Adipoq (adiponectin, C1Q and collagen domain containing) - Rat Genome Database

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Gene: Adipoq (adiponectin, C1Q and collagen domain containing) Rattus norvegicus
Symbol: Adipoq
Name: adiponectin, C1Q and collagen domain containing
RGD ID: 628748
Description: Enables identical protein binding activity. Involved in several processes, including cellular response to epinephrine stimulus; cellular response to organonitrogen compound; and response to linoleic acid. Located in extracellular space. Part of protein-containing complex. Used to study brain infarction. Biomarker of several diseases, including end stage renal disease; glucose metabolism disease (multiple); hyperthyroidism; obesity; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); liver disease (multiple); primary open angle glaucoma; prostate adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human ADIPOQ (adiponectin, C1Q and collagen domain containing); PARTICIPATES IN adiponectin signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; type 2 diabetes mellitus pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acdc; Acrp30; Adid; adipocyte complement related protein of 30 kDa; adiponectin; adiponectin d
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adipoqm1Mcwi   Adipoqm2Mcwi   Adipoqm3Mcwi   Adipoqem1Mcwi   Adipoqem2Mcwi  
Genetic Models: SS-Adipoqem1Mcwi SS-Adipoqem2Mcwi FHH-Adipoqm2Mcwi FHH-Adipoqm3Mcwi FHH-Adipoqm1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81191,226,524 - 91,240,244 (-)NCBIGRCr8
mRatBN7.21177,721,912 - 77,735,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,721,912 - 77,735,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,472,365 - 86,486,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,110,057 - 79,123,727 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,186,662 - 78,200,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,330,845 - 81,344,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1181,330,293 - 81,344,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01184,363,940 - 84,382,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,908,291 - 79,911,065 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,965,888 - 79,968,654 (-)NCBI
Celera1176,596,543 - 76,599,824 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
3MC syndrome 1  (ISO)
Acute Lung Injury  (ISO)
Alcoholic Fatty Liver  (ISO)
Alzheimer's disease  (ISO)
amyloidosis  (ISO)
ankylosing spondylitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune hepatitis  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
bipolar disorder  (ISO)
brain infarction  (IDA)
breast cancer  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (IDA,IEP,ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
congestive heart failure  (ISO)
coronary aneurysm  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Crohn's disease  (ISO)
dementia  (ISO)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (IEP,ISO)
Endotoxemia  (IEP)
Experimental Arthritis  (IEP,ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
familial hyperlipidemia  (IEP)
familial mediterranean fever  (ISO)
Fetal Growth Retardation  (IEP)
genetic disease  (ISO)
gestational diabetes  (IEP,ISO)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
HIV-Associated Lipodystrophy Syndrome  (ISO)
Human Viral Hepatitis  (ISO)
Huntington's disease  (ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
hyperinsulinism  (IEP)
hypertension  (ISO)
hyperthyroidism  (IEP)
Hypertriglyceridemia  (ISO)
Hypoadiponectinemia  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (IEP,ISO)
Jaundice  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IDA)
Masked Hypertension  (ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
myocardial infarction  (IEP)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
obesity  (IEP,ISO)
Oxygen-Induced Retinopathy  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral artery disease  (ISO)
polycystic ovary syndrome  (ISO)
primary open angle glaucoma  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate adenocarcinoma  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IMP)
Rett syndrome  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IEP,ISO)
sleep apnea  (ISO)
Spinal Cord Injuries  (ISO)
steatotic liver disease  (IEP,ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
tongue squamous cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ulcerative colitis  (ISO)
vascular disease  (ISO)
visual epilepsy  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-schisandrin B  (EXP)
(R)-adrenaline  (EXP)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-aminobenzamide  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-methylumbelliferone  (ISO)
4-nonylphenol  (EXP)
5,6,7,8-tetrahydrobiopterin  (EXP)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
[6]-Shogaol  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetic acid  (EXP)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
allopurinol  (EXP)
alloxan  (EXP)
Aloe emodin  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
avobenzone  (ISO)
benzamides  (ISO)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzyl parahydroxybenzoate  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bongkrekic acid  (ISO)
boric acid  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
calcium silicate  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carvacrol  (EXP)
carvedilol  (ISO)
chrysin  (ISO)
cilazapril monohydrate  (ISO)
cimetidine  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
conjugated linoleic acid  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (EXP)
cyproterone acetate  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
dicamba  (ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
disodium cromoglycate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
efavirenz  (ISO)
Elemicin  (ISO)
enalapril  (ISO)
endrin  (ISO)
equilin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
fentin chloride  (ISO)
flavonoids  (EXP)
fructooligosaccharide  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gadobutrol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
Ganoderic acid A  (ISO)
gemcitabine  (ISO)
geraniol  (EXP)
Gingerenone A  (ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glycine  (ISO)
graphite  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
hemin  (EXP)
hesperetin  (ISO)
hexadecanoic acid  (EXP,ISO)
hispidulin  (ISO)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indometacin  (ISO)
iron dextran  (ISO)
isoflavones  (EXP)
isoscutellarein  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
lamivudine  (ISO)
lead diacetate  (EXP)
letrozole  (EXP)
levonorgestrel  (ISO)
