Arhgap17 (Rho GTPase activating protein 17) - Rat Genome Database

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Gene: Arhgap17 (Rho GTPase activating protein 17) Rattus norvegicus
Analyze
Symbol: Arhgap17
Name: Rho GTPase activating protein 17
RGD ID: 628767
Description: Predicted to enable GTPase activator activity. Acts upstream of or within actin filament organization and calcium-ion regulated exocytosis. Located in cytoplasm. Biomarker of acute myocardial infarction. Orthologous to human ARHGAP17 (Rho GTPase activating protein 17); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93451; nadrin; neuron-associated developmentally regulated protein; neuron-associated developmentally-regulated protein; neuron-specific GTPase activating protein; neuron-specific GTPase-activating protein; rho GTPase-activating protein 17; rho-type GTPase-activating protein 17; Rich1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,238,675 - 187,328,093 (-)NCBIGRCr8
mRatBN7.21177,807,579 - 177,897,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,807,583 - 177,896,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,143,532 - 186,232,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,329,522 - 193,418,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,007,252 - 186,096,430 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,239,036 - 193,328,425 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,239,040 - 193,328,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,297,800 - 200,387,169 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,145,313 - 182,234,995 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,285,231 - 182,375,315 (-)NCBI
Celera1175,495,700 - 175,585,527 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
bicellular tight junction  (IEA)
cytoplasm  (IDA,IEA)
cytosol  (IBA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Nadrin, a novel neuron-specific GTPase-activating protein involved in regulated exocytosis. Harada A, etal., J Biol Chem 2000 Nov 24;275(47):36885-91.
3. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12358749   PMID:12477932   PMID:15489334   PMID:22750946  


Genomics

Comparative Map Data
Arhgap17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81187,238,675 - 187,328,093 (-)NCBIGRCr8
mRatBN7.21177,807,579 - 177,897,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,807,583 - 177,896,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,143,532 - 186,232,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01193,329,522 - 193,418,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01186,007,252 - 186,096,430 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01193,239,036 - 193,328,425 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1193,239,040 - 193,328,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01200,297,800 - 200,387,169 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,145,313 - 182,234,995 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,285,231 - 182,375,315 (-)NCBI
Celera1175,495,700 - 175,585,527 (-)NCBICelera
Cytogenetic Map1q36NCBI
ARHGAP17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381624,919,389 - 25,015,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1624,919,389 - 25,015,666 (-)EnsemblGRCh38hg38GRCh38
GRCh371624,930,710 - 25,026,690 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361624,838,211 - 24,934,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341624,838,214 - 24,934,176NCBI
Celera1623,711,720 - 23,807,687 (-)NCBICelera
Cytogenetic Map16p12.1NCBI
HuRef1623,024,541 - 23,120,621 (-)NCBIHuRef
CHM1_11625,944,641 - 26,040,593 (-)NCBICHM1_1
T2T-CHM13v2.01625,199,011 - 25,294,991 (-)NCBIT2T-CHM13v2.0
Arhgap17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397122,878,372 - 122,969,171 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7122,878,441 - 122,969,138 (-)EnsemblGRCm39 Ensembl
GRCm387123,279,149 - 123,369,948 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7123,279,218 - 123,369,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv377130,422,663 - 130,513,429 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367123,070,419 - 123,161,030 (-)NCBIMGSCv36mm8
Celera7123,162,260 - 123,253,139 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map767.42NCBI
Arhgap17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554933,327,584 - 3,384,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554933,326,893 - 3,384,621 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21826,328,248 - 26,428,220 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11630,848,933 - 30,949,020 (-)NCBINHGRI_mPanPan1
PanPan1.11625,160,485 - 25,255,913 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1625,161,229 - 25,220,151 (-)Ensemblpanpan1.1panPan2
ARHGAP17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1621,081,965 - 21,176,685 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl621,073,912 - 21,176,205 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha626,076,872 - 26,171,875 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0621,222,691 - 21,315,817 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl621,222,712 - 21,311,972 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1621,025,615 - 21,120,189 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0620,928,650 - 21,023,425 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0621,323,131 - 21,417,935 (+)NCBIUU_Cfam_GSD_1.0
Arhgap17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344121,159,093 - 121,209,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365019,257,654 - 9,307,230 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365019,256,950 - 9,307,228 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP17
(Sus scrofa - pig)
No map positions available.
