Duox2 (dual oxidase 2) - Rat Genome Database

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Gene: Duox2 (dual oxidase 2) Rattus norvegicus
Analyze
Symbol: Duox2
Name: dual oxidase 2
RGD ID: 628761
Description: Predicted to enable NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in several processes, including hydrogen peroxide biosynthetic process; response to cAMP; and superoxide anion generation. Predicted to act upstream of or within several processes, including bone mineralization; endocrine system development; and thyroid hormone metabolic process. Predicted to be located in several cellular components, including cell leading edge; cell surface; and endoplasmic reticulum. Predicted to be part of NADPH oxidase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 6. Orthologous to human DUOX2 (dual oxidase 2); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: large NOX 2; long NOX 2; NADH/NADPH thyroid oxidase THOX2; Thox2; thyroid oxidase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,680,543 - 129,698,886 (-)NCBIGRCr8
mRatBN7.23109,223,809 - 109,247,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,226,924 - 109,245,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,900,635 - 112,918,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,496,154 - 121,514,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,156,528 - 119,174,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,218,187 - 114,237,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,218,193 - 114,235,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,757,633 - 120,776,304 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,059,360 - 109,077,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,964,932 - 108,982,679 (-)NCBI
Celera3108,124,745 - 108,142,508 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (ISO)
carbon monoxide  (EXP)
cerium trichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
irinotecan  (EXP)
lanthanum trichloride  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
mercaptopurine  (EXP)
methyl vanillate  (ISO)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenylmercury acetate  (ISO)
potassium iodide  (EXP)
purine-6-thiol  (EXP)
pyrethrins  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium nitrate  (EXP)
sotorasib  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thyroxine  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Analysis of the Human Mucosal Response to Cholera Reveals Sustained Activation of Innate Immune Signaling Pathways. Bourque DL, etal., Infect Immun. 2018 Jan 22;86(2). pii: IAI.00594-17. doi: 10.1128/IAI.00594-17. Print 2018 Feb.
2. Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5. Dupuy C, etal., Biochem Biophys Res Commun 2000 Oct 22;277(2):287-92.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung. Kim BJ, etal., Appl Microbiol Biotechnol. 2018 Jan;102(1):105-115. doi: 10.1007/s00253-017-8512-1. Epub 2017 Sep 21.
5. The Induction of Pattern-Recognition Receptor Expression against Influenza A Virus through Duox2-Derived Reactive Oxygen Species in Nasal Mucosa. Kim HJ, etal., Am J Respir Cell Mol Biol. 2015 Oct;53(4):525-35. doi: 10.1165/rcmb.2014-0334OC.
6. Chemiluminescence imaging of Duox2-derived hydrogen peroxide for longitudinal visualization of biological response to viral infection in nasal mucosa. Kim HJ, etal., Theranostics. 2018 Feb 12;8(7):1798-1807. doi: 10.7150/thno.22481. eCollection 2018.
7. The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori. Li H, etal., Dig Dis Sci. 2016 Aug;61(8):2328-2337. doi: 10.1007/s10620-016-4144-z. Epub 2016 Apr 5.
8. DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses. Lipinski S, etal., J Cell Sci. 2009 Oct 1;122(Pt 19):3522-30. doi: 10.1242/jcs.050690.
9. Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. Morand S, etal., Endocrinology 2003 Feb;144(2):567-74.
10. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. Moreno JC, etal., N Engl J Med 2002 Jul 11;347(2):95-102.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12824283   PMID:15062544   PMID:15972824   PMID:16111680   PMID:16651268   PMID:17440044   PMID:19199708   PMID:19339556   PMID:21565790   PMID:22814254   PMID:23675434   PMID:25761904  


