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Gene: G6pc1 (glucose-6-phosphatase catalytic subunit 1) Rattus rattus

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Symbol:

G6pc1

Name:

glucose-6-phosphatase catalytic subunit 1

RGD ID:

626108853

Description:

ENCODES a protein that exhibits glucose-6-phosphatase activity (ortholog); phosphate ion binding (ortholog); phosphotransferase activity, alcohol group as acceptor (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cholesterol homeostasis (ortholog); gluconeogenesis (ortholog); PARTICIPATES IN altered galactose metabolic pathway; Fanconi syndrome pathway; forkhead class A signaling pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Dwarfism (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN endoplasmic reticulum (ortholog); membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

G6pc; glucose-6-phosphatase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly

Position:

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	60,665,700 - 60,677,140 (+)	NCBI		Rrattus_CSIRO_v1

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Dwarfism (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

Fetal Growth Retardation (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

glycogen storage disease (ISO)

glycogen storage disease I (ISO)

glycogen storage disease Ia (ISO)

hepatocellular carcinoma (ISO)

hypoglycemia (ISO)

Liver Failure (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Metabolic Syndrome (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

cholesterol homeostasis (ISO)

gluconeogenesis (ISO)

glucose 6-phosphate metabolic process (ISO)

glucose homeostasis (ISO)

glucose-6-phosphate transport (ISO)

glycogen catabolic process (ISO)

glycogen metabolic process (ISO)

lipid homeostasis (ISO)

multicellular organism growth (ISO)

regulation of gene expression (ISO)

response to caloric restriction (ISO)

response to carbohydrate (ISO)

response to food (ISO)

response to insulin (ISO)

response to nutrient levels (ISO)

response to resveratrol (ISO)

steroid metabolic process (ISO)

triglyceride metabolic process (ISO)

urate metabolic process (ISO)

Cellular Component

endoplasmic reticulum (ISO)

membrane (ISO)

Molecular Function

glucose-6-phosphatase activity (ISO)

phosphate ion binding (ISO)

phosphotransferase activity, alcohol group as acceptor (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

altered galactose metabolic pathway (ISO)

Fanconi syndrome pathway (ISO)

forkhead class A signaling pathway (ISO)

fructose-1,6-bisphosphatase deficiency pathway (ISO)

galactose metabolic pathway (ISO)

galactosemia pathway (ISO)

gluconeogenesis pathway (ISO)

Glut1 deficiency syndrome pathway (ISO)

glycogen storage disease type Ia pathway (ISO)

glycogen storage disease type Ib pathway (ISO)

glycogen storage disease type VII pathway (ISO)

glycolysis pathway (ISO)

lactose biosynthetic pathway (ISO)

phosphoenolpyruvate carboxykinase deficiency pathway (ISO)

triosephosphate isomerase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

G6pc1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	60,665,700 - 60,677,140 (+)	NCBI		Rrattus_CSIRO_v1

G6PC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,900,799 - 42,914,438 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,900,797 - 42,914,438 (+)	Ensembl			hg38	GRCh38
GRCh37	17	41,052,816 - 41,066,455 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	38,306,341 - 38,318,912 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	38,306,340 - 38,318,912	NCBI
Celera	17	37,708,948 - 37,721,525 (+)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	36,817,624 - 36,831,212 (+)	NCBI		HuRef
CHM1_1	17	41,288,425 - 41,302,053 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	43,757,942 - 43,771,581 (+)	NCBI		T2T-CHM13v2.0

G6pc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	101,258,542 - 101,268,729 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	101,258,387 - 101,268,729 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	101,367,716 - 101,377,903 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	101,367,561 - 101,377,903 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	101,229,044 - 101,239,217 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	101,183,820 - 101,193,993 (+)	NCBI		MGSCv36	mm8
MGSCv36	11	102,147,317 - 102,157,491 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	D	NCBI
cM Map	11	64.83	NCBI

G6pc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	86,807,659 - 86,819,023 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	86,757,899 - 86,818,033 (+)	Ensembl				GRCr8
mRatBN7.2	10	86,307,400 - 86,318,766 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,257,668 - 86,333,804 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	91,345,012 - 91,356,309 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,819,762 - 90,831,058 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	86,213,072 - 86,224,369 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	89,286,009 - 89,296,213 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	89,285,855 - 89,296,213 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	89,084,064 - 89,094,265 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	90,393,531 - 90,403,485 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	85,025,492 - 85,036,580 (+)	NCBI		Celera
RGSC_v3.1	10	90,407,938 - 90,417,855 (+)	NCBI
RH 3.4 Map	10	837.1	RGD
Cytogenetic Map	10	q31	NCBI

G6pc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	16,672,979 - 16,680,001 (+)	Ensembl
ChiLan1.0	NW_004955451	16,672,512 - 16,680,001 (+)	NCBI	ChiLan1.0	ChiLan1.0

G6PC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	22,072,152 - 22,087,542 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	23,961,401 - 23,976,773 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	14,407,355 - 14,419,660 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	14,635,667 - 14,646,674 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	14,635,667 - 14,646,674 (-)	Ensembl			panPan2	panpan1.1

G6PC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,132,973 - 20,143,642 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	20,132,978 - 20,143,642 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	19,594,513 - 19,605,089 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	20,851,596 - 20,862,184 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	20,852,175 - 20,862,060 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	19,636,449 - 19,647,026 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	19,902,743 - 19,913,338 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,005,407 - 20,015,994 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

G6pc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	19,459,203 - 19,469,287 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	17,605,865 - 17,615,145 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	17,605,865 - 17,614,754 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

G6PC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	19,965,330 - 19,975,857 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	19,965,885 - 19,975,783 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

G6PC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	63,380,921 - 63,392,122 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	63,381,382 - 63,391,540 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	34,170,149 - 34,181,234 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

G6pc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	1,331,601 - 1,339,580 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624795	1,331,592 - 1,339,575 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_032912858	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_032912859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAAIVD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_032912858 ⟹ XP_032768749

Type:

CODING

Position:

Black Rat Assembly	Chr	Position (strand)	Source
Rrattus_CSIRO_v1	9	60,665,700 - 60,677,140 (+)	NCBI

RefSeq Acc Id:

XM_032912859 ⟹ XP_032768750

Type:

CODING

Position:

Black Rat Assembly	Chr	Position (strand)	Source
Rrattus_CSIRO_v1	9	60,665,778 - 60,675,503 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_032768749	(Get FASTA)	NCBI Sequence Viewer
	XP_032768750	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_032768749 ⟸ XM_032912858
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_032768750 ⟸ XM_032912859
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	G6pc1	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - PID (archival)