ARHGAP17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1522,634,252 - 22,739,810 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl522,640,686 - 22,703,115 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660686,993,921 - 7,091,716 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247829,882,317 - 9,974,090 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247829,881,631 - 9,974,238 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap17
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:663
Count of miRNA genes:215
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000019304, ENSRNOT00000019309, ENSRNOT00000031770
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1164747558181133855Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1166532971191278129Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1172949660181830018Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat

Markers in Region
RH138176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,810,081 - 177,810,202 (+)MAPPERmRatBN7.2
Rnor_6.01193,241,539 - 193,241,659NCBIRnor6.0
Rnor_5.01200,300,303 - 200,300,423UniSTSRnor5.0
RGSC_v3.41182,147,816 - 182,147,936UniSTSRGSC3.4
Celera1175,498,203 - 175,498,323UniSTS
RH 3.4 Map11378.0UniSTS
Cytogenetic Map1q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 32 16 19 16 1 4 53 35 35 11 1
Low 13 25 25 25 7 7 21 6 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_350690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB042827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB060556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB060557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB080637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC145427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000019304   ⟹   ENSRNOP00000019305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,807,583 - 177,896,853 (-)Ensembl
Rnor_6.0 Ensembl1193,239,040 - 193,328,371 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000019309   ⟹   ENSRNOP00000019309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,807,583 - 177,854,061 (-)Ensembl
Rnor_6.0 Ensembl1193,239,040 - 193,328,371 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000031770   ⟹   ENSRNOP00000038504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,807,583 - 177,896,853 (-)Ensembl
Rnor_6.0 Ensembl1193,239,040 - 193,328,371 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097528   ⟹   ENSRNOP00000076440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,807,889 - 177,896,854 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105291   ⟹   ENSRNOP00000080152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,813,699 - 177,896,854 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117754   ⟹   ENSRNOP00000094873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,807,889 - 177,896,854 (-)Ensembl
RefSeq Acc Id: NM_001270692   ⟹   NP_001257621
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,327,936 (-)NCBI
mRatBN7.21177,807,579 - 177,896,853 (-)NCBI
Rnor_6.01193,239,036 - 193,328,371 (-)NCBI
Rnor_5.01200,297,800 - 200,387,169 (-)NCBI
Celera1175,495,700 - 175,585,527 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270693   ⟹   NP_001257622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,327,936 (-)NCBI
mRatBN7.21177,807,579 - 177,896,853 (-)NCBI
Rnor_6.01193,239,036 - 193,328,371 (-)NCBI
Rnor_5.01200,297,800 - 200,387,169 (-)NCBI
Celera1175,495,700 - 175,585,527 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270694   ⟹   NP_001257623
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,327,936 (-)NCBI
mRatBN7.21177,807,579 - 177,896,853 (-)NCBI
Rnor_6.01193,239,036 - 193,328,371 (-)NCBI
Rnor_5.01200,297,800 - 200,387,169 (-)NCBI
Celera1175,495,700 - 175,585,527 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022244   ⟹   NP_071580
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,327,936 (-)NCBI
mRatBN7.21177,807,579 - 177,896,853 (-)NCBI
Rnor_6.01193,239,036 - 193,328,371 (-)NCBI
Rnor_5.01200,297,800 - 200,387,169 (-)NCBI
RGSC_v3.41182,145,313 - 182,234,995 (-)RGD
Celera1175,495,700 - 175,585,527 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230194   ⟹   XP_006230256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,243,186 - 187,328,091 (-)NCBI
mRatBN7.21177,808,286 - 177,897,024 (-)NCBI
Rnor_6.01193,239,785 - 193,328,424 (-)NCBI
Rnor_5.01200,297,800 - 200,387,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089209   ⟹   XP_038945137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,328,093 (-)NCBI
mRatBN7.21177,807,579 - 177,897,027 (-)NCBI
RefSeq Acc Id: XM_039089216   ⟹   XP_038945144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,328,089 (-)NCBI
mRatBN7.21177,807,579 - 177,897,022 (-)NCBI
RefSeq Acc Id: XM_039089217   ⟹   XP_038945145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,238,675 - 187,273,631 (-)NCBI
mRatBN7.21177,807,579 - 177,842,568 (-)NCBI
RefSeq Acc Id: XM_063272630   ⟹   XP_063128700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,243,217 - 187,328,091 (-)NCBI
RefSeq Acc Id: XM_063272639   ⟹   XP_063128709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81187,243,217 - 187,328,088 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001257621 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257622 (Get FASTA)   NCBI Sequence Viewer  
  NP_001257623 (Get FASTA)   NCBI Sequence Viewer  
  NP_071580 (Get FASTA)   NCBI Sequence Viewer  