Genomics

Comparative Map Data
Duox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,680,543 - 129,698,886 (-)NCBIGRCr8
mRatBN7.23109,223,809 - 109,247,023 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,226,924 - 109,245,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3112,900,635 - 112,918,867 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,496,154 - 121,514,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,156,528 - 119,174,762 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03114,218,187 - 114,237,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,218,193 - 114,235,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,757,633 - 120,776,304 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,059,360 - 109,077,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13108,964,932 - 108,982,679 (-)NCBI
Celera3108,124,745 - 108,142,508 (-)NCBICelera
Cytogenetic Map3q35NCBI
DUOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,092,650 - 45,114,172 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,092,650 - 45,114,172 (-)EnsemblGRCh38hg38GRCh38
GRCh371545,384,848 - 45,406,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,172,144 - 43,193,651 (-)NCBINCBI36Build 36hg18NCBI36
Build 341543,172,144 - 43,193,651NCBI
Celera1522,276,281 - 22,297,794 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,209,058 - 22,230,571 (-)NCBIHuRef
CHM1_11545,503,163 - 45,524,692 (-)NCBICHM1_1
T2T-CHM13v2.01542,900,666 - 42,922,193 (-)NCBIT2T-CHM13v2.0
Duox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,109,727 - 122,129,221 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,109,728 - 122,128,930 (-)EnsemblGRCm39 Ensembl
GRCm382122,279,246 - 122,298,740 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,279,247 - 122,298,449 (-)EnsemblGRCm38mm10GRCm38
MGSCv372122,106,173 - 122,123,901 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362121,971,878 - 121,989,606 (-)NCBIMGSCv36mm8
Celera2123,430,543 - 123,448,297 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.61NCBI
Duox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,271,164 - 8,287,096 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,270,657 - 8,288,201 (+)NCBIChiLan1.0ChiLan1.0
DUOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,333,405 - 34,353,780 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,511,302 - 38,531,933 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,040,513 - 24,061,758 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,393,643 - 42,414,281 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,395,135 - 42,414,281 (-)Ensemblpanpan1.1panPan2
DUOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,521,833 - 11,541,719 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,521,845 - 11,541,716 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,578,140 - 11,598,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,658,603 - 11,679,500 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,658,612 - 11,678,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,564,842 - 11,585,734 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,687,574 - 11,708,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,806,853 - 11,827,575 (-)NCBIUU_Cfam_GSD_1.0
Duox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864089,964,100 - 89,983,254 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,813,128 - 7,831,258 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,812,163 - 7,831,258 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,620,510 - 126,641,406 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,620,468 - 126,641,406 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,221,502 - 141,241,329 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DUOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,090,053 - 38,110,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2638,090,648 - 38,109,636 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048102,947,646 - 102,968,937 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Duox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,122,608 - 14,138,121 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,121,855 - 14,139,344 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Duox2
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:473
Count of miRNA genes:248
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000023939
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)384091273129091273Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 24 106 55 54 23 23 23 6 146 70 86 38 57 31

Sequence


Ensembl Acc Id: ENSRNOT00000023939   ⟹   ENSRNOP00000023939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3109,226,924 - 109,245,902 (-)Ensembl
Rnor_6.0 Ensembl3114,218,193 - 114,235,933 (-)Ensembl
RefSeq Acc Id: NM_024141   ⟹   NP_077055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,680,546 - 129,698,753 (-)NCBI
mRatBN7.23109,226,924 - 109,245,152 (-)NCBI
Rnor_6.03114,218,187 - 114,235,933 (-)NCBI
Rnor_5.03120,757,633 - 120,776,304 (-)NCBI
RGSC_v3.43109,059,360 - 109,077,106 (-)RGD
Celera3108,124,745 - 108,142,508 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105894   ⟹   XP_038961822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,680,543 - 129,698,886 (-)NCBI
mRatBN7.23109,223,809 - 109,247,023 (-)NCBI
RefSeq Acc Id: XM_063284602   ⟹   XP_063140672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,680,543 - 129,698,886 (-)NCBI
RefSeq Acc Id: XM_063284603   ⟹   XP_063140673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,680,543 - 129,698,886 (-)NCBI
Protein Sequences
Protein RefSeqs NP_077055 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961822 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140672 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140673 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG21895 (Get FASTA)   NCBI Sequence Viewer  
  AAN39340 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023939.3
GenBank Protein Q9ES45 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077055   ⟸   NM_024141
- Peptide Label: precursor
- UniProtKB: Q9ES45 (UniProtKB/Swiss-Prot),   Q811Y4 (UniProtKB/Swiss-Prot),   A6HPS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023939   ⟸   ENSRNOT00000023939
RefSeq Acc Id: XP_038961822   ⟸   XM_039105894
- Peptide Label: isoform X1
- UniProtKB: Q9ES45 (UniProtKB/Swiss-Prot),   Q811Y4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063140672   ⟸   XM_063284602
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063140673   ⟸   XM_063284603
- Peptide Label: isoform X3
Protein Domains
EF-hand   FAD-binding FR-type   Ferric oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES45-F1-model_v2 AlphaFold Q9ES45 1-1517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628761 AgrOrtholog
BioCyc Gene G2FUF-48103 BioCyc
Ensembl Genes ENSRNOG00000017395 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023939.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DUOX_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBOH/FRE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79107 UniProtKB/Swiss-Prot
NCBI Gene 79107 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11972:SF67 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferric_reduct UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Duox2 PhenoGen
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_FR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017395 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HPS6 ENTREZGENE, UniProtKB/TrEMBL
  DUOX2_RAT UniProtKB/Swiss-Prot
  G3V8A3_RAT UniProtKB/TrEMBL
  Q811Y4 ENTREZGENE
  Q9ES45 ENTREZGENE
UniProt Secondary Q811Y4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Duox2  dual oxidase 2      Symbol and Name updated 629477 APPROVED
2003-03-07 Duox2  dual oxidase 2  Thox2  NADH/NADPH thyroid oxidase THOX2  Data merged from RGD:621474 628472 PROVISIONAL
2003-02-27 Duox2  dual oxidase 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-08-07 Thox2  NADH/NADPH thyroid oxidase THOX2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in thyroid, intestine, duodenum, and colon 632567