Acox2 (acyl-CoA oxidase 2) - Rat Genome Database

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Gene: Acox2 (acyl-CoA oxidase 2) Rattus norvegicus
Analyze
Symbol: Acox2
Name: acyl-CoA oxidase 2
RGD ID: 628684
Description: Enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 6. Orthologous to human ACOX2 (acyl-CoA oxidase 2); PARTICIPATES IN bile acid biosynthetic pathway; cerebrotendinous xanthomatosis pathway; congenital bile acid synthesis defect pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; acyl-CoA oxidase 2, branched chain; acyl-Coenzyme A oxidase 2; acyl-Coenzyme A oxidase 2, branched chain; peroxisomal acyl-coenzyme A oxidase 2; THCA-CoA oxidase; THCCox; trihydroxycoprostanoyl-CoA oxidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,090,820 - 19,122,392 (+)NCBIGRCr8
mRatBN7.21516,660,584 - 16,692,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,660,272 - 16,692,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1518,836,640 - 18,868,092 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01519,795,088 - 19,826,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,049,986 - 18,081,440 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,449,304 - 18,481,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,451,144 - 18,481,470 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,418,099 - 22,449,500 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,645,349 - 18,677,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,645,348 - 18,677,855 (+)NCBI
Celera1516,620,632 - 16,652,578 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzamides  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
difenoconazole  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
fludioxonil  (ISO)
fluoranthene  (EXP)
flutamide  (EXP)
genistein  (ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GW 4064  (ISO)
GW 7647  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
Triptolide  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase. Baumgart E, etal., Biochem J 1996 Nov 15;320 ( Pt 1):115-21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. Van Veldhoven PP, etal., FEBS Lett. 1996 Jun 10;388(1):80-4.
11. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven PP, etal., J Biol Chem. 1992 Oct 5;267(28):20065-74.
Additional References at PubMed
PMID:2079609   PMID:8943006   PMID:16396499   PMID:16672280   PMID:20178365   PMID:27884763  


Genomics

Comparative Map Data
Acox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81519,090,820 - 19,122,392 (+)NCBIGRCr8
mRatBN7.21516,660,584 - 16,692,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1516,660,272 - 16,692,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1518,836,640 - 18,868,092 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01519,795,088 - 19,826,544 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01518,049,986 - 18,081,440 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01518,449,304 - 18,481,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1518,451,144 - 18,481,470 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01522,418,099 - 22,449,500 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41518,645,349 - 18,677,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11518,645,348 - 18,677,855 (+)NCBI
Celera1516,620,632 - 16,652,578 (+)NCBICelera
Cytogenetic Map15p14NCBI
ACOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38358,505,136 - 58,537,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl358,505,136 - 58,537,283 (-)EnsemblGRCh38hg38GRCh38
GRCh37358,490,863 - 58,522,917 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36358,465,903 - 58,497,956 (-)NCBINCBI36Build 36hg18NCBI36
Build 34358,465,903 - 58,497,956NCBI
Celera358,504,526 - 58,536,479 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef358,587,451 - 58,619,350 (-)NCBIHuRef
CHM1_1358,441,069 - 58,473,060 (-)NCBICHM1_1
T2T-CHM13v2.0358,545,514 - 58,577,544 (-)NCBIT2T-CHM13v2.0
Acox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391414,210,406 - 14,244,262 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1414,210,420 - 14,244,262 (+)EnsemblGRCm39 Ensembl
GRCm38148,225,511 - 8,259,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl148,225,511 - 8,259,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv37149,058,025 - 9,091,533 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36147,019,267 - 7,052,692 (-)NCBIMGSCv36mm8
Celera143,848,464 - 3,882,056 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map144.77NCBI
Acox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554301,638,431 - 1,665,141 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554301,638,931 - 1,665,308 (+)NCBIChiLan1.0ChiLan1.0
ACOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2258,476,727 - 58,508,835 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1358,479,316 - 58,519,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0358,442,532 - 58,474,601 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1359,852,771 - 59,884,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl359,852,771 - 59,884,548 (-)Ensemblpanpan1.1panPan2
ACOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12032,110,788 - 32,141,751 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2032,113,217 - 32,141,734 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2032,035,767 - 32,068,722 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02032,378,012 - 32,411,337 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2032,378,302 - 32,410,072 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12031,836,223 - 31,868,139 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02032,191,158 - 32,224,121 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02032,363,394 - 32,396,348 (+)NCBIUU_Cfam_GSD_1.0
Acox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,355,964 - 169,386,915 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,494,554 - 2,526,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,494,568 - 2,525,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1340,223,010 - 40,255,967 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11340,220,952 - 40,255,967 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21344,232,258 - 44,264,976 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12219,805,736 - 19,838,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2219,804,440 - 19,838,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041146,983,928 - 147,016,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,536,421 - 5,561,781 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,535,086 - 5,561,867 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acox2
185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:23
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000010260
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
AU048401  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01518,469,221 - 18,469,349NCBIRnor6.0
RGSC_v3.41518,666,231 - 18,666,357UniSTSRGSC3.4
Celera1516,640,956 - 16,641,082UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 43 113 91 90 59 25 59 6 211 91 93 45 56 31

Sequence


Ensembl Acc Id: ENSRNOT00000010260   ⟹   ENSRNOP00000010260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,662,472 - 16,692,160 (+)Ensembl
Rnor_6.0 Ensembl1518,451,144 - 18,481,470 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101610   ⟹   ENSRNOP00000095724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1516,660,272 - 16,692,160 (+)Ensembl
RefSeq Acc Id: NM_145770   ⟹   NP_665713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,090,955 - 19,122,392 (+)NCBI
mRatBN7.21516,660,718 - 16,692,160 (+)NCBI
Rnor_6.01518,449,390 - 18,481,470 (+)NCBI
Rnor_5.01522,418,099 - 22,449,500 (+)NCBI
RGSC_v3.41518,645,349 - 18,677,855 (+)RGD
Celera1516,620,632 - 16,652,578 (+)RGD
Sequence:
RefSeq Acc Id: XM_006251743   ⟹   XP_006251805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,091,049 - 19,122,391 (+)NCBI
mRatBN7.21516,660,812 - 16,692,160 (+)NCBI
Rnor_6.01518,449,407 - 18,481,472 (+)NCBI
Rnor_5.01522,418,099 - 22,449,500 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006251744   ⟹   XP_006251806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,090,820 - 19,122,391 (+)NCBI
mRatBN7.21516,660,584 - 16,692,160 (+)NCBI
Rnor_6.01518,449,304 - 18,481,472 (+)NCBI
Rnor_5.01522,418,099 - 22,449,500 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093004   ⟹   XP_038948932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81519,091,332 - 19,122,391 (+)NCBI
mRatBN7.21516,661,097 - 16,692,160 (+)NCBI
RefSeq Acc Id: NP_665713   ⟸   NM_145770
- UniProtKB: P97562 (UniProtKB/Swiss-Prot),   F1LNW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251806   ⟸   XM_006251744
- Peptide Label: isoform X1
- UniProtKB: P97562 (UniProtKB/Swiss-Prot),   F1LNW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251805   ⟸   XM_006251743
- Peptide Label: isoform X1
- UniProtKB: P97562 (UniProtKB/Swiss-Prot),   F1LNW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010260   ⟸   ENSRNOT00000010260
RefSeq Acc Id: XP_038948932   ⟸   XM_039093004
- Peptide Label: isoform X1
- UniProtKB: P97562 (UniProtKB/Swiss-Prot),   F1LNW3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095724   ⟸   ENSRNOT00000101610
Protein Domains
Acyl-CoA oxidase C-terminal   Acyl-coenzyme A oxidase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97562-F1-model_v2 AlphaFold P97562 1-681 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699586
Promoter ID:EPDNEW_R10110
Type:initiation region
Name:Acox2_1
Description:acyl-CoA oxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01518,451,142 - 18,451,202EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628684 AgrOrtholog
BioCyc Gene G2FUF-14293 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000007378 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010260.5 UniProtKB/TrEMBL
  ENSRNOT00000101610.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ACO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACOX_C_alpha1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:252898 UniProtKB/TrEMBL
NCBI Gene 252898 ENTREZGENE
PANTHER PEROXISOMAL ACYL-COENZYME A OXIDASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ACOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACOX_C_alpha1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acox2 PhenoGen
PIRSF Acyl-CoA_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007378 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AM11_RAT UniProtKB/TrEMBL
  A6K0B3_RAT UniProtKB/TrEMBL
  A6K0B4_RAT UniProtKB/TrEMBL
  ACOX2_RAT UniProtKB/Swiss-Prot
  F1LNW3 ENTREZGENE, UniProtKB/TrEMBL
  P97562 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Acox2  acyl-CoA oxidase 2  Acox2  acyl-CoA oxidase 2, branched chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Acox2  acyl-CoA oxidase 2, branched chain  Acox2  acyl-Coenzyme A oxidase 2, branched chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Acox2  acyl-Coenzyme A oxidase 2, branched chain      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Acox2  acyl-Coenzyme A oxidase 2, branched chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_function oxidizes the CoA esters of the bile acid intermediates di- and tri-hyroxycoprostanic acids; does not act on 2-methyl-branched fatty acids 724707
gene_process decreased in liver peroxisomes after treatment with bezafibrate 724759