Tubb3 (tubulin, beta 3 class III) - Rat Genome Database

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Gene: Tubb3 (tubulin, beta 3 class III) Rattus norvegicus
Analyze
Symbol: Tubb3
Name: tubulin, beta 3 class III
RGD ID: 628595
Description: Enables peptide binding activity. Involved in neuron differentiation. Located in axon. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Orthologous to human TUBB3 (tubulin beta 3 class III); PARTICIPATES IN phagocytosis pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron-specific class III beta-tubulin; tubulin beta-3 chain; tubulin, beta 3
RGD Orthologs
Human
Mouse
Dog
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,365,687 - 68,374,741 (+)NCBIGRCr8
mRatBN7.21951,457,187 - 51,466,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,251,389 - 58,260,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,928,868 - 58,937,934 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,149,989 - 61,158,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,220,759 - 56,229,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,931,880 - 66,940,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,742,652 - 53,751,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14155,058,769 - 155,059,105 (+)NCBI
Celera1950,689,724 - 50,698,713 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethylmorpholine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
abamectin  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
Anatoxin a  (ISO)
aristolochic acid A  (ISO)
atorvastatin calcium  (EXP)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
DAPT  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
disulfiram  (ISO)
Doramectin  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
fenpropidin  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glyphosate  (ISO)
heptachlor  (EXP)
Icaritin  (ISO)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead tetraacetate  (ISO)
Licochalcone B  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
niclosamide  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PD123319  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenol red  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
rotenone  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
sarin  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
spiroxamine  (ISO)
sterigmatocystin  (EXP)
sunitinib  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
WIN 55212-2  (ISO)
XL147  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axon  (IDA,ISO)
cell periphery  (ISO)
cytoplasm  (IBA,ISO)
dendrite  (ISO,ISS)
filopodium  (ISO,ISS)
growth cone  (ISO,ISS)
intercellular bridge  (IEA,ISO)
lamellipodium  (ISO,ISS)
microtubule  (IBA,ISO)
microtubule cytoskeleton  (ISO,ISS)
mitotic spindle  (IEA,ISO)
motile cilium  (IEA)
neuronal cell body  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of the 5'-flanking region of the rat neuron-specific Class III beta-tubulin gene. Dennis K, etal., Gene 2002 Jul 10;294(1-2):269-77.
2. Peptide neuroprotection through specific interaction with brain tubulin. Divinski I, etal., J Neurochem. 2006 Aug;98(3):973-84.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. Milochau A, etal., FEBS Lett. 2014 Jun 27;588(14):2217-22. doi: 10.1016/j.febslet.2014.05.031. Epub 2014 May 29.
7. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Olave I, etal., Genes Dev. 2002 Oct 1;16(19):2509-17.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8855335   PMID:12134159   PMID:12477932   PMID:15003631   PMID:15255972   PMID:15277470   PMID:15489334   PMID:16892058   PMID:17761882   PMID:18076286   PMID:18556119   PMID:18614158  
PMID:19036983   PMID:19389377   PMID:20074521   PMID:21499258   PMID:21525035   PMID:21630459   PMID:21734264   PMID:21958528   PMID:22949634   PMID:23090999   PMID:23284756   PMID:23434913  
PMID:23533145   PMID:24378336   PMID:24464040   PMID:25433207   PMID:26561800   PMID:28223217   PMID:28426968   PMID:28483977   PMID:29476059   PMID:31686426  


Genomics

Comparative Map Data
Tubb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81968,365,687 - 68,374,741 (+)NCBIGRCr8