linoleic acid  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lopinavir  (ISO)
losartan  (ISO)
lovastatin  (ISO)
LY294002  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
Melengestrol acetate  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methimazole  (EXP)
metronidazole  (ISO)
mifepristone  (ISO)
mirabegron  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
morin  (EXP)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
naproxen  (ISO)
naringin  (ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nevirapine  (ISO)
nicotinamide  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nitrofen  (EXP)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
norgestrel  (ISO)
norwogonin  (ISO)
nuarimol  (ISO)
octadecanoic acid  (ISO)
Octicizer  (ISO)
octocrylene  (ISO)
olanzapine  (ISO)
oleic acid  (EXP)
oleuropein  (EXP)
omaveloxolone  (ISO)
orientin  (ISO)
orlistat  (EXP,ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paraquat  (ISO)
paricalcitol  (ISO)
PCB138  (ISO)
pencycuron  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
Phenylamil  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
phosphatidylcholine  (ISO)
picolinic acid  (EXP)
pioglitazone  (EXP,ISO)
piperine  (EXP)
pirinixic acid  (ISO)
pluronic P-123  (EXP)
Poloxamer  (EXP)
prednisone  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
raffinose  (ISO)
raloxifene  (ISO)
ramipril  (ISO)
reactive oxygen species  (ISO)
RES-701-1  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
risperidone  (ISO)
ritonavir  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP)
Rutamarin  (ISO)
ruthenium red  (ISO)
salicylic acid  (EXP)
sapropterin  (EXP)
saquinavir  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
scopoletin  (EXP)
serpentine asbestos  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
Sodium oleate  (ISO)
Sophocarpine  (EXP)
spironolactone  (EXP,ISO)
stavudine  (ISO)
stilben-4-ol  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tadalafil  (EXP)
telmisartan  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
Thiocarbohydrazide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
tolylfluanid  (ISO)
topiramate  (ISO)
triamcinolone  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
umbelliferone  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (EXP)
wogonin  (ISO)
XL147  (ISO)
zidovudine  (ISO)
zinc molecular entity  (EXP)
zinc protoporphyrin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brown fat cell differentiation  (ISO,ISS)
cellular response to cAMP  (IDA)
cellular response to epinephrine stimulus  (IDA)
cellular response to insulin stimulus  (IDA,ISO,ISS)
cellular response to xenobiotic stimulus  (ISO,ISS)
circadian rhythm  (IEP)
detection of oxidative stress  (ISO,ISS)
fatty acid beta-oxidation  (ISO,ISS)
fatty acid oxidation  (ISO,ISS,NAS)
gene expression  (ISO)
glucose homeostasis  (ISO,ISS)
glucose metabolic process  (ISO,ISS)
low-density lipoprotein particle clearance  (ISO,ISS)
negative regulation of blood pressure  (ISO,ISS)
negative regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
negative regulation of cell migration  (ISO,ISS)
negative regulation of cold-induced thermogenesis  (ISO,ISS)
negative regulation of DNA biosynthetic process  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (ISO,ISS)
negative regulation of fat cell differentiation  (ISO,ISS)
negative regulation of gluconeogenesis  (ISO,ISS)
negative regulation of granulocyte differentiation  (ISO,ISS)
negative regulation of heterotypic cell-cell adhesion  (ISO,ISS)
negative regulation of hormone secretion  (IDA)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of intracellular protein transport  (ISO,ISS)
negative regulation of macrophage derived foam cell differentiation  (ISO,ISS)
negative regulation of macrophage differentiation  (ISO,ISS)
negative regulation of metanephric mesenchymal cell migration  (ISO,ISS)
negative regulation of phagocytosis  (ISO,ISS)
negative regulation of platelet-derived growth factor receptor signaling pathway  (ISO,ISS)
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway  (ISO,ISS)
negative regulation of protein autophosphorylation  (ISO,ISS)
negative regulation of synaptic transmission  (ISO,ISS)
negative regulation of tumor necrosis factor production  (ISO,ISS)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO,ISS)
negative regulation of vascular associated smooth muscle cell migration  (ISO,ISS)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
positive regulation of cholesterol efflux  (ISO,ISS)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of fatty acid metabolic process  (ISO,ISS)
positive regulation of glucose import  (ISO,ISS)
positive regulation of interleukin-8 production  (ISO,ISS)
positive regulation of metanephric podocyte development  (ISO,ISS)
positive regulation of monocyte chemotactic protein-1 production  (ISO,ISS)
positive regulation of myeloid cell apoptotic process  (ISO,ISS)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein kinase A signaling  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of renal albumin absorption  (ISO,ISS)
positive regulation of signal transduction  (ISO,ISS)
protein localization to plasma membrane  (ISO,ISS)
regulation of glucose metabolic process  (ISO,ISS)
response to activity  (IEP)
response to bacterium  (ISO)
response to ethanol  (IEP)
response to glucocorticoid  (IEP)
response to glucose  (ISO,ISS)
response to hypoxia  (IEP)
response to linoleic acid  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (IEP)
response to sucrose  (IEP)
response to tumor necrosis factor  (ISO,ISS)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA,ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. [Serum and synovial adiponectin, resistin, and visfatin levels in rheumatoid arthritis patients. Relation to disease activity]. Alkady EA, etal., Z Rheumatol. 2011 Sep;70(7):602-8.
2. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. Aprahamian T, etal., J Immunol. 2009 Jan 1;182(1):340-6.
3. Effect of experimental hypo- and hyperthyroidism on serum adiponectin. Aragao CN, etal., Metabolism. 2007 Jan;56(1):6-11.
4. Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients. Arakawa H, etal., Exp Dermatol. 2011 Sep;20(9):764-6. doi: 10.1111/j.1600-0625.2011.01310.x. Epub 2011 May 25.
5. Adiponectin and plant-derived mammalian adiponectin homolog exert a protective effect in murine colitis. Arsenescu V, etal., Dig Dis Sci. 2011 Oct;56(10):2818-32. Epub 2011 Apr 11.
6. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. Bagley HN, etal., J Obes. 2013;2013:312153. doi: 10.1155/2013/312153. Epub 2013 Mar 6.
7. Adiponectin in outpatients with coronary artery disease: Independent predictors and relationship with heart failure. Baldasseroni S, etal., Nutr Metab Cardiovasc Dis. 2011 Oct 25.