  XP_006230256 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945137 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945144 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945145 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128700 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128709 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85736 (Get FASTA)   NCBI Sequence Viewer  
  BAB12426 (Get FASTA)   NCBI Sequence Viewer  
  BAB43864 (Get FASTA)   NCBI Sequence Viewer  
  BAB43865 (Get FASTA)   NCBI Sequence Viewer  
  BAB85655 (Get FASTA)   NCBI Sequence Viewer  
  EDM17530 (Get FASTA)   NCBI Sequence Viewer  
  EDM17531 (Get FASTA)   NCBI Sequence Viewer  
  EDM17532 (Get FASTA)   NCBI Sequence Viewer  
  EDM17533 (Get FASTA)   NCBI Sequence Viewer  
  EDM17534 (Get FASTA)   NCBI Sequence Viewer  
  EDM17535 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019305
  ENSRNOP00000019305.8
  ENSRNOP00000019309.8
  ENSRNOP00000038504
  ENSRNOP00000038504.7
  ENSRNOP00000076440
  ENSRNOP00000076440.1
  ENSRNOP00000080152.1
  ENSRNOP00000094873
  ENSRNOP00000094873.1
GenBank Protein Q99N37 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071580   ⟸   NM_022244
- Peptide Label: isoform 2
- UniProtKB: A6I8Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257623   ⟸   NM_001270694
- Peptide Label: isoform 4
- UniProtKB: A0A8I6ALM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257621   ⟸   NM_001270692
- Peptide Label: isoform 1
- UniProtKB: Q99N38 (UniProtKB/Swiss-Prot),   Q8R506 (UniProtKB/Swiss-Prot),   Q9EQV7 (UniProtKB/Swiss-Prot),   Q99N37 (UniProtKB/Swiss-Prot),   F1M6X7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257622   ⟸   NM_001270693
- Peptide Label: isoform 3
- UniProtKB: D4AAV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230256   ⟸   XM_006230194
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y535 (UniProtKB/TrEMBL),   A0A8I5ZP42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038504   ⟸   ENSRNOT00000031770
RefSeq Acc Id: ENSRNOP00000019309   ⟸   ENSRNOT00000019309
RefSeq Acc Id: ENSRNOP00000019305   ⟸   ENSRNOT00000019304
RefSeq Acc Id: XP_038945137   ⟸   XM_039089209
- Peptide Label: isoform X1
- UniProtKB: F1M6X7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945144   ⟸   XM_039089216
- Peptide Label: isoform X4
- UniProtKB: A6I8Z6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945145   ⟸   XM_039089217
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000076440   ⟸   ENSRNOT00000097528
RefSeq Acc Id: ENSRNOP00000094873   ⟸   ENSRNOT00000117754
RefSeq Acc Id: ENSRNOP00000080152   ⟸   ENSRNOT00000105291
RefSeq Acc Id: XP_063128700   ⟸   XM_063272630
- Peptide Label: isoform X2
- UniProtKB: D4AAV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128709   ⟸   XM_063272639
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ALM5 (UniProtKB/TrEMBL)
Protein Domains
BAR   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99N37-F1-model_v2 AlphaFold Q99N37 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690380
Promoter ID:EPDNEW_R905
Type:initiation region
Name:Arhgap17_1
Description:Rho GTPase activating protein 17
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01193,328,403 - 193,328,463EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628767 AgrOrtholog
BioCyc Gene G2FUF-57522 BioCyc
Ensembl Genes ENSRNOG00000013836 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019304 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000019304.8 UniProtKB/Swiss-Prot
  ENSRNOT00000019309.9 UniProtKB/TrEMBL
  ENSRNOT00000031770 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000031770.8 UniProtKB/Swiss-Prot
  ENSRNOT00000097528.1 UniProtKB/TrEMBL
  ENSRNOT00000105291.1 UniProtKB/TrEMBL
  ENSRNOT00000117754 ENTREZGENE
  ENSRNOT00000117754.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130218 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHG17/44/SH3BP1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63994 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93451 IMAGE-MGC_LOAD
NCBI Gene 63994 ENTREZGENE
PANTHER 3BP-1 RELATED RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GTPASE-ACTIVATING PROTEIN 17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgap17 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013836 RatGTEx
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y535 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZP42 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALM5 ENTREZGENE, UniProtKB/TrEMBL
  A6I8Z5_RAT UniProtKB/TrEMBL
  A6I8Z6 ENTREZGENE, UniProtKB/TrEMBL
  A6I8Z7_RAT UniProtKB/TrEMBL
  A6I8Z8_RAT UniProtKB/TrEMBL
  A6I8Z9_RAT UniProtKB/TrEMBL
  A6I900_RAT UniProtKB/TrEMBL
  D4AAV2_RAT UniProtKB/TrEMBL
  D4AAV4 ENTREZGENE, UniProtKB/TrEMBL
  F1M6X7 ENTREZGENE, UniProtKB/TrEMBL
  Q8R506 ENTREZGENE
  Q99N37 ENTREZGENE
  Q99N38 ENTREZGENE
  Q9EQV7 ENTREZGENE
  RHG17_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8R506 UniProtKB/Swiss-Prot
  Q99N38 UniProtKB/Swiss-Prot
  Q9EQV7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Arhgap17  Rho GTPase activating protein 17    nadrin  Name updated 1299863 APPROVED
2004-09-10 Arhgap17  nadrin  Nadrin    Symbol and Name updated 1299863 APPROVED
2003-02-27 Nadrin  nadrin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a GTPase-activating protein domain for Rho family GTPases, a coiled-coil domain, and a run of 29 glutamines 633422