mRatBN7.21951,457,187 - 51,466,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1958,251,389 - 58,260,397 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01958,928,868 - 58,937,934 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01961,149,989 - 61,158,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01956,220,759 - 56,229,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01966,931,880 - 66,940,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41953,742,652 - 53,751,706 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14155,058,769 - 155,059,105 (+)NCBI
Celera1950,689,724 - 50,698,713 (+)NCBICelera
Cytogenetic Map19q12NCBI
TUBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381689,921,925 - 89,936,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1689,921,392 - 89,938,761 (+)EnsemblGRCh38hg38GRCh38
GRCh371689,988,333 - 90,002,505 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,517,246 - 88,530,006 (+)NCBINCBI36Build 36hg18NCBI36
Build 341688,517,245 - 88,530,006NCBI
Celera1675,054,835 - 75,067,595 (+)NCBICelera
Cytogenetic Map16q24.3NCBI
HuRef1675,681,526 - 75,695,522 (+)NCBIHuRef
CHM1_11691,400,537 - 91,414,621 (+)NCBICHM1_1
T2T-CHM13v2.01696,008,170 - 96,022,338 (+)NCBIT2T-CHM13v2.0
Tubb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398124,138,292 - 124,148,754 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8124,138,163 - 124,148,754 (+)EnsemblGRCm39 Ensembl
GRCm388123,411,553 - 123,422,015 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8123,411,424 - 123,422,015 (+)EnsemblGRCm38mm10GRCm38
MGSCv378125,935,464 - 125,945,910 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368126,297,654 - 126,308,100 (+)NCBIMGSCv36mm8
Celera8127,654,088 - 127,664,534 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map872.1NCBI
TUBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1563,681,765 - 63,690,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl563,681,752 - 63,729,684 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha563,694,960 - 63,704,093 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0563,909,742 - 63,918,874 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl563,909,745 - 63,919,020 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1563,930,270 - 63,939,401 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0563,767,793 - 63,776,934 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0564,174,159 - 64,183,292 (-)NCBIUU_Cfam_GSD_1.0
Tubb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934924,431,189 - 24,440,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936641184,765 - 193,819 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936641184,736 - 193,835 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Tubb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624746124,014 - 130,476 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tubb3
46 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:46
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023452
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194997648153225766Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat

Markers in Region
BE108480  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,467,365 - 51,467,573 (+)MAPPERmRatBN7.2
Rnor_6.01956,230,936 - 56,231,143NCBIRnor6.0
Rnor_5.01966,942,053 - 66,942,260UniSTSRnor5.0
RGSC_v3.41953,752,829 - 53,753,036UniSTSRGSC3.4
Celera1950,699,836 - 50,700,043UniSTS
RH 3.4 Map19716.7UniSTS
Cytogenetic Map19q12UniSTS
MARC_24021-24022:1029778648:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,188 - 51,465,794 (+)MAPPERmRatBN7.2
mRatBN7.291,918,543 - 1,919,149 (-)MAPPERmRatBN7.2
Rnor_6.099,967,112 - 9,967,717NCBIRnor6.0
Rnor_6.01956,228,759 - 56,229,364NCBIRnor6.0
Rnor_5.098,966,864 - 8,967,469UniSTSRnor5.0
Rnor_5.01966,939,876 - 66,940,481UniSTSRnor5.0
RGSC_v3.41953,750,652 - 53,751,257UniSTSRGSC3.4
Celera1950,697,659 - 50,698,264UniSTS
Celera96,598,574 - 6,599,179UniSTS
Cytogenetic Map19q12UniSTS
UniSTS:498328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21951,465,873 - 51,466,083 (+)MAPPERmRatBN7.2
Rnor_6.01956,229,444 - 56,229,653NCBIRnor6.0
Rnor_5.01966,940,561 - 66,940,770UniSTSRnor5.0
RGSC_v3.41953,751,337 - 53,751,546UniSTSRGSC3.4
Celera1950,698,344 - 50,698,553UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 216 97 93 43 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023452   ⟹   ENSRNOP00000023452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1951,457,184 - 51,466,243 (+)Ensembl