8. Increased levels of adipokines in bipolar disorder. Barbosa IG, etal., J Psychiatr Res. 2011 Dec 2.
9. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Bensaid M, etal., Mol Pharmacol 2003 Apr;63(4):908-14.
10. Circadian profile of peripheral hormone levels in sprague-dawley rats and in common marmosets (Callithrix jacchus). Bertani S, etal., In Vivo. 2010 Nov-Dec;24(6):827-36.
11. Long-term plasma levels of leptin and adiponectin in Rett syndrome. Blardi P, etal., Clin Endocrinol (Oxf). 2009 May;70(5):706-9. Epub 2008 Aug 15.
12. Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control. Bobbert P, etal., Eur Heart J. 2011 May;32(9):1134-47. Epub 2011 Jan 29.
13. Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. Bora PS, etal., FEBS J. 2006 Apr;273(7):1403-14.
14. Expression of adiponectin in choroidal tissue and inhibition of laser induced choroidal neovascularization by adiponectin. Bora PS, etal., FEBS Lett. 2007 May 15;581(10):1977-82. Epub 2007 Apr 20.
15. Analysis of serum adiponectin, resistin and leptin levels in children and adolescents with autoimmune thyroid disorders. Bossowski A, etal., J Pediatr Endocrinol Metab. 2010 Apr;23(4):369-77.
16. The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk. Cai X, etal., Clin Transl Oncol. 2014 Feb;16(2):166-72. doi: 10.1007/s12094-013-1056-7. Epub 2013 Jun 6.
17. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats. Cammisotto PG, etal., Am J Physiol Renal Physiol. 2008 Apr;294(4):F881-9. doi: 10.1152/ajprenal.00373.2007. Epub 2008 Feb 6.
18. Increased circulating adiponectin in males with chronic HCV hepatitis. Canavesi E, etal., Eur J Intern Med. 2015 Oct;26(8):635-9. doi: 10.1016/j.ejim.2015.08.001. Epub 2015 Aug 17.
19. Serum leptin, resistin, visfatin and adiponectin levels in tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Cantarini L, etal., Clin Exp Rheumatol. 2012 May-Jun;30(3 Suppl 72):S108-14. Epub 2012 Sep 25.
20. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action. Chen B, etal., Brain Res. 2009 Jun 1;1273:129-37. Epub 2009 Apr 9.
21. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Chen DC, etal., Cancer Lett. 2006 Jun 8;237(1):109-14. Epub 2005 Jul 12.
22. The role of ADIPOQ methylation in curcumin-administrated experimental nonalcoholic fatty liver disease. Chen WJ, etal., J Dig Dis. 2016 Dec;17(12):829-836. doi: 10.1111/1751-2980.12431.
23. Chronic ethanol feeding to rats decreases adiponectin secretion by subcutaneous adipocytes. Chen X, etal., Am J Physiol Endocrinol Metab. 2006 Oct 17;.
24. Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARalpha-heme oxygenase-1 signaling pathway. Cheng CF, etal., J Cell Physiol. 2012 Jan;227(1):239-49. doi: 10.1002/jcp.22726.
25. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Cheng KH, etal., Int J Obes (Lond). 2008 Feb;32(2):268-74. Epub 2007 Sep 18.
26. Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes. Choe EY, etal., Metabolism. 2013 May;62(5):677-85. doi: 10.1016/j.metabol.2012.11.005. Epub 2012 Dec 20.
27. Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity. Declercq V, etal., J Nutr Biochem. 2011 Jun 16.
28. Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Denzel MS, etal., Clin Cancer Res. 2009 May 15;15(10):3256-64. doi: 10.1158/1078-0432.CCR-08-2661. Epub 2009 May 15.
29. Leptin and adiponectin levels in patients with ankylosing spondylitis. The effect of infliximab treatment. Derdemezis CS, etal., Clin Exp Rheumatol. 2010 Nov-Dec;28(6):880-3. Epub 2011 Jan 3.
30. Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? Durazzo M, etal., J Gastroenterol. 2009;44(5):476-82. Epub 2009 Mar 20.
31. Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice. Ebina K, etal., Biochem Biophys Res Commun. 2009 Jan 9;378(2):186-91. Epub 2008 Nov 21.
32. Adiponectin and E-selectin concentrations in relation to inflammation in obese type 2 diabetic patients with coronary heart disease(s). El-Mesallamy HO, etal., Minerva Endocrinol. 2011 Sep;36(3):163-70.
33. Area postrema neurons are modulated by the adipocyte hormone adiponectin. Fry M, etal., J Neurosci. 2006 Sep 20;26(38):9695-702.
34. Mesenteric adipose tissue alterations resulting from experimental reactivated colitis. Gambero A, etal., Inflamm Bowel Dis. 2007 Nov;13(11):1357-64.
35. Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat. Garekani ET, etal., Peptides. 2011 May;32(5):1008-12. Epub 2011 Feb 1.
36. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Glintborg D, etal., Eur J Endocrinol. 2006 Aug;155(2):337-45.
37. Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma. Guo XH, etal., Cancer Sci. 2013 Feb;104(2):206-13. doi: 10.1111/cas.12077. Epub 2013 Jan 20.
38. Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats. Guo Z, etal., J Pharm Pharmacol. 2011 Jan;63(1):87-94. doi: 10.1111/j.2042-7158.2010.01157.x. Epub 2010 Oct 11.
39. Association of adiponectin gene functional polymorphisms (-11377C/G and +45T/G) with nonalcoholic fatty liver disease. Gupta AC, etal., Gene. 2012 Mar 15;496(1):63-7. doi: 10.1016/j.gene.2011.12.023. Epub 2011 Dec 29.
40. Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats. Ha SK, etal., J Comp Pathol. 2011 Jul;145(1):88-94. Epub 2011 Jan 20.
41. Low plasma levels of adiponectin are associated with low risk for future cardiovascular events in patients with clinical evident vascular disease. Hajer GR, etal., Am Heart J. 2007 Oct;154(4):750.e1-7.
42. Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression. Higuchi A, etal., Circ Res. 2009 May 8;104(9):1058-65. doi: 10.1161/CIRCRESAHA.109.194506. Epub 2009 Apr 2.
43. Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia. Honsawek S, etal., BMC Gastroenterol. 2011 Feb 28;11:16.
44. Association of adiponectin gene polymorphism with nonalcoholic fatty liver disease in Taiwanese patients with type 2 diabetes. Hsieh CJ, etal., PLoS One. 2015 Jun 4;10(6):e0127521. doi: 10.1371/journal.pone.0127521. eCollection 2015.
45. Serum leptin and adiponectin levels correlate with severity of allergic rhinitis. Hsueh KC, etal., Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 2):e155-9. doi: 10.1111/j.1399-3038.2009.00878.x. Epub 2009 Aug 30.
46. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hui JM, etal., Hepatology. 2004 Jul;40(1):46-54.
47. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Hui X, etal., Cell Metab. 2015 Aug 4;22(2):279-90. doi: 10.1016/j.cmet.2015.06.004. Epub 2015 Jul 9.
48. SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea. Hwang JY, etal., Eur J Clin Nutr. 2009 Aug 19.
49. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
50. Adiponectin and inflammatory markers in peripheral arterial occlusive disease. Iwashima Y, etal., Atherosclerosis. 2006 Oct;188(2):384-90.
51. Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. Jadhav A and Ndisang JF, Free Radic Biol Med. 2012 Dec 15;53(12):2277-86. doi: 10.1016/j.freeradbiomed.2012.10.529. Epub 2012 Oct 23.
52. Adiponectin protects against Toll-like receptor 4-mediated cardiac inflammation and injury. Jenke A, etal., Cardiovasc Res. 2013 Aug 1;99(3):422-31. doi: 10.1093/cvr/cvt118. Epub 2013 May 13.
53. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Kadowaki T, etal., J Clin Invest. 2006 Jul;116(7):1784-92.
54. Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Kaklamani V, etal., Metabolism. 2011 Sep;60(9):1234-43. doi: 10.1016/j.metabol.2011.01.005. Epub 2011 Mar 12.
55. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Kaklamani VG, etal., Cancer Res. 2008 May 1;68(9):3178-84. doi: 10.1158/0008-5472.CAN-08-0533.
56. Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Karmiris K, etal., Inflamm Bowel Dis. 2006 Feb;12(2):100-5.
57. Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. Kaser S, etal., J Intern Med. 2005 Sep;258(3):274-80.
58. Characteristics of sleep-disordered breathing in Japanese patients with type 2 diabetes mellitus. Kashine S, etal., Metabolism. 2010 May;59(5):690-6. Epub 2009 Nov 14.
59. Serum total and high molecular weight adiponectin levels are correlated with the severity of diabetic retinopathy and nephropathy. Kato K, etal., Clin Endocrinol (Oxf). 2008 Mar;68(3):442-9. Epub 2007 Oct 29.
60. Serum adiponectin levels in patients with familial Mediterranean fever. Keskin G, etal., Protein Pept Lett. 2010 Oct;17(10):1258-62.
61. Extracellular conversion of adiponectin hexamers into trimers. Kim JA, etal., Biosci Rep. 2012 Dec;32(6):641-52. doi: 10.1042/BSR20120067.
62. The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue. Kloting N, etal., Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):146-54.
63. Adiponectin Attenuates Lipopolysaccharide-Induced Acute Lung Injury through Suppression of Endothelial Cell Activation. Konter JM, etal., J Immunol. 2012 Jan 15;188(2):854-63. Epub 2011 Dec 7.
64. Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. Korner A, etal., J Clin Endocrinol Metab. 2007 Mar;92(3):1041-8. Epub 2006 Dec 27.
65. Role of serum adiponectin level in the development of liver cirrhosis in patients with hepatitis C virus. Latif HA, etal., Clin Exp Med. 2011 Jun;11(2):123-9. doi: 10.1007/s10238-010-0108-3. Epub 2010 Aug 17.
66. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. Lee EB, etal., J Neurosci. 2011 Oct 5;31(40):14361-6.
67. Intercellular adhesion molecule, plasma adiponectin and albuminuria in type 2 diabetic patients. Lenghel AR, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):55-61. Epub 2011 Sep 25.
68. Analysis of the association between adiponectin, adiponectin receptor 1 and diabetic cardiomyopathy. Li J, etal., Exp Ther Med. 2014 Apr;7(4):1023-1027. Epub 2014 Feb 12.
69. Therapeutic effect of topical adiponectin in a mouse model of desiccating stress-induced dry eye. Li Z, etal., Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):155-62. doi: 10.1167/iovs.12-10648.
70. Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels. Lihn AS, etal., Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1072-80. Epub 2003 Jul 22.
71. Adiponectin ameliorates iron-overload cardiomyopathy through the PPARalpha-PGC-1-dependent signaling pathway. Lin H, etal., Mol Pharmacol. 2013 Aug;84(2):275-85. doi: 10.1124/mol.112.083964. Epub 2013 May 30.
72. [Expressions of adiponectin and its receptors in the retina of normal and type 1 diabetic mice]. Lin T, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2012 Nov;32(11):1543-7.
73. [Effects of telmisartan on nonalcoholic steatohepatitis rat model by activating peroxisome proliferator-activated receptor r]. Liu JK, etal., Zhonghua Gan Zang Bing Za Zhi. 2011 Aug;19(8):614-8. doi: 10.3760/cma.j.issn.1007-3418.2011.08.013.
74. Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease. Liu R, etal., Transl Res. 2012 Aug;160(2):131-6. doi: 10.1016/j.trsl.2012.01.013. Epub 2012 Feb 2.
75. Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link. Ljubic S, etal., Clin Invest Med. 2009 Aug 1;32(4):E271-9.
76. Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. Lorente-Cebrian S, etal., J Physiol Biochem. 2006 Jun;62(2):61-9.
77. Inhibitory role of adiponectin peptide I on rat choroidal neovascularization. Lyzogubov VV, etal., Biochim Biophys Acta. 2012 Aug;1823(8):1264-72. doi: 10.1016/j.bbamcr.2012.05.017. Epub 2012 May 23.
78. Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. Ma H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):233-7. Epub 2008 Aug 17.
79. Aqueous humor and plasma adiponectin levels in proliferative diabetic retinopathy patients. Mao D, etal., Curr Eye Res. 2012 Sep;37(9):803-8. doi: 10.3109/02713683.2012.676700. Epub 2012 May 7.
80. Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory role. Marousi S, etal., Acta Neurol Scand. 2010 Apr;121(4):277-84. Epub 2009 Dec 28.
81. The effect of polymorphisms in candidate genes on the long-term risk of lipodystrophy and dyslipidemia in HIV-infected white patients starting antiretroviral therapy. Marzocchetti A, etal., AIDS Res Hum Retroviruses. 2011 Dec;27(12):1299-309. doi: 10.1089/aid.2010.0172. Epub 2011 Jun 20.
82. Activation of peroxisome proliferator-activated receptor-alpha inhibits the injurious effects of adiponectin in rat steatotic liver undergoing ischemia-reperfusion. Massip-Salcedo M, etal., Hepatology. 2008 Feb;47(2):461-72.
83. Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling. Medoff BD, etal., Am J Respir Cell Mol Biol. 2009 Oct;41(4):397-406. Epub 2009 Jan 23.
84. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
85. Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema. Miller M, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Dec;299(6):L834-42. Epub 2010 Oct 8.
86. Association of KALRN, ADIPOQ, and FTO gene polymorphism in type 2 diabetic patients with coronary artery disease: possible predisposing markers. Mofarrah M, etal., Coron Artery Dis. 2016 Sep;27(6):490-6. doi: 10.1097/MCA.0000000000000386.
87. Protective effect of soy protein on collagen-induced arthritis in rat. Mohammad Shahi M, etal., Rheumatol Int. 2011 Jun 17.
88. Serum adiponectin, TNF-alpha, IL-12p70, and IL-13 levels in multiple sclerosis and the effects of different therapy regimens. Musabak U, etal., Neuroimmunomodulation. 2011;18(1):57-66. Epub 2010 Aug 17.
89. Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients. Nakasone H, etal., Blood. 2011 Mar 24;117(12):3469-72. Epub 2011 Jan 21.
90. Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus. Nan MH, etal., J Drug Target. 2009 Aug 26.
91. Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice. Nan YM, etal., Scand J Gastroenterol. 2009;44(9):1121-31.
92. Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin-resistant type-2 diabetes. Ndisang JF and Jadhav A, Diabetes Obes Metab. 2013 Nov;15(11):1029-39. doi: 10.1111/dom.12130. Epub 2013 Jun 30.
93. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. Neumeier M, etal., World J Gastroenterol. 2006 Sep 14;12(34):5490-4.
94. Physiological difference between obese (fa/fa) Zucker rats and lean Zucker rats concerning adiponectin. Oana F, etal., Metabolism. 2005 Aug;54(8):995-1001.
95. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Okamoto Y, etal., Circulation. 2002 Nov 26;106(22):2767-70.
96. Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. Osuka K, etal., Neurosci Lett. 2012 Apr 11;514(1):2-5. doi: 10.1016/j.neulet.2011.12.041. Epub 2012 Jan 3.
97. Serum adiponectin and vaspin levels in rheumatoid arthritis. Ozgen M, etal., Arch Med Res. 2010 Aug;41(6):457-63. doi: 10.1016/j.arcmed.2010.08.012.
98. Masked hypertension and atherogenesis: the impact on adiponectin and resistin plasma levels. Papadopoulos DP, etal., J Clin Hypertens (Greenwich). 2009 Feb;11(2):61-5.
99. Adiponectin relates to smooth muscle function and folate in obese children. Pena AS, etal., Int J Pediatr Obes. 2009 Jul 15:1-7.
100. Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models. Phan J, etal., Hum Mol Genet. 2009 Mar 15;18(6):1006-16. Epub 2009 Jan 5.
101. Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans. Phillips SA, etal., Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E767-73. Epub 2009 Jul 21.
102. Obesity and adiponectin in acute myocardial infarction. Piestrzeniewicz K, etal., Cardiol J. 2007;14(1):29-36.
103. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
104. Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease. Poulain M, etal., Chron Respir Dis. 2008;5(1):35-41.
105. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Qi L, etal., Diabetes. 2006 May;55(5):1512-6.
106. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Qiao L, etal., Diabetologia. 2014 May;57(5):1027-36. doi: 10.1007/s00125-014-3180-5. Epub 2014 Feb 16.
107. Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia. Raff H and Bruder ED, Endocrine. 2006 Apr;29(2):341-4.
108. GOA pipeline RGD automated data pipeline
109. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
110. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
111. Comprehensive gene review and curation RGD comprehensive gene curation
112. Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD. Rizza S, etal., Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):54-60. Epub 2008 May 9.
113. Regulation of pituitary cell function by adiponectin. Rodriguez-Pacheco F, etal., Endocrinology. 2007 Jan;148(1):401-10. Epub 2006 Oct 12.
114. Mild obesity reduces survival and adiponectin sensitivity in endotoxemic rats. Sakai S, etal., J Surg Res. 2013 Nov;185(1):353-63. doi: 10.1016/j.jss.2013.06.002. Epub 2013 Jun 25.
115. A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis. Santucci N, etal., PLoS One. 2011;6(10):e26363. Epub 2011 Oct 13.
117. Low adiponectin serum level--reduced protective effect on the left ventricular wall thickness. Selthofer-Relatic K, etal., Coll Antropol. 2011 Sep;35(3):787-91.
118. Role of IRS-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance at late pregnancy. Sevillano J, etal., Endocrinology. 2007 Sep 6;.
119. Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients. Sieminska L, etal., J Endocrinol Invest. 2008 Sep;31(9):745-9.
120. TNF-alpha (g.-308 G > A) and ADIPOQ (g. + 45 T > G) Gene Polymorphisms in Type 2 Diabetes and Microvascular Complications in the Region of Punjab (North-West India). Sikka R, etal., Curr Eye Res. 2014 Mar 21.
121. Immunological and biochemical parameters of patients with metabolic syndrome and the participation of oxidative and nitroactive stress. Simao AN, etal., Braz J Med Biol Res. 2011 Jul;44(7):707-12. Epub 2011 May 27.
122. Maternal serum adiponectin concentration in gestational diabetes. Soheilykhah S, etal., Gynecol Endocrinol. 2009 Jul 16:1-4.
123. Are systemic inflammatory profiles different in patients with COPD and metabolic syndrome as compared to those with COPD alone? Stanciu S, etal., Rom J Intern Med. 2009;47(4):381-6.
124. Short-term regulation of adiponectin secretion in rat adipocytes. Szkudelski T, etal., Physiol Res. 2011;60(3):521-30. Epub 2011 Mar 14.
125. Adiponectin is released from the heart in patients with heart failure. Takano H, etal., Int J Cardiol. 2009 Feb 20;132(2):221-6. Epub 2008 Jan 14.
126. Circulating adiponectin levels in Kawasaki disease. Takeshita S, etal., Acta Paediatr. 2006 Oct;95(10):1312-4.
127. Elevated serum adiponectin level in patients with Mycobacterium avium-intracellulare complex pulmonary disease. Tasaka S, etal., Respiration. 2010;79(5):383-7. Epub 2009 Jul 29.
128. Dietary intake of medium- and long-chain triacylglycerols ameliorates insulin resistance in rats fed a high-fat diet. Terada S, etal., Nutrition. 2012 Jan;28(1):92-7. doi: 10.1016/j.nut.2011.04.008. Epub 2011 Aug 26.
129. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Teras LR, etal., Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2553-7. doi: 10.1158/1055-9965.EPI-09-0542. Epub 2009 Sep 1.
130. Circulating concentrations of adiponectin, an endogenous lipopolysaccharide neutralizing protein, decrease in rats with polymicrobial sepsis. Tsuchihashi H, etal., J Surg Res. 2006 Aug;134(2):348-53. Epub 2006 Feb 20.
131. Effects of pioglitazone on survival and omental adipocyte function in mice with sepsis induced by cecal ligation and puncture. Tsujimura Y, etal., J Surg Res. 2011 Dec;171(2):e215-21. Epub 2011 Sep 9.
132. Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity. Tuttolomondo A, etal., Cardiovasc Diabetol. 2010 Sep 13;9:50.
133. Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. Uji Y, etal., J Surg Res. 2010 Jun 15;161(2):301-11. Epub 2009 Jan 14.
134. Adiponectin in plasma and cerebrospinal fluid in MCI and Alzheimer's disease. Une K, etal., Eur J Neurol. 2011 Jul;18(7):1006-9. doi: 10.1111/j.1468-1331.2010.03194.x. Epub 2010 Aug 18.
135. Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease. Valentini L, etal., Nutrition. 2009 Feb;25(2):172-81. Epub 2008 Oct 11.
136. Biomarkers for Insulin Resistance and Inflammation and the Risk for All-Cause Dementia and Alzheimer Disease: Results From the Framingham Heart Study. van Himbergen TM, etal., Arch Neurol. 2012 Jan 2.
137. Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. Wan R, etal., J Nutr Biochem. 2010 May;21(5):413-7. Epub 2009 May 7.
138. Preventive effects of ophiopogon-polysaccharide on apiponectin in gestational diabetes mellitus rat. Wang H Asian Pac J Trop Med. 2013 Apr 13;6(4):296-9. doi: 10.1016/S1995-7645(13)60059-0.
139. N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats. Wang T, etal., PLoS One. 2011;6(8):e23967. Epub 2011 Aug 30.
140. Fasting serum levels of adiponectin, ghrelin, and leptin in men with spinal cord injury. Wang YH, etal., Arch Phys Med Rehabil. 2005 Oct;86(10):1964-8.
141. Adiponectin--a key adipokine in the metabolic syndrome. Whitehead JP, etal., Diabetes Obes Metab. 2006 May;8(3):264-80.
142. Effects of adiponectin on acute lung injury in cecal ligation and puncture-induced sepsis rats. Xu L, etal., J Surg Res. 2013 Aug;183(2):752-9. doi: 10.1016/j.jss.2013.01.055. Epub 2013 Feb 16.
143. [Effect of electroacupuncture intervention on blood-lipid, high-sensitivity C-reactive protein and adiponectin levels in hyperlipidemia rats]. Yan ZK, etal., Zhen Ci Yan Jiu. 2013 Oct;38(5):365-8, 385.
144. Changes of skeletal muscle adiponectin content in diet-induced insulin resistant rats. Yang B, etal., Biochem Biophys Res Commun. 2006 Mar 3;341(1):209-17. Epub 2006 Jan 9.
145. Gene expression of adiponectin and adiponectin receptor 1 in type 2 diabetic rats and the relationship with the parameters of glucose and lipid metabolism. Yao H, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(3):285-8.
146. Pathophysiological dual action of adiponectin after transient focal ischemia in mouse brain. Yatomi K, etal., Brain Res. 2009 Nov 10;1297:169-76. Epub 2009 Aug 21.
147. Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes. Yaturu S, etal., Cytokine. 2006 May;34(3-4):219-23. Epub 2006 Jul 5.
148. The complex relationship of serum adiponectin to COPD outcomes. Yoon H, etal., Chest. 2011 Dec 29.
149. Changes of adiponectin and its receptors in rats following chronic renal failure. Yu Y, etal., Ren Fail. 2014 Feb;36(1):92-7. doi: 10.3109/0886022X.2013.830975. Epub 2013 Sep 13.
150. Recombinant adiponectin ameliorates liver ischemia reperfusion injury via activating the AMPK/eNOS pathway. Zhang C, etal., PLoS One. 2013 Jun 7;8(6):e66382. doi: 10.1371/journal.pone.0066382. Print 2013.
151. Changes in adiponectin expression in acute myocardial infarction rats and the significance of bisoprolol intervention. Zhang S, etal., Can J Physiol Pharmacol. 2011 Feb;89(2):109-15.
152. IL-10-592 polymorphism is associated with IL-10 expression and severity of enterovirus 71 infection in chinese children. Zhao N, etal., J Clin Virol. 2017 Oct;95:42-46. doi: 10.1016/j.jcv.2017.08.005. Epub 2017 Aug 19.
153. Single nucleotide polymorphisms of metabolic syndrome-related genes in primary open angle glaucoma. Zhou G and Liu B, Int J Ophthalmol. 2010;3(1):36-42. doi: 10.3980/j.issn.2222-3959.2010.01.09. Epub 2010 Mar 18.
154. Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model. Zhu Z, etal., Cancer Prev Res (Phila). 2012 Mar;5(3):414-22. doi: 10.1158/1940-6207.CAPR-11-0454. Epub 2012 Jan 13.
Additional References at PubMed
PMID:7592907   PMID:10403784   PMID:10444069   PMID:10604883   PMID:10961870   PMID:10982546   PMID:11222466   PMID:11479628   PMID:12021245   PMID:12032136   PMID:12068289   PMID:12070119  
PMID:12087086   PMID:12151381   PMID:12429872   PMID:12477932   PMID:12540600   PMID:12660872   PMID:12802337   PMID:12898458   PMID:14522956   PMID:14578283   PMID:14617771   PMID:15210937  
PMID:15231994   PMID:15585515   PMID:16218043   PMID:16410364   PMID:16621799   PMID:16733851   PMID:16889803   PMID:17022944   PMID:17292892   PMID:17321040   PMID:17327451   PMID:17327472  
PMID:17418807   PMID:17565119   PMID:17569760   PMID:17643403   PMID:17660720   PMID:17671736   PMID:17690452   PMID:17693256   PMID:17716811   PMID:17906103   PMID:17912467   PMID:18155694  
PMID:18179777   PMID:18239591   PMID:18327632   PMID:18334666   PMID:18431508   PMID:18492766   PMID:18498888   PMID:18703020   PMID:18761357   PMID:18783346   PMID:18815186   PMID:18941912  
PMID:18948398   PMID:19011089   PMID:19073900   PMID:19084046   PMID:19141678   PMID:19356108   PMID:19460854   PMID:19474526   PMID:19523167   PMID:19524870   PMID:19531641   PMID:19633450  
PMID:19855092   PMID:19958641   PMID:20093130   PMID:20094971   PMID:20117976   PMID:20206399   PMID:20206611   PMID:20226796   PMID:20303976   PMID:20600433   PMID:20702148   PMID:20798331  
PMID:20838752   PMID:21176639   PMID:21357416   PMID:21441829   PMID:21536037   PMID:21557150   PMID:21733354   PMID:21784858   PMID:21868319   PMID:22127636   PMID:22562959   PMID:22575042  
PMID:22582096   PMID:22583869   PMID:22645452   PMID:22808905   PMID:22859860   PMID:22935137   PMID:22956308   PMID:23012479   PMID:23015294   PMID:23111552   PMID:23239819   PMID:23300647  
PMID:23376485   PMID:23392875   PMID:23478100   PMID:23497197   PMID:23667684   PMID:23756398   PMID:23842676   PMID:23867317   PMID:24289757   PMID:24913911   PMID:25065280   PMID:25099270  
PMID:25233838   PMID:25445438   PMID:25480577   PMID:25525608   PMID:25536648   PMID:25703252   PMID:25795513   PMID:25959017   PMID:26108677   PMID:26126515   PMID:26579573   PMID:26616727  
PMID:26639503   PMID:26715807   PMID:26731409   PMID:26823767   PMID:26845040   PMID:27068509   PMID:27923787   PMID:28033741   PMID:28051329   PMID:28219936   PMID:28387990   PMID:28542560  
PMID:28667102   PMID:28841247   PMID:28877872   PMID:28879415   PMID:29115380   PMID:29243095   PMID:29438632   PMID:29750888   PMID:29870775   PMID:30919218   PMID:31708912   PMID:32412814  
PMID:32495657   PMID:32566092   PMID:33271223   PMID:34307691   PMID:34588752   PMID:35720361   PMID:36197773   PMID:36501173   PMID:36765308   PMID:36877358  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81191,226,524 - 91,240,244 (-)NCBIGRCr8
mRatBN7.21177,721,912 - 77,735,644 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1177,721,912 - 77,735,564 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1186,472,365 - 86,486,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01179,110,057 - 79,123,727 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01178,186,662 - 78,200,306 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01181,330,845 - 81,344,488 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1181,330,293 - 81,344,488 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01184,363,940 - 84,382,663 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41179,908,291 - 79,911,065 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11179,965,888 - 79,968,654 (-)NCBI
Celera1176,596,543 - 76,599,824 (-)NCBICelera
Cytogenetic Map11q23NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383186,842,710 - 186,858,463 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3186,842,704 - 186,858,463 (+)EnsemblGRCh38hg38GRCh38
GRCh373186,560,499 - 186,576,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363188,043,157 - 188,058,946 (+)NCBINCBI36Build 36hg18NCBI36
Build 343188,043,164 - 188,058,952NCBI
Celera3184,996,682 - 185,012,474 (+)NCBICelera
Cytogenetic Map3q27.3NCBI
HuRef3183,969,546 - 183,985,186 (+)NCBIHuRef
CHM1_13186,523,992 - 186,539,778 (+)NCBICHM1_1
T2T-CHM13v2.03189,664,780 - 189,680,531 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391622,965,286 - 22,976,718 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1622,965,286 - 22,976,778 (+)EnsemblGRCm39 Ensembl
