Tpmt (thiopurine S-methyltransferase) - Rat Genome Database

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Gene: Tpmt (thiopurine S-methyltransferase) Rattus rattus
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Symbol: Tpmt
Name: thiopurine S-methyltransferase
RGD ID: 626097598
Description: ENCODES a protein that exhibits S-adenosyl-L-methionine binding (ortholog); thiopurine S-methyltransferase activity (ortholog); INVOLVED IN response to testosterone (ortholog); xenobiotic metabolic process (ortholog); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); alopecia (ortholog); autism spectrum disorder (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly
Position:
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11466,018,278 - 66,036,277 (-)NCBIRrattus_CSIRO_v1



Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tpmt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11466,018,278 - 66,036,277 (-)NCBIRrattus_CSIRO_v1
TPMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38618,128,311 - 18,155,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl618,128,311 - 18,155,348 (-)Ensemblhg38GRCh38
GRCh37618,128,542 - 18,155,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36618,236,521 - 18,263,353 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34618,059,377 - 18,263,263NCBI
Celera619,366,550 - 19,393,384 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef618,072,922 - 18,099,749 (-)NCBIHuRef
CHM1_1618,131,149 - 18,157,981 (-)NCBICHM1_1
T2T-CHM13v2.0618,000,482 - 18,027,339 (-)NCBIT2T-CHM13v2.0
Tpmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391347,175,463 - 47,196,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1347,175,958 - 47,198,213 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381347,021,987 - 47,043,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1347,022,482 - 47,044,737 (-)Ensemblmm10GRCm38
MGSCv371347,118,912 - 47,138,586 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361347,036,149 - 47,054,175 (-)NCBIMGSCv36mm8
Celera1348,108,353 - 48,127,836 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.5NCBI
Tpmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81717,850,308 - 17,868,976 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1717,850,279 - 17,868,976 (+)EnsemblGRCr8
mRatBN7.21717,644,088 - 17,662,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,644,173 - 17,662,709 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1717,529,367 - 17,547,810 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,133,224 - 19,151,667 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,456,484 - 17,474,931 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensemblrn6Rnor6.0
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
Tpmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554838,052,849 - 8,072,764 (+)Ensembl
ChiLan1.0NW_0049554838,052,867 - 8,072,235 (+)NCBIChiLan1.0ChiLan1.0
TPMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2532,789,158 - 32,814,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1628,774,422 - 28,799,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0617,977,544 - 18,002,839 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1618,330,000 - 18,355,201 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl618,330,000 - 18,355,157 (-)EnsemblpanPan2panpan1.1
TPMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13516,928,991 - 16,953,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3516,929,240 - 16,953,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3516,879,116 - 16,902,874 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03517,035,847 - 17,060,453 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3517,035,872 - 17,060,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13516,849,193 - 16,872,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03516,906,511 - 16,930,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03518,237,408 - 18,261,325 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tpmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049467,813,141 - 7,831,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365523,897,375 - 3,917,772 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365523,899,445 - 3,917,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl713,820,866 - 13,846,012 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1713,821,656 - 13,846,107 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2714,563,347 - 14,587,813 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11753,987,561 - 54,012,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1753,987,559 - 54,014,650 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604418,353,974 - 18,379,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247568,511,315 - 8,531,745 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247568,511,275 - 8,532,100 (+)NCBIHetGla 1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_032884817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAAIVD010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_032884817   ⟹   XP_032740708
Type: CODING
Position:
Black Rat AssemblyChrPosition (strand)Source
Rrattus_CSIRO_v11466,018,278 - 66,036,277 (-)NCBI
Protein Sequences
Protein RefSeqs XP_032740708 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_032740708   ⟸   XM_032884817


Additional Information

Database Acc Id Source(s)
NCBI Gene Tpmt ENTREZGENE