2.01262,239,218 - 62,395,185 (+)NCBIT2T-CHM13v2.0
Usp15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910122,940,911 - 123,032,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10122,940,911 - 123,032,900 (-)EnsemblGRCm39 Ensembl
GRCm3810123,105,006 - 123,197,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10123,105,006 - 123,196,995 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710122,550,300 - 122,633,979 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610122,516,304 - 122,599,983 (-)NCBIMGSCv36mm8
Celera10125,493,807 - 125,579,763 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1072.31NCBI
Usp15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554589,403,097 - 9,533,653 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554589,440,645 - 9,533,653 (+)NCBIChiLan1.0ChiLan1.0
USP15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21031,944,328 - 32,090,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11231,937,511 - 32,086,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01226,533,441 - 26,682,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11226,808,337 - 26,954,099 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1226,808,337 - 26,954,099 (-)Ensemblpanpan1.1panPan2
USP15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1105,510,759 - 5,634,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl105,510,022 - 5,634,202 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha105,502,702 - 5,627,025 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0105,544,390 - 5,667,454 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl105,544,428 - 5,668,750 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1105,485,628 - 5,610,126 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0105,734,844 - 5,859,330 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0105,874,448 - 5,998,972 (+)NCBIUU_Cfam_GSD_1.0
Usp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494553,015,395 - 53,131,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936545978,280 - 1,095,659 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936545978,318 - 1,094,729 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USP15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl526,964,553 - 27,097,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1526,964,380 - 27,082,549 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2529,580,789 - 29,800,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USP15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11158,154,905 - 58,300,431 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1158,154,919 - 58,300,522 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037187,509,595 - 187,654,699 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Usp15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248025,560,574 - 5,682,300 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248025,559,107 - 5,682,338 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Usp15
1236 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000031191
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
61435Cia4Collagen induced arthritis QTL 45.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)75999866163890004Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH131414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2758,758,323 - 58,758,425 (-)MAPPERmRatBN7.2
Rnor_6.0766,685,996 - 66,686,097NCBIRnor6.0
Rnor_5.0766,883,822 - 66,883,923UniSTSRnor5.0
RH 3.4 Map7503.7UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001433837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001433850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006241431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_593438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF106657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000031191   ⟹   ENSRNOP00000034485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl760,643,613 - 60,734,099 (-)Ensembl
mRatBN7.2 Ensembl758,756,872 - 58,848,700 (-)Ensembl
Rnor_6.0 Ensembl766,595,742 - 66,686,198 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079410   ⟹   ENSRNOP00000071983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl760,643,613 - 60,734,099 (-)Ensembl
mRatBN7.2 Ensembl758,757,067 - 58,848,721 (-)Ensembl
Rnor_6.0 Ensembl766,624,512 - 66,687,278 (+)Ensembl
RefSeq Acc Id: NM_145184   ⟹   NP_660185
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,613 - 60,734,099 (-)NCBI
mRatBN7.2758,758,223 - 58,848,721 (-)NCBI
Rnor_6.0766,595,742 - 66,686,198 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
RGSC_v3.4762,871,167 - 62,961,405 (-)RGD
Celera755,929,201 - 56,019,813 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241431   ⟹   XP_006241493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,735,305 (-)NCBI
mRatBN7.2758,756,714 - 58,848,778 (-)NCBI
Rnor_6.0766,595,711 - 66,687,707 (+)NCBI
Rnor_5.0766,793,539 - 66,885,533 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765376   ⟹   XP_008763598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,709,300 (-)NCBI
mRatBN7.2758,756,714 - 58,823,442 (-)NCBI
Rnor_6.0766,620,530 - 66,687,707 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078350   ⟹   XP_038934278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,684,187 (-)NCBI
mRatBN7.2758,756,714 - 58,798,800 (-)NCBI
RefSeq Acc Id: XM_039078351   ⟹   XP_038934279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
mRatBN7.2758,756,714 - 58,822,656 (-)NCBI
RefSeq Acc Id: XM_039078353   ⟹   XP_038934281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,670,346 (-)NCBI
mRatBN7.2758,756,714 - 58,784,959 (-)NCBI
RefSeq Acc Id: XM_063262953   ⟹   XP_063119023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,805,137 (-)NCBI
RefSeq Acc Id: XM_063262954   ⟹   XP_063119024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,027 - 60,734,172 (-)NCBI
RefSeq Acc Id: XM_063262955   ⟹   XP_063119025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,653,029 - 60,734,167 (-)NCBI
RefSeq Acc Id: XM_063262956   ⟹   XP_063119026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,643,611 - 60,708,034 (-)NCBI
RefSeq Acc Id: XM_063262957   ⟹   XP_063119027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XM_063262958   ⟹   XP_063119028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,689,660 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052935
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,956 (-)NCBI
RefSeq Acc Id: XR_010052936
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052937
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052938
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,662,405 - 60,735,305 (-)NCBI
RefSeq Acc Id: XR_010052939
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8760,674,796 - 60,735,305 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001420766 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420767 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420768 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420769 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420770 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420771 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420772 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420773 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420774 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420775 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420776 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420777 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420778 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420779 (Get FASTA)   NCBI Sequence Viewer  
  NP_660185 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241493 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763598 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934278 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934279 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934281 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119023 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119025 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119026 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119027 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF14188 (Get FASTA)   NCBI Sequence Viewer  
  EDM16532 (Get FASTA)   NCBI Sequence Viewer  
  EDM16533 (Get FASTA)   NCBI Sequence Viewer  
  EDM16534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034485
  ENSRNOP00000071983
GenBank Protein Q9R085 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_660185   ⟸   NM_145184
- UniProtKB: Q9R085 (UniProtKB/Swiss-Prot),   E9PSP9 (UniProtKB/Swiss-Prot),   A0A0G2K1U1 (UniProtKB/TrEMBL),   A6HQN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241493   ⟸   XM_006241431
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008763598   ⟸   XM_008765376
- Peptide Label: isoform X4
- UniProtKB: Q9R085 (UniProtKB/Swiss-Prot),   E9PSP9 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071983   ⟸   ENSRNOT00000079410
Ensembl Acc Id: ENSRNOP00000034485   ⟸   ENSRNOT00000031191
RefSeq Acc Id: XP_038934279   ⟸   XM_039078351
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038934278   ⟸   XM_039078350
- Peptide Label: isoform X7
- UniProtKB: A6HQP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934281   ⟸   XM_039078353
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063119023   ⟸   XM_063262953
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063119026   ⟸   XM_063262956
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063119024   ⟸   XM_063262954
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063119025   ⟸   XM_063262955
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063119028   ⟸   XM_063262958
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063119027   ⟸   XM_063262957
- Peptide Label: isoform X10
Protein Domains
DUSP   USP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R085-F1-model_v2 AlphaFold Q9R085 1-952 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695238
Promoter ID:EPDNEW_R5762
Type:initiation region
Name:Usp15_1
Description:ubiquitin specific peptidase 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0766,595,766 - 66,595,826EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628795 AgrOrtholog
BioCyc Gene G2FUF-33843 BioCyc
Ensembl Genes ENSRNOG00000023202 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031191 ENTREZGENE
  ENSRNOT00000079410 ENTREZGENE
Gene3D-CATH 3.30.2230.10 UniProtKB/Swiss-Prot
  Cysteine proteinases UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
InterPro DUSP-like_sf UniProtKB/Swiss-Prot
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_C19_DUSP UniProtKB/Swiss-Prot
  Peptidase_C19_UCH UniProtKB/Swiss-Prot
  RNA3'P_cycl/enolpyr_Trfase_a/b UniProtKB/Swiss-Prot
  Ub_carboxyl-term_hydrolase UniProtKB/Swiss-Prot
  Ub_USP-typ UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
  USP_C UniProtKB/Swiss-Prot
  USP_CS UniProtKB/Swiss-Prot
  USP_dom UniProtKB/Swiss-Prot
KEGG Report rno:171329 UniProtKB/Swiss-Prot
NCBI Gene 171329 ENTREZGENE
PANTHER UBIQUITIN CARBOXYL-TERMINAL HYDROLASE UniProtKB/Swiss-Prot
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 UniProtKB/Swiss-Prot
Pfam DUSP UniProtKB/Swiss-Prot
  Ubiquitin_3 UniProtKB/Swiss-Prot
  UCH UniProtKB/Swiss-Prot
  USP7_C2 UniProtKB/Swiss-Prot
PhenoGen Usp15 PhenoGen
PROSITE DUSP UniProtKB/Swiss-Prot
  USP_1 UniProtKB/Swiss-Prot
  USP_2 UniProtKB/Swiss-Prot
  USP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000023202 RatGTEx
SMART DUSP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF143791 UniProtKB/Swiss-Prot
  SSF54001 UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
  SSF55205 UniProtKB/Swiss-Prot
UniProt A0A0A0MY07 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K1U1 ENTREZGENE, UniProtKB/TrEMBL
  A6HQN8 ENTREZGENE, UniProtKB/TrEMBL
  A6HQN9 ENTREZGENE, UniProtKB/TrEMBL
  A6HQP0 ENTREZGENE, UniProtKB/TrEMBL
  E9PSP9 ENTREZGENE
  Q9R085 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E9PSP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Usp15  ubiquitin specific peptidase 15    ubiquitin specific protease 15  Name updated 1299863 APPROVED
2004-02-26 Usp15  ubiquitin specific protease 15      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Usp15  ubiquitin specific protease 15      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is developmentally regulated in liver, spinal cord and brain 634484