Rnor_6.0 Ensembl1956,220,755 - 56,229,813 (+)Ensembl
RefSeq Acc Id: NM_139254   ⟹   NP_640347
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81968,365,687 - 68,374,741 (+)NCBI
mRatBN7.21951,457,187 - 51,466,243 (+)NCBI
Rnor_6.01956,220,759 - 56,229,813 (+)NCBI
Rnor_5.01966,931,880 - 66,940,930 (+)NCBI
RGSC_v3.41953,742,652 - 53,751,706 (+)RGD
Celera1950,689,724 - 50,698,713 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_640347 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97281 (Get FASTA)   NCBI Sequence Viewer  
  AAM28680 (Get FASTA)   NCBI Sequence Viewer  
  EDL92810 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023452.3
  ENSRNOP00055029493
  ENSRNOP00060028437
  ENSRNOP00065025528
GenBank Protein Q4QRB4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_640347   ⟸   NM_139254
- UniProtKB: Q6P9T8 (UniProtKB/Swiss-Prot),   Q8K5B6 (UniProtKB/Swiss-Prot),   Q4QRB4 (UniProtKB/Swiss-Prot),   A6IZY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023452   ⟸   ENSRNOT00000023452
Protein Domains
Tubulin/FtsZ 2-layer sandwich   Tubulin/FtsZ GTPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QRB4-F1-model_v2 AlphaFold Q4QRB4 1-450 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701226
Promoter ID:EPDNEW_R11750
Type:single initiation site
Name:Tubb3_1
Description:tubulin, beta 3 class III
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01956,220,755 - 56,220,815EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628595 AgrOrtholog
BioCyc Gene G2FUF-5325 BioCyc
Ensembl Genes ENSRNOG00000017209 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055021245 UniProtKB/Swiss-Prot
  ENSRNOG00060019993 UniProtKB/Swiss-Prot
  ENSRNOG00065019010 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023452.7 UniProtKB/Swiss-Prot
  ENSRNOT00055036301 UniProtKB/Swiss-Prot
  ENSRNOT00060034625 UniProtKB/Swiss-Prot
  ENSRNOT00065031986 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.600 UniProtKB/Swiss-Prot
  3.30.1330.20 UniProtKB/Swiss-Prot
  3.40.50.1440 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/TrEMBL
  Tubulin/FtsZ, C-terminal domain UniProtKB/TrEMBL
  Tubulin/FtsZ, GTPase domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7461390 IMAGE-MGC_LOAD
InterPro Beta-tubulin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta_tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tub_FtsZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ-like_C UniProtKB/TrEMBL
  Tubulin/FtsZ_2-layer-sand-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin/FtsZ_C_sf UniProtKB/Swiss-Prot
  Tubulin/FtsZ_GTPase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_FtsZ_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246118 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114260 IMAGE-MGC_LOAD
NCBI Gene 246118 ENTREZGENE
PANTHER PTHR11588 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN BETA-3 CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tubb3 PhenoGen
PRINTS BETATUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TUBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUBULIN_B_AUTOREG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017209 RatGTEx
  ENSRNOG00055021245 RatGTEx
  ENSRNOG00060019993 RatGTEx
  ENSRNOG00065019010 RatGTEx
SMART Tubulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52490 UniProtKB/Swiss-Prot
  SSF55307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tubulin nucleotide-binding domain-like UniProtKB/TrEMBL
UniProt A6IZY2 ENTREZGENE, UniProtKB/TrEMBL
  Q4QRB4 ENTREZGENE
  Q6P9T8 ENTREZGENE
  Q8K5B6 ENTREZGENE
  TBB3_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K5B6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-19 Tubb3  tubulin, beta 3 class III  Tubb3  tubulin, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-12 Tubb3  tubulin, beta 3  Tubb3  tubulin, beta 3 class III  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-10-10 Tubb3  tubulin, beta 3 class III  Tubb3  tubulin, beta 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tubb3  tubulin, beta 3      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Tubb3  tubulin, beta 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference