![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pxmp4 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PXMP4 mRNA | CTD | PMID:22079256 | Pxmp4 | Rat | 1,2-dichloroethane | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of PXMP4 mRNA | CTD | PMID:28960355 | Pxmp4 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PXMP4 mRNA | CTD | PMID:22206623 | Pxmp4 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PXMP4 mRNA | CTD | PMID:22206623 | Pxmp4 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PXMP4 mRNA | CTD | PMID:17555576 | Pxmp4 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of PXMP4 mRNA | CTD | PMID:32145629 | Pxmp4 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:27291303 | Pxmp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PXMP4 mRNA | CTD | PMID:19490992 | Pxmp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of PXMP4 mRNA | CTD | PMID:29704546 | Pxmp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PXMP4 mRNA | CTD | PMID:21570461 | Pxmp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PXMP4 mRNA | CTD | PMID:22298810 | Pxmp4 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PXMP4 mRNA | CTD | PMID:19770486 and PMID:28922406 | Pxmp4 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Pxmp4 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PXMP4 mRNA | CTD | PMID:21346803 | Pxmp4 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PXMP4 mRNA | CTD | PMID:20188158 | Pxmp4 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PXMP4 mRNA | CTD | PMID:28628672 | Pxmp4 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of PXMP4 mRNA | CTD | PMID:31881176 | Pxmp4 | Rat | acrylamide | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of PXMP4 mRNA | CTD | PMID:32763439 | Pxmp4 | Rat | aflatoxin B1 | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of PXMP4 mRNA | CTD | PMID:22100608 | Pxmp4 | Rat | amiodarone | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Amiodarone results in increased expression of PXMP4 mRNA | CTD | PMID:24489787 | Pxmp4 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PXMP4 mRNA | CTD | PMID:16483693 | Pxmp4 | Rat | aristolochic acid A | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of PXMP4 mRNA | CTD | PMID:33212167 | Pxmp4 | Rat | arsenite(3-) | increases methylation | ISO | PXMP4 (Homo sapiens) | 6480464 | arsenite results in increased methylation of PXMP4 promoter | CTD | PMID:23974009 | Pxmp4 | Rat | benzo[a]pyrene | increases methylation | ISO | PXMP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PXMP4 promoter | CTD | PMID:27901495 | Pxmp4 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PXMP4 mRNA | CTD | PMID:25181051 and PMID:30903817 | Pxmp4 | Rat | bisphenol A | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PXMP4 mRNA | CTD | PMID:28628672 | Pxmp4 | Rat | butanal | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PXMP4 mRNA | CTD | PMID:26079696 | Pxmp4 | Rat | carbon nanotube | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Pxmp4 | Rat | carbon nanotube | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PXMP4 mRNA | CTD | PMID:25620056 | Pxmp4 | Rat | CGP 52608 | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PXMP4 gene] | CTD | PMID:28238834 | Pxmp4 | Rat | chlorpyrifos | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PXMP4 mRNA | CTD | PMID:37019170 | Pxmp4 | Rat | ciguatoxin CTX1B | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of PXMP4 mRNA | CTD | PMID:18353800 | Pxmp4 | Rat | cisplatin | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PXMP4 mRNA | CTD | PMID:27594783 | Pxmp4 | Rat | cyclosporin A | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of PXMP4 mRNA | CTD | PMID:19770486 | Pxmp4 | Rat | dexamethasone | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PXMP4 mRNA | CTD | PMID:28628672 | Pxmp4 | Rat | dibenz[a,h]anthracene | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:26377693 | Pxmp4 | Rat | Dibutyl phosphate | affects expression | ISO | PXMP4 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PXMP4 mRNA | CTD | PMID:37042841 | Pxmp4 | Rat | diquat | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Diquat results in increased expression of PXMP4 mRNA | CTD | PMID:36851058 | Pxmp4 | Rat | dorsomorphin | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PXMP4 mRNA | CTD | PMID:27188386 | Pxmp4 | Rat | epoxiconazole | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | epoxiconazole results in increased expression of PXMP4 mRNA | CTD | PMID:35436446 | Pxmp4 | Rat | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of PXMP4 mRNA | CTD | PMID:17920746 | Pxmp4 | Rat | folic acid | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PXMP4 mRNA | CTD | PMID:22206623 | Pxmp4 | Rat | folic acid | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Folic Acid results in increased expression of PXMP4 mRNA | CTD | PMID:25629700 | Pxmp4 | Rat | indometacin | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PXMP4 mRNA | CTD | PMID:28628672 | Pxmp4 | Rat | indometacin | decreases expression | EXP | | 6480464 | Indomethacin results in decreased expression of PXMP4 mRNA | CTD | PMID:36868495 | Pxmp4 | Rat | isotretinoin | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of PXMP4 mRNA | CTD | PMID:20436886 | Pxmp4 | Rat | linalool | decreases expression | EXP | | 6480464 | linalool results in decreased expression of PXMP4 mRNA | CTD | PMID:20536181 | Pxmp4 | Rat | lipopolysaccharide | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PXMP4 mRNA | CTD | PMID:35811015 | Pxmp4 | Rat | lipopolysaccharide | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Lipopolysaccharides results in decreased expression of PXMP4 mRNA | CTD | PMID:35811015 | Pxmp4 | Rat | menadione | affects expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of PXMP4 mRNA | CTD | PMID:20044591 | Pxmp4 | Rat | metformin | increases expression | EXP | | 6480464 | Metformin results in increased expression of PXMP4 mRNA | CTD | PMID:31324951 | Pxmp4 | Rat | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of PXMP4 mRNA | CTD | PMID:30467583 | Pxmp4 | Rat | methotrexate | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of PXMP4 mRNA | CTD | PMID:24449571 | Pxmp4 | Rat | methylmercury chloride | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PXMP4 mRNA | CTD | PMID:28001369 | Pxmp4 | Rat | monosodium L-glutamate | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | [Sodium Glutamate co-treated with Trans Fatty Acids] results in increased expression of PXMP4 mRNA | CTD | PMID:19001666 | Pxmp4 | Rat | nickel atom | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Nickel results in decreased expression of PXMP4 mRNA | CTD | PMID:24768652 and PMID:25583101 | Pxmp4 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PXMP4 mRNA | CTD | PMID:25729387 | Pxmp4 | Rat | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of PXMP4 mRNA | CTD | PMID:25729387 | Pxmp4 | Rat | oxycodone | increases expression | EXP | | 6480464 | Oxycodone results in increased expression of PXMP4 mRNA | CTD | PMID:23439660 | Pxmp4 | Rat | paracetamol | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PXMP4 mRNA | CTD | PMID:17562736 | Pxmp4 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PXMP4 mRNA | CTD | PMID:32479839 and PMID:33387578 | Pxmp4 | Rat | pentanal | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | pentanal results in decreased expression of PXMP4 mRNA | CTD | PMID:26079696 | Pxmp4 | Rat | perfluorononanoic acid | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of PXMP4 mRNA | CTD | PMID:32588087 | Pxmp4 | Rat | perfluorononanoic acid | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of PXMP4 mRNA | CTD | PMID:25543169 | Pxmp4 | Rat | perfluorooctane-1-sulfonic acid | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | perfluorooctane sulfonic acid results in increased expression of PXMP4 mRNA | CTD | PMID:19429403 and PMID:20936131 | Pxmp4 | Rat | perfluorooctanoic acid | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of PXMP4 mRNA] | CTD | PMID:18467677 | Pxmp4 | Rat | perfluorooctanoic acid | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of PXMP4 mRNA | CTD | PMID:18467677 more ... | Pxmp4 | Rat | phenobarbital | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of PXMP4 mRNA | CTD | PMID:19270015 | Pxmp4 | Rat | phenylmercury acetate | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PXMP4 mRNA | CTD | PMID:26272509 | Pxmp4 | Rat | phenylmercury acetate | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PXMP4 mRNA | CTD | PMID:27188386 | Pxmp4 | Rat | pinosylvin | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | pinosylvin results in increased expression of PXMP4 mRNA | CTD | PMID:23333577 | Pxmp4 | Rat | pirinixic acid | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PXMP4 mRNA | CTD | PMID:19710929 | Pxmp4 | Rat | pirinixic acid | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PXMP4 mRNA | CTD | PMID:17426115 more ... | Pxmp4 | Rat | pirinixic acid | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PXMP4 mRNA and PPARA protein promotes the reaction [pirinixic acid results in increased expression of PXMP4 mRNA] | CTD | PMID:18467677 and PMID:19710929 | Pxmp4 | Rat | potassium chromate | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PXMP4 mRNA | CTD | PMID:22079256 | Pxmp4 | Rat | potassium chromate | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PXMP4 mRNA | CTD | PMID:22079256 | Pxmp4 | Rat | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of PXMP4 mRNA | CTD | PMID:28903501 | Pxmp4 | Rat | resveratrol | increases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | resveratrol results in increased expression of PXMP4 protein | CTD | PMID:25505154 | Pxmp4 | Rat | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of PXMP4 mRNA | CTD | PMID:28374803 | Pxmp4 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of PXMP4 mRNA | CTD | PMID:35811015 | Pxmp4 | Rat | SB 431542 | multiple interactions | ISO | PXMP4 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PXMP4 mRNA | CTD | PMID:27188386 | Pxmp4 | Rat | sevoflurane | affects expression | EXP | | 6480464 | sevoflurane affects the expression of PXMP4 mRNA | CTD | PMID:15967596 | Pxmp4 | Rat | sodium arsenite | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PXMP4 mRNA | CTD | PMID:17879257 | Pxmp4 | Rat | sodium arsenite | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PXMP4 mRNA | CTD | PMID:38568856 | Pxmp4 | Rat | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of PXMP4 mRNA | CTD | PMID:25993096 | Pxmp4 | Rat | succimer | multiple interactions | ISO | Pxmp4 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PXMP4 mRNA | CTD | PMID:21641980 | Pxmp4 | Rat | sunitinib | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PXMP4 mRNA | CTD | PMID:31533062 | Pxmp4 | Rat | tamoxifen | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PXMP4 mRNA | CTD | PMID:17555576 | Pxmp4 | Rat | tetrachloromethane | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PXMP4 mRNA | CTD | PMID:17484886 | Pxmp4 | Rat | thimerosal | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Thimerosal results in decreased expression of PXMP4 mRNA | CTD | PMID:27188386 | Pxmp4 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PXMP4 mRNA | CTD | PMID:34492290 | Pxmp4 | Rat | thiram | decreases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | Thiram results in decreased expression of PXMP4 mRNA | CTD | PMID:38568856 | Pxmp4 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PXMP4 mRNA | CTD | PMID:25729387 | Pxmp4 | Rat | trans-pinosylvin | increases expression | ISO | PXMP4 (Homo sapiens) | 6480464 | pinosylvin results in increased expression of PXMP4 mRNA | CTD | PMID:23333577 | Pxmp4 | Rat | tributylstannane | decreases expression | ISO | Pxmp4 (Mus musculus) | 6480464 | tributyltin results in decreased expression of PXMP4 mRNA | CTD | PMID:31939706 | Pxmp4 | Rat | triphenyl phosphate | affects expression | ISO | PXMP4 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PXMP4 mRNA | CTD | PMID:37042841 | Pxmp4 | Rat | valproic acid | affects expression | ISO | Pxmp4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of PXMP4 mRNA | CTD | PMID:17292431 | Pxmp4 | Rat | vitamin E | increases expression | EXP | | 6480464 | Vitamin E results in increased expression of PXMP4 mRNA | CTD | PMID:28923436 | |