GRCm381623,146,536 - 23,157,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1623,146,536 - 23,158,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv371623,146,609 - 23,158,041 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361623,061,870 - 23,073,302 (+)NCBIMGSCv36mm8
Celera1623,704,853 - 23,716,285 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1613.96NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542020,912,348 - 20,914,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542020,911,181 - 20,922,992 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22184,727,865 - 184,729,597 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13184,732,580 - 184,734,312 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03183,876,051 - 183,889,723 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13192,341,471 - 192,354,885 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3192,341,320 - 192,354,885 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13419,398,310 - 19,410,519 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3419,354,825 - 19,409,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3423,492,088 - 23,493,907 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03419,309,590 - 19,321,861 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3419,309,535 - 19,321,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13419,349,075 - 19,350,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03419,348,981 - 19,350,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03419,582,218 - 19,584,037 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405602117,076,470 - 117,087,548 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365783,168,331 - 3,171,928 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365783,168,599 - 3,179,369 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl13124,633,685 - 124,646,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113124,633,906 - 124,646,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213134,076,753 - 134,077,342 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11581,128,427 - 81,142,779 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1581,129,795 - 81,147,391 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604154,621,772 - 54,634,568 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473069,941,001 - 69,957,012 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473069,941,963 - 69,959,266 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Adipoq
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:250
Interacting mature miRNAs:295
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21177,722,028 - 77,722,124 (+)MAPPERmRatBN7.2
Rnor_6.01181,330,962 - 81,331,057NCBIRnor6.0
Rnor_5.01184,364,057 - 84,364,152UniSTSRnor5.0
RGSC_v3.41327,240,254 - 27,240,348UniSTSRGSC3.4
RGSC_v3.41179,907,901 - 79,907,996UniSTSRGSC3.4
Celera1176,596,660 - 76,596,755UniSTS
RH 3.4 Map11643.5UniSTS
Cytogenetic Map11q23UniSTS

Genetic Models
This gene Adipoq is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 3 15 7 6 6 18 12 8 6
Low 1 40 42 41 12 41 2 5 74 17 29 3 2
Below cutoff


RefSeq Acc Id: ENSRNOT00000002492   ⟹   ENSRNOP00000002492
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,721,912 - 77,735,564 (-)Ensembl
Rnor_6.0 Ensembl1181,330,845 - 81,344,488 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089988   ⟹   ENSRNOP00000074467
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1177,722,433 - 77,735,564 (-)Ensembl
Rnor_6.0 Ensembl1181,330,293 - 81,334,120 (-)Ensembl
RefSeq Acc Id: NM_144744   ⟹   NP_653345
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81191,226,524 - 91,240,169 (-)NCBI
mRatBN7.21177,721,912 - 77,735,564 (-)NCBI
Rnor_6.01181,330,845 - 81,344,488 (-)NCBI
Rnor_5.01184,363,940 - 84,382,663 (-)NCBI
RGSC_v3.41179,908,291 - 79,911,065 (-)RGD
Celera1176,596,543 - 76,599,824 (-)NCBI
RefSeq Acc Id: XM_039087986   ⟹   XP_038943914
Rat AssemblyChrPosition (strand)Source
GRCr81191,226,524 - 91,240,244 (-)NCBI
mRatBN7.21177,721,912 - 77,735,644 (-)NCBI
RefSeq Acc Id: NP_653345   ⟸   NM_144744
- Peptide Label: precursor
- UniProtKB: Q8K3R4 (UniProtKB/TrEMBL),   A6JS27 (UniProtKB/TrEMBL),   A0A3B0IT73 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074467   ⟸   ENSRNOT00000089988
RefSeq Acc Id: ENSRNOP00000002492   ⟸   ENSRNOT00000002492
RefSeq Acc Id: XP_038943914   ⟸   XM_039087986
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K845 (UniProtKB/TrEMBL)
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3R4-F1-model_v2 AlphaFold Q8K3R4 1-244 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698244
Promoter ID:EPDNEW_R8769
Type:multiple initiation site
Description:adiponectin, C1Q and collagen domain containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01181,344,461 - 81,344,521EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628748 AgrOrtholog
BioCyc Gene G2FUF-20858 BioCyc
Ensembl Genes ENSRNOG00000001821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002492 ENTREZGENE
  ENSRNOT00000002492.6 UniProtKB/TrEMBL
  ENSRNOT00000089988.2 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:246253 UniProtKB/TrEMBL
  PTHR15427:SF20 UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
PhenoGen Adipoq PhenoGen
RatGTEx ENSRNOG00000001821 RatGTEx
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt Secondary A6JS27 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Adipoq  adiponectin, C1Q and collagen domain containing  Acdc  adipocyte complement related protein of 30 kDa  Symbol and Name updated 1299863 APPROVED
2004-09-10 Acdc  adipocyte complement related protein of 30 kDa  Acrp30    Symbol and Name updated 1299863 APPROVED
2003-02-27 Acrp30  adipocyte complement related protein of 30 kDa      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation expression in adipose tissue is induced by the cannabinoid receptor antagonist SR141